DE602005022471D1 - Zusammensetzungen enthaltend lipase, protease und amylase zur behandlung von pankreasinsuffizienz - Google Patents
Zusammensetzungen enthaltend lipase, protease und amylase zur behandlung von pankreasinsuffizienzInfo
- Publication number
- DE602005022471D1 DE602005022471D1 DE602005022471T DE602005022471T DE602005022471D1 DE 602005022471 D1 DE602005022471 D1 DE 602005022471D1 DE 602005022471 T DE602005022471 T DE 602005022471T DE 602005022471 T DE602005022471 T DE 602005022471T DE 602005022471 D1 DE602005022471 D1 DE 602005022471D1
- Authority
- DE
- Germany
- Prior art keywords
- compositions
- treatment
- amylase
- protease
- lipase
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000000203 mixture Substances 0.000 title abstract 4
- 239000004382 Amylase Substances 0.000 title abstract 2
- 102000013142 Amylases Human genes 0.000 title abstract 2
- 108010065511 Amylases Proteins 0.000 title abstract 2
- 102000004882 Lipase Human genes 0.000 title abstract 2
- 239000004367 Lipase Substances 0.000 title abstract 2
- 108090001060 Lipase Proteins 0.000 title abstract 2
- 108091005804 Peptidases Proteins 0.000 title abstract 2
- 239000004365 Protease Substances 0.000 title abstract 2
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 title abstract 2
- 235000019418 amylase Nutrition 0.000 title abstract 2
- 235000019421 lipase Nutrition 0.000 title abstract 2
- 102100040107 Serine protease 27 Human genes 0.000 title 1
- 101710197422 Serine protease 27 Proteins 0.000 title 1
- 208000035467 Pancreatic insufficiency Diseases 0.000 abstract 3
- 230000009286 beneficial effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 235000019419 proteases Nutrition 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/54—Mixtures of enzymes or proenzymes covered by more than a single one of groups A61K38/44 - A61K38/46 or A61K38/51 - A61K38/53
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Nutrition Science (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US61876404P | 2004-10-14 | 2004-10-14 | |
PCT/US2005/036802 WO2006044529A1 (en) | 2004-10-14 | 2005-10-14 | Compositions containing lipase; protease and amylase for treating pancreatic insufficiency |
Publications (1)
Publication Number | Publication Date |
---|---|
DE602005022471D1 true DE602005022471D1 (de) | 2010-09-02 |
Family
ID=35840531
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE602005022471T Active DE602005022471D1 (de) | 2004-10-14 | 2005-10-14 | Zusammensetzungen enthaltend lipase, protease und amylase zur behandlung von pankreasinsuffizienz |
Country Status (24)
Country | Link |
---|---|
US (1) | US7718169B2 (de) |
EP (2) | EP2198880B1 (de) |
JP (1) | JP4908420B2 (de) |
KR (1) | KR101333664B1 (de) |
CN (1) | CN101068565B (de) |
AT (1) | ATE474592T1 (de) |
AU (1) | AU2005295754B2 (de) |
BR (1) | BRPI0516515B1 (de) |
CA (1) | CA2584069C (de) |
CY (2) | CY1110838T1 (de) |
DE (1) | DE602005022471D1 (de) |
DK (2) | DK2198880T3 (de) |
ES (2) | ES2614157T3 (de) |
HK (1) | HK1109068A1 (de) |
HR (1) | HRP20161684T1 (de) |
HU (1) | HUE031245T2 (de) |
LT (1) | LT2198880T (de) |
MX (1) | MX2007004534A (de) |
PL (2) | PL1809320T3 (de) |
PT (2) | PT1809320E (de) |
RU (1) | RU2385736C2 (de) |
SI (2) | SI2198880T1 (de) |
UA (1) | UA91521C2 (de) |
WO (1) | WO2006044529A1 (de) |
Families Citing this family (71)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6632429B1 (en) | 1999-12-17 | 2003-10-14 | Joan M. Fallon | Methods for treating pervasive development disorders |
US20010046493A1 (en) * | 2000-02-24 | 2001-11-29 | Alex Margolin | Lipase-containing composition and methods of use thereof |
US20070053895A1 (en) * | 2000-08-14 | 2007-03-08 | Fallon Joan M | Method of treating and diagnosing parkinsons disease and related dysautonomic disorders |
IT1319655B1 (it) | 2000-11-15 | 2003-10-23 | Eurand Int | Microsfere di enzimi pancreatici con elevata stabilita' e relativometodo di preparazione. |
US8030002B2 (en) | 2000-11-16 | 2011-10-04 | Curemark Llc | Methods for diagnosing pervasive development disorders, dysautonomia and other neurological conditions |
PT1729797E (pt) | 2004-03-22 | 2008-12-17 | Solvay Pharm Gmbh | Composições farmacêuticas orais de produtos contendo lipase, em particular de pancreatina, contendo tensioactivos |
EP1771194A2 (de) * | 2004-07-07 | 2007-04-11 | Biodevelops Pharma Entwicklung GmbH | Verwendung einer deubiquitinierenden verbindung zur steigerung der expression von membranproteinen auf der zelloberfläche |
US20060198838A1 (en) * | 2004-09-28 | 2006-09-07 | Fallon Joan M | Combination enzyme for cystic fibrosis |
CA2616943C (en) | 2005-07-29 | 2016-04-12 | Solvay Pharmaceuticals Gmbh | Processes for the manufacture of sterilized pancreatin powder |
US9198871B2 (en) | 2005-08-15 | 2015-12-01 | Abbott Products Gmbh | Delayed release pancreatin compositions |
US11266607B2 (en) | 2005-08-15 | 2022-03-08 | AbbVie Pharmaceuticals GmbH | Process for the manufacture and use of pancreatin micropellet cores |
US20080058282A1 (en) | 2005-08-30 | 2008-03-06 | Fallon Joan M | Use of lactulose in the treatment of autism |
US20070116695A1 (en) * | 2005-09-21 | 2007-05-24 | Fallon Joan M | Pharmaceutical preparations for attention deficit disorder, attention deficit hyperactivity disorder and other associated disorders |
US8071089B2 (en) | 2005-11-01 | 2011-12-06 | Bio-Cat, Inc. | Composition with a fungal (yeast) lipase and method for treating lipid malabsorption in cystic fibrosis as well as people suffering from pancreatic lipase insufficiency |
US10072256B2 (en) | 2006-05-22 | 2018-09-11 | Abbott Products Gmbh | Process for separating and determining the viral load in a pancreatin sample |
EP2455461B1 (de) | 2006-12-21 | 2016-03-16 | Novozymes A/S | Lipasevarianten zur pharmazeutischen Verwendung |
US20080199448A1 (en) * | 2007-02-16 | 2008-08-21 | Ross Mairi R | Enzyme composition for improving food digestion |
TWI609693B (zh) | 2007-02-20 | 2018-01-01 | 艾泰醫藥有限公司 | 穩定之消化酵素組合物 |
RU2445952C2 (ru) * | 2007-02-20 | 2012-03-27 | Юранд Фармасьютикалз Лимитед | Стабильные композиции пищеварительных ферментов |
WO2009109856A2 (en) | 2008-03-07 | 2009-09-11 | Axcan Pharma Inc. | Method for detecting infectious parvovirus in pharmaceutical preparations |
US8658163B2 (en) | 2008-03-13 | 2014-02-25 | Curemark Llc | Compositions and use thereof for treating symptoms of preeclampsia |
US8084025B2 (en) | 2008-04-18 | 2011-12-27 | Curemark Llc | Method for the treatment of the symptoms of drug and alcohol addiction |
US20090324730A1 (en) * | 2008-06-26 | 2009-12-31 | Fallon Joan M | Methods and compositions for the treatment of symptoms of complex regional pain syndrome |
US9320780B2 (en) | 2008-06-26 | 2016-04-26 | Curemark Llc | Methods and compositions for the treatment of symptoms of Williams Syndrome |
US11016104B2 (en) | 2008-07-01 | 2021-05-25 | Curemark, Llc | Methods and compositions for the treatment of symptoms of neurological and mental health disorders |
US10776453B2 (en) * | 2008-08-04 | 2020-09-15 | Galenagen, Llc | Systems and methods employing remote data gathering and monitoring for diagnosing, staging, and treatment of Parkinsons disease, movement and neurological disorders, and chronic pain |
EP2328609A1 (de) * | 2008-08-26 | 2011-06-08 | Cystic Fibrosis Foundation Therapeutics, Inc. | Schnell auflösende tabletten mit lipase, amylase und protease |
EP2165717A1 (de) | 2008-08-27 | 2010-03-24 | Nordmark Arzneimittel GmbH & Co.KG | Verfahren zur Verringerung der viralen und mikrobiellen Belastung feststoffhaltiger biologischer Extrakte |
US20110171294A1 (en) * | 2008-09-30 | 2011-07-14 | Dsm Ip Assets B.V. | Enzyme composition and application thereof in the treatment of pancreatic insufficiency |
US20100092447A1 (en) | 2008-10-03 | 2010-04-15 | Fallon Joan M | Methods and compositions for the treatment of symptoms of prion diseases |
CN105031628B (zh) * | 2009-01-06 | 2020-10-02 | 加尔纳根有限责任公司 | 治疗或预防大肠杆菌导致的经口感染的组合物和方法 |
ES2882518T3 (es) | 2009-01-06 | 2021-12-02 | Galenagen Llc | Composición que comprende proteasa, amilasa y lipasa |
AU2015252099B2 (en) * | 2009-01-06 | 2017-08-10 | Galenagen, Llc | Compositions and methods for the treatment or prevention of staphylococcus aureus infections and for the eradication or reduction of staphylococcus aureus on surfaces |
WO2010085975A1 (de) | 2009-01-29 | 2010-08-05 | Nordmark Arzneimittel Gmbh & Co. Kg | Pharmazeutisches präparat enthaltend lipase bakteriellen ursprungs |
US9056050B2 (en) | 2009-04-13 | 2015-06-16 | Curemark Llc | Enzyme delivery systems and methods of preparation and use |
WO2010130622A1 (en) * | 2009-05-11 | 2010-11-18 | Dsm Ip Assets B.V. | Enzyme composition for the treatment of prancreatic insufficiency |
EP2295039B2 (de) | 2009-08-28 | 2022-10-26 | Nordmark Pharma GmbH | Verfahren zur Herstellung von Pankreatin-Pellets, insbesondere Pankreatin-Mikropellets, und hiernach hergestellte Pankreatin-Pellets |
US8784884B2 (en) * | 2009-09-17 | 2014-07-22 | Stephen Perrett | Pancreatic enzyme compositions and methods for treating pancreatitis and pancreatic insufficiency |
AU2016216662B2 (en) * | 2009-09-17 | 2017-09-07 | Allergan Therapeutics LLC | Pancreatic enzyme compositions and methods for treating pancreatitis and pancreatic insufficiency |
US9511125B2 (en) | 2009-10-21 | 2016-12-06 | Curemark Llc | Methods and compositions for the treatment of influenza |
EP2509635A4 (de) * | 2009-12-08 | 2013-09-18 | Depomed Inc | Gastroretentive pharmazeutische zusammensetzungen zur verlängerten freisetzung von polypeptiden |
JP2011162491A (ja) * | 2010-02-10 | 2011-08-25 | Ezaki Glico Co Ltd | 乾燥麹抽出物及びこれを用いた口腔用組成物 |
SE535296C2 (sv) * | 2010-09-08 | 2012-06-19 | Anara Ab | Mognad av mag-tarmkanalen |
PT2621476E (pt) | 2010-10-01 | 2014-10-16 | Aptalis Pharma Ltd | Formulações de pancrelipase de baixa potência com revestimento entérico |
FR2966734B1 (fr) * | 2010-10-29 | 2014-07-18 | Max Rombi | Composition comprenant au moins une enzyme proteolytique pour son utilisation pour empecher la synthese des triglycerides |
PL2489349T3 (pl) | 2011-02-17 | 2014-09-30 | Nordmark Arzneimittel Gmbh & Co Kg | Granulki pankreatynowe, zwłaszcza mikrogranulki pankreatynowe, oraz sposób ich produkcji |
MX347770B (es) | 2011-04-21 | 2017-05-12 | Curemark Llc | Compuesto para el tratamiento de alteraciones neuropsiquiatricas. |
HUE026560T2 (hu) | 2011-08-08 | 2016-06-28 | Allergan Pharmaceuticals Int Ltd | Eljárás emésztõ enzimeket tartalmazó szilárd készítmények feloldódási viselkedésének vizsgálatára |
US8268305B1 (en) | 2011-09-23 | 2012-09-18 | Bio-Cat, Inc. | Method and compositions to reduce serum levels of triacylglycerides in human beings using a fungal lipase |
DK3384902T3 (da) | 2012-02-17 | 2021-01-18 | Alcresta Therapeutics Inc | Fremgangsmåder, sammensætninger og indretninger til opfyldelse af diætmæssige behov for fedtsyre |
US10350278B2 (en) | 2012-05-30 | 2019-07-16 | Curemark, Llc | Methods of treating Celiac disease |
EP2897604B1 (de) * | 2012-09-19 | 2018-07-04 | Grespo AB | Zusammensetzungen zur verbesserung der hirnfunktion |
JP2016513634A (ja) | 2013-03-15 | 2016-05-16 | アプタリス ファーマ リミテッド | 消化酵素および栄養素を含む経腸投与に適した組成物 |
WO2014172309A2 (en) | 2013-04-18 | 2014-10-23 | The United States Of America As Represented By The Secretary Of The Army, On Behalf Of The United | Therapeutic compositions for neutralizing type i interferons, and methods of use |
BR112016001289A2 (pt) | 2013-07-22 | 2018-03-20 | Allergan Pharmaceuticals International Limited | pancreatina de alta atividade (ha-pancreatina), composição farmacêutica de alta potência, processo para preparação da ha-pancreatina com atividade de lipase específica de, pelo menos, cerca de 120 ui usp/mg e método de tratamento de um paciente que apresenta uma condição fisiológica associada à insuficiência enzimática pancreática |
MX2016001593A (es) | 2013-08-09 | 2016-09-29 | Allergan Pharmaceuticals Int Ltd | Composicion de enzima digestiva adecuada para administracion enterica. |
KR20170052520A (ko) | 2013-11-05 | 2017-05-12 | 앨러간 파마슈티컬스 인터내셔널 리미티드 | 고효능 판크레아틴 약학적 조성물 |
JP2014193909A (ja) * | 2014-06-04 | 2014-10-09 | Nordmark Arzneimittel Gmbh & Co Kg | 医薬調製物 |
EP3157568A1 (de) | 2014-06-19 | 2017-04-26 | Aptalis Pharma Limited | Verfahren zur entfernung von viralen verunreinigungen aus pankreatischen extrakten |
GB201501081D0 (en) | 2015-01-22 | 2015-03-11 | Cilian Ag | Use of enzymes with a wide pH activity range as medicaments for promoting digestion |
JP6797107B2 (ja) * | 2015-03-02 | 2020-12-09 | 東レ株式会社 | 膵臓機能異常の検出方法及び検出用キット |
DE102015114859A1 (de) | 2015-09-04 | 2017-03-09 | Nordmark Arzneimittel Gmbh & Co. Kg | Verwendung einer pharmazeutischen Zusammensetzung, enthaltend mindestens ein Verdauungsenzym, bei der künstlichen Ernährung |
US10258590B2 (en) | 2015-10-14 | 2019-04-16 | Alcresta Therapeutics, Inc. | Enteral feeding device and related methods of use |
DE102017104472A1 (de) | 2017-03-03 | 2018-09-06 | Nordmark Arzneimittel Gmbh & Co. Kg | Schmelztablette enthaltend Burlulipase und daraus hergestellte pharmazeutische Zusammensetzung |
US11045396B2 (en) | 2017-08-17 | 2021-06-29 | Alcresta Therapeutics, Inc. | Devices and methods for the supplementation of a nutritional formula |
FR3079146B1 (fr) | 2018-03-23 | 2020-04-17 | Karim Ioualalen | Formulation gastroprotectrice de complexes d’enzymes permettant de restaurer la fonction digestive. |
US11547745B1 (en) * | 2018-08-23 | 2023-01-10 | Vets Plus, Inc. | Compositions and methods for treating pancreatic enzyme deficiencies in mammals |
MX2022002473A (es) | 2019-08-30 | 2022-08-02 | Codexis Inc | Variantes de lipasa modificadas geneticamente. |
US20230138700A1 (en) * | 2020-03-30 | 2023-05-04 | Jai WALL | Combined animal-derived and synthetically produced pancreatic enzyme replacement therapy |
US11541009B2 (en) | 2020-09-10 | 2023-01-03 | Curemark, Llc | Methods of prophylaxis of coronavirus infection and treatment of coronaviruses |
CA3233449A1 (en) * | 2021-09-30 | 2023-04-06 | Robert Gallotto | Engineered lipase enzymes, manufacture and use thereof |
Family Cites Families (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5017559B2 (de) | 1972-09-20 | 1975-06-21 | ||
JPS5428820Y2 (de) * | 1974-06-14 | 1979-09-14 | ||
GB1509866A (en) * | 1975-06-10 | 1978-05-04 | Johnson & Johnson | Enteric coated digestive enzyme compositions |
US4659667A (en) * | 1985-02-26 | 1987-04-21 | Miles Laboratories, Inc. | Process to recover crystalline enzymes and crystalline enzymes produced thereby |
DK154572C (da) * | 1985-08-07 | 1989-04-24 | Novo Industri As | Enzymatisk detergentadditiv, detergent og fremgangsmaade til vask af tekstiler |
JP3079276B2 (ja) * | 1988-02-28 | 2000-08-21 | 天野製薬株式会社 | 組換え体dna、それを含むシュードモナス属菌及びそれを用いたリパーゼの製造法 |
DE3808695A1 (de) * | 1988-03-16 | 1989-10-05 | Henkel Kgaa | Fluessiges waschmittel |
DK0387945T3 (da) | 1989-03-08 | 1993-12-20 | Simon Lodewijk Scharpe | Middel til behandling af eksokrin pancresinsufficiens og midlets anvendelse til fremstilling af et lægemiddel til behandlingen |
DE69003253T2 (de) | 1989-12-21 | 1994-01-20 | Novonordisk As | Enzymhaltige zubereitung und eine solche zubereitung enthaltendes detergens. |
DK173590D0 (da) | 1990-06-06 | 1990-07-19 | Novo Nordisk As | Rekombinante terapeutiske lipaser |
SK283185B6 (sk) | 1990-08-03 | 2003-03-04 | Vertex Pharmaceuticals Incorporated | Zosietené kryštály proteínov, zariadenie ich obsahujúce a ich použitie |
US5618710A (en) * | 1990-08-03 | 1997-04-08 | Vertex Pharmaceuticals, Inc. | Crosslinked enzyme crystals |
US5892013A (en) * | 1990-09-13 | 1999-04-06 | Novo Nordisk A/S | Lipase variants |
ATE175117T1 (de) * | 1991-07-01 | 1999-01-15 | Basf Ag | Verwendung von lipasen zur herstellung von arzneimitteln |
EP0681609A1 (de) * | 1991-12-20 | 1995-11-15 | Novo Nordisk A/S | Verfahren zur herstellung von lipase |
US5928640A (en) * | 1992-06-30 | 1999-07-27 | Cortecs Limited | Use of enzymes, especially bromelain, in the treatment of diarrhoea |
DK154292D0 (da) * | 1992-12-23 | 1992-12-23 | Novo Nordisk As | Nyt enzym |
DK39693D0 (da) * | 1993-04-02 | 1993-04-02 | Novo Nordisk As | Enzym |
GB9403344D0 (en) * | 1994-02-22 | 1994-04-13 | Cortecs Ltd | Medical application of bromelain |
DE4408152A1 (de) * | 1994-03-11 | 1995-09-14 | Studiengesellschaft Kohle Mbh | Immobilisierte Lipasen in hydrophoben Sol-Gel-Materialien |
DK0755442T3 (da) * | 1994-05-04 | 2003-04-14 | Genencor Int | Lipaser med forbedret resistens over for overfladeaktive midler |
ATE287725T1 (de) | 1995-05-31 | 2005-02-15 | Medzyme N V | Zusammensetzungen zur verbesserung der verdaulichkeit und ausnutzung von nähestoffen |
US5932212A (en) * | 1996-05-24 | 1999-08-03 | Altus Biologics, Inc. | Crosslinked protein crystal formulations and their use as catalysts in organic solvents |
US5750104A (en) * | 1996-05-29 | 1998-05-12 | Digestive Care Inc. | High buffer-containing enteric coating digestive enzyme bile acid compositions and method of treating digestive disorders therewith |
US6140475A (en) | 1997-04-11 | 2000-10-31 | Altus Biologics Inc. | Controlled dissolution crosslinked protein crystals |
AU8772498A (en) | 1997-09-05 | 1999-03-29 | Altus Biologics Inc. | Carbohydrate crosslinked glycoprotein crystals |
US6013680A (en) * | 1997-10-21 | 2000-01-11 | Amano Pharmaceutical Co., Ltd. | Digestive enzyme-containing medicament |
US6541606B2 (en) * | 1997-12-31 | 2003-04-01 | Altus Biologics Inc. | Stabilized protein crystals formulations containing them and methods of making them |
US6156552A (en) * | 1998-02-18 | 2000-12-05 | Novo Nordisk A/S | Lipase variants |
EP2311436A1 (de) | 1998-04-27 | 2011-04-20 | Altus Pharmaceuticals Inc. | Stabilisierte Protein-Kristalle, diese enthaltende Formulierungen und ihre Herstellungsverfahren |
US6042823A (en) * | 1998-07-02 | 2000-03-28 | Amano Pharmaceuticals Co., Ltd. | Enzyme composition and use thereof |
US20010046493A1 (en) * | 2000-02-24 | 2001-11-29 | Alex Margolin | Lipase-containing composition and methods of use thereof |
AR032392A1 (es) * | 2001-01-19 | 2003-11-05 | Solvay Pharm Gmbh | Mezcla de enzimas, preparado farmaceutico y utilizacion de dicho preparado. |
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