BG60238B1 - Човешки тумор- некротизиращ фактор - Google Patents

Човешки тумор- некротизиращ фактор

Info

Publication number
BG60238B1
BG60238B1 BG075334A BG7533486A BG60238B1 BG 60238 B1 BG60238 B1 BG 60238B1 BG 075334 A BG075334 A BG 075334A BG 7533486 A BG7533486 A BG 7533486A BG 60238 B1 BG60238 B1 BG 60238B1
Authority
BG
Bulgaria
Prior art keywords
tnf
human tumor
human
factor
necrotising
Prior art date
Application number
BG075334A
Other languages
English (en)
Other versions
BG60238B2 (bg
Inventor
David Mark
Martha Ladner
Leo Shun Lin
Alice Wang
Abla Creasey
Janelle Noble Arsdell
Original Assignee
Chiron Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/730,696 external-priority patent/US4677064A/en
Priority claimed from US06/760,661 external-priority patent/US4677063A/en
Application filed by Chiron Corporation filed Critical Chiron Corporation
Publication of BG60238B2 publication Critical patent/BG60238B2/bg
Publication of BG60238B1 publication Critical patent/BG60238B1/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/525—Tumour necrosis factor [TNF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Човешкият туморнекротизиращ фактор (тnf) намира приложение в медицината. Тnf и мутантните белтъци (мутеини) са с n-крайни делеции и с по-висока биологична активност. Тnf се получава чрез рекомбинантни методи, като човешка промиелоцитна левкемична клетъчна линия се индуцира чрез подобрен метод и тnf се пречиства до хомогенност. Прилагат се методи, вектори и клетки, необходими за получаването на човешки тnf в количества, достатъчни за практическо приложение. 19 претенции, 8 фигури
BG075334A 1984-10-15 1986-06-13 Човешки тумор- некротизиращ фактор BG60238B1 (bg)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US66102684A 1984-10-15 1984-10-15
US67036084A 1984-11-09 1984-11-09
US06/730,696 US4677064A (en) 1984-11-09 1985-05-02 Human tumor necrosis factor
US06/760,661 US4677063A (en) 1985-05-02 1985-07-30 Human tumor necrosis factor
PCT/US1985/001921 WO1986002381A1 (en) 1984-10-15 1985-10-03 Human tumor necrosis factor

Publications (2)

Publication Number Publication Date
BG60238B2 BG60238B2 (bg) 1994-01-18
BG60238B1 true BG60238B1 (bg) 1994-01-24

Family

ID=27505306

Family Applications (1)

Application Number Title Priority Date Filing Date
BG075334A BG60238B1 (bg) 1984-10-15 1986-06-13 Човешки тумор- некротизиращ фактор

Country Status (11)

Country Link
EP (1) EP0200748B1 (bg)
JP (1) JPH0866194A (bg)
AU (1) AU589919B2 (bg)
BG (1) BG60238B1 (bg)
DE (1) DE3581730D1 (bg)
DK (1) DK279886A (bg)
ES (1) ES8704547A1 (bg)
FI (1) FI862531A (bg)
IL (1) IL76699A (bg)
NO (1) NO174970C (bg)
WO (1) WO1986002381A1 (bg)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0155549B1 (en) * 1984-03-06 1991-03-20 Dainippon Pharmaceutical Co., Ltd. Dna encoding human tumor necrosis factor and human tumor necrosis factor polypeptide
US5288852A (en) * 1984-03-06 1994-02-22 Dainippon Pharmaceutical Co., Ltd. Human tumor necrosis factor polypeptides
JPS6248634A (ja) * 1985-07-23 1987-03-03 Mochida Pharmaceut Co Ltd 新規アミノ酸組成物、その製造方法及び該アミノ酸組成物を含有する医療組成物
CA1286843C (en) * 1985-10-30 1991-07-23 Leo S. Lin Purification method for proteins
US5425940A (en) * 1986-04-09 1995-06-20 Cetus Oncology Corporation Combination therapy using interleukin-2 and tumor necrosis factor
DE3750056T2 (de) * 1986-06-20 1995-04-06 Dainippon Pharmaceutical Co Polypeptid-Mutanten des menschlichen TNF und für diese Mutanten codierende DNS.
FR2601678B1 (fr) * 1986-07-18 1989-11-24 Inst Nat Sante Rech Med Peptides comprenant la sequence seryl-aspartyl-lysyl-prolyle, procede pour l'extraction du tetrapeptide correspondant, et applications, notamment a la protection de la moelle osseuse au cours de traitements anticancereux par la chimiotherapie
AU1346488A (en) * 1987-02-26 1988-09-26 Cetus Corporation Arginine-depleted human tumor necrosis factor
DE3837012A1 (de) * 1988-01-15 1989-07-27 Knoll Ag Verwendung von tnf und lt zur herstellung von arzneimitteln
JPH0797997B2 (ja) * 1988-04-28 1995-10-25 帝人株式会社 新規生理活性ポリペプチド
DE3841754A1 (de) * 1988-12-12 1990-06-13 Basf Ag Neue tnf-peptide
DE3841768A1 (de) * 1988-12-12 1990-06-13 Basf Ag Neue tnf-peptide
DE3841764A1 (de) * 1988-12-12 1990-06-13 Basf Ag Neue tnf-peptide
DE3843534A1 (de) * 1988-12-23 1990-07-12 Basf Ag Neue tnf-polypeptide
GB8905606D0 (en) * 1989-03-11 1989-04-26 Scras Peptides
EP0491878B1 (en) 1989-08-16 1997-02-19 Chiron Corporation Compositions for the inhibition of protein hormone formation and uses thereof
CA2067821A1 (en) * 1989-10-24 1991-04-25 Cetus Oncology Corporation Infective drug delivery system using recombinant retroviral vectors
DK2953634T3 (da) 2013-02-07 2021-08-30 Massachusetts Gen Hospital Fremgangsmåder til udvidelse eller udtømning af regulerende t-celler

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL90047A (en) * 1982-10-19 1992-12-01 Cetus Oncology Corp Cysteine-depleted biologically active muteins other than interferon - '
US4518584A (en) 1983-04-15 1985-05-21 Cetus Corporation Human recombinant interleukin-2 muteins
DE3472793D1 (en) * 1983-12-26 1988-08-25 Asahi Chemical Ind A novel physiologically active polypeptide
EP0155549B1 (en) * 1984-03-06 1991-03-20 Dainippon Pharmaceutical Co., Ltd. Dna encoding human tumor necrosis factor and human tumor necrosis factor polypeptide
US4879226A (en) * 1984-04-06 1989-11-07 Asahi Kasei Kogyo Kabushiki Kaisha Novel human physiologically active polypeptide
DE3517153A1 (de) * 1985-01-07 1986-07-10 Murillo Contreras, Jesús, México Feuerhemmende beschichtungsmischung und verfahren zu deren herstellung
JP2515975B2 (ja) * 1985-02-26 1996-07-10 大日本製薬株式会社 抗腫瘍作用を有するポリペプチド

Also Published As

Publication number Publication date
NO862353L (no) 1986-06-12
AU589919B2 (en) 1989-10-26
NO174970B (no) 1994-05-02
DE3581730D1 (de) 1991-03-14
NO174970C (no) 1994-08-10
IL76699A (en) 1998-03-10
ES8704547A1 (es) 1987-04-01
DK279886D0 (da) 1986-06-13
EP0200748A1 (en) 1986-11-12
IL76699A0 (en) 1986-02-28
WO1986002381A1 (en) 1986-04-24
EP0200748B1 (en) 1991-02-06
ES547871A0 (es) 1987-04-01
NO862353D0 (no) 1986-06-12
BG60238B2 (bg) 1994-01-18
FI862531A0 (fi) 1986-06-13
JPH0866194A (ja) 1996-03-12
AU5010685A (en) 1986-05-02
DK279886A (da) 1986-06-13
FI862531A (fi) 1986-06-13

Similar Documents

Publication Publication Date Title
BG60238B1 (bg) Човешки тумор- некротизиращ фактор
MY101887A (en) A novel human physiologically active polypeptide.
KR880701736A (ko) Il-6의 제조방법 및 용도
AU8007087A (en) New forms of colony stimulating factor-1
ES8600783A1 (es) Procedimiento para la preparacion de la hormona polipeptidica factor de crecimiento de nervios de humano.
GR3021198T3 (en) Interleukin-4 protein having bcgf and tcgf activity on human cells (human interleukin-4)
BG60256B1 (bg) Рекомбинантен метод за получаване на лимфотоксин
ATE112687T1 (de) Mutanten des hiv-1 hüllproteins mit fehlenden hypervariabelen domänen.
ATE183775T1 (de) Cysteinfreie il-6 mutanten
SE9201966D0 (sv) Interleukin-1beta deletion mutant
GR3015689T3 (en) Process for the construction of an animal cell line for the production of human beta-interferon.
ATE127842T1 (de) Megakaryocytopoietin, seine herstellung und benutzung.
ATE45675T1 (de) Verwendung von interferon gamma (ifn-gamma) zur herstellung von praeparationen zur behandlung rheumatischer erkrankungen.
Godard et al. Preparative two-step purification of human IL-2 by HPLC and hydrophobic affinity chromatography
ATE119938T1 (de) Produktion von menschlichen nervenwachstumsfaktoren.
EP0386240A4 (en) Novel polypeptide compounds
Ohkawa Cell electrophoresis using agarose gel
YU47397B (sh) Postupak za dobivanje aktivatora plazminogena ljudskog tkiva