DE3062101D1 - Imidazole thromboxane synthetase inhibitors, processes for preparing them, and pharmaceutical compositions containing them - Google Patents

Imidazole thromboxane synthetase inhibitors, processes for preparing them, and pharmaceutical compositions containing them

Info

Publication number
DE3062101D1
DE3062101D1 DE8080300521T DE3062101T DE3062101D1 DE 3062101 D1 DE3062101 D1 DE 3062101D1 DE 8080300521 T DE8080300521 T DE 8080300521T DE 3062101 T DE3062101 T DE 3062101T DE 3062101 D1 DE3062101 D1 DE 3062101D1
Authority
DE
Germany
Prior art keywords
imidazole
preparing
processes
pharmaceutical compositions
compositions containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8080300521T
Other languages
English (en)
Inventor
Peter Edward Cross
Roger Peter Dickinson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Ltd
Pfizer Corp
Original Assignee
Pfizer Ltd
Pfizer Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Ltd, Pfizer Corp filed Critical Pfizer Ltd
Application granted granted Critical
Publication of DE3062101D1 publication Critical patent/DE3062101D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/335—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
DE8080300521T 1979-02-24 1980-02-22 Imidazole thromboxane synthetase inhibitors, processes for preparing them, and pharmaceutical compositions containing them Expired DE3062101D1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB7906617 1979-02-24

Publications (1)

Publication Number Publication Date
DE3062101D1 true DE3062101D1 (en) 1983-03-31

Family

ID=10503416

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8080300521T Expired DE3062101D1 (en) 1979-02-24 1980-02-22 Imidazole thromboxane synthetase inhibitors, processes for preparing them, and pharmaceutical compositions containing them

Country Status (7)

Country Link
US (1) US4259345A (de)
EP (1) EP0015155B1 (de)
JP (1) JPS55120585A (de)
DE (1) DE3062101D1 (de)
DK (1) DK77880A (de)
GR (1) GR73560B (de)
IE (1) IE49273B1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR75101B (de) * 1980-10-23 1984-07-13 Pfizer
ZA824343B (en) * 1981-07-01 1983-04-27 Upjohn Co Pyridinyl- and imidazolyl-benzofurane and benzothiophenes
US4608374A (en) * 1983-11-07 1986-08-26 Hoechst-Roussel Pharmaceuticals Inc. 11-substituted 5H,11H-pyrrolo[2,1-c][1,4]benzoxazepines as antipsychotic and analgesic agents
JPS61110266A (ja) * 1984-11-05 1986-05-28 Omron Tateisi Electronics Co カード発行方法
GB8518741D0 (en) * 1985-07-24 1985-08-29 Glaxo Group Ltd Process
JP2581556B2 (ja) * 1986-05-06 1997-02-12 メレルダウファーマスーティカルズ インコーポレーテッド 新規なドパミンベ−タヒドロキシラ−ゼ抑制剤
US4737511A (en) * 1986-11-03 1988-04-12 Schering A.G. Cardiotonic imidazolylphenylpyrrol-2-ones
CH683260A5 (it) * 1991-11-29 1994-02-15 Applied Pharma Res Derivati pirrolici trisostituiti ad attività antifungina ed antibatterica, procedimento per la loro preparazione e relative composizioni farmaceutiche.
ZA929788B (en) * 1991-12-18 1993-06-22 Schering Corp Imidazolyl or imidazoylalkyl substituted with a four or five membered nitrogen containing heterocyclic ring.
KR100381216B1 (ko) * 1997-11-28 2003-08-30 주식회사 엘지생명과학 피롤구조를갖는파네실전이효소억제제및그의제조방법
KR100388789B1 (ko) * 1998-02-02 2003-10-04 주식회사 엘지생명과학 피롤구조를갖는파네실전이효소억제제및그의제조방법
NZ520640A (en) * 2000-02-15 2005-04-29 Upjohn Co Pyrrole substituted 2-indolinone protein kinase inhibitors
AR042586A1 (es) * 2001-02-15 2005-06-29 Sugen Inc 3-(4-amidopirrol-2-ilmetiliden)-2-indolinona como inhibidores de la protein quinasa; sus composiciones farmaceuticas; un metodo para la modulacion de la actividad catalitica de la proteinquinasa; un metodo para tratar o prevenir una afeccion relacionada con la proteinquinasa
WO2003031438A1 (en) 2001-10-10 2003-04-17 Sugen, Inc. 3-[4-(substituted heterocyclyl)-pyrrol-2-ylmethylidene]-2-indolinone derivatives as kinase inhibitors

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4115578A (en) * 1975-12-18 1978-09-19 Rohm And Haas Company 1-Substituted aralkyl imidazoles
DE2862340D1 (en) * 1978-02-01 1983-11-24 Wellcome Found Imidazole derivatives and salts thereof, their synthesis, and pharmaceutical formulations thereof
GB2016452B (en) * 1978-02-18 1982-07-21 Kissei Pharmaceutical Imidazole compounds
DE2960547D1 (en) * 1978-02-24 1981-11-05 Pfizer Ltd 3-(imidazol-1-ylalkyl)indoles as selective inhibitors of thromboxane synthetase,pharmaceutical compositions thereof, and methods for preparing them

Also Published As

Publication number Publication date
US4259345A (en) 1981-03-31
DK77880A (da) 1980-08-25
GR73560B (de) 1984-03-15
EP0015155A1 (de) 1980-09-03
IE800359L (en) 1980-08-24
JPS55120585A (en) 1980-09-17
IE49273B1 (en) 1985-09-04
EP0015155B1 (de) 1983-02-23

Similar Documents

Publication Publication Date Title
DE3165703D1 (en) Heterocyclic thromboxane synthetase inhibitors, processes for their preparation, and pharmaceutical compositions containing them
DE3173434D1 (en) Trisubstituted imidazole derivatives, processes for preparing them, pharmaceutical compositions containing them, and their use
DE3167879D1 (en) Indole thromboxane synthetase inhibitors, processes for their preparation, and pharmaceutical compositions containing them
DE3060129D1 (en) Tetrahydroisoquinoline compounds, process for preparing them and pharmaceutical compositions containing them
PT70707A (en) Process for preparing n-benzyl-imidazoles as selective inhibitors of the thromboxane synthetase enzyme and pharmaceutical compositions
GB2038821B (en) N-(phenoxyalkyl)imidazoles as selective inhibitors of the thromboxane synthetase enzyme pharmaceutical compositions thereof and process for their preparation
IL63576A0 (en) Imidazole derivatives,their manufacture and pharmaceutical compositions containing them
DE3168564D1 (en) Piperidyl - urea, - thiourea and - guanidine derivatives, and intermediates therefor, processes for preparing them and pharmaceutical compositions containing the derivatives
DE2960547D1 (en) 3-(imidazol-1-ylalkyl)indoles as selective inhibitors of thromboxane synthetase,pharmaceutical compositions thereof, and methods for preparing them
HK63186A (en) Heterocyclic compounds,processes for their preparation and pharmaceutical compositions containing them
DE3062101D1 (en) Imidazole thromboxane synthetase inhibitors, processes for preparing them, and pharmaceutical compositions containing them
DE3161260D1 (en) Imidazole derivatives, process for their preparation and pharmaceutical compositions thereof
IL62039A0 (en) Imidazoline derivative,processes for the preparation thereof and pharmaceutical compositions containing the same
ZA818240B (en) Substituted imidazolylphenyl amidines,processes for their preparation,and pharmaceutical compositions containing these
DE3275545D1 (en) Indole thromboxane synthetase inhibitors, processes for their preparation, and pharmaceutical compositions containing them
IL60470A0 (en) Imidazole derivatives,their preparation and pharmaceutical compositions containing them
NZ192941A (en) 1-substituted imidazoles;pharmaceutical compositions
DE3067564D1 (en) 1,2,4-triazole derivatives, processes for the preparation thereof and pharmaceutical compositions containing them
DE3167664D1 (en) Pyrazoloindazole derivatives, process for preparing the same, and pharmaceutical composition containing the same
DE2966413D1 (en) Pyrimidinone derivatives, processes for preparing them and pharmaceutical compositions containing them
GB2047238B (en) Triazole derivatives processes for their production and pharmaceutical compositions containing them
ZA824789B (en) Indole thomboxane synthetase inhibitors, processes for their preparation, and pharmaceutical compositions containing them
DE3160987D1 (en) Benzodiazepine derivatives, intermediates and processes for preparing them, their use and pharmaceutical compositions containing them
GB2063253B (en) Triazole derivatives processes for their production and pharmaceutical compositions containing them
IL52148A (en) Substituted 1-phenoxy-2-hydroxy-3-aminopropanes,process for preparing same and pharmaceutical compositions containing them

Legal Events

Date Code Title Description
8339 Ceased/non-payment of the annual fee