DE3778626D1 - Nukleosid-phospholipid-konjugat. - Google Patents
Nukleosid-phospholipid-konjugat.Info
- Publication number
- DE3778626D1 DE3778626D1 DE8787308497T DE3778626T DE3778626D1 DE 3778626 D1 DE3778626 D1 DE 3778626D1 DE 8787308497 T DE8787308497 T DE 8787308497T DE 3778626 T DE3778626 T DE 3778626T DE 3778626 D1 DE3778626 D1 DE 3778626D1
- Authority
- DE
- Germany
- Prior art keywords
- phospholipid conjugate
- nucleoside
- nucleoside phospholipid
- conjugate
- phospholipid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP22920386A JPS6383093A (ja) | 1986-09-27 | 1986-09-27 | ヌクレオシド−リン脂質複合体 |
JP22920486A JPS6383094A (ja) | 1986-09-27 | 1986-09-27 | エ−テル型ヌクレオシド−リン脂質複合体 |
Publications (1)
Publication Number | Publication Date |
---|---|
DE3778626D1 true DE3778626D1 (de) | 1992-06-04 |
Family
ID=26528684
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE8787308497T Expired - Lifetime DE3778626D1 (de) | 1986-09-27 | 1987-09-25 | Nukleosid-phospholipid-konjugat. |
Country Status (3)
Country | Link |
---|---|
US (2) | US4921951A (de) |
EP (1) | EP0262876B1 (de) |
DE (1) | DE3778626D1 (de) |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5106963A (en) * | 1984-12-28 | 1992-04-21 | Miles, Inc., Successor In Interest To Technicon Instruments Corp. | Phospholipid conjugates and their preparation |
US5223263A (en) | 1988-07-07 | 1993-06-29 | Vical, Inc. | Liponucleotide-containing liposomes |
EP0262876B1 (de) * | 1986-09-27 | 1992-04-29 | Toyo Jozo Kabushiki Kaisha | Nukleosid-Phospholipid-Konjugat |
ZA894534B (en) * | 1988-06-20 | 1990-03-28 | Merrell Dow Pharma | Novel neplanocin derivatives |
US6599887B2 (en) | 1988-07-07 | 2003-07-29 | Chimerix, Inc. | Methods of treating viral infections using antiviral liponucleotides |
US6252060B1 (en) | 1988-07-07 | 2001-06-26 | Nexstar Pharmaceuticals, Inc. | Antiviral liponucleosides: treatment of hepatitis B |
US5817638A (en) * | 1988-07-07 | 1998-10-06 | Nexstar Pharmaceuticals, Inc. | Antiviral liponucleosides: treatment of hepatitis B |
CA2004695C (en) * | 1988-12-12 | 1999-08-10 | Rosanne Bonjouklian | Phospholipid nucleosides |
IE980216A1 (en) * | 1989-04-17 | 2000-02-23 | Scotia Holdings Plc | Anti-virals |
JPH0421694A (ja) * | 1990-05-16 | 1992-01-24 | Asahi Chem Ind Co Ltd | 新規なヌクレオシド―リン脂質複合体 |
CA2083961A1 (en) * | 1990-05-29 | 1991-11-30 | Henk Van Den Bosch | Synthesis of glycerol di- and triphosphate derivatives |
CA2085354C (en) * | 1990-06-15 | 2002-08-27 | Claude Piantadosi | Ether lipid-nucleoside covalent conjugates |
DE4026265A1 (de) * | 1990-08-20 | 1992-02-27 | Boehringer Mannheim Gmbh | Neue phospholipid-derivate von nucleosiden, deren herstellung sowie deren verwendung als antivirale arzneimittel |
US5563257A (en) * | 1990-08-20 | 1996-10-08 | Boehringer Mannheim Gmbh | Phospholipid derivatives of nucleosides |
ES2033193B1 (es) * | 1990-10-30 | 1994-01-16 | Ganadera Union Ind Agro | Mezcla grasa para nutricion infantil y de adultos. |
JPH04364198A (ja) * | 1991-04-04 | 1992-12-16 | Asahi Chem Ind Co Ltd | 5’−ホスファチジル−5−フルオロウリジン誘導体 |
SE9101709L (sv) * | 1991-06-03 | 1992-12-04 | Karlshamns Lipidteknik Ab | Lipidderivat som diagnostikum eller kontrastmedel |
US5304325A (en) * | 1991-11-13 | 1994-04-19 | Hemagen/Pfc | Emulsions containing alkyl- or alkylglycerophosphoryl choline surfactants and methods of use |
US5512671A (en) * | 1993-02-16 | 1996-04-30 | Wake Forest University | Ether lipid-nucleoside covalent conjugates |
US5696097A (en) * | 1993-03-18 | 1997-12-09 | Yamasa Corporation | Antineoplastic 5'-diacylglycerylphosphatidyl-2-deoxy-2'-methylenylcytidines and method of making |
WO1995018533A1 (en) * | 1994-01-04 | 1995-07-13 | The Trustees Of The University Of Pennsylvania | Methods and compounds affecting adipocyte differentiation and obesity |
DE4418690A1 (de) * | 1994-05-28 | 1996-01-11 | Boehringer Mannheim Gmbh | Neue Lipidester von Nucleosid-Monophosphaten und deren Verwendung als immunsuppressive Arzneimittel |
CA2197319C (en) | 1994-08-29 | 2009-01-27 | Louis S. Kucera | Lipid analogs for treating viral infections |
US7135584B2 (en) * | 1995-08-07 | 2006-11-14 | Wake Forest University | Lipid analogs for treating viral infections |
US7026469B2 (en) * | 2000-10-19 | 2006-04-11 | Wake Forest University School Of Medicine | Compositions and methods of double-targeting virus infections and cancer cells |
US7309696B2 (en) | 2000-10-19 | 2007-12-18 | Wake Forest University | Compositions and methods for targeting cancer cells |
US6960738B2 (en) * | 2001-05-29 | 2005-11-01 | Koninklijke Philips Electronics N.V. | Metal-ceramic bond |
JP4714413B2 (ja) * | 2001-08-31 | 2011-06-29 | トムソン ライセンシング | オーディオビジュアルストリームのためのシーケンスカウンタ |
US7045547B2 (en) * | 2002-08-20 | 2006-05-16 | University Of Delaware | Acyl-CoA dehydrogenase allenic inhibitors |
US20050187191A1 (en) * | 2004-02-20 | 2005-08-25 | Kucera Louis S. | Methods and compositions for the treatment of respiratory syncytial virus |
ES2401285T3 (es) | 2004-12-16 | 2013-04-18 | The Regents Of The University Of California | Fármacos con el pulmón como diana |
ES2687958T3 (es) | 2013-03-15 | 2018-10-30 | The Regents Of The University Of California | Fosfonato diésteres de nucleósido acíclico |
SG11201701957XA (en) | 2014-09-15 | 2017-04-27 | Univ California | Nucleotide analogs |
EP3350191B9 (de) | 2015-09-15 | 2021-12-22 | The Regents of the University of California | Nukleotidanaloga |
MX2023002233A (es) | 2020-08-24 | 2023-03-15 | Gilead Sciences Inc | Compuestos fosfolipidos y usos de estos. |
TWI811812B (zh) | 2020-10-16 | 2023-08-11 | 美商基利科學股份有限公司 | 磷脂化合物及其用途 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4291024A (en) * | 1978-04-10 | 1981-09-22 | Turcotte Joseph G | Cytotoxic liponucleotide analogs |
US4471113A (en) * | 1982-02-03 | 1984-09-11 | The United States Of America As Represented By The Department Of Energy | Prodrugs based on phospholipid-nucleoside conjugates |
DE3476770D1 (en) * | 1983-04-11 | 1989-03-23 | Meito Sangyo Kk | Production of primary or secondary alcohol derivatives of phospholipids by the enzymatic technique |
JPS59187786A (ja) * | 1983-04-11 | 1984-10-24 | Meito Sangyo Kk | 酵素法リン脂質二級アルコ−ル誘導体の製法 |
JPS6188890A (ja) * | 1984-10-08 | 1986-05-07 | Meito Sangyo Kk | 酵素法リン脂質複素環化合物誘導体の製法 |
JPS6188887A (ja) * | 1984-10-08 | 1986-05-07 | Meito Sangyo Kk | 酵素法1−o−アルキル−2−アシルグリセロリン脂質誘導体の製法 |
JPS61152694A (ja) * | 1984-12-27 | 1986-07-11 | Toyama Chem Co Ltd | 新規な5−フルオロ−2′−デオキシウリジン−5′−ホスフエ−ト誘導体およびその塩 |
IT1188654B (it) * | 1985-04-15 | 1988-01-20 | Toyo Jozo Kk | Coniugato nucleo side-fosfolipide |
EP0262876B1 (de) * | 1986-09-27 | 1992-04-29 | Toyo Jozo Kabushiki Kaisha | Nukleosid-Phospholipid-Konjugat |
FI82169C (fi) * | 1987-08-21 | 1991-01-10 | Nokia Mobira Oy | Rf-skyddad hybridkrets. |
JPH01238793A (ja) * | 1988-03-18 | 1989-09-22 | Toto Ltd | 管の接続構造 |
-
1987
- 1987-09-25 EP EP87308497A patent/EP0262876B1/de not_active Expired - Lifetime
- 1987-09-25 DE DE8787308497T patent/DE3778626D1/de not_active Expired - Lifetime
- 1987-09-28 US US07/102,043 patent/US4921951A/en not_active Expired - Fee Related
-
1989
- 1989-11-28 US US07/445,965 patent/US5051499A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP0262876A3 (en) | 1989-11-29 |
US5051499A (en) | 1991-09-24 |
EP0262876B1 (de) | 1992-04-29 |
US4921951A (en) | 1990-05-01 |
EP0262876A2 (de) | 1988-04-06 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8327 | Change in the person/name/address of the patent owner |
Owner name: ASAHI KASEI KOGYO K.K., OSAKA, JP |
|
8339 | Ceased/non-payment of the annual fee |