DE60041264D1 - Durchfluss-Mikroreaktor in dem lokale Temperaturzyklen auf eine fliessende Probe einwirken - Google Patents
Durchfluss-Mikroreaktor in dem lokale Temperaturzyklen auf eine fliessende Probe einwirkenInfo
- Publication number
- DE60041264D1 DE60041264D1 DE60041264T DE60041264T DE60041264D1 DE 60041264 D1 DE60041264 D1 DE 60041264D1 DE 60041264 T DE60041264 T DE 60041264T DE 60041264 T DE60041264 T DE 60041264T DE 60041264 D1 DE60041264 D1 DE 60041264D1
- Authority
- DE
- Germany
- Prior art keywords
- act
- local temperature
- temperature cycles
- sample
- flowing sample
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/08—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a stream of discrete samples flowing along a tube system, e.g. flow injection analysis
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L7/00—Heating or cooling apparatus; Heat insulating devices
- B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L7/00—Heating or cooling apparatus; Heat insulating devices
- B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
- B01L7/525—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples with physical movement of samples between temperature zones
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L7/00—Heating or cooling apparatus; Heat insulating devices
- B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
- B01L7/525—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples with physical movement of samples between temperature zones
- B01L7/5255—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples with physical movement of samples between temperature zones by moving sample containers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0673—Handling of plugs of fluid surrounded by immiscible fluid
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0832—Geometry, shape and general structure cylindrical, tube shaped
- B01L2300/0845—Filaments, strings, fibres, i.e. not hollow
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/0867—Multiple inlets and one sample wells, e.g. mixing, dilution
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/087—Multiple sequential chambers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/18—Means for temperature control
- B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/18—Means for temperature control
- B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
- B01L2300/1822—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using Peltier elements
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/18—Means for temperature control
- B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
- B01L2300/1827—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using resistive heater
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/18—Means for temperature control
- B01L2300/1838—Means for temperature control using fluid heat transfer medium
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/18—Means for temperature control
- B01L2300/1883—Means for temperature control using thermal insulation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
- B01L2400/0418—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic electro-osmotic flow [EOF]
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
- B01L2400/0421—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic electrophoretic flow
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
- B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5025—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L7/00—Heating or cooling apparatus; Heat insulating devices
- B01L7/02—Water baths; Sand baths; Air baths
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F28—HEAT EXCHANGE IN GENERAL
- F28F—DETAILS OF HEAT-EXCHANGE AND HEAT-TRANSFER APPARATUS, OF GENERAL APPLICATION
- F28F2260/00—Heat exchangers or heat exchange elements having special size, e.g. microstructures
- F28F2260/02—Heat exchangers or heat exchange elements having special size, e.g. microstructures having microchannels
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Clinical Laboratory Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Dispersion Chemistry (AREA)
- Hematology (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Sampling And Sample Adjustment (AREA)
- Optical Measuring Cells (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9909806A FR2796863B1 (fr) | 1999-07-28 | 1999-07-28 | Procede et dispositif permettant de realiser en flux continu un protocole de traitement thermique sur une substance |
FR9911652A FR2798604B1 (fr) | 1999-09-17 | 1999-09-17 | Dispositif pour la realisation de reactions chimiques ou biochimiques par cyclage thermique |
FR9912317A FR2799139B1 (fr) | 1999-10-01 | 1999-10-01 | Dispositif d'analyse biochimique comprenant un substrat microfluidique notamment pour l'amplification ou l'analyse d'acides nucleiques. |
PCT/IB2000/001137 WO2001007159A2 (en) | 1999-07-28 | 2000-07-28 | Integration of biochemical protocols in a continuous flow microfluidic device |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60041264D1 true DE60041264D1 (de) | 2009-02-12 |
Family
ID=27253548
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60041264T Expired - Lifetime DE60041264D1 (de) | 1999-07-28 | 2000-07-28 | Durchfluss-Mikroreaktor in dem lokale Temperaturzyklen auf eine fliessende Probe einwirken |
Country Status (8)
Country | Link |
---|---|
US (2) | US7015030B1 (de) |
EP (1) | EP1203096B1 (de) |
JP (1) | JP2003505059A (de) |
AT (1) | ATE419384T1 (de) |
AU (1) | AU782726B2 (de) |
CA (1) | CA2379927A1 (de) |
DE (1) | DE60041264D1 (de) |
WO (1) | WO2001007159A2 (de) |
Families Citing this family (108)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6977145B2 (en) * | 1999-07-28 | 2005-12-20 | Serono Genetics Institute S.A. | Method for carrying out a biochemical protocol in continuous flow in a microreactor |
CA2290731A1 (en) * | 1999-11-26 | 2001-05-26 | D. Jed Harrison | Apparatus and method for trapping bead based reagents within microfluidic analysis system |
US6432290B1 (en) | 1999-11-26 | 2002-08-13 | The Governors Of The University Of Alberta | Apparatus and method for trapping bead based reagents within microfluidic analysis systems |
US8900811B2 (en) * | 2000-11-16 | 2014-12-02 | Caliper Life Sciences, Inc. | Method and apparatus for generating thermal melting curves in a microfluidic device |
FR2822848B1 (fr) * | 2001-03-28 | 2004-05-07 | Genesystems | Dispositif integre et miniature de sequencage d'acides nucleiques |
US20030032172A1 (en) * | 2001-07-06 | 2003-02-13 | The Regents Of The University Of California | Automated nucleic acid assay system |
AUPR707101A0 (en) | 2001-08-16 | 2001-09-06 | Corbett Research Pty Ltd | Continuous flow thermal device |
US20030108664A1 (en) * | 2001-10-05 | 2003-06-12 | Kodas Toivo T. | Methods and compositions for the formation of recessed electrical features on a substrate |
FR2831081B1 (fr) * | 2001-10-24 | 2004-09-03 | Commissariat Energie Atomique | Dispositif d'injection parallelisee et synchronisee pour injections sequentielles de reactifs differents |
US7094379B2 (en) | 2001-10-24 | 2006-08-22 | Commissariat A L'energie Atomique | Device for parallel and synchronous injection for sequential injection of different reagents |
US20030217923A1 (en) * | 2002-05-24 | 2003-11-27 | Harrison D. Jed | Apparatus and method for trapping bead based reagents within microfluidic analysis systems |
AU2003283663A1 (en) * | 2002-11-01 | 2004-05-25 | Cellectricon Ab | Computer programs,workstations, systems and methods for microfluidic substrates in cell |
DE10258398A1 (de) * | 2002-12-11 | 2004-08-12 | Hans-Knöll-Institut für Naturstoff-Forschung e.V. | Verfahren zur Amplifikation von DNA |
KR20050088476A (ko) | 2002-12-30 | 2005-09-06 | 더 리전트 오브 더 유니버시티 오브 캘리포니아 | 병원균 검출과 분석을 위한 방법과 기구 |
US7041481B2 (en) | 2003-03-14 | 2006-05-09 | The Regents Of The University Of California | Chemical amplification based on fluid partitioning |
JP2004305009A (ja) * | 2003-04-02 | 2004-11-04 | Hitachi Ltd | 核酸増幅装置及び核酸増幅方法 |
US8293471B2 (en) * | 2004-01-28 | 2012-10-23 | Marshall University Research Corporation | Apparatus and method for a continuous rapid thermal cycle system |
KR100552706B1 (ko) * | 2004-03-12 | 2006-02-20 | 삼성전자주식회사 | 핵산 증폭 방법 및 장치 |
EP1598429A1 (de) * | 2004-05-19 | 2005-11-23 | Amplion Ltd. | Detektion von Amplikon-Kontamination während einer PCR, die zwei verschiedene Annealing-Temperaturen aufweist |
JP4482929B2 (ja) * | 2004-06-01 | 2010-06-16 | 富士フイルム株式会社 | 科学現象の評価装置の製造方法 |
US7799553B2 (en) * | 2004-06-01 | 2010-09-21 | The Regents Of The University Of California | Microfabricated integrated DNA analysis system |
JP2008513022A (ja) * | 2004-09-15 | 2008-05-01 | マイクロチップ バイオテクノロジーズ, インコーポレイテッド | マイクロ流体デバイス |
JPWO2006046433A1 (ja) * | 2004-10-27 | 2008-05-22 | コニカミノルタエムジー株式会社 | 遺伝子検査用マイクロリアクタ |
US7727477B2 (en) * | 2004-12-10 | 2010-06-01 | Bio-Rad Laboratories, Inc. | Apparatus for priming microfluidics devices with feedback control |
CA2611700C (en) * | 2005-01-25 | 2012-08-21 | Oscillogy Llc | Temperature controller for small fluid samples having different heat capacities |
US20090305216A1 (en) * | 2005-03-23 | 2009-12-10 | Fujifilm Corporation | Experimental method for scientific phenomenon evaluating apparatus, and scientific phenomenon evaluating apparatus |
JP4501158B2 (ja) * | 2005-03-30 | 2010-07-14 | 富士フイルム株式会社 | マイクロ化学装置の運転方法 |
KR100714988B1 (ko) * | 2005-08-09 | 2007-05-09 | 삼성전자주식회사 | 산화막이 표면에 형성된 실리콘 구조물 표면을 이용한dna 정제 방법 및 정제장치 |
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US7766033B2 (en) * | 2006-03-22 | 2010-08-03 | The Regents Of The University Of California | Multiplexed latching valves for microfluidic devices and processors |
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US7851184B2 (en) | 2006-04-18 | 2010-12-14 | Advanced Liquid Logic, Inc. | Droplet-based nucleic acid amplification method and apparatus |
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JP5138093B2 (ja) | 2009-03-31 | 2013-02-06 | 財団法人神奈川科学技術アカデミー | 液体還流型高速遺伝子増幅装置 |
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- 2000-07-28 JP JP2001512031A patent/JP2003505059A/ja not_active Withdrawn
- 2000-07-28 US US09/627,647 patent/US7015030B1/en not_active Expired - Fee Related
- 2000-07-28 EP EP00949852A patent/EP1203096B1/de not_active Expired - Lifetime
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2005
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WO2001007159A3 (en) | 2001-05-25 |
AU6310900A (en) | 2001-02-13 |
US20060011478A1 (en) | 2006-01-19 |
CA2379927A1 (en) | 2001-02-01 |
US7015030B1 (en) | 2006-03-21 |
JP2003505059A (ja) | 2003-02-12 |
EP1203096B1 (de) | 2008-12-31 |
WO2001007159A2 (en) | 2001-02-01 |
AU782726B2 (en) | 2005-08-25 |
ATE419384T1 (de) | 2009-01-15 |
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