DE3685626D1 - Sequenzierung von peptiden. - Google Patents
Sequenzierung von peptiden.Info
- Publication number
- DE3685626D1 DE3685626D1 DE8686307356T DE3685626T DE3685626D1 DE 3685626 D1 DE3685626 D1 DE 3685626D1 DE 8686307356 T DE8686307356 T DE 8686307356T DE 3685626 T DE3685626 T DE 3685626T DE 3685626 D1 DE3685626 D1 DE 3685626D1
- Authority
- DE
- Germany
- Prior art keywords
- sequencing
- peptides
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
- C07K1/08—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using activating agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US78026485A | 1985-09-26 | 1985-09-26 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE3685626D1 true DE3685626D1 (de) | 1992-07-16 |
DE3685626T2 DE3685626T2 (de) | 1993-01-28 |
Family
ID=25119096
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE8686307356T Expired - Fee Related DE3685626T2 (de) | 1985-09-26 | 1986-09-25 | Sequenzierung von peptiden. |
Country Status (5)
Country | Link |
---|---|
US (1) | US4837165A (de) |
EP (1) | EP0217634B1 (de) |
JP (1) | JPH0718882B2 (de) |
CA (1) | CA1292840C (de) |
DE (1) | DE3685626T2 (de) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4935494A (en) * | 1988-11-15 | 1990-06-19 | City Of Hope | C-terminal peptide and protein sequencing |
US5066785A (en) * | 1988-11-15 | 1991-11-19 | City Of Hope | Carboxyl terminal peptide and protein sequencing |
US5041388A (en) * | 1989-12-21 | 1991-08-20 | Applied Biosystems, Inc. | C-terminal peptide sequencing, activated support and reagent system therefor, and method of producing the activated support |
US5049507A (en) * | 1989-12-21 | 1991-09-17 | Applied Biosystems, Inc. | Method of C-terminal peptide sequencing |
DE69030316T2 (de) * | 1990-05-18 | 1997-10-23 | Hope City | Schrittweiser c-terminaler abbau von peptiden und proteinen |
US5059540A (en) * | 1990-08-13 | 1991-10-22 | City Of Hope | Sequential C-terminal degradation of peptides and proteins using cleaving reagents such as sodium trimethylsilanolate or trimethylamine N-oxide |
US5254475A (en) * | 1990-08-13 | 1993-10-19 | City Of Hope | Sequential C-terminal degradation of peptides and proteins |
US5051368A (en) * | 1990-06-29 | 1991-09-24 | Applied Biosystems, Inc. | Method for forming an amino acid thiohydantoin using an N-substituted ketenimine activator |
WO1992001938A1 (en) * | 1990-07-20 | 1992-02-06 | City Of Hope | Derivatization of c-terminal proline |
US5185266A (en) * | 1991-10-15 | 1993-02-09 | Applied Biosystems, Inc. | Cleavage method for acyl thiohydantoins and use of the method in c-terminal peptide sequencing |
US5304497A (en) * | 1991-10-15 | 1994-04-19 | Applied Biosystems, Inc. | Method of forming N-protected amino acid thiohydantoins |
US5180807A (en) * | 1991-12-03 | 1993-01-19 | City Of Hope | C-terminal peptide or protein sequencing reagent and method |
US5432092A (en) * | 1991-12-03 | 1995-07-11 | City Of Hope | C-terminal peptide sequencing using diphenyl phosphoroisothiocyanatidate and pyridine |
US5470703A (en) * | 1992-10-21 | 1995-11-28 | Shimadzu Corporation | Method for peptide C-terminal fragment sequence analysis and apparatus for collecting peptide fragment |
US5641685A (en) * | 1995-04-24 | 1997-06-24 | Smithkline Beecham Corporation | Method carboxy terminal protein or peptide sequencing |
AUPN896396A0 (en) * | 1996-03-27 | 1996-04-26 | Garvan Institute Of Medical Research | Method for preparing amino acid thiohydantoins |
JP3124507B2 (ja) * | 1996-05-24 | 2001-01-15 | セイコーインスツルメンツ株式会社 | タンパク質あるいはペプチドのカルボキシ末端からのアミノ酸配列を決定する方法 |
US6756394B1 (en) * | 1999-10-15 | 2004-06-29 | President And Fellow Of Harvard College | Small molecule inhibitors of necrosis |
US7491743B2 (en) * | 2003-08-29 | 2009-02-17 | President And Fellows Of Harvard College | Inhibitors of cellular necrosis |
ES2524449T3 (es) * | 2004-07-02 | 2014-12-09 | Genentech, Inc. | Inhibidores de IAP |
CN101146803A (zh) | 2004-12-20 | 2008-03-19 | 健泰科生物技术公司 | Iap的吡咯烷抑制剂 |
EP1973899A4 (de) * | 2005-12-19 | 2010-10-20 | Genentech Inc | Hemmer von iap |
JP2010513561A (ja) * | 2006-12-19 | 2010-04-30 | ジェネンテック, インコーポレイテッド | Iapのイミダゾピリジンインヒビター |
TWI432212B (zh) * | 2007-04-30 | 2014-04-01 | Genentech Inc | Iap抑制劑 |
JP2011509938A (ja) * | 2008-01-11 | 2011-03-31 | ジェネンテック, インコーポレイテッド | Iapのインヒビター |
CA2730448A1 (en) | 2008-08-02 | 2010-02-11 | Genentech, Inc. | Inhibitors of iap |
CN102316735A (zh) | 2008-12-23 | 2012-01-11 | 哈佛大学校长及研究员协会 | 坏死性凋亡的小分子抑制剂 |
JP2016514693A (ja) | 2013-03-15 | 2016-05-23 | プレジデント アンド フェローズ オブ ハーバード カレッジ | ハイブリッド型ネクロトーシス阻害剤 |
JP2017538712A (ja) | 2014-12-11 | 2017-12-28 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 細胞壊死の抑制剤及びそれに関連する方法 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3725010A (en) | 1971-08-23 | 1973-04-03 | Beckman Instruments Inc | Apparatus for automatically performing chemical processes |
US4065412A (en) * | 1976-05-07 | 1977-12-27 | Durrum Instrument Corporation | Peptide or protein sequencing method and apparatus |
-
1986
- 1986-09-25 CA CA000519119A patent/CA1292840C/en not_active Expired - Lifetime
- 1986-09-25 DE DE8686307356T patent/DE3685626T2/de not_active Expired - Fee Related
- 1986-09-25 EP EP86307356A patent/EP0217634B1/de not_active Expired - Lifetime
- 1986-09-26 JP JP61227905A patent/JPH0718882B2/ja not_active Expired - Fee Related
-
1988
- 1988-04-20 US US07/186,667 patent/US4837165A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP0217634A2 (de) | 1987-04-08 |
US4837165A (en) | 1989-06-06 |
EP0217634B1 (de) | 1992-06-10 |
JPS62156562A (ja) | 1987-07-11 |
JPH0718882B2 (ja) | 1995-03-06 |
EP0217634A3 (en) | 1988-08-31 |
CA1292840C (en) | 1991-12-03 |
DE3685626T2 (de) | 1993-01-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |