DE602006003420D1 - Virusreinigung mit ultrafiltration - Google Patents
Virusreinigung mit ultrafiltrationInfo
- Publication number
- DE602006003420D1 DE602006003420D1 DE602006003420T DE602006003420T DE602006003420D1 DE 602006003420 D1 DE602006003420 D1 DE 602006003420D1 DE 602006003420 T DE602006003420 T DE 602006003420T DE 602006003420 T DE602006003420 T DE 602006003420T DE 602006003420 D1 DE602006003420 D1 DE 602006003420D1
- Authority
- DE
- Germany
- Prior art keywords
- ultra filtration
- virus
- virus cleaning
- cleaning
- adenovirus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 241000700605 Viruses Species 0.000 title abstract 2
- 238000000108 ultra-filtration Methods 0.000 title abstract 2
- 238000004140 cleaning Methods 0.000 title 1
- 241000701161 unidentified adenovirus Species 0.000 abstract 2
- 238000004113 cell culture Methods 0.000 abstract 1
- 238000004587 chromatography analysis Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000012466 permeate Substances 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- 239000012465 retentate Substances 0.000 abstract 1
- 238000005199 ultracentrifugation Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10051—Methods of production or purification of viral material
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Virology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US67006405P | 2005-04-11 | 2005-04-11 | |
EP05102842 | 2005-04-11 | ||
PCT/EP2006/003722 WO2006108707A1 (en) | 2005-04-11 | 2006-04-11 | Virus purification using ultrafiltration |
Publications (1)
Publication Number | Publication Date |
---|---|
DE602006003420D1 true DE602006003420D1 (de) | 2008-12-11 |
Family
ID=36572264
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE602006003420T Active DE602006003420D1 (de) | 2005-04-11 | 2006-04-11 | Virusreinigung mit ultrafiltration |
Country Status (10)
Country | Link |
---|---|
US (1) | US8574595B2 (de) |
EP (1) | EP1869171B2 (de) |
CN (1) | CN101155915B (de) |
AT (1) | ATE412737T1 (de) |
AU (1) | AU2006233800B2 (de) |
CA (1) | CA2602944C (de) |
DE (1) | DE602006003420D1 (de) |
DK (1) | DK1869171T4 (de) |
ES (1) | ES2317517T5 (de) |
WO (1) | WO2006108707A1 (de) |
Families Citing this family (61)
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US20080131955A1 (en) * | 2006-11-30 | 2008-06-05 | Canon U.S. Life Sciences, Inc. | Method of Separating Target DNA from Mixed DNA |
PL2195418T3 (pl) * | 2007-10-02 | 2013-05-31 | Ptc Phage Tech Center Gmbh | Sposób i układ do oczyszczania na skalę przemysłową bakteriofagów z przeznaczeniem do terapii bakteriofagowej |
DK2242479T3 (da) * | 2007-12-28 | 2012-01-02 | Baxter Int | Modtryksfiltrering af proteiner |
US10273502B2 (en) * | 2008-06-18 | 2019-04-30 | Oxford Biomedica (Uk) Limited | Virus purification |
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FR2944292B1 (fr) | 2009-04-08 | 2013-08-23 | Sanofi Pasteur | Procede de purification du virus rabique |
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KR20130109004A (ko) * | 2010-06-01 | 2013-10-07 | 노파르티스 아게 | 동결건조하지 않는 인플루엔자 백신 항원의 농축 |
WO2012019354A1 (en) | 2010-08-12 | 2012-02-16 | Yisheng Biopharma Holdings Ltd. | Method for reducing dna impurities in viral compositions |
CN103118702A (zh) | 2010-09-20 | 2013-05-22 | 克鲁塞尔荷兰公司 | 活动性结核病的治疗性接种 |
AU2011310838B2 (en) | 2010-09-27 | 2015-11-05 | Crucell Holland B.V. | Heterologous prime boost vaccination regimen against malaria |
EP2697369B1 (de) | 2011-03-25 | 2018-06-27 | F.Hoffmann-La Roche Ag | Neue proteinreinigungsverfahren |
ES2813413T3 (es) | 2011-08-05 | 2021-03-23 | Sillajen Biotherapeutics Inc | Métodos y composiciones para la producción de virus vaccina |
CN102688485A (zh) * | 2011-09-16 | 2012-09-26 | 扬州优邦生物制药有限公司 | 一种猪细小病毒灭活疫苗的制备方法 |
US20130122038A1 (en) | 2011-11-14 | 2013-05-16 | The United States Of America As Represented By The Secretary Of The Department | Heterologous prime-boost immunization using measles virus-based vaccines |
WO2013106337A1 (en) * | 2012-01-09 | 2013-07-18 | Sanofi Pasteur Biologics, Llc | Purification of flaviviruses |
KR102044051B1 (ko) | 2012-03-12 | 2019-11-12 | 얀센 백신스 앤드 프리벤션 비.브이. | 터미널 말단이 변경된 재조합 아데노바이러스의 배치 |
US8932607B2 (en) | 2012-03-12 | 2015-01-13 | Crucell Holland B.V. | Batches of recombinant adenovirus with altered terminal ends |
US9119813B2 (en) | 2012-03-22 | 2015-09-01 | Crucell Holland B.V. | Vaccine against RSV |
JP5805908B2 (ja) | 2012-03-22 | 2015-11-10 | クルセル ホランド ベー ヴェー | Rsvに対するワクチン |
CN103923883A (zh) * | 2013-01-16 | 2014-07-16 | 辽宁成大生物股份有限公司 | 一种流感病毒的浓缩、纯化方法 |
EA035522B1 (ru) | 2013-04-25 | 2020-06-29 | Янссен Вэксинс Энд Превеншн Б.В. | Стабильные растворимые f-полипептиды rsv в конформации "до слияния" |
AU2014283334B2 (en) | 2013-06-17 | 2018-10-18 | Janssen Vaccines & Prevention B.V. | Stabilized soluble pre-fusion RSV F polypeptides |
EP3022306B1 (de) | 2013-07-18 | 2020-01-22 | Cincinnati Children's Hospital Medical Center | Verfahren zur titer-verbesserung in transfektionsbasierten produktionssystemen mittels eukaryotischer zellen |
CN103601793A (zh) * | 2013-10-23 | 2014-02-26 | 乾元浩生物股份有限公司 | 一种禽用疫苗抗原纯化的方法 |
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CN106574252B (zh) * | 2014-07-24 | 2021-06-01 | 扬森疫苗与预防公司 | 从细胞培养物中纯化脊髓灰质炎病毒的方法 |
JP6735288B2 (ja) | 2015-04-14 | 2020-08-05 | ヤンセン ファッシンズ アンド プリベンション ベーフェーJanssen Vaccines & Prevention B.V. | 双方向性プロモーターを有する2つの導入遺伝子を発現する組換えアデノウイルス |
JP7189014B2 (ja) | 2015-07-07 | 2022-12-13 | ヤンセン ファッシンズ アンド プリベンション ベーフェー | Rsvに対するワクチン |
WO2017005848A1 (en) | 2015-07-07 | 2017-01-12 | Janssen Vaccines & Prevention B.V. | Stabilized soluble pre-fusion rsv f polypeptides |
MD3439672T2 (ro) | 2016-04-05 | 2021-04-30 | Janssen Vaccines & Prevention Bv | Proteine F RVS de pre-fuziune solubile stabilizate pentru utilizare în profilixia infecţiilor cu RSV |
KR102500970B1 (ko) | 2016-04-05 | 2023-02-17 | 얀센 백신스 앤드 프리벤션 비.브이. | Rsv에 대한 백신 |
KR102573534B1 (ko) | 2016-05-12 | 2023-08-31 | 얀센 백신스 앤드 프리벤션 비.브이. | 강력하고 균형 잡힌 양방향성 프로모터 |
EA039124B1 (ru) | 2016-05-30 | 2021-12-08 | Янссен Вэксинс Энд Превеншн Б.В. | Стабилизированные f-белки rsv до слияния |
JP6683847B2 (ja) | 2016-06-20 | 2020-04-22 | ヤンセン ファッシンズ アンド プリベンション ベーフェーJanssen Vaccines & Prevention B.V. | 強力でバランスのとれた双方向性プロモーター |
WO2018011196A1 (en) | 2016-07-14 | 2018-01-18 | Janssen Vaccines & Prevention B.V. | Hpv vaccines |
US20190352615A1 (en) * | 2016-12-22 | 2019-11-21 | Blue Sky Vaccines Gmbh | Method for purifying virus |
CN110268061A (zh) | 2017-02-09 | 2019-09-20 | 扬森疫苗与预防公司 | 用于表达异源基因的有效的短启动子 |
JP7262449B2 (ja) * | 2017-05-15 | 2023-04-21 | シー‐レクタ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 酵素産物 |
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CN107603959A (zh) * | 2017-08-30 | 2018-01-19 | 四川大学 | 提高缓冲液盐离子浓度纯化病毒的方法 |
BR112020004143A2 (pt) | 2017-09-15 | 2020-09-01 | Janssen Vaccines & Prevention B.V. | método para a indução segura de imunidade contra vírus sincicial respiratório (rsv) |
GB201806736D0 (en) * | 2018-04-25 | 2018-06-06 | Ge Healthcare Bioprocess R&D Ab | Method for virus purification |
CN111454914A (zh) * | 2019-01-18 | 2020-07-28 | 嘉兴安宇生物科技有限公司 | 一种腺病毒快速纯化方法 |
US20220090140A1 (en) * | 2019-05-14 | 2022-03-24 | Janssen Biotech, Inc. | Efficient Impurity Removal Using A Diafiltration Process |
CN110129287B (zh) * | 2019-05-15 | 2023-07-14 | 青岛蔚蓝生物制品有限公司 | 一种猪伪狂犬病毒双重超滤***及纯化方法 |
CN111394390A (zh) * | 2020-03-26 | 2020-07-10 | 赛诺(深圳)生物医药研究有限公司 | 用于新型冠状病毒基因疫苗的批量生产重组腺病毒的方法 |
CN111575244B (zh) * | 2020-05-06 | 2021-07-23 | 江苏金迪克生物技术股份有限公司 | 一种低Vero细胞残留DNA狂犬病疫苗原液的制备方法 |
CN112226418B (zh) * | 2020-09-25 | 2022-07-08 | 阜外华中心血管病医院 | 重组腺相关病毒纯化方法 |
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CN112899242A (zh) * | 2021-02-03 | 2021-06-04 | 苏州博腾生物制药有限公司 | 慢病毒纯化工艺 |
CN113373120B (zh) * | 2021-06-18 | 2022-04-26 | 浙江康佰裕生物科技有限公司 | Gmp级逆转录病毒载体的纯化方法与应用 |
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CA2477954C (en) | 2002-04-25 | 2012-07-10 | Crucell Holland B.V. | Means and methods for the production of adenovirus vectors |
ES2285120T3 (es) * | 2002-05-14 | 2007-11-16 | MERCK & CO., INC. | Procedimientos de purificacion de adenovirus. |
US20050095705A1 (en) | 2003-04-15 | 2005-05-05 | Michael Kadan | Method for production of oncolytic adenoviruses |
WO2004112707A2 (en) * | 2003-06-18 | 2004-12-29 | Onyx Pharmaceuticals, Inc. | Method for purifying virus |
JP2007522814A (ja) * | 2004-02-23 | 2007-08-16 | クルセル ホランド ベー ヴェー | ウイルスの精製方法 |
-
2006
- 2006-04-11 DK DK06724513.4T patent/DK1869171T4/en active
- 2006-04-11 EP EP06724513.4A patent/EP1869171B2/de active Active
- 2006-04-11 DE DE602006003420T patent/DE602006003420D1/de active Active
- 2006-04-11 US US11/909,955 patent/US8574595B2/en active Active
- 2006-04-11 ES ES06724513.4T patent/ES2317517T5/es active Active
- 2006-04-11 AU AU2006233800A patent/AU2006233800B2/en active Active
- 2006-04-11 WO PCT/EP2006/003722 patent/WO2006108707A1/en not_active Application Discontinuation
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Also Published As
Publication number | Publication date |
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AU2006233800B2 (en) | 2011-07-07 |
US20090123989A1 (en) | 2009-05-14 |
DK1869171T4 (en) | 2016-01-18 |
CA2602944A1 (en) | 2006-10-19 |
AU2006233800A1 (en) | 2006-10-19 |
EP1869171B2 (de) | 2015-10-14 |
CN101155915B (zh) | 2013-12-04 |
EP1869171B1 (de) | 2008-10-29 |
ES2317517T3 (es) | 2009-04-16 |
ES2317517T5 (es) | 2016-01-21 |
ATE412737T1 (de) | 2008-11-15 |
US8574595B2 (en) | 2013-11-05 |
CN101155915A (zh) | 2008-04-02 |
EP1869171A1 (de) | 2007-12-26 |
WO2006108707A1 (en) | 2006-10-19 |
DK1869171T3 (da) | 2009-02-16 |
CA2602944C (en) | 2015-08-11 |
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