DE602006003420D1 - Virusreinigung mit ultrafiltration - Google Patents

Virusreinigung mit ultrafiltration

Info

Publication number
DE602006003420D1
DE602006003420D1 DE602006003420T DE602006003420T DE602006003420D1 DE 602006003420 D1 DE602006003420 D1 DE 602006003420D1 DE 602006003420 T DE602006003420 T DE 602006003420T DE 602006003420 T DE602006003420 T DE 602006003420T DE 602006003420 D1 DE602006003420 D1 DE 602006003420D1
Authority
DE
Germany
Prior art keywords
ultra filtration
virus
virus cleaning
cleaning
adenovirus
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602006003420T
Other languages
English (en)
Inventor
Miranda Weggeman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Vaccines and Prevention BV
Original Assignee
Crucell Holand BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36572264&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE602006003420(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Crucell Holand BV filed Critical Crucell Holand BV
Publication of DE602006003420D1 publication Critical patent/DE602006003420D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011Details
    • C12N2710/10011Adenoviridae
    • C12N2710/10051Methods of production or purification of viral material

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Virology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
DE602006003420T 2005-04-11 2006-04-11 Virusreinigung mit ultrafiltration Active DE602006003420D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US67006405P 2005-04-11 2005-04-11
EP05102842 2005-04-11
PCT/EP2006/003722 WO2006108707A1 (en) 2005-04-11 2006-04-11 Virus purification using ultrafiltration

Publications (1)

Publication Number Publication Date
DE602006003420D1 true DE602006003420D1 (de) 2008-12-11

Family

ID=36572264

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602006003420T Active DE602006003420D1 (de) 2005-04-11 2006-04-11 Virusreinigung mit ultrafiltration

Country Status (10)

Country Link
US (1) US8574595B2 (de)
EP (1) EP1869171B2 (de)
CN (1) CN101155915B (de)
AT (1) ATE412737T1 (de)
AU (1) AU2006233800B2 (de)
CA (1) CA2602944C (de)
DE (1) DE602006003420D1 (de)
DK (1) DK1869171T4 (de)
ES (1) ES2317517T5 (de)
WO (1) WO2006108707A1 (de)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006052302A2 (en) * 2004-11-03 2006-05-18 Introgen Therapeutics Inc. Method of producing and purifying adenoviral vectors
EP1998804B1 (de) * 2006-03-27 2014-04-16 Crucell Holland B.V. Zusammensetzungen, die einen rekombinanten adenovirus und ein adjuvans umfassen
FR2907453B1 (fr) 2006-10-24 2008-12-26 Sanofi Aventis Sa Nouveaux derives du fluorene,compositions les contenant et utilisation
US20080131955A1 (en) * 2006-11-30 2008-06-05 Canon U.S. Life Sciences, Inc. Method of Separating Target DNA from Mixed DNA
PL2195418T3 (pl) * 2007-10-02 2013-05-31 Ptc Phage Tech Center Gmbh Sposób i układ do oczyszczania na skalę przemysłową bakteriofagów z przeznaczeniem do terapii bakteriofagowej
DK2242479T3 (da) * 2007-12-28 2012-01-02 Baxter Int Modtryksfiltrering af proteiner
US10273502B2 (en) * 2008-06-18 2019-04-30 Oxford Biomedica (Uk) Limited Virus purification
AU2009319254B2 (en) 2008-11-03 2015-04-30 Janssen Vaccines & Prevention B.V. Method for the production of adenoviral vectors
FR2944292B1 (fr) 2009-04-08 2013-08-23 Sanofi Pasteur Procede de purification du virus rabique
CN102791852B (zh) 2009-10-15 2014-05-07 克鲁塞尔荷兰公司 纯化腺病毒颗粒的方法
DK2488635T3 (en) 2009-10-15 2014-02-24 Crucell Holland Bv A method for purifying adenovirus of cultures with high cell density
MX2012007936A (es) 2010-02-15 2012-11-22 Crucell Holland Bv Metodo para la produccion de vectores adenovirales del serotipo 26 del adenovirus.
SG184833A1 (en) 2010-04-14 2012-11-29 Emd Millipore Corp Methods of producing high titer, high purity virus stocks and methods of use thereof
KR20130109004A (ko) * 2010-06-01 2013-10-07 노파르티스 아게 동결건조하지 않는 인플루엔자 백신 항원의 농축
WO2012019354A1 (en) 2010-08-12 2012-02-16 Yisheng Biopharma Holdings Ltd. Method for reducing dna impurities in viral compositions
CN103118702A (zh) 2010-09-20 2013-05-22 克鲁塞尔荷兰公司 活动性结核病的治疗性接种
AU2011310838B2 (en) 2010-09-27 2015-11-05 Crucell Holland B.V. Heterologous prime boost vaccination regimen against malaria
EP2697369B1 (de) 2011-03-25 2018-06-27 F.Hoffmann-La Roche Ag Neue proteinreinigungsverfahren
ES2813413T3 (es) 2011-08-05 2021-03-23 Sillajen Biotherapeutics Inc Métodos y composiciones para la producción de virus vaccina
CN102688485A (zh) * 2011-09-16 2012-09-26 扬州优邦生物制药有限公司 一种猪细小病毒灭活疫苗的制备方法
US20130122038A1 (en) 2011-11-14 2013-05-16 The United States Of America As Represented By The Secretary Of The Department Heterologous prime-boost immunization using measles virus-based vaccines
WO2013106337A1 (en) * 2012-01-09 2013-07-18 Sanofi Pasteur Biologics, Llc Purification of flaviviruses
KR102044051B1 (ko) 2012-03-12 2019-11-12 얀센 백신스 앤드 프리벤션 비.브이. 터미널 말단이 변경된 재조합 아데노바이러스의 배치
US8932607B2 (en) 2012-03-12 2015-01-13 Crucell Holland B.V. Batches of recombinant adenovirus with altered terminal ends
US9119813B2 (en) 2012-03-22 2015-09-01 Crucell Holland B.V. Vaccine against RSV
JP5805908B2 (ja) 2012-03-22 2015-11-10 クルセル ホランド ベー ヴェー Rsvに対するワクチン
CN103923883A (zh) * 2013-01-16 2014-07-16 辽宁成大生物股份有限公司 一种流感病毒的浓缩、纯化方法
EA035522B1 (ru) 2013-04-25 2020-06-29 Янссен Вэксинс Энд Превеншн Б.В. Стабильные растворимые f-полипептиды rsv в конформации "до слияния"
AU2014283334B2 (en) 2013-06-17 2018-10-18 Janssen Vaccines & Prevention B.V. Stabilized soluble pre-fusion RSV F polypeptides
EP3022306B1 (de) 2013-07-18 2020-01-22 Cincinnati Children's Hospital Medical Center Verfahren zur titer-verbesserung in transfektionsbasierten produktionssystemen mittels eukaryotischer zellen
CN103601793A (zh) * 2013-10-23 2014-02-26 乾元浩生物股份有限公司 一种禽用疫苗抗原纯化的方法
US10583397B2 (en) * 2014-05-13 2020-03-10 Amgen Inc. Process control systems and methods for use with filters and filtration processes
WO2015179598A2 (en) 2014-05-21 2015-11-26 Freeslate, Inc. Systems and methods for exchange of buffer solutions
CN106574252B (zh) * 2014-07-24 2021-06-01 扬森疫苗与预防公司 从细胞培养物中纯化脊髓灰质炎病毒的方法
JP6735288B2 (ja) 2015-04-14 2020-08-05 ヤンセン ファッシンズ アンド プリベンション ベーフェーJanssen Vaccines & Prevention B.V. 双方向性プロモーターを有する2つの導入遺伝子を発現する組換えアデノウイルス
JP7189014B2 (ja) 2015-07-07 2022-12-13 ヤンセン ファッシンズ アンド プリベンション ベーフェー Rsvに対するワクチン
WO2017005848A1 (en) 2015-07-07 2017-01-12 Janssen Vaccines & Prevention B.V. Stabilized soluble pre-fusion rsv f polypeptides
MD3439672T2 (ro) 2016-04-05 2021-04-30 Janssen Vaccines & Prevention Bv Proteine F RVS de pre-fuziune solubile stabilizate pentru utilizare în profilixia infecţiilor cu RSV
KR102500970B1 (ko) 2016-04-05 2023-02-17 얀센 백신스 앤드 프리벤션 비.브이. Rsv에 대한 백신
KR102573534B1 (ko) 2016-05-12 2023-08-31 얀센 백신스 앤드 프리벤션 비.브이. 강력하고 균형 잡힌 양방향성 프로모터
EA039124B1 (ru) 2016-05-30 2021-12-08 Янссен Вэксинс Энд Превеншн Б.В. Стабилизированные f-белки rsv до слияния
JP6683847B2 (ja) 2016-06-20 2020-04-22 ヤンセン ファッシンズ アンド プリベンション ベーフェーJanssen Vaccines & Prevention B.V. 強力でバランスのとれた双方向性プロモーター
WO2018011196A1 (en) 2016-07-14 2018-01-18 Janssen Vaccines & Prevention B.V. Hpv vaccines
US20190352615A1 (en) * 2016-12-22 2019-11-21 Blue Sky Vaccines Gmbh Method for purifying virus
CN110268061A (zh) 2017-02-09 2019-09-20 扬森疫苗与预防公司 用于表达异源基因的有效的短启动子
JP7262449B2 (ja) * 2017-05-15 2023-04-21 シー‐レクタ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 酵素産物
EP3624844A1 (de) 2017-05-17 2020-03-25 Janssen Vaccines & Prevention B.V. Verfahren und zusammensetzungen zur induzierung schützender immunität gegen rsv-infektionen
CN107603959A (zh) * 2017-08-30 2018-01-19 四川大学 提高缓冲液盐离子浓度纯化病毒的方法
BR112020004143A2 (pt) 2017-09-15 2020-09-01 Janssen Vaccines & Prevention B.V. método para a indução segura de imunidade contra vírus sincicial respiratório (rsv)
GB201806736D0 (en) * 2018-04-25 2018-06-06 Ge Healthcare Bioprocess R&D Ab Method for virus purification
CN111454914A (zh) * 2019-01-18 2020-07-28 嘉兴安宇生物科技有限公司 一种腺病毒快速纯化方法
US20220090140A1 (en) * 2019-05-14 2022-03-24 Janssen Biotech, Inc. Efficient Impurity Removal Using A Diafiltration Process
CN110129287B (zh) * 2019-05-15 2023-07-14 青岛蔚蓝生物制品有限公司 一种猪伪狂犬病毒双重超滤***及纯化方法
CN111394390A (zh) * 2020-03-26 2020-07-10 赛诺(深圳)生物医药研究有限公司 用于新型冠状病毒基因疫苗的批量生产重组腺病毒的方法
CN111575244B (zh) * 2020-05-06 2021-07-23 江苏金迪克生物技术股份有限公司 一种低Vero细胞残留DNA狂犬病疫苗原液的制备方法
CN112226418B (zh) * 2020-09-25 2022-07-08 阜外华中心血管病医院 重组腺相关病毒纯化方法
CA3203570A1 (en) * 2020-12-10 2022-06-16 Astrazeneca Uk Limited Methods of purifying adenovirus
CN112899242A (zh) * 2021-02-03 2021-06-04 苏州博腾生物制药有限公司 慢病毒纯化工艺
CN113373120B (zh) * 2021-06-18 2022-04-26 浙江康佰裕生物科技有限公司 Gmp级逆转录病毒载体的纯化方法与应用
CN113817689B (zh) * 2021-11-22 2023-10-03 北京艺妙神州医药科技有限公司 慢病毒纯化工艺
CN115747017B (zh) * 2022-10-25 2023-06-09 上海华新生物高技术有限公司 一种腺病毒纯化装置

Family Cites Families (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE434914B (sv) * 1975-07-07 1984-08-27 Jonsson U R S Forfarande for att ur en suspension av bakterier och ett vetskeformigt medium genom filtrering avskilja mediet under samtidig anrikning av bakterierna
US4435289A (en) * 1981-12-23 1984-03-06 Romicon, Inc. Series ultrafiltration with pressurized permeate
US5173418A (en) * 1985-05-10 1992-12-22 Benzon Pharma, A/S Production in Escherichia coli of extracellular Serratia spp. hydrolases
US4808315A (en) * 1986-04-28 1989-02-28 Asahi Kasei Kogyo Kabushiki Kaisha Porous hollow fiber membrane and a method for the removal of a virus by using the same
FR2705686B1 (fr) * 1993-05-28 1995-08-18 Transgene Sa Nouveaux adénovirus défectifs et lignées de complémentation correspondantes.
FR2716682B1 (fr) * 1994-01-28 1996-04-26 Centre Nat Rech Scient Procédé de préparation de virus adéno-associés (AAV) recombinants et utilisations.
CA2192442C (en) * 1994-06-10 2007-09-25 Imre Kovesdi Complementary adenoviral vector systems and cell lines
US5851806A (en) * 1994-06-10 1998-12-22 Genvec, Inc. Complementary adenoviral systems and cell lines
SE9500724D0 (sv) 1994-06-23 1995-02-24 Pharmacia Ab Filtrering
US5965541A (en) * 1995-11-28 1999-10-12 Genvec, Inc. Vectors and methods for gene transfer to cells
US5846782A (en) * 1995-11-28 1998-12-08 Genvec, Inc. Targeting adenovirus with use of constrained peptide motifs
US5559099A (en) * 1994-09-08 1996-09-24 Genvec, Inc. Penton base protein and methods of using same
US6146873A (en) * 1994-11-10 2000-11-14 Baxter Aktiengesellschaft Production of orthomyxoviruses in monkey kidney cells using protein-free media
US5770442A (en) 1995-02-21 1998-06-23 Cornell Research Foundation, Inc. Chimeric adenoviral fiber protein and methods of using same
US5837520A (en) * 1995-03-07 1998-11-17 Canji, Inc. Method of purification of viral vectors
AU731767B2 (en) * 1995-06-15 2001-04-05 Crucell Holland B.V. Packaging systems for human recombinant adenovirus to be used in gene therapy
FR2737730B1 (fr) * 1995-08-10 1997-09-05 Pasteur Merieux Serums Vacc Procede de purification de virus par chromatographie
US5840565A (en) * 1995-08-22 1998-11-24 The Regents Of The University Of California Methods for enhancing the production of viral vaccines in PKR-deficient cell culture
CA2625279A1 (en) * 1995-08-30 1997-03-06 Genzyme Corporation Chromatographic purification of adenovirus and aav
US5837511A (en) * 1995-10-02 1998-11-17 Cornell Research Foundation, Inc. Non-group C adenoviral vectors
CA2177085C (en) * 1996-04-26 2007-08-14 National Research Council Of Canada Adenovirus e1-complementing cell lines
BR9710030A (pt) * 1996-07-01 1999-08-10 Rhone Poulenc Rorer Sa Processo de produção de adenovírus recombinantes processo de purificação de adenovírus recombinantes a partir de um meio biológico preparação viral purificada composição farmacêutica e utilização de iodixanol-5,5'-[(2-Hidroxipropil-1,3-Propanottl)-Bis[N,N'-Bis(2,3-Didroxipropil-2,4,6-Triodo-1,3-Benzenocarboxamida]
FR2751343B1 (fr) * 1996-07-16 1998-12-18 Transgene Sa Procede de conservation de virus recombinants infectieux, suspension aqueuse virale et utilisation comme medicament
US7732129B1 (en) * 1998-12-01 2010-06-08 Crucell Holland B.V. Method for the production and purification of adenoviral vectors
WO1998022588A2 (en) * 1996-11-20 1998-05-28 Introgen Therapeutics, Inc. An improved method for the production and purification of adenoviral vectors
US6261823B1 (en) * 1996-12-13 2001-07-17 Schering Corporation Methods for purifying viruses
EP0981601B1 (de) * 1997-01-31 2006-09-06 Schering Corporation Verfahren zur kultivierung von zellen und zur vermehrung von viren
US6168944B1 (en) * 1997-01-31 2001-01-02 Schering Corporation Methods for cultivating cells and propagating viruses
JP2000509614A (ja) 1997-03-04 2000-08-02 バクスター インターナショナル インコーポレイテッド アデノウイルスe1−相補性細胞系
TW570803B (en) * 1997-04-09 2004-01-11 Duphar Int Res Influenza vaccine
US6020191A (en) * 1997-04-14 2000-02-01 Genzyme Corporation Adenoviral vectors capable of facilitating increased persistence of transgene expression
US5947689A (en) * 1997-05-07 1999-09-07 Scilog, Inc. Automated, quantitative, system for filtration of liquids having a pump controller
DE122009000037I2 (de) * 1997-08-28 2011-06-16 Cheil Jedang Corp Ein an vero-zellen angepasstes abgeschwächtes japanisches enzephalitis virus und ein impfstoff gegen japanische enzephalitis
US6210683B1 (en) 1997-09-05 2001-04-03 Merck & Co., Inc. Stabilizers containing recombinant human serum albumin for live virus vaccines
PL197747B1 (pl) 1998-02-17 2008-04-30 Schering Corp Kompozycja zawierająca adenowirusa, sposoby zatężania preparatu wirusa oraz sposób oczyszczania preparatu wirusa
US5981225A (en) * 1998-04-16 1999-11-09 Baylor College Of Medicine Gene transfer vector, recombinant adenovirus particles containing the same, method for producing the same and method of use of the same
EP1073721B1 (de) * 1998-04-22 2005-08-31 Genvec, Inc. Effiziente reinigung von adenovirus
US5994134A (en) * 1998-05-04 1999-11-30 Canji, Inc. Viral production process
US6113913A (en) * 1998-06-26 2000-09-05 Genvec, Inc. Recombinant adenovirus
US20030017138A1 (en) 1998-07-08 2003-01-23 Menzo Havenga Chimeric adenoviruses
US6342384B1 (en) * 1998-08-21 2002-01-29 The University Of Va Patent Foundation Production of adenoviral vectors using serum-free suspension cell culture in a hollow fiber system
EP1133316B1 (de) 1998-11-16 2009-01-21 Introgen Therapeutics, Inc. Adenovirus-formulierungen zur gentherapie
CZ20012428A3 (cs) * 1998-12-31 2001-11-14 Aventis Pharma S. A. Způsob separace virových částic
DE60029195T2 (de) 1999-02-22 2007-06-28 Transgene S.A. Verfahren zur Gewinnung von purifizierter Virenzusammensetzung
US6120820A (en) * 1999-02-22 2000-09-19 Land O'lakes, Inc. Method of modifying the color of a dairy material
EP1054064B2 (de) 1999-05-17 2009-12-16 Crucell Holland B.V. Von Adenovirus abgeleitete Gentransfervehikel, die zumindest ein Element des Adenovirus Typ 35 enthalten
US6492169B1 (en) * 1999-05-18 2002-12-10 Crucell Holland, B.V. Complementing cell lines
DE19955558C2 (de) 1999-11-18 2003-03-20 Stefan Kochanek Permanente Amniozyten-Zelllinie, ihre Herstellung und Verwendung zur Herstellung von Gentransfervektoren
EP1103610A1 (de) 1999-11-26 2001-05-30 Introgene B.V. Impfstoffherstellung von immortalisierten Säugetierzellinien
CA2399321C (en) 2000-03-07 2013-04-30 Robert K. Evans Adenovirus formulations
US6168941B1 (en) * 2000-04-07 2001-01-02 Genvec, Inc. Method of producing adenoviral vector stocks
DE10022258A1 (de) * 2000-05-08 2001-11-15 Bayer Ag Reinigung von Proteineinschlusskörpern durch Querstrom-Mikrofiltration
AU2001294562B2 (en) 2000-09-15 2007-05-24 Merck & Co., Inc. Enhanced First Generation Adenovirus Vaccines Expressing Codon Optimized HIV1-Gag, Pol, Nef and Modifications
US6365395B1 (en) * 2000-11-03 2002-04-02 Millipore Corporation Process for removing protein aggregates and virus from a protein solution
US20020064860A1 (en) 2000-11-29 2002-05-30 Schering Corporation Method for purifying adenoviruses
IL152420A0 (en) 2001-02-23 2003-05-29 Novartis Ag Novel oncolytic adenoviral vectors
DE60238970D1 (de) 2001-03-01 2011-03-03 Bayer Schering Pharma Ag Zellen in derselben prozesseinheit
EP1504112A4 (de) 2001-10-01 2006-02-08 Us Health Entwicklung einer vakzine zur prävention von infektionen mit dem filovirus bei primaten
CA2469491A1 (en) 2001-12-12 2003-06-19 Kerrie Setiawan Composition for viral preservation
US20030180936A1 (en) 2002-03-15 2003-09-25 Memarzadeh Bahram Eric Method for the purification, production and formulation of oncolytic adenoviruses
CA2478932A1 (en) 2002-03-29 2003-10-16 Merck & Co., Inc. Large scale methods of producing adenovirus and adenovirus seed stocks
AU2003271738C1 (en) 2002-04-25 2008-04-17 Crucell Holland B.V. Stable adenoviral vectors and methods for propagation thereof
CA2477954C (en) 2002-04-25 2012-07-10 Crucell Holland B.V. Means and methods for the production of adenovirus vectors
ES2285120T3 (es) * 2002-05-14 2007-11-16 MERCK & CO., INC. Procedimientos de purificacion de adenovirus.
US20050095705A1 (en) 2003-04-15 2005-05-05 Michael Kadan Method for production of oncolytic adenoviruses
WO2004112707A2 (en) * 2003-06-18 2004-12-29 Onyx Pharmaceuticals, Inc. Method for purifying virus
JP2007522814A (ja) * 2004-02-23 2007-08-16 クルセル ホランド ベー ヴェー ウイルスの精製方法

Also Published As

Publication number Publication date
AU2006233800B2 (en) 2011-07-07
US20090123989A1 (en) 2009-05-14
DK1869171T4 (en) 2016-01-18
CA2602944A1 (en) 2006-10-19
AU2006233800A1 (en) 2006-10-19
EP1869171B2 (de) 2015-10-14
CN101155915B (zh) 2013-12-04
EP1869171B1 (de) 2008-10-29
ES2317517T3 (es) 2009-04-16
ES2317517T5 (es) 2016-01-21
ATE412737T1 (de) 2008-11-15
US8574595B2 (en) 2013-11-05
CN101155915A (zh) 2008-04-02
EP1869171A1 (de) 2007-12-26
WO2006108707A1 (en) 2006-10-19
DK1869171T3 (da) 2009-02-16
CA2602944C (en) 2015-08-11

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