DE60007530D1 - Oral wirksame androgene - Google Patents

Oral wirksame androgene

Info

Publication number
DE60007530D1
DE60007530D1 DE60007530T DE60007530T DE60007530D1 DE 60007530 D1 DE60007530 D1 DE 60007530D1 DE 60007530 T DE60007530 T DE 60007530T DE 60007530 T DE60007530 T DE 60007530T DE 60007530 D1 DE60007530 D1 DE 60007530D1
Authority
DE
Germany
Prior art keywords
androgene
oral effective
oral
effective
effective androgene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60007530T
Other languages
English (en)
Other versions
DE60007530T2 (de
Inventor
Jan Loozen
Dirk Leysen
Der Louw Jaap Van
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Akzo Nobel NV
Original Assignee
Akzo Nobel NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel NV filed Critical Akzo Nobel NV
Publication of DE60007530D1 publication Critical patent/DE60007530D1/de
Application granted granted Critical
Publication of DE60007530T2 publication Critical patent/DE60007530T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
    • C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
    • C07J1/0074—Esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/16—Masculine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/26—Androgens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
    • C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE60007530T 1999-07-16 2000-07-10 Oral wirksame androgene Expired - Fee Related DE60007530T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP99202348 1999-07-16
EP99202348 1999-07-16
PCT/EP2000/006544 WO2001005806A1 (en) 1999-07-16 2000-07-10 Orally active androgens

Publications (2)

Publication Number Publication Date
DE60007530D1 true DE60007530D1 (de) 2004-02-05
DE60007530T2 DE60007530T2 (de) 2004-12-23

Family

ID=8240463

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60007530T Expired - Fee Related DE60007530T2 (de) 1999-07-16 2000-07-10 Oral wirksame androgene

Country Status (28)

Country Link
US (3) US6313108B1 (de)
EP (1) EP1203011B1 (de)
JP (1) JP2003505394A (de)
KR (1) KR20020092890A (de)
CN (1) CN1360589A (de)
AR (1) AR024746A1 (de)
AT (1) ATE257159T1 (de)
AU (1) AU770412B2 (de)
BR (1) BR0012489A (de)
CA (1) CA2379223A1 (de)
CO (1) CO5200765A1 (de)
CZ (1) CZ2002192A3 (de)
DE (1) DE60007530T2 (de)
ES (1) ES2213596T3 (de)
HK (1) HK1043797A1 (de)
HU (1) HUP0201952A3 (de)
IL (1) IL147332A0 (de)
MX (1) MXPA02000601A (de)
NO (1) NO20020222L (de)
NZ (1) NZ516525A (de)
PE (1) PE20010330A1 (de)
PL (1) PL353007A1 (de)
RU (1) RU2002103883A (de)
SK (1) SK712002A3 (de)
TR (1) TR200200076T2 (de)
TW (1) TW548277B (de)
WO (1) WO2001005806A1 (de)
ZA (1) ZA200200106B (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000059920A2 (en) * 1999-04-06 2000-10-12 Akzo Nobel N.V. Orally active 7.alpha.-alkyl androgens
ATE334682T1 (de) * 2000-03-31 2006-08-15 Us Gov Health & Human Serv Verfahren zur herstellung von den trans-4-n- butylcyclohexanoicsaüre- und undecanoicsaüreestern von (7-alpha,11-beta)- dimethyl-17 beta -hydroxy-4-estren-3-one und deren medizynische anwendung
US20030069215A1 (en) * 2001-03-30 2003-04-10 The Government Of The United States Of America, Methods of making and using 7a,11b-dimethyl-17b-hydroxy-4-estren-3-one 17b-trans-4-n-butylcyclohexane carboxylate and 7a,11b-dimethyl-17b-hydroxyestr-4-en-3-one 17-undecanoate
WO2003045398A1 (en) * 2001-03-30 2003-06-05 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Methods of making and pharmaceutical formulations comprising 7alpha, 11beta-dimethy-17beta-hydroxyestra-4, 14-dien-3-one and 17 esters thereof
SK882003A3 (en) * 2000-07-28 2003-07-01 Akzo Nobel Nv 16alpha-substituted steroid compounds, pharmaceutical composition comprising same and their use
TWI322813B (en) * 2002-01-21 2010-04-01 Organon Nv Process for the preparation of 7alpha-methylsteroids
GB0304927D0 (en) * 2003-03-04 2003-04-09 Resolution Chemicals Ltd Process for the production of tibolone
PE20050677A1 (es) 2003-12-22 2005-10-04 Akzo Nobel Nv Esteroides con perfil androgenico y progestagenico mixto
UA89964C2 (ru) 2004-09-08 2010-03-25 Н.В. Органон 15β-ЗАМЕЩЕННЫЕ СТЕРОИДЫ, КОТОРЫЕ ИМЕЮТ СЕЛЕКТИВНУЮ ЭСТРОГЕННУЮ АКТИВНОСТЬ
CN102227441A (zh) * 2008-10-15 2011-10-26 斯索恩有限公司 制备氟维司群的方法和中间体
RS55293B1 (sr) * 2011-06-01 2017-03-31 Estetra Sprl Postupak proizvodnje intermedijara estetrola
JP6425540B2 (ja) 2011-06-01 2018-11-21 エステトラ エス．ペ．エール．エル． エステトロール中間体を製造するための方法
EP2383279A1 (de) 2011-07-19 2011-11-02 Pantarhei Bioscience B.V. Herstellungsverfahren für Esterol
ES2593316T3 (es) * 2011-10-07 2016-12-07 Estetra S.P.R.L. Proceso para la producción de Estetrol
WO2015181116A1 (en) 2014-05-26 2015-12-03 Crystal Pharma, S.A.U. Process and intermediades for the preparation of 7-alkylated steroids
TN2017000497A1 (en) 2015-06-18 2019-04-12 Mithra Pharmaceuticals S A Orodispersible dosage unit containing an estetrol component
ES2877186T3 (es) 2015-06-18 2021-11-16 Estetra Sprl Comprimido orodispersable que contiene estetrol
LT3106148T (lt) 2015-06-18 2018-06-25 Mithra Pharmaceuticals S.A. Burnoje disperguojamos dozės vienetas, turintis estetrolio komponentą
CN107750157B (zh) 2015-06-18 2021-07-13 埃斯特拉私人有限责任公司 含雌四醇的口腔分散片剂
KR20220144885A (ko) 2016-08-05 2022-10-27 에스테트라, 소시에떼 아 레스폰서빌리떼 리미떼 월경통 및 생리통의 관리방법
JP7003144B2 (ja) * 2017-02-23 2022-02-10 シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレイテッド 化学発光アンドロステンジオンコンジュゲート
TWI801561B (zh) 2018-04-19 2023-05-11 比利時商依思特拉私人有限責任公司 化合物及其用於緩解絕經相關症狀的用途
JOP20200260A1 (ar) 2018-04-19 2019-10-19 Estetra Sprl مركبات واستخداماتها للتخفيف من الأعراض المصاحبة لانقطاع الطمث

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA712312B (en) * 1970-04-28 1972-01-26 Ochsner Med Found Alton 4,14-estradiene compounds

Also Published As

Publication number Publication date
US20020022609A1 (en) 2002-02-21
NO20020222L (no) 2002-01-25
US20030087886A1 (en) 2003-05-08
US6541465B2 (en) 2003-04-01
NZ516525A (en) 2003-06-30
SK712002A3 (en) 2002-06-04
TW548277B (en) 2003-08-21
RU2002103883A (ru) 2004-02-27
HK1043797A1 (zh) 2002-09-27
CN1360589A (zh) 2002-07-24
JP2003505394A (ja) 2003-02-12
US6780854B2 (en) 2004-08-24
CA2379223A1 (en) 2001-01-25
CO5200765A1 (es) 2002-09-27
AR024746A1 (es) 2002-10-23
HUP0201952A2 (en) 2002-10-28
EP1203011B1 (de) 2004-01-02
US6313108B1 (en) 2001-11-06
PL353007A1 (en) 2003-09-22
ATE257159T1 (de) 2004-01-15
ES2213596T3 (es) 2004-09-01
CZ2002192A3 (cs) 2002-06-12
BR0012489A (pt) 2002-04-02
MXPA02000601A (es) 2002-07-30
TR200200076T2 (tr) 2002-04-22
PE20010330A1 (es) 2001-03-22
IL147332A0 (en) 2002-08-14
AU770412B2 (en) 2004-02-19
AU6562900A (en) 2001-02-05
NO20020222D0 (no) 2002-01-15
ZA200200106B (en) 2003-06-25
DE60007530T2 (de) 2004-12-23
HUP0201952A3 (en) 2003-10-28
EP1203011A1 (de) 2002-05-08
KR20020092890A (ko) 2002-12-12
WO2001005806A1 (en) 2001-01-25

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee