DE122007000077I1 - Verfahren zur Herstellung von substituierten Octanoyl-Amiden - Google Patents

Verfahren zur Herstellung von substituierten Octanoyl-Amiden

Info

Publication number
DE122007000077I1
DE122007000077I1 DE200712000077 DE122007000077C DE122007000077I1 DE 122007000077 I1 DE122007000077 I1 DE 122007000077I1 DE 200712000077 DE200712000077 DE 200712000077 DE 122007000077 C DE122007000077 C DE 122007000077C DE 122007000077 I1 DE122007000077 I1 DE 122007000077I1
Authority
DE
Germany
Prior art keywords
octanoylamides
substituted
preparation
substituted octanoylamides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
DE200712000077
Other languages
English (en)
Other versions
DE122007000077I2 (de
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Speedel Pharma AG
Original Assignee
Speedel Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Speedel Pharma AG filed Critical Speedel Pharma AG
Publication of DE122007000077I1 publication Critical patent/DE122007000077I1/de
Publication of DE122007000077I2 publication Critical patent/DE122007000077I2/de
Active legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C247/00—Compounds containing azido groups
    • C07C247/02—Compounds containing azido groups with azido groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C247/12—Compounds containing azido groups with azido groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrrole Compounds (AREA)
  • Furan Compounds (AREA)
DE122007000077C 2000-07-25 2001-06-26 Verfahren zur herstellung von substituierten octanoyl-amiden Active DE122007000077I2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH14642000 2000-07-25
PCT/CH2001/000400 WO2002008172A1 (en) 2000-07-25 2001-06-26 Process for the preparation of substituted octanoyl amides

Publications (2)

Publication Number Publication Date
DE122007000077I1 true DE122007000077I1 (de) 2008-02-14
DE122007000077I2 DE122007000077I2 (de) 2008-08-21

Family

ID=4565499

Family Applications (2)

Application Number Title Priority Date Filing Date
DE122007000077C Active DE122007000077I2 (de) 2000-07-25 2001-06-26 Verfahren zur herstellung von substituierten octanoyl-amiden
DE60103545T Expired - Lifetime DE60103545T2 (de) 2000-07-25 2001-06-26 Verfahren zur herstellung von substituierten octanoyl-amiden

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE60103545T Expired - Lifetime DE60103545T2 (de) 2000-07-25 2001-06-26 Verfahren zur herstellung von substituierten octanoyl-amiden

Country Status (17)

Country Link
US (1) US6800769B2 (de)
EP (1) EP1303478B1 (de)
JP (1) JP4853888B2 (de)
AR (1) AR029870A1 (de)
AT (1) ATE267800T1 (de)
AU (1) AU2001273764A1 (de)
CA (1) CA2412452C (de)
CY (1) CY2007029I2 (de)
DE (2) DE122007000077I2 (de)
DK (1) DK1303478T3 (de)
ES (1) ES2220776T3 (de)
FR (1) FR07C0070I2 (de)
NL (1) NL300305I2 (de)
PT (1) PT1303478E (de)
TR (1) TR200401871T4 (de)
TW (1) TWI222434B (de)
WO (1) WO2002008172A1 (de)

Families Citing this family (47)

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US20060154926A1 (en) * 2002-06-11 2006-07-13 Elan Pharmaceuticals, Inc. Methods of treating alzheimer's disease using aryl alkanoic acid amides
JP4645986B2 (ja) 2002-12-09 2011-03-09 旭硝子株式会社 （４ｅ）−５−クロロ−２−イソプロピル−４−ペンテン酸エステルおよびその光学活性体の製造方法
JPWO2006041062A1 (ja) * 2004-10-15 2008-05-15 旭硝子株式会社 （４ｅ）−５−クロロ−２−イソプロピル−４−ペンテン酸エステルおよびその光学活性体の製造方法
TW200631929A (en) * 2004-12-10 2006-09-16 Speedel Experimenta Ag ω -phenyloctanamides
AU2006268907B2 (en) * 2005-07-11 2010-06-10 Novartis Ag New pyrocatechin derivatives
GB2431654A (en) * 2005-10-25 2007-05-02 Novartis Ag Alternative synthesis of aryl-octanoyl amide compounds
GB2431647A (en) * 2005-10-25 2007-05-02 Novartis Ag Synthesis of aryl-octanoyl amide compounds
GB2431651A (en) * 2005-10-25 2007-05-02 Novartis Ag Synthesis of aryl-octanoyl amide compounds
GB2431643A (en) * 2005-10-25 2007-05-02 Novartis Ag Synthesis of aryl-octanoyl amide compounds
GB2431644A (en) * 2005-10-25 2007-05-02 Novartis Ag Synthesis of aryl-octanoyl amide compounds
GB2431640A (en) * 2005-10-25 2007-05-02 Novartis Ag Alternative synthesis of aryl-octanoyl amide compounds
GB2431652A (en) * 2005-10-25 2007-05-02 Novartis Ag Alternative synthesis of aryl-octanoyl amide compounds
GB2431641A (en) * 2005-10-25 2007-05-02 Novartis Ag Alternative synthesis of aryl-octanoyl amide compounds
GB2431650A (en) * 2005-10-25 2007-05-02 Novartis Ag Alternative synthesis of aryl-octanoyl amide compounds
DE102005052195A1 (de) 2005-10-28 2007-05-03 Reuter Chemischer Apparatebau Kg Verfahren zur Herstellung von chiralen Octensäurederivaten
WO2007069745A1 (ja) * 2005-12-16 2007-06-21 Asahi Glass Company, Limited 光学活性な（４ｅ）－５－クロロ－２－イソプロピル－４－ペンテン酸またはその塩基性アミノ酸塩の製造方法
JP2009520753A (ja) * 2005-12-23 2009-05-28 ビーエーエスエフ ソシエタス・ヨーロピア 純粋な形態のα−キラルクロロメチル化合物の製造方法
DE102006017681A1 (de) * 2006-04-12 2007-10-18 Reuter Chemischer Apparatebau Kg Verfahren zur Herstellung von 8-Aryl-Octanoylderivaten
TW200837046A (en) * 2006-11-08 2008-09-16 Speedel Experimenta Ag Process for preparing organic compounds
EP1958666A1 (de) 2007-02-13 2008-08-20 Speedel Experimenta AG Heterozyklische substituierte Alkanamide als therapeutische Verbindungen
WO2008113835A1 (en) * 2007-03-21 2008-09-25 Novartis Ag Process for preparing (r or s)-5-{1-azido-3-[6-methoxy-5-(3-methoxy-propoxy)-pyridin-3-ylmethyl]-4-methyl-pentyl}-3-alkyl-dihydro-furan-2-one
DE102007049039A1 (de) 2007-10-11 2009-04-16 Reuter Chemischer Apparatebau Kg Verfahren zur Herstellung von 8-Hydrazino-8-Aryl-Octanoylderivaten und deren Verwendung
EP2062874B1 (de) 2007-11-20 2014-12-17 KRKA, tovarna zdravil, d.d., Novo mesto Verfahren und Zwischenprodukte für die Herstellung von Aliskiren
EP2189442B1 (de) 2008-11-20 2014-10-01 Krka Tovarna Zdravil, D.D., Novo Mesto Verfahren und Zwischenprodukte für die Herstellung von Aliskiren
EA201190091A1 (ru) 2009-02-05 2012-01-30 Крка, Товарна Здравил, Д. Д., Ново Место Активируемый влагой способ грануляции
US8203005B2 (en) 2009-10-29 2012-06-19 Carbo Design Llc Manufacturing process for enantiomerically pure 8-aryloctanoic acids as Aliskiren
CN101774986B (zh) 2010-01-06 2012-03-28 浙江天宇药业股份有限公司 一种制备阿利克伦及其中间体的方法
CN102241650B (zh) * 2010-05-14 2014-05-07 浙江九洲药业股份有限公司 用于制备阿立克仑的中间体化合物及相关制备方法
WO2011148392A1 (en) * 2010-05-28 2011-12-01 Msn Laboratories Limited Process for the preparation of (2s,4s,5s,7s)-n-(2-carbamyl-2- methylpropyl)-5-amino-4-hydroxy-2,7-diisopropyl-8-[4-methoxy-3-(3- methoxypropoxy)phenyl]-octanamide hemifumarate and its intermediates thereof
IT1402925B1 (it) * 2010-12-10 2013-09-27 Chemo Iberica Sa Processo per la produzione di aliskiren
TW201202178A (en) * 2010-06-04 2012-01-16 Chemo Iberica Sa Process for producing Aliskiren
WO2012034065A1 (en) * 2010-09-09 2012-03-15 Teva Pharmaceutical Industries Ltd. Aliskiren intermediates and a process for analyzing the purity of aliskiren
WO2012052829A1 (en) 2010-10-19 2012-04-26 Matrix Laboratories Ltd Synthesis of aliskiren
EP2551260A1 (de) 2011-07-28 2013-01-30 Chemo Ibérica, S.A. Chemisches Verfahren zum Öffnen von Ringverbindungen
ITMI20111719A1 (it) * 2011-09-23 2013-03-24 Friulchem Spa Sintesi totale di aliskiren con alta resa e purezza elevata per applicazione industriale
US8703976B2 (en) 2011-10-02 2014-04-22 Milan Soukup Manufacturing process for 8-aryloctanoic acids such as Aliskiren
US9056816B2 (en) 2011-10-25 2015-06-16 Jubilant Life Sciences Limited Process for the preparation of aliskiren
WO2013118138A1 (en) 2011-12-13 2013-08-15 Laboratories Ltd Mylan Novel process for the preparation of renin inhibitors
EP2814806B1 (de) 2012-02-17 2016-05-25 Mylan Laboratories Ltd. Verbessertes verfahren zur herstellung von aliskiren
WO2013124868A2 (en) 2012-02-21 2013-08-29 Mylan Laboratories Limited Solid form of aliskiren intermediate
WO2013144979A1 (en) 2012-03-28 2013-10-03 Maylan Laboratories Ltd Process for the preparation of aliskiren
WO2013171767A1 (en) 2012-05-18 2013-11-21 Mylan Laboratories Limited An improved process for the preparation of aliskiren
CN103130677B (zh) * 2013-03-12 2015-01-07 博瑞生物医药技术(苏州)有限公司 一种阿利克仑的制备方法
CN103351300A (zh) * 2013-06-30 2013-10-16 北京万全德众医药生物技术有限公司 一种制备阿利克仑中间体侧链（s）-2-溴代异戊酸甲酯的方法
CN103896794B (zh) * 2014-04-23 2015-10-07 中国科学院长春应用化学研究所 阿利克仑中间体以及阿利克仑的制备方法
CN105294478B (zh) * 2014-07-01 2017-06-13 华润双鹤药业股份有限公司 阿利吉仑的一种非对映异构体、其制备方法及用途
CN113387828A (zh) * 2020-03-14 2021-09-14 江巨东 一种阿利克仑中间体的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY119161A (en) * 1994-04-18 2005-04-30 Novartis Ag Delta-amino-gamma-hydroxy-omega-aryl-alkanoic acid amides with enzyme especially renin inhibiting activities
US5659065A (en) * 1994-04-18 1997-08-19 Novartis Corporation Alpha-aminoalkanoic acids and reduction products
US5606078A (en) 1994-04-18 1997-02-25 Ciba-Geigy Corporation 3,5-Disubstituted tetrahydrofuran-2-ones

Also Published As

Publication number Publication date
EP1303478B1 (de) 2004-05-26
NL300305I2 (nl) 2008-02-01
NL300305I1 (nl) 2008-01-02
US20030181765A1 (en) 2003-09-25
FR07C0070I1 (de) 2008-01-02
WO2002008172A1 (en) 2002-01-31
DE60103545D1 (de) 2004-07-01
JP2004504373A (ja) 2004-02-12
DK1303478T3 (da) 2004-08-30
TWI222434B (en) 2004-10-21
CA2412452C (en) 2008-12-30
CY2007029I1 (el) 2009-11-04
ES2220776T3 (es) 2004-12-16
FR07C0070I2 (de) 2009-01-15
DE60103545T2 (de) 2005-08-25
CY2007029I2 (el) 2009-11-04
PT1303478E (pt) 2004-10-29
TR200401871T4 (tr) 2004-08-23
ATE267800T1 (de) 2004-06-15
AU2001273764A1 (en) 2002-02-05
JP4853888B2 (ja) 2012-01-11
CA2412452A1 (en) 2002-01-31
EP1303478A1 (de) 2003-04-23
AR029870A1 (es) 2003-07-16
DE122007000077I2 (de) 2008-08-21
US6800769B2 (en) 2004-10-05

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