DE3750612D1 - Cc-1065 analoge. - Google Patents

Cc-1065 analoge.

Info

Publication number
DE3750612D1
DE3750612D1 DE3750612T DE3750612T DE3750612D1 DE 3750612 D1 DE3750612 D1 DE 3750612D1 DE 3750612 T DE3750612 T DE 3750612T DE 3750612 T DE3750612 T DE 3750612T DE 3750612 D1 DE3750612 D1 DE 3750612D1
Authority
DE
Germany
Prior art keywords
formula
compounds
useful
analog
spirocyclopropylpyrroloindole
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE3750612T
Other languages
English (en)
Other versions
DE3750612T2 (de
Inventor
Robert Kelly
David Martin
Paul Aristoff
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of DE3750612D1 publication Critical patent/DE3750612D1/de
Application granted granted Critical
Publication of DE3750612T2 publication Critical patent/DE3750612T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Fire Alarms (AREA)
  • Diaphragms For Electromechanical Transducers (AREA)
  • Superconductors And Manufacturing Methods Therefor (AREA)
  • Silicon Polymers (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Emergency Protection Circuit Devices (AREA)
  • Design And Manufacture Of Integrated Circuits (AREA)
  • Bidet-Like Cleaning Device And Other Flush Toilet Accessories (AREA)
  • Reduction Or Emphasis Of Bandwidth Of Signals (AREA)
  • Forms Removed On Construction Sites Or Auxiliary Members Thereof (AREA)
  • Control Of Driving Devices And Active Controlling Of Vehicle (AREA)
DE3750612T 1986-12-19 1987-12-11 Cc-1065 analoge. Expired - Fee Related DE3750612T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US94463386A 1986-12-19 1986-12-19
PCT/US1987/003227 WO1988004659A2 (en) 1986-12-19 1987-12-11 Novel cc-1065 analogs

Publications (2)

Publication Number Publication Date
DE3750612D1 true DE3750612D1 (de) 1994-11-03
DE3750612T2 DE3750612T2 (de) 1995-03-02

Family

ID=25481770

Family Applications (1)

Application Number Title Priority Date Filing Date
DE3750612T Expired - Fee Related DE3750612T2 (de) 1986-12-19 1987-12-11 Cc-1065 analoge.

Country Status (9)

Country Link
EP (1) EP0340243B1 (de)
JP (1) JP2598819B2 (de)
KR (1) KR960009264B1 (de)
AT (1) ATE112279T1 (de)
AU (1) AU617304B2 (de)
DE (1) DE3750612T2 (de)
HK (1) HK1000510A1 (de)
MX (1) MX9203200A (de)
WO (1) WO1988004659A2 (de)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3783588T2 (de) * 1986-04-17 1993-06-09 Kyowa Hakko Kogyo Kk Neue verbindungen dc-88a und dc-89a1 und deren herstellungsverfahren.
US4994578A (en) * 1987-11-27 1991-02-19 Meiji Seika Kaisha, Ltd. Certain anti-tumor duocarmycin antibiotics from streptomyces
JP2562935B2 (ja) * 1988-04-28 1996-12-11 明治製菓株式会社 抗腫瘍性物質ｓｆ２５８２誘導体
JP2642165B2 (ja) * 1988-07-22 1997-08-20 協和醗酵工業株式会社 新規ｄｃ−８９化合物およびその製造法
US5084468A (en) * 1988-08-11 1992-01-28 Kyowa Hakko Kogyo Co., Ltd. Dc-88a derivatives
KR0137959B1 (ko) * 1988-09-12 1998-05-15 로버트 에이. 아미테이지 2개의 cpi 소단위를 갖는 신규한 cc-1065 유사화합물
US5008271A (en) * 1988-10-21 1991-04-16 Kyowa Hakko Kogyo Co., Ltd. DC-88A derivatives
US5187186A (en) * 1989-07-03 1993-02-16 Kyowa Hakko Kogyo Co., Ltd. Pyrroloindole derivatives
JP2510335B2 (ja) * 1989-07-03 1996-06-26 協和醗酵工業株式会社 Ｄｃ―８８ａ誘導体
KR100208957B1 (ko) * 1990-04-25 1999-07-15 로렌스 티. 마이젠헬더 신규한 cc-1065 유사체
US5248692A (en) * 1990-06-11 1993-09-28 Kyowa Hakko Kogyo Co., Ltd. DC-89 derivatives as anti-tumor agents
US5214065A (en) * 1990-06-11 1993-05-25 Kyowa Hakko Kogyo Co., Ltd. Dc-89 derivatives
US5258383A (en) * 1991-06-28 1993-11-02 Kyowa Hakko Kogyo Co., Ltd. DC-89 derivatives
EP0563475B1 (de) * 1992-03-25 2000-05-31 Immunogen Inc Konjugaten von Zell-bindender Mittel und Derivaten von CC-1065
US5248691A (en) * 1992-09-03 1993-09-28 Eli Lilly And Company Furanoindolines
EP0702014A4 (de) * 1994-04-01 1996-08-07 Kyowa Hakko Kogyo Kk Dc-89 derivate
ES2220927T3 (es) * 1994-04-22 2004-12-16 Kyowa Hakko Kogyo Co., Ltd. Derivados de dc-89.
CA2205872A1 (en) * 1994-11-29 1996-06-06 Kyorin Pharmaceutical Co., Ltd. Acrylamide derivatives and process for production thereof
GB9516943D0 (en) * 1995-08-18 1995-10-18 Cancer Soc Auckland Div Nz Inc Novel cyclopropylindoles and their secoprecursors,and their use as prodrugs
DE69734722T2 (de) * 1996-09-12 2006-07-20 Auckland Uniservices Ltd. Kondensierte n-acylindole als antitumormittel
US6130237A (en) * 1996-09-12 2000-10-10 Cancer Research Campaign Technology Limited Condensed N-aclyindoles as antitumor agents
PT1413582E (pt) 1998-08-27 2006-07-31 Spirogen Ltd Pirrolobenzodiazepinas dimericas
GB9818730D0 (en) 1998-08-27 1998-10-21 Univ Portsmouth Collections of compounds
US6909006B1 (en) 1999-08-27 2005-06-21 Spirogen Limited Cyclopropylindole derivatives
MXPA03011094A (es) * 2001-05-31 2004-12-06 Medarex Inc Citotoxinas, profarmacos, ligadores, y estabilizadores utiles para ello.
GB0226593D0 (en) 2002-11-14 2002-12-24 Consultants Ltd Compounds
GB0321295D0 (en) 2003-09-11 2003-10-15 Spirogen Ltd Synthesis of protected pyrrolobenzodiazepines
KR20090122439A (ko) 2007-02-21 2009-11-30 메다렉스, 인코포레이티드 단일 아미노산을 갖는 화학적 링커 및 이의 접합체
US9901567B2 (en) 2007-08-01 2018-02-27 Syntarga B.V. Substituted CC-1065 analogs and their conjugates
HUE035798T2 (en) 2008-11-03 2018-05-28 Syntarga Bv CC-1065 analogues and conjugates
HUE030846T2 (en) 2010-04-21 2017-06-28 Syntarga Bv Conjugates of CC-1065 analogues and bifunctional linkers
AU2015205574B2 (en) 2014-01-10 2019-08-15 Byondis B.V. Method for purifying Cys-linked antibody-drug conjugates

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1238907A (en) * 1984-02-21 1988-07-05 Robert C. Kelly 1,2,8,8a-tetrahydrocyclopropa¬c|pyrrolo(3,2-e)- indol-4(5h)-ones and related compounds

Also Published As

Publication number Publication date
EP0340243B1 (de) 1994-09-28
AU617304B2 (en) 1991-11-28
WO1988004659A3 (en) 1988-08-11
KR890700127A (ko) 1989-03-02
ATE112279T1 (de) 1994-10-15
HK1000510A1 (en) 1998-04-03
WO1988004659A2 (en) 1988-06-30
JP2598819B2 (ja) 1997-04-09
KR960009264B1 (en) 1996-07-16
MX9203200A (es) 1992-09-01
DE3750612T2 (de) 1995-03-02
EP0340243A1 (de) 1989-11-08
JPH02502005A (ja) 1990-07-05
AU1229088A (en) 1988-07-15

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: PHARMACIA & UPJOHN CO., KALAMAZOO, MICH., US

8339 Ceased/non-payment of the annual fee