DE602005027258D1 - Humane monoklonale antikörper gegen hendra- und nipah-viren - Google Patents

Humane monoklonale antikörper gegen hendra- und nipah-viren

Info

Publication number
DE602005027258D1
DE602005027258D1 DE602005027258T DE602005027258T DE602005027258D1 DE 602005027258 D1 DE602005027258 D1 DE 602005027258D1 DE 602005027258 T DE602005027258 T DE 602005027258T DE 602005027258 T DE602005027258 T DE 602005027258T DE 602005027258 D1 DE602005027258 D1 DE 602005027258D1
Authority
DE
Germany
Prior art keywords
antibodies
hendra
monoclonal antibodies
nipah virus
human monoclonal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602005027258T
Other languages
English (en)
Inventor
Diviter S Dimitrov
Zhongyu Zhu
Christopher C Broder
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
US Department of Health and Human Services
Henry M Jackson Foundation for Advancedment of Military Medicine Inc
Original Assignee
US Department of Health and Human Services
Henry M Jackson Foundation for Advancedment of Military Medicine Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by US Department of Health and Human Services, Henry M Jackson Foundation for Advancedment of Military Medicine Inc filed Critical US Department of Health and Human Services
Publication of DE602005027258D1 publication Critical patent/DE602005027258D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1009—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against material from bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1027—Paramyxoviridae, e.g. respiratory syncytial virus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983—Viruses
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/08—RNA viruses
    • G01N2333/115—Paramyxoviridae, e.g. parainfluenza virus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2469/00—Immunoassays for the detection of microorganisms
    • G01N2469/10—Detection of antigens from microorganism in sample from host

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Pulmonology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Optics & Photonics (AREA)
  • Epidemiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DE602005027258T 2005-03-14 2005-11-04 Humane monoklonale antikörper gegen hendra- und nipah-viren Active DE602005027258D1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US66176605P 2005-03-14 2005-03-14
US67854705P 2005-05-05 2005-05-05
US71890205P 2005-09-20 2005-09-20
PCT/US2005/040050 WO2006137931A2 (en) 2005-03-14 2005-11-04 Human monoclonal antibodies against hendra and nipah viruses

Publications (1)

Publication Number Publication Date
DE602005027258D1 true DE602005027258D1 (de) 2011-05-12

Family

ID=37570906

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602005027258T Active DE602005027258D1 (de) 2005-03-14 2005-11-04 Humane monoklonale antikörper gegen hendra- und nipah-viren

Country Status (7)

Country Link
US (5) US7988971B2 (de)
EP (2) EP2336174B8 (de)
AT (1) ATE503770T1 (de)
AU (1) AU2005333155B2 (de)
DE (1) DE602005027258D1 (de)
ES (1) ES2546543T3 (de)
WO (1) WO2006137931A2 (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR045563A1 (es) 2003-09-10 2005-11-02 Warner Lambert Co Anticuerpos dirigidos a m-csf
ES2673972T3 (es) * 2004-07-09 2018-06-26 The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. Formas solubles de la glicoproteína G de los virus hendra y nipah
ES2546543T3 (es) 2005-03-14 2015-09-24 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Anticuerpos monoclonales humanos contra los virus Hendra y Nipah
US7858752B2 (en) * 2006-12-05 2010-12-28 Abbott Laboratories Recombinant antibodies against hepatitis C virus and methods of obtaining and using same
GB0700133D0 (en) 2007-01-04 2007-02-14 Humabs Llc Human cytomegalovirus neutralising antibodies and use thereof
US7947274B2 (en) 2007-01-04 2011-05-24 Humabs, LLC. Human cytomegalovirus neutralising antibodies and use thereof
PT2178921E (pt) 2007-07-17 2016-03-23 Squibb & Sons Llc Anticorpos monoclonais contra glipicano-3
KR20150002895A (ko) * 2008-07-16 2015-01-07 인스티튜트 포 리서치 인 바이오메드슨 인간 사이토메갈바이러스 중화 항체 및 이의 용도
ES2654543T3 (es) 2008-07-16 2018-02-14 Institute For Research In Biomedicine Anticuerpos neutralizantes del citomegalovirus humano y uso de los mismos
AU2011282423B2 (en) 2010-07-22 2015-05-14 Schrader, Sabariah Cross-protective pathogen protection, methods and compositions thereof
CA3037903A1 (en) * 2010-10-09 2012-04-26 Mayo Foundation For Medical Education & Research Human antibodies and diagnostic and therapeutic uses thereof for the treatment of neurological disease
WO2012149536A1 (en) * 2011-04-28 2012-11-01 The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. Neutralizing antibodies to nipah and hendra virus
MX352604B (es) 2011-05-13 2017-11-30 Zoetis Llc Composiciones inmunogenicas de la glucoproteina g de los virus hendra y nipah.
ES2735289T3 (es) * 2012-02-08 2019-12-17 Igm Biosciences Inc Proteínas de unión a cdim y usos de las mismas
RU2660566C2 (ru) * 2012-10-01 2018-07-06 Томас Джефферсон Юниверсити Иммунизация вектором на основе вируса бешенства, экспрессирующим чужеродный белковый антиген
WO2014105849A1 (en) * 2012-12-28 2014-07-03 Xoma (Us) Llc Antibodies specific for fgfr4 and methods of use
DK2968520T3 (da) 2013-03-14 2021-08-09 Macrogenics Inc Bispecifikke molekyler som er immunoreaktive med immuneffektorceller der udtrykker en aktiverende receptor
KR20160077214A (ko) 2013-12-16 2016-07-01 조에티스 서비시즈 엘엘씨 헨드라 및 니파 바이러스 ｇ 당단백질 면역원성 조성물
WO2015112836A2 (en) * 2014-01-24 2015-07-30 The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. Antibodies against f glycoprotein of hendra and nipah viruses
WO2016054101A1 (en) 2014-09-29 2016-04-07 Duke University Bispecific molecules comprising an hiv-1 envelope targeting arm
WO2016090365A1 (en) * 2014-12-05 2016-06-09 Dessain Scott Kendall Pdk1 binding molecules and uses thereof
US20190183997A1 (en) * 2016-07-22 2019-06-20 University Of Washington Identification and production of high affinity igm antibodies and derivatives thereof
JP7370983B2 (ja) 2017-12-20 2023-10-30 ゾエティス・サービシーズ・エルエルシー ヘンドラウイルス感染症及びニパウイルス感染症に対するワクチン
WO2019143884A1 (en) * 2018-01-19 2019-07-25 Vanderbilt University Conserved hiv antibody clonotypes and methods of use
CN110028579B (zh) * 2019-05-05 2020-12-18 中国人民解放军军事科学院军事医学研究院 一种抗尼帕病毒包膜糖蛋白的单克隆抗体及其应用
KR102264873B1 (ko) 2020-01-17 2021-06-14 대한민국(질병관리청장) 니파바이러스 g 당단백질에 특이적인 단클론 항체 및 이의 용도
WO2021257894A1 (en) * 2020-06-19 2021-12-23 Board Of Regents, The University Of Texas System Anti-bst2 antibodies targeting bst2 long isoform
CN113968907B (zh) * 2020-07-22 2023-05-26 中国人民解放军军事科学院军事医学研究院 具有中和活性的抗尼帕病毒单克隆抗体及应用
CN113968908B (zh) * 2020-07-22 2023-03-14 中国人民解放军军事科学院军事医学研究院 具有广谱中和活性的抗亨尼帕病毒单克隆抗体及应用
WO2022177913A1 (en) * 2021-02-16 2022-08-25 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Molecules that bind to mesothelin polypeptides
WO2023109844A1 (en) * 2021-12-14 2023-06-22 Doma Biopharmaceutical (Suzhou) Co., Ltd. Antibodies and uses thereof

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US661766A (en) 1899-11-07 1900-11-13 Carl J Mellin Piston-valve.
US678547A (en) 1901-05-31 1901-07-16 Seth S Crocker Fountain-pen.
GB9221654D0 (en) * 1992-10-15 1992-11-25 Scotgen Ltd Recombinant human anti-cytomegalovirus antibodies
US7666431B2 (en) 2001-11-13 2010-02-23 The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. Compositions and methods for the inhibition of membrane fusion by paramyxoviruses
WO2005028673A1 (en) * 2003-09-22 2005-03-31 Institut Pasteur A method for detecting nipah virus and method for providing immunoprotection against henipaviruses
ES2546543T3 (es) * 2005-03-14 2015-09-24 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Anticuerpos monoclonales humanos contra los virus Hendra y Nipah

Also Published As

Publication number Publication date
EP2336174A2 (de) 2011-06-22
US8858938B2 (en) 2014-10-14
AU2005333155B2 (en) 2011-11-17
US20140079715A1 (en) 2014-03-20
ATE503770T1 (de) 2011-04-15
AU2005333155A1 (en) 2006-12-28
ES2546543T3 (es) 2015-09-24
US20120064000A1 (en) 2012-03-15
EP2336174B1 (de) 2015-06-03
WO2006137931A3 (en) 2007-04-26
EP2336174A3 (de) 2012-07-04
US20090214428A1 (en) 2009-08-27
US20150071854A1 (en) 2015-03-12
US8313746B2 (en) 2012-11-20
EP2336174B8 (de) 2015-09-23
WO2006137931A2 (en) 2006-12-28
EP1861424A2 (de) 2007-12-05
US20130149246A1 (en) 2013-06-13
EP1861424B1 (de) 2011-03-30
US7988971B2 (en) 2011-08-02

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