DE3789859D1 - Formen des Koloniestimulierungsfaktors 1. - Google Patents

Formen des Koloniestimulierungsfaktors 1.

Info

Publication number
DE3789859D1
DE3789859D1 DE3789859T DE3789859T DE3789859D1 DE 3789859 D1 DE3789859 D1 DE 3789859D1 DE 3789859 T DE3789859 T DE 3789859T DE 3789859 T DE3789859 T DE 3789859T DE 3789859 D1 DE3789859 D1 DE 3789859D1
Authority
DE
Germany
Prior art keywords
forms
stimulation factor
colony stimulation
csf
protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE3789859T
Other languages
English (en)
Other versions
DE3789859T2 (de
Inventor
Kirston Edward Koths
Robert Forgan Halenbeck
Ernest Seigo Kawasaki
Martha Ballie Ladner
Mazie Yee Coyne
Arsdell Janelle Nobel Van
George Arthur Martin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis Vaccines and Diagnostics Inc
Original Assignee
Cetus Oncology Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cetus Oncology Corp filed Critical Cetus Oncology Corp
Publication of DE3789859D1 publication Critical patent/DE3789859D1/de
Application granted granted Critical
Publication of DE3789859T2 publication Critical patent/DE3789859T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/53—Colony-stimulating factor [CSF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pyrane Compounds (AREA)
  • Liquid Crystal Substances (AREA)
  • Luminescent Compositions (AREA)
DE3789859T 1986-10-24 1987-10-23 Formen des Koloniestimulierungsfaktors 1. Expired - Fee Related DE3789859T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US92306786A 1986-10-24 1986-10-24
US3965487A 1987-04-16 1987-04-16
US3965787A 1987-04-16 1987-04-16

Publications (2)

Publication Number Publication Date
DE3789859D1 true DE3789859D1 (de) 1994-06-23
DE3789859T2 DE3789859T2 (de) 1994-09-15

Family

ID=27365583

Family Applications (1)

Application Number Title Priority Date Filing Date
DE3789859T Expired - Fee Related DE3789859T2 (de) 1986-10-24 1987-10-23 Formen des Koloniestimulierungsfaktors 1.

Country Status (12)

Country Link
EP (1) EP0272779B1 (de)
JP (1) JP2644794B2 (de)
AT (1) ATE105869T1 (de)
AU (2) AU8007087A (de)
CA (1) CA1339032C (de)
DE (1) DE3789859T2 (de)
DK (1) DK174237B1 (de)
ES (1) ES2052580T3 (de)
FI (1) FI102190B (de)
HU (1) HU215241B (de)
NO (1) NO301775B1 (de)
WO (1) WO1988003173A2 (de)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5556620A (en) * 1985-02-05 1996-09-17 Cetus Oncology Corporation Use of recombinant colony stimulating factor-1 to enhance wound healing
US5422105A (en) * 1985-02-05 1995-06-06 Cetus Oncology Corporation Use of recombinant colony stimulating factor 1
US5573930A (en) * 1985-02-05 1996-11-12 Cetus Oncology Corporation DNA encoding various forms of colony stimulating factor-1
US6156300A (en) * 1985-02-05 2000-12-05 Chiron Corporation Point mutants of N∇2 CSF-1 and carboxy truncated fragments thereof
US5104650A (en) * 1985-02-05 1992-04-14 Cetus Corporation Uses of recombinant colony stimulating factor-1
US6103224A (en) * 1985-02-05 2000-08-15 Chiron Corporation N∇2 CSF-1 (short form) and carboxy truncated fragments thereof
US5837229A (en) * 1985-02-05 1998-11-17 Chiron Corporation Uses of recombinant colony stimulating factor-1
AU595864B2 (en) * 1986-03-14 1990-04-12 Otsuka Pharmaceutical Co., Ltd. Il-1 alpha derivatives and drugs
MX9203130A (es) * 1986-05-06 1992-07-01 Genetics Inst Produccion de m-csf
JP2583829B2 (ja) * 1986-09-17 1997-02-19 大塚製薬株式会社 ヒトｍ−ｃｓｆ
US5650297A (en) * 1986-09-17 1997-07-22 Otsuka Pharmaceutical Co., Ltd. DNA encoding human colony-stimulating factors
JP2583770B2 (ja) * 1986-09-17 1997-02-19 大塚製薬株式会社 遺伝子
DE3777623D1 (de) * 1986-12-07 1992-04-23 Morinaga Milk Industry Co Ltd Kolonie-stimulierender faktor und verfahren zu seiner herstellung.
CA1339757C (en) 1987-04-16 1998-03-17 Robert F. Halenbeck Production of purified biologically active, bacterially produced recombinant human csf-1
US4929700A (en) * 1987-04-16 1990-05-29 Cetus Corporation Production of purified, biologically active, bacterially produced recombinant human CSF-1
AU2251488A (en) * 1987-07-24 1989-03-01 Cetus Corporation Production of biologically active forms of csf using a baculovirus (acnpv)-insect cell expression system
DK54589A (da) * 1988-02-08 1989-08-09 Otsuka Pharma Co Ltd Humane kolonistmulerende faktorer
JPH0610137B2 (ja) * 1988-02-29 1994-02-09 新技術事業団 ヒト単球−マクロファージコロニー刺激因子を有効成分とする造血器疾患治療剤
US5171675A (en) * 1988-07-28 1992-12-15 Cerretti Douglas P Macrophage colony stimulating factor-γ
WO1990012877A1 (en) * 1989-04-19 1990-11-01 Cetus Corporation Multifunctional m-csf proteins and genes encoding therefor
EP0410751B1 (de) * 1989-07-27 1996-04-10 Denki Kagaku Kogyo Kabushiki Kaisha Für M-CSF kodierendes Gen und dazu gehörende rekombinante Systeme
KR920701253A (ko) * 1989-11-07 1992-08-11 오오쓰까 아끼히꼬 M-csf 유도체, 그 유도체의 발현 벡터, 그 벡터를 갖는 형질 전환체 및 이들의 제조방법
US5714140A (en) * 1989-12-13 1998-02-03 Otsuka Pharmaceutical Co., Ltd. Method for inhibiting the production of bioactive IL-1 by administering M-CSF
DE4014750A1 (de) * 1990-05-08 1991-11-14 Boehringer Mannheim Gmbh Muteine des granulozyten-stimulierenden faktors (g-csf)
AU639091B2 (en) * 1991-04-24 1993-07-15 Otsuka Pharmaceutical Co., Ltd. M-csf derivatives, expression vectors for said derivatives, transformants carrying said vectors and production of these
ATE195553T1 (de) 1992-06-09 2000-09-15 Chiron Corp Kristallisierung von m-csf
JPH08505534A (ja) * 1993-01-13 1996-06-18 森永乳業株式会社 Ｍ−ｃｓｆ２２３の製造方法
GB2355791B (en) 1999-10-28 2004-10-20 Molecular Light Tech Res Ltd Detection of mRNA expression using chemiluminescent labelled probes
KR100371264B1 (ko) * 2000-01-25 2003-02-05 양문식 무라인 그래뉼로사이트-매크로파지 콜로니 자극 인자를포함하는 재조합 벡터와 그것을 발현하는 재조합아스퍼질러스 나이거
CA2776583C (en) 2009-10-06 2019-06-11 Regeneron Pharmaceuticals, Inc. Genetically modified mice and engraftment
MX350385B (es) 2011-02-15 2017-09-04 Regeneron Pharma Ratones de m-csf humanizada.
CN108782459B (zh) 2012-09-07 2021-11-05 再生元制药公司 经遗传修饰的非人动物及其使用方法
EP4389764A2 (de) 2012-11-05 2024-06-26 Regeneron Pharmaceuticals, Inc. Genetisch modifizierte nichtmenschliche tiere und verfahren zur verwendung davon
CA2947309A1 (en) 2014-05-19 2015-11-26 Regeneron Pharmaceuticals, Inc. Genetically modified non-human animals expressing human epo
ES2950399T3 (es) 2015-04-13 2023-10-09 Regeneron Pharma Ratones humanizados Sirpa-IL15 insertados y métodos de uso de los mismos

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0209601B1 (de) * 1985-02-05 1993-12-15 Cetus Oncology Corporation Rekombinanter koloniestimulierender faktor-1
JP2583770B2 (ja) * 1986-09-17 1997-02-19 大塚製薬株式会社 遺伝子

Also Published As

Publication number Publication date
NO882772D0 (no) 1988-06-22
FI883056A0 (fi) 1988-06-23
WO1988003173A3 (en) 1988-07-28
NO882772L (no) 1988-08-22
FI883056A (fi) 1988-06-23
JPH01501283A (ja) 1989-05-11
CA1339032C (en) 1997-04-01
FI102190B1 (fi) 1998-10-30
WO1988003173A2 (en) 1988-05-05
NO301775B1 (no) 1997-12-08
ES2052580T3 (es) 1994-07-16
DK174237B1 (da) 2002-10-07
DK350188A (da) 1988-08-19
DE3789859T2 (de) 1994-09-15
ATE105869T1 (de) 1994-06-15
EP0272779B1 (de) 1994-05-18
AU646277B2 (en) 1994-02-17
HUT47635A (en) 1989-03-28
AU8007087A (en) 1988-04-28
DK350188D0 (da) 1988-06-24
JP2644794B2 (ja) 1997-08-25
AU8149491A (en) 1991-10-31
FI102190B (fi) 1998-10-30
HU215241B (hu) 1998-11-30
EP0272779A2 (de) 1988-06-29
EP0272779A3 (en) 1988-08-03

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: CHIRON CORP. (N.D.GES.D. STAATES DELAWARE), EMERYV

8339 Ceased/non-payment of the annual fee