DE3750669D1 - Verfahren zur Herstellung von alpha-L-Aspartyl-L-phenylalaninmethylester mit verbesserter Löslichkeit. - Google Patents
Verfahren zur Herstellung von alpha-L-Aspartyl-L-phenylalaninmethylester mit verbesserter Löslichkeit.Info
- Publication number
- DE3750669D1 DE3750669D1 DE3750669T DE3750669T DE3750669D1 DE 3750669 D1 DE3750669 D1 DE 3750669D1 DE 3750669 T DE3750669 T DE 3750669T DE 3750669 T DE3750669 T DE 3750669T DE 3750669 D1 DE3750669 D1 DE 3750669D1
- Authority
- DE
- Germany
- Prior art keywords
- aspartyl
- alpha
- preparation
- methyl ester
- improved solubility
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06104—Dipeptides with the first amino acid being acidic
- C07K5/06113—Asp- or Asn-amino acid
- C07K5/06121—Asp- or Asn-amino acid the second amino acid being aromatic or cycloaliphatic
- C07K5/0613—Aspartame
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Seasonings (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP61187757A JPH07103152B2 (ja) | 1986-08-12 | 1986-08-12 | 溶解性の改善されたα−L−アスパルチル−L−フエニルアラニンメチルエステルの製造方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE3750669D1 true DE3750669D1 (de) | 1994-11-24 |
DE3750669T2 DE3750669T2 (de) | 1995-05-11 |
Family
ID=16211668
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE3750669T Expired - Fee Related DE3750669T2 (de) | 1986-08-12 | 1987-08-12 | Verfahren zur Herstellung von alpha-L-Aspartyl-L-phenylalaninmethylester mit verbesserter Löslichkeit. |
Country Status (6)
Country | Link |
---|---|
US (1) | US4831180A (de) |
EP (1) | EP0256513B1 (de) |
JP (1) | JPH07103152B2 (de) |
AU (1) | AU590439B2 (de) |
CA (1) | CA1319787C (de) |
DE (1) | DE3750669T2 (de) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5543554A (en) * | 1982-04-12 | 1996-08-06 | Ajinomoto Co., Inc. | Process for preparing dry crystals of the methyl ester of α-L-aspartyl-L-phenylalanine, having improved solubility |
US4835303A (en) * | 1986-08-12 | 1989-05-30 | Toyo Soda Manufacturing Company, Ltd. | Process for producing dry α-L-aspartyl-L-phenylalanine methyl ester |
JPH07103154B2 (ja) * | 1986-08-13 | 1995-11-08 | 東ソー株式会社 | 安定なα−L−アスパルチル−L−フエニルアラニンメチルエステルの製造方法 |
EP0680971A1 (de) * | 1988-10-03 | 1995-11-08 | Ajinomoto Co., Inc. | Trockene Krystalle des Alpha-L-aspartyl-L-phenylalaninmethylesters, die eine verbesserte Löslichkeit benutzen |
JP2946853B2 (ja) * | 1991-05-09 | 1999-09-06 | 味の素株式会社 | アスパルテームの晶析法 |
US5473097A (en) * | 1991-05-24 | 1995-12-05 | Ajinomoto Company, Inc. | Granules of α-L-aspartyl-L-phenylalanine methyl ester |
JP2000026496A (ja) | 1998-05-08 | 2000-01-25 | Ajinomoto Co Inc | 新規アスパルテーム誘導体結晶及びその製造法 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5742623A (en) * | 1980-08-29 | 1982-03-10 | Sawai Seiyaku Kk | Antialcoholic adipohepatic agent |
JPS5995862A (ja) * | 1982-11-25 | 1984-06-02 | Ajinomoto Co Inc | ジペプチド甘味料顆粒の製造法 |
JPH0631312B2 (ja) * | 1983-03-18 | 1994-04-27 | 味の素株式会社 | ジペプチド結晶及びその製造方法 |
JPH0710878B2 (ja) * | 1986-07-28 | 1995-02-08 | 東ソー株式会社 | 溶解性の改善されたα−L−アスパルチル−L−フエニルアラニンメチルエステルの製造方法 |
US4835303A (en) * | 1986-08-12 | 1989-05-30 | Toyo Soda Manufacturing Company, Ltd. | Process for producing dry α-L-aspartyl-L-phenylalanine methyl ester |
JPH07103154B2 (ja) * | 1986-08-13 | 1995-11-08 | 東ソー株式会社 | 安定なα−L−アスパルチル−L−フエニルアラニンメチルエステルの製造方法 |
JPH0637949A (ja) * | 1992-07-17 | 1994-02-10 | Ricoh Co Ltd | ファクシミリ装置 |
-
1986
- 1986-08-12 JP JP61187757A patent/JPH07103152B2/ja not_active Expired - Lifetime
-
1987
- 1987-08-11 CA CA000544246A patent/CA1319787C/en not_active Expired - Fee Related
- 1987-08-11 US US07/084,090 patent/US4831180A/en not_active Expired - Lifetime
- 1987-08-12 DE DE3750669T patent/DE3750669T2/de not_active Expired - Fee Related
- 1987-08-12 AU AU76819/87A patent/AU590439B2/en not_active Ceased
- 1987-08-12 EP EP87111695A patent/EP0256513B1/de not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP0256513A3 (en) | 1989-04-26 |
US4831180A (en) | 1989-05-16 |
AU590439B2 (en) | 1989-11-02 |
DE3750669T2 (de) | 1995-05-11 |
EP0256513B1 (de) | 1994-10-19 |
JPH07103152B2 (ja) | 1995-11-08 |
AU7681987A (en) | 1988-02-18 |
EP0256513A2 (de) | 1988-02-24 |
CA1319787C (en) | 1993-06-29 |
JPS6344592A (ja) | 1988-02-25 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE3852381D1 (de) | Verfahren zur Herstellung von para-Ethylphenol. | |
DE68910145T2 (de) | Verfahren zur Herstellung von Azolylmethyl-cyclopentanol-Derivaten. | |
DE3888647D1 (de) | Verfahren zur Herstellung von Aminopropylsilanen. | |
DE3889595D1 (de) | Verfahren zur Herstellung von Arylpiperidincarbinolen. | |
DE59004490D1 (de) | Verfahren zur Herstellung von alpha-Fluoracrylsäurederivaten. | |
DE3884272D1 (de) | Verfahren zur Herstellung von Triglyceriden. | |
DE3750669D1 (de) | Verfahren zur Herstellung von alpha-L-Aspartyl-L-phenylalaninmethylester mit verbesserter Löslichkeit. | |
DE3882167T2 (de) | Verfahren zur Herstellung von Fluorbenzaldehyden. | |
DE59106900D1 (de) | Verfahren zur Herstellung von substituierten 3-Aminoacrylestern. | |
DE3886877D1 (de) | Verfahren zur Herstellung von Triphendioxazinen. | |
DE59006113D1 (de) | Verfahren zur Herstellung von Tetronsäurealkylestern. | |
DE3751193D1 (de) | Verfahren zur Herstellung von trockenem alpha-L-Aspartyl-L-phenylalaninmethylester. | |
DE69113840D1 (de) | Verfahren zur Herstellung von 2-Halogeno-3-Hydroxy-3-Phenyl-Propionsäureesterverbindungen. | |
DE58909208D1 (de) | Verfahren zur Herstellung von Imidazol-2-carbonsäuren. | |
DE3852408D1 (de) | Verfahren zur Herstellung von Acyloxialkansulfonaten. | |
DE59200677D1 (de) | Verfahren zur Herstellung von Alkansulfonylbenzoesäuren. | |
DE3883919D1 (de) | Verfahren zur Herstellung von o-Nitrophenetol. | |
DE68924093T2 (de) | Verfahren zur Herstellung von 3-Exomethylencepham-Derivaten. | |
DE68907097T2 (de) | Verfahren zur Herstellung von Ketodiestern. | |
DE3850236T2 (de) | Verfahren zur Herstellung von 1-Acyl-2-pyrazolin-Derivaten. | |
DE58907865D1 (de) | Verfahren zur Herstellung von alpha-Ketocarbonsäureestern. | |
DE69020372D1 (de) | Verfahren zur Herstellung von Aminothiazolylessigsäure-Derivate. | |
DE68920755T2 (de) | Verfahren zur Herstellung von alpha-Aspartyl-phenylalaninderivaten. | |
DE69012663T2 (de) | Verfahren zur Herstellung von alpha-Asparaginsäure-L-phenylalaninmethylester. | |
DE59105754D1 (de) | Verfahren zur Herstellung von beta-Resorcylsäurederivaten. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |