DE2557342A1 - Basisch substituierte indolderivate und verfahren zu ihrer herstellung - Google Patents
Basisch substituierte indolderivate und verfahren zu ihrer herstellungInfo
- Publication number
- DE2557342A1 DE2557342A1 DE19752557342 DE2557342A DE2557342A1 DE 2557342 A1 DE2557342 A1 DE 2557342A1 DE 19752557342 DE19752557342 DE 19752557342 DE 2557342 A DE2557342 A DE 2557342A DE 2557342 A1 DE2557342 A1 DE 2557342A1
- Authority
- DE
- Germany
- Prior art keywords
- formula
- substituted
- compound
- group
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
Priority Applications (11)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19752557342 DE2557342A1 (de) | 1975-12-19 | 1975-12-19 | Basisch substituierte indolderivate und verfahren zu ihrer herstellung |
NL7614050A NL7614050A (nl) | 1975-12-19 | 1976-12-17 | Basisch gesubstitueerde indoolderivaten en hun bereiding. |
IT30582/76A IT1065683B (it) | 1975-12-19 | 1976-12-17 | Derivati indolici sostituiti con sostituenti basici e processo per la loro preparazione |
AT936276A ATA936276A (de) | 1975-12-19 | 1976-12-17 | Verfahren zur herstellung von neuen, basisch substituierter indolderivate |
DK571376A DK571376A (da) | 1975-12-19 | 1976-12-17 | Indolderivater deres fremstilling og anvendelse |
LU76427A LU76427A1 (da) | 1975-12-19 | 1976-12-17 | |
CA268,139A CA1079739A (en) | 1975-12-19 | 1976-12-17 | Basically substituted indole derivatives and process for their manufacture |
JP51151501A JPS5277060A (en) | 1975-12-19 | 1976-12-18 | Basic substituted indole derivatives and preparation thereof |
BE173447A BE849626A (fr) | 1975-12-19 | 1976-12-20 | Nouveaux derives d'indol substitues par des bases, leur procede de preparation et leurs applications |
FR7638400A FR2335216A1 (fr) | 1975-12-19 | 1976-12-20 | Nouveaux derives d'indol substitues par des bases, leur procede de preparation et leurs applications |
GB53124/76A GB1566307A (en) | 1975-12-19 | 1976-12-20 | Indole derivatives of amides and amino esters and process for their manufacture |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19752557342 DE2557342A1 (de) | 1975-12-19 | 1975-12-19 | Basisch substituierte indolderivate und verfahren zu ihrer herstellung |
Publications (1)
Publication Number | Publication Date |
---|---|
DE2557342A1 true DE2557342A1 (de) | 1977-06-30 |
Family
ID=5964905
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE19752557342 Withdrawn DE2557342A1 (de) | 1975-12-19 | 1975-12-19 | Basisch substituierte indolderivate und verfahren zu ihrer herstellung |
Country Status (11)
Country | Link |
---|---|
JP (1) | JPS5277060A (da) |
AT (1) | ATA936276A (da) |
BE (1) | BE849626A (da) |
CA (1) | CA1079739A (da) |
DE (1) | DE2557342A1 (da) |
DK (1) | DK571376A (da) |
FR (1) | FR2335216A1 (da) |
GB (1) | GB1566307A (da) |
IT (1) | IT1065683B (da) |
LU (1) | LU76427A1 (da) |
NL (1) | NL7614050A (da) |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2152049A (en) * | 1983-12-23 | 1985-07-31 | Sandoz Ltd | Benzoic acid derivative |
US7781436B2 (en) | 2005-07-29 | 2010-08-24 | Hoffmann-La Roche Inc. | Indol-3-y-carbonyl-piperidin and piperazin-derivatives |
US8304413B2 (en) | 2008-06-03 | 2012-11-06 | Intermune, Inc. | Compounds and methods for treating inflammatory and fibrotic disorders |
US8741936B2 (en) | 2005-05-10 | 2014-06-03 | Intermune, Inc. | Method of modulating stress-activated protein kinase system |
US9359379B2 (en) | 2012-10-02 | 2016-06-07 | Intermune, Inc. | Anti-fibrotic pyridinones |
US10233195B2 (en) | 2014-04-02 | 2019-03-19 | Intermune, Inc. | Anti-fibrotic pyridinones |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5936675A (ja) * | 1982-07-13 | 1984-02-28 | サンド・アクチエンゲゼルシヤフト | 二環性複素環式カルボン酸アザビシクロアルキルエステルまたはアミド |
US4861880A (en) * | 1982-09-20 | 1989-08-29 | Pfizer Inc. | 1-phenyl-2(1H,3H)-indolone psycho-therapeutic agents |
US4476307A (en) * | 1982-09-20 | 1984-10-09 | Pfizer Inc. | Heteroylidene indolone compounds |
US4879391A (en) * | 1982-09-20 | 1989-11-07 | Pfizer Inc. | 1-Phenyl-2(1H,3H)-indolone psychotherapeutic agents |
US4977178A (en) * | 1982-09-20 | 1990-12-11 | Pfizer Inc. | Method of treating anxiety and depression with 1-phenyl-2(1H,3H)-indolone psycho-therapeutic agents |
JPS6084281A (ja) * | 1983-09-14 | 1985-05-13 | Yoshitomi Pharmaceut Ind Ltd | 3−インド−ルカルボキサミド類 |
US5852014A (en) * | 1992-03-12 | 1998-12-22 | Smithkline Beecham P.L.C. | Condensed indole derivatives as 5HT4 -receptor antagonists |
ES2219813T3 (es) * | 1992-03-12 | 2004-12-01 | Smithkline Beecham Plc | N-(1-nbutil-4-piperidinil)metil-3,4-dihidro-2h-1,3-oxazino-3,2-a-indol-10-carboxamida, o una de sus sales farmaceuticamente aceptables. |
ATE206701T1 (de) * | 1996-04-19 | 2001-10-15 | American Home Prod | Östrogene verbindungen |
US6069153A (en) * | 1998-05-12 | 2000-05-30 | American Home Products Corporation | Indenoindoles and benzocarbazoles as estrogenic agents |
US6479535B1 (en) | 1998-05-15 | 2002-11-12 | Wyeth | 2-phenyl-1-[4-(2-aminoethoxy)-benzyl]-indole and estrogen formulations |
US6159959A (en) * | 1999-05-06 | 2000-12-12 | American Home Products Corporation | Combined estrogen and antiestrogen therapy |
AU2006292429A1 (en) * | 2005-09-16 | 2007-03-29 | Serenex, Inc. | Carbazole derivatives |
EA020332B1 (ru) * | 2007-08-10 | 2014-10-30 | Х. Лундбекк А/С | Аналоги гетероариламидов |
-
1975
- 1975-12-19 DE DE19752557342 patent/DE2557342A1/de not_active Withdrawn
-
1976
- 1976-12-17 IT IT30582/76A patent/IT1065683B/it active
- 1976-12-17 CA CA268,139A patent/CA1079739A/en not_active Expired
- 1976-12-17 AT AT936276A patent/ATA936276A/de not_active Application Discontinuation
- 1976-12-17 NL NL7614050A patent/NL7614050A/xx not_active Application Discontinuation
- 1976-12-17 DK DK571376A patent/DK571376A/da not_active Application Discontinuation
- 1976-12-17 LU LU76427A patent/LU76427A1/xx unknown
- 1976-12-18 JP JP51151501A patent/JPS5277060A/ja active Pending
- 1976-12-20 BE BE173447A patent/BE849626A/xx unknown
- 1976-12-20 FR FR7638400A patent/FR2335216A1/fr not_active Withdrawn
- 1976-12-20 GB GB53124/76A patent/GB1566307A/en not_active Expired
Cited By (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2152049A (en) * | 1983-12-23 | 1985-07-31 | Sandoz Ltd | Benzoic acid derivative |
US5001133A (en) * | 1983-12-23 | 1991-03-19 | Sandoz Ltd. | Benzoic acid derivatives |
US9527816B2 (en) | 2005-05-10 | 2016-12-27 | Intermune, Inc. | Method of modulating stress-activated protein kinase system |
US10010536B2 (en) | 2005-05-10 | 2018-07-03 | Intermune, Inc. | Method of modulating stress-activated protein kinase system |
US8741936B2 (en) | 2005-05-10 | 2014-06-03 | Intermune, Inc. | Method of modulating stress-activated protein kinase system |
US7781436B2 (en) | 2005-07-29 | 2010-08-24 | Hoffmann-La Roche Inc. | Indol-3-y-carbonyl-piperidin and piperazin-derivatives |
US8969347B2 (en) | 2008-06-03 | 2015-03-03 | Intermune, Inc. | Compounds and methods for treating inflammatory and fibrotic disorders |
US9290450B2 (en) | 2008-06-03 | 2016-03-22 | Intermune, Inc. | Compounds and methods for treating inflammatory and fibrotic disorders |
USRE47142E1 (en) | 2008-06-03 | 2018-11-27 | Intermune, Inc. | Compounds and methods for treating inflammatory and fibrotic disorders |
US8304413B2 (en) | 2008-06-03 | 2012-11-06 | Intermune, Inc. | Compounds and methods for treating inflammatory and fibrotic disorders |
US9675593B2 (en) | 2012-10-02 | 2017-06-13 | Intermune, Inc. | Anti-fibrotic pyridinones |
US9359379B2 (en) | 2012-10-02 | 2016-06-07 | Intermune, Inc. | Anti-fibrotic pyridinones |
US10376497B2 (en) | 2012-10-02 | 2019-08-13 | Intermune, Inc. | Anti-fibrotic pyridinones |
US10898474B2 (en) | 2012-10-02 | 2021-01-26 | Intermune, Inc. | Anti-fibrotic pyridinones |
US10233195B2 (en) | 2014-04-02 | 2019-03-19 | Intermune, Inc. | Anti-fibrotic pyridinones |
US10544161B2 (en) | 2014-04-02 | 2020-01-28 | Intermune, Inc. | Anti-fibrotic pyridinones |
Also Published As
Publication number | Publication date |
---|---|
FR2335216A1 (fr) | 1977-07-15 |
LU76427A1 (da) | 1977-07-05 |
JPS5277060A (en) | 1977-06-29 |
IT1065683B (it) | 1985-03-04 |
GB1566307A (en) | 1980-04-30 |
ATA936276A (de) | 1980-02-15 |
CA1079739A (en) | 1980-06-17 |
NL7614050A (nl) | 1977-06-21 |
BE849626A (fr) | 1977-06-20 |
DK571376A (da) | 1977-06-20 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE2557342A1 (de) | Basisch substituierte indolderivate und verfahren zu ihrer herstellung | |
CH667268A5 (de) | 1,2-benzisothiazol-3-ylpiperazine. | |
CH618425A5 (da) | ||
DE2557341A1 (de) | Basisch substituierte indolderivate und verfahren zu ihrer herstellung | |
EP0047923B1 (de) | Isochinolinderivate, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Zubereitungen | |
DE2845499A1 (de) | Alkanoylprolin-derivate und deren homologen, ihre herstellung und verwendung | |
DE2065636A1 (de) | Neue tricyclische verbindungen | |
EP0670318A2 (de) | Acetamide mit analgetischer und neuroprotektiver Wirkung | |
DE3035086C2 (da) | ||
DE69406853T2 (de) | Alpha Aminosäurederivate, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zusammensetzungen | |
DE69720021T2 (de) | 1,4-disubstituierte piperazine | |
DE3442860A1 (de) | 5-alkyl-1-phenyl-2-piperazinoalkylpyrazolin-3- on-verbindungen sowie verfahren und zwischenprodukte zu ihrer herstellung und diese verbindungen enthaltende arzneimittel | |
EP0018360B1 (de) | N-(5-Methoxybentofuran-2-ylcarbonyl)-N'-benzylpiperazin und Verfahren zu dessen Herstellung | |
DE3233424A1 (de) | Isochinolinderivate, verfahren zu ihrer herstellung, pharmazeutische praeparate auf basis dieser verbindungen und ihre verwendung | |
DD202563A5 (de) | Verfahren zur herstellung von 1,5-diphenylpyrazolin-3-on-verbindungen | |
DE3014813A1 (de) | 2-hydroxy-5-(1-hydroxy-2-piperazinylethyl)benzoesaeure-derivate | |
CH616934A5 (en) | Process for the preparation of chromone derivatives | |
DE2314114A1 (de) | Neue thiazolcarbonsaeurederivate, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen | |
DE1695812C3 (de) | Dibenzo [c,f] -1,2-thiazepin-derivate, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Zubereitung | |
EP0004332A1 (de) | Isochinole,Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel | |
DE1075620B (de) | Verfahren zur Herstellung von Phenthiazmderivaten | |
DE69512104T2 (de) | Substituierte Sulfonamide, Verfahren zu deren Herstellung und sie enthaltende pharmazeutische Zusammensetzungen | |
DE1944759B2 (de) | 3-Indolylacetamide, ihre Salze und Verfahren zu ihrer Herstellung | |
DE2734270C2 (da) | ||
DE2528194C2 (de) | Benzhydryloxyäthylamin-Derivate, deren Salze, Verfahren zur Herstellung derselben und solche enthaltende Arzneimittel |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8130 | Withdrawal |