ATE112279T1 - Cc-1065 analoge. - Google Patents

Cc-1065 analoge.

Info

Publication number: ATE112279T1
Authority: AT; Austria
Prior art keywords: formula; compounds; useful; analogue; spirocyclopropylpyrroloindole
Prior art date: 1986-12-19

Application number

AT88901185T

Other languages

English (en)

Inventor

Robert C Kelly

David G Martin

Paul A Aristoff

Original Assignee

Upjohn Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-12-19

Filing date

1987-12-11

Publication date

1994-10-15

1987-12-11 Application filed by Upjohn Co filed Critical Upjohn Co

1994-10-15 Application granted granted Critical

1994-10-15 Publication of ATE112279T1 publication Critical patent/ATE112279T1/de

Links

KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
239000000126 substance Substances 0.000 abstract 2
241001465754 Metazoa Species 0.000 abstract 1
239000006096 absorbing agent Substances 0.000 abstract 1
238000010171 animal model Methods 0.000 abstract 1
230000000259 anti-tumor effect Effects 0.000 abstract 1
229940054051 antipsychotic indole derivative Drugs 0.000 abstract 1
150000002475 indoles Chemical class 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
229940002612 prodrug Drugs 0.000 abstract 1
239000000651 prodrug Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Molecular Biology (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Biochemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Fire Alarms (AREA)
Diaphragms For Electromechanical Transducers (AREA)
Superconductors And Manufacturing Methods Therefor (AREA)
Silicon Polymers (AREA)
Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
Plural Heterocyclic Compounds (AREA)
Emergency Protection Circuit Devices (AREA)
Design And Manufacture Of Integrated Circuits (AREA)
Bidet-Like Cleaning Device And Other Flush Toilet Accessories (AREA)
Reduction Or Emphasis Of Bandwidth Of Signals (AREA)
Forms Removed On Construction Sites Or Auxiliary Members Thereof (AREA)
Control Of Driving Devices And Active Controlling Of Vehicle (AREA)

AT88901185T 1986-12-19 1987-12-11 Cc-1065 analoge. ATE112279T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US94463386A	1986-12-19	1986-12-19

Publications (1)

Publication Number	Publication Date
ATE112279T1 true ATE112279T1 (de)	1994-10-15

Family

ID=25481770

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT88901185T ATE112279T1 (de)	1986-12-19	1987-12-11	Cc-1065 analoge.

Country Status (9)

Country	Link
EP (1)	EP0340243B1 (de)
JP (1)	JP2598819B2 (de)
KR (1)	KR960009264B1 (de)
AT (1)	ATE112279T1 (de)
AU (1)	AU617304B2 (de)
DE (1)	DE3750612T2 (de)
HK (1)	HK1000510A1 (de)
MX (1)	MX9203200A (de)
WO (1)	WO1988004659A2 (de)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3783588T2 (de) *	1986-04-17	1993-06-09	Kyowa Hakko Kogyo Kk	Neue verbindungen dc-88a und dc-89a1 und deren herstellungsverfahren.
US4994578A (en) *	1987-11-27	1991-02-19	Meiji Seika Kaisha, Ltd.	Certain anti-tumor duocarmycin antibiotics from streptomyces
JP2562935B2 (ja) *	1988-04-28	1996-12-11	明治製菓株式会社	抗腫瘍性物質ｓｆ２５８２誘導体
JP2642165B2 (ja) *	1988-07-22	1997-08-20	協和醗酵工業株式会社	新規ｄｃ−８９化合物およびその製造法
US5084468A (en) *	1988-08-11	1992-01-28	Kyowa Hakko Kogyo Co., Ltd.	Dc-88a derivatives
KR0137959B1 (ko) *	1988-09-12	1998-05-15	로버트 에이. 아미테이지	2개의 cpi 소단위를 갖는 신규한 cc-1065 유사화합물
US5008271A (en) *	1988-10-21	1991-04-16	Kyowa Hakko Kogyo Co., Ltd.	DC-88A derivatives
US5187186A (en) *	1989-07-03	1993-02-16	Kyowa Hakko Kogyo Co., Ltd.	Pyrroloindole derivatives
JP2510335B2 (ja) *	1989-07-03	1996-06-26	協和醗酵工業株式会社	Ｄｃ―８８ａ誘導体
KR100208957B1 (ko) *	1990-04-25	1999-07-15	로렌스 티. 마이젠헬더	신규한 cc-1065 유사체
US5248692A (en) *	1990-06-11	1993-09-28	Kyowa Hakko Kogyo Co., Ltd.	DC-89 derivatives as anti-tumor agents
US5214065A (en) *	1990-06-11	1993-05-25	Kyowa Hakko Kogyo Co., Ltd.	Dc-89 derivatives
US5258383A (en) *	1991-06-28	1993-11-02	Kyowa Hakko Kogyo Co., Ltd.	DC-89 derivatives
EP0563475B1 (de) *	1992-03-25	2000-05-31	Immunogen Inc	Konjugaten von Zell-bindender Mittel und Derivaten von CC-1065
US5248691A (en) *	1992-09-03	1993-09-28	Eli Lilly And Company	Furanoindolines
EP0702014A4 (de) *	1994-04-01	1996-08-07	Kyowa Hakko Kogyo Kk	Dc-89 derivate
ES2220927T3 (es) *	1994-04-22	2004-12-16	Kyowa Hakko Kogyo Co., Ltd.	Derivados de dc-89.
CA2205872A1 (en) *	1994-11-29	1996-06-06	Kyorin Pharmaceutical Co., Ltd.	Acrylamide derivatives and process for production thereof
GB9516943D0 (en) *	1995-08-18	1995-10-18	Cancer Soc Auckland Div Nz Inc	Novel cyclopropylindoles and their secoprecursors,and their use as prodrugs
DE69734722T2 (de) *	1996-09-12	2006-07-20	Auckland Uniservices Ltd.	Kondensierte n-acylindole als antitumormittel
US6130237A (en) *	1996-09-12	2000-10-10	Cancer Research Campaign Technology Limited	Condensed N-aclyindoles as antitumor agents
PT1413582E (pt)	1998-08-27	2006-07-31	Spirogen Ltd	Pirrolobenzodiazepinas dimericas
GB9818730D0 (en)	1998-08-27	1998-10-21	Univ Portsmouth	Collections of compounds
US6909006B1 (en)	1999-08-27	2005-06-21	Spirogen Limited	Cyclopropylindole derivatives
MXPA03011094A (es) *	2001-05-31	2004-12-06	Medarex Inc	Citotoxinas, profarmacos, ligadores, y estabilizadores utiles para ello.
GB0226593D0 (en)	2002-11-14	2002-12-24	Consultants Ltd	Compounds
GB0321295D0 (en)	2003-09-11	2003-10-15	Spirogen Ltd	Synthesis of protected pyrrolobenzodiazepines
KR20090122439A (ko)	2007-02-21	2009-11-30	메다렉스, 인코포레이티드	단일 아미노산을 갖는 화학적 링커 및 이의 접합체
US9901567B2 (en)	2007-08-01	2018-02-27	Syntarga B.V.	Substituted CC-1065 analogs and their conjugates
HUE035798T2 (en)	2008-11-03	2018-05-28	Syntarga Bv	CC-1065 analogues and conjugates
HUE030846T2 (en)	2010-04-21	2017-06-28	Syntarga Bv	Conjugates of CC-1065 analogues and bifunctional linkers
AU2015205574B2 (en)	2014-01-10	2019-08-15	Byondis B.V.	Method for purifying Cys-linked antibody-drug conjugates

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1238907A (en) *	1984-02-21	1988-07-05	Robert C. Kelly	1,2,8,8a-tetrahydrocyclopropa¬c\|pyrrolo(3,2-e)- indol-4(5h)-ones and related compounds

1987
- 1987-12-11 WO PCT/US1987/003227 patent/WO1988004659A2/en active IP Right Grant
- 1987-12-11 EP EP88901185A patent/EP0340243B1/de not_active Expired - Lifetime
- 1987-12-11 AT AT88901185T patent/ATE112279T1/de not_active IP Right Cessation
- 1987-12-11 JP JP63501400A patent/JP2598819B2/ja not_active Expired - Lifetime
- 1987-12-11 MX MX9203200A patent/MX9203200A/es unknown
- 1987-12-11 AU AU12290/88A patent/AU617304B2/en not_active Ceased
- 1987-12-11 DE DE3750612T patent/DE3750612T2/de not_active Expired - Fee Related
1988
- 1988-08-19 KR KR88701019A patent/KR960009264B1/ko not_active IP Right Cessation
1997
- 1997-11-06 HK HK97102115A patent/HK1000510A1/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
EP0340243B1 (de)	1994-09-28
DE3750612D1 (de)	1994-11-03
AU617304B2 (en)	1991-11-28
WO1988004659A3 (en)	1988-08-11
KR890700127A (ko)	1989-03-02
HK1000510A1 (en)	1998-04-03
WO1988004659A2 (en)	1988-06-30
JP2598819B2 (ja)	1997-04-09
KR960009264B1 (en)	1996-07-16
MX9203200A (es)	1992-09-01
DE3750612T2 (de)	1995-03-02
EP0340243A1 (de)	1989-11-08
JPH02502005A (ja)	1990-07-05
AU1229088A (en)	1988-07-15

Legal Events

Date	Code	Title	Description
2003-09-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE112279T1 (de)	1994-10-15	Cc-1065 analoge.
FI853625L (fi)	1986-03-23	Tetralinderivat, deras framstaellning och anvaendning.
FI852974L (fi)	1986-02-04	Nya n-hydroxylgruppen skyddande grupper och framstaellningsfoerfarande foer 3-acylamino-1-hydroxi-2-azetidinoner.
FI103668B1 (fi)	1999-08-13	Menetelmä farmakologisesti aktiivisten pyrrolo[3,2-e]indol-4(5H)-onidimeerien valmistamiseksi
NO20004978D0 (no)	2000-10-03	Semi-syntetiske ecteinascidiner
MX168494B (es)	1993-05-27	Nuevos derivados de pirazolina su preparacion y su uso como plaguisidas
MX9203687A (es)	1992-08-01	Nuevos derivados de 6&-metilprednisolona, su obtencion y uso.
ATE53837T1 (de)	1990-06-15	Pyridin-derivate, ihre herstellung und verwendung.
FR2392989A1 (fr)	1978-12-29	Nouveaux phenyl-benzimidazolyl-furannes, leur procede de preparation et leur utilisation comme azurants optiques des matieres organiques
ES2164050T3 (es)	2002-02-16	Preparacion de compuestos de interleuquina-6.
GR3003656T3 (de)	1993-03-16
ATE93846T1 (de)	1993-09-15	S-substituierte beta-thioacrylamide und deren verwendung als mikrobizide.
BR8108862A (pt)	1983-05-31	Hidroximidato e tiol-hidroximidatos heterobiciclicos e seus derivados ester -carbamato com atividade biologica
DE3785368D1 (de)	1993-05-19	Neues glucopyranosid.
ES2039270T3 (es)	1993-09-16	Derivados de gamma-l-glutamil-4-nitroanilida y procedimiento para determinar actividad de gamma-gtp utilizandolos.
IT1093302B (it)	1985-07-19	Cuvetta per la miscelazine di sostanze mediante rotazione
GR3002699T3 (en)	1993-01-25	Process for stabilising procaterol
LT2336B (lt)	1993-12-15	5-aminonaftalin-1-sulfamidai kaip detektuojamos substratu grupes peptidaziu fliuorescencinei analizei
IT8024758A0 (it)	1980-09-19	N-mercaptoacil derivati di tripeptidi e di composti affini utili come antiipertensivi e processi per la loro preparazione.