DE60034961D1 - Aminobenzophenone als inhibitoren von il-1beta und tnf-alpha - Google Patents
Aminobenzophenone als inhibitoren von il-1beta und tnf-alphaInfo
- Publication number
- DE60034961D1 DE60034961D1 DE60034961T DE60034961T DE60034961D1 DE 60034961 D1 DE60034961 D1 DE 60034961D1 DE 60034961 T DE60034961 T DE 60034961T DE 60034961 T DE60034961 T DE 60034961T DE 60034961 D1 DE60034961 D1 DE 60034961D1
- Authority
- DE
- Germany
- Prior art keywords
- group
- alkyl
- hydrogen
- alkoxycarbonyl
- alkylthio
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C325/00—Thioaldehydes; Thioketones; Thioquinones; Oxides thereof
- C07C325/02—Thioketones; Oxides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/136—Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
- C07C225/22—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C251/32—Oximes
- C07C251/34—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
- C07C251/48—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atom of at least one of the oxyimino groups bound to a carbon atom of a six-membered aromatic ring
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US16933399P | 1999-12-06 | 1999-12-06 | |
US169333P | 1999-12-06 | ||
PCT/DK2000/000653 WO2001042189A1 (en) | 1999-12-06 | 2000-11-29 | AMINOBENZOPHENONES AS INHIBITORS OF IL-1β AND TNF-$g(a) |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60034961D1 true DE60034961D1 (de) | 2007-07-05 |
DE60034961T2 DE60034961T2 (de) | 2008-01-24 |
Family
ID=22615235
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60034961T Expired - Lifetime DE60034961T2 (de) | 1999-12-06 | 2000-11-29 | Aminobenzophenone als inhibitoren von il-1beta und tnf-alpha |
Country Status (19)
Country | Link |
---|---|
US (1) | US6541670B2 (de) |
EP (1) | EP1237845B1 (de) |
JP (1) | JP4684515B2 (de) |
KR (1) | KR20020071876A (de) |
CN (1) | CN1193003C (de) |
AT (1) | ATE362912T1 (de) |
AU (1) | AU776395B2 (de) |
BR (1) | BR0016164A (de) |
CA (1) | CA2393312C (de) |
CZ (1) | CZ20021940A3 (de) |
DE (1) | DE60034961T2 (de) |
ES (1) | ES2287040T3 (de) |
HK (1) | HK1053463A1 (de) |
HU (1) | HUP0203813A3 (de) |
MX (1) | MXPA02005604A (de) |
NZ (1) | NZ519172A (de) |
PL (1) | PL356049A1 (de) |
RU (1) | RU2260422C2 (de) |
WO (1) | WO2001042189A1 (de) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5763429A (en) * | 1993-09-10 | 1998-06-09 | Bone Care International, Inc. | Method of treating prostatic diseases using active vitamin D analogues |
US6242434B1 (en) * | 1997-08-08 | 2001-06-05 | Bone Care International, Inc. | 24-hydroxyvitamin D, analogs and uses thereof |
US20020128240A1 (en) * | 1996-12-30 | 2002-09-12 | Bone Care International, Inc. | Treatment of hyperproliferative diseases using active vitamin D analogues |
US6566353B2 (en) * | 1996-12-30 | 2003-05-20 | Bone Care International, Inc. | Method of treating malignancy associated hypercalcemia using active vitamin D analogues |
US6087350A (en) * | 1997-08-29 | 2000-07-11 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Use of pretreatment chemicals to enhance efficacy of cytotoxic agents |
AU762481C (en) * | 1998-03-27 | 2004-08-19 | Oregon Health Sciences University | Vitamin D and its analogs in the treatment of tumors and other hyperproliferative disorders |
RU2270194C2 (ru) | 2000-05-22 | 2006-02-20 | Лео Фарма А/С | Бензофеноны как ингибиторы il-1бета и tnf-альфа, фармацевтическая композиция и способ лечения |
WO2002006218A2 (en) * | 2000-07-18 | 2002-01-24 | Bone Care International, Inc. | STABILIZED 1α-HYDROXY VITAMIN D |
CA2420576C (en) * | 2000-08-29 | 2005-06-14 | Nobex Corporation | Immunoregulatory compounds, derivatives thereof and their use |
US20020165286A1 (en) * | 2000-12-08 | 2002-11-07 | Hanne Hedeman | Dermal anti-inflammatory composition |
GB0107368D0 (en) * | 2001-03-23 | 2001-05-16 | Novartis Ag | Organic compounds |
KR100896667B1 (ko) | 2001-08-28 | 2009-05-14 | 레오 파마 에이/에스 | 신규한 아미노벤조페논 및 이를 포함하는 약제학적 조성물 |
US8048924B2 (en) * | 2001-08-29 | 2011-11-01 | Biocon Limited | Methods and compositions employing 4-aminophenylacetic acid compounds |
WO2004004725A2 (en) | 2002-07-09 | 2004-01-15 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Pharmaceutical compositions of anticholinergics and p38 kinase inhibitors in the treatment of respiratory diseases |
CA2510711A1 (en) * | 2002-12-20 | 2004-07-08 | Leo Pharma A/S | Novel aminobenzophenone compounds |
CN1826310B (zh) * | 2003-07-24 | 2010-07-21 | 利奥制药有限公司 | 新的氨基二苯酮化合物 |
US20060003950A1 (en) * | 2004-06-30 | 2006-01-05 | Bone Care International, Inc. | Method of treating prostatic diseases using a combination of vitamin D analogues and other agents |
US7094775B2 (en) * | 2004-06-30 | 2006-08-22 | Bone Care International, Llc | Method of treating breast cancer using a combination of vitamin D analogues and other agents |
PL1773767T3 (pl) | 2004-07-07 | 2016-07-29 | Biocon Ltd | Synteza azowo związanych związków immunoregulacyjnych |
US20060035893A1 (en) | 2004-08-07 | 2006-02-16 | Boehringer Ingelheim International Gmbh | Pharmaceutical compositions for treatment of respiratory and gastrointestinal disorders |
PL1828148T3 (pl) * | 2004-12-13 | 2010-08-31 | Leo Pharma As | Triazol podstawiony związkami aminobenzofenonu |
PE20060777A1 (es) | 2004-12-24 | 2006-10-06 | Boehringer Ingelheim Int | Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas |
EP1992344A1 (de) | 2007-05-18 | 2008-11-19 | Institut Curie | P38 Alpha als therapeutisches Target für Erkrankungen, die mit einer FGFR3- Mutation assoziiert sind |
EP2206534A1 (de) | 2008-10-09 | 2010-07-14 | c-a-i-r biosciences GmbH | Dibenzocycloheptanonderivate und pharmazeutische Mittel, welche diese Verbindungen enthalten |
RU2571489C2 (ru) * | 2009-10-26 | 2015-12-20 | Нестек С.А. | Способы выявления препаратов и аутоантител против tnf |
EP2799537B1 (de) | 2011-12-28 | 2021-09-22 | Kyoto Prefectural Public University Corporation | Normalisierung der züchtung von hornhautendothelzellen |
WO2015050984A1 (en) | 2013-10-01 | 2015-04-09 | New York University | Amino, amido, and heterocyclic compounds as modulators of rage activity and uses thereof |
US10813920B2 (en) | 2013-11-14 | 2020-10-27 | The Doshisha | Drug for treating corneal endothelium by promoting cell proliferation or inhibiting cell damage |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS57177058A (en) | 1981-04-24 | 1982-10-30 | Hodogaya Chem Co Ltd | Novel fluoran compound |
KR920702606A (ko) * | 1989-06-13 | 1992-10-06 | 스튜어트 알. 슈터 | 모노킨(Monokine)의 활성저해 |
JPH08104817A (ja) * | 1994-10-03 | 1996-04-23 | Nippon Soda Co Ltd | 新規なフルオラン化合物及びそれを用いた発色性記録材料 |
GB9701453D0 (en) * | 1997-01-24 | 1997-03-12 | Leo Pharm Prod Ltd | Aminobenzophenones |
DE69829875T2 (de) * | 1997-10-14 | 2006-03-09 | Mitsubishi Pharma Corp. | Piperazin-verbindungen und ihre medizinische verwendung |
JPH11217387A (ja) * | 1998-01-27 | 1999-08-10 | Yamada Chem Co Ltd | フルオラン化合物及びこれを用いた発色性記録材料 |
ATE251117T1 (de) * | 1999-07-16 | 2003-10-15 | Leo Pharma As | Neue aminobenzophenone |
-
2000
- 2000-11-29 AU AU16935/01A patent/AU776395B2/en not_active Ceased
- 2000-11-29 ES ES00979457T patent/ES2287040T3/es not_active Expired - Lifetime
- 2000-11-29 RU RU2002118113/15A patent/RU2260422C2/ru not_active IP Right Cessation
- 2000-11-29 EP EP00979457A patent/EP1237845B1/de not_active Expired - Lifetime
- 2000-11-29 KR KR1020027007188A patent/KR20020071876A/ko not_active Application Discontinuation
- 2000-11-29 JP JP2001543491A patent/JP4684515B2/ja not_active Expired - Fee Related
- 2000-11-29 MX MXPA02005604A patent/MXPA02005604A/es active IP Right Grant
- 2000-11-29 WO PCT/DK2000/000653 patent/WO2001042189A1/en active IP Right Grant
- 2000-11-29 BR BR0016164-0A patent/BR0016164A/pt not_active IP Right Cessation
- 2000-11-29 US US09/787,532 patent/US6541670B2/en not_active Expired - Lifetime
- 2000-11-29 CZ CZ20021940A patent/CZ20021940A3/cs unknown
- 2000-11-29 PL PL00356049A patent/PL356049A1/xx not_active Application Discontinuation
- 2000-11-29 CA CA2393312A patent/CA2393312C/en not_active Expired - Fee Related
- 2000-11-29 AT AT00979457T patent/ATE362912T1/de not_active IP Right Cessation
- 2000-11-29 DE DE60034961T patent/DE60034961T2/de not_active Expired - Lifetime
- 2000-11-29 CN CNB008177767A patent/CN1193003C/zh not_active Expired - Fee Related
- 2000-11-29 HU HU0203813A patent/HUP0203813A3/hu unknown
- 2000-11-29 NZ NZ519172A patent/NZ519172A/en not_active IP Right Cessation
-
2003
- 2003-08-14 HK HK03105831A patent/HK1053463A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
AU1693501A (en) | 2001-06-18 |
HUP0203813A3 (en) | 2008-03-28 |
CA2393312C (en) | 2011-07-12 |
HK1053463A1 (en) | 2003-10-24 |
NZ519172A (en) | 2004-03-26 |
ATE362912T1 (de) | 2007-06-15 |
EP1237845A1 (de) | 2002-09-11 |
ES2287040T3 (es) | 2007-12-16 |
HUP0203813A2 (hu) | 2003-03-28 |
US6541670B2 (en) | 2003-04-01 |
AU776395B2 (en) | 2004-09-09 |
CZ20021940A3 (cs) | 2003-01-15 |
CA2393312A1 (en) | 2001-06-14 |
RU2002118113A (ru) | 2004-02-20 |
US20030013770A1 (en) | 2003-01-16 |
JP2003516377A (ja) | 2003-05-13 |
MXPA02005604A (es) | 2004-09-10 |
BR0016164A (pt) | 2002-08-13 |
PL356049A1 (en) | 2004-06-14 |
DE60034961T2 (de) | 2008-01-24 |
KR20020071876A (ko) | 2002-09-13 |
WO2001042189A1 (en) | 2001-06-14 |
EP1237845B1 (de) | 2007-05-23 |
CN1193003C (zh) | 2005-03-16 |
JP4684515B2 (ja) | 2011-05-18 |
RU2260422C2 (ru) | 2005-09-20 |
CN1413186A (zh) | 2003-04-23 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |