DE2557342A1 - Basisch substituierte indolderivate und verfahren zu ihrer herstellung - Google Patents

Basisch substituierte indolderivate und verfahren zu ihrer herstellung

Info

Publication number
DE2557342A1
DE2557342A1 DE19752557342 DE2557342A DE2557342A1 DE 2557342 A1 DE2557342 A1 DE 2557342A1 DE 19752557342 DE19752557342 DE 19752557342 DE 2557342 A DE2557342 A DE 2557342A DE 2557342 A1 DE2557342 A1 DE 2557342A1
Authority
DE
Germany
Prior art keywords
formula
substituted
compound
group
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19752557342
Other languages
German (de)
English (en)
Inventor
Wilhelm Dipl Chem Dr Bartmann
Joachim Dr Kaiser
Rudolf Dipl Chem Dr Lattrell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Priority to DE19752557342 priority Critical patent/DE2557342A1/de
Priority to NL7614050A priority patent/NL7614050A/xx
Priority to IT30582/76A priority patent/IT1065683B/it
Priority to AT936276A priority patent/ATA936276A/de
Priority to DK571376A priority patent/DK571376A/da
Priority to LU76427A priority patent/LU76427A1/xx
Priority to CA268,139A priority patent/CA1079739A/en
Priority to JP51151501A priority patent/JPS5277060A/ja
Priority to BE173447A priority patent/BE849626A/xx
Priority to FR7638400A priority patent/FR2335216A1/fr
Priority to GB53124/76A priority patent/GB1566307A/en
Publication of DE2557342A1 publication Critical patent/DE2557342A1/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
DE19752557342 1975-12-19 1975-12-19 Basisch substituierte indolderivate und verfahren zu ihrer herstellung Withdrawn DE2557342A1 (de)

Priority Applications (11)

Application Number Priority Date Filing Date Title
DE19752557342 DE2557342A1 (de) 1975-12-19 1975-12-19 Basisch substituierte indolderivate und verfahren zu ihrer herstellung
NL7614050A NL7614050A (nl) 1975-12-19 1976-12-17 Basisch gesubstitueerde indoolderivaten en hun bereiding.
IT30582/76A IT1065683B (it) 1975-12-19 1976-12-17 Derivati indolici sostituiti con sostituenti basici e processo per la loro preparazione
AT936276A ATA936276A (de) 1975-12-19 1976-12-17 Verfahren zur herstellung von neuen, basisch substituierter indolderivate
DK571376A DK571376A (da) 1975-12-19 1976-12-17 Indolderivater deres fremstilling og anvendelse
LU76427A LU76427A1 (da) 1975-12-19 1976-12-17
CA268,139A CA1079739A (en) 1975-12-19 1976-12-17 Basically substituted indole derivatives and process for their manufacture
JP51151501A JPS5277060A (en) 1975-12-19 1976-12-18 Basic substituted indole derivatives and preparation thereof
BE173447A BE849626A (fr) 1975-12-19 1976-12-20 Nouveaux derives d'indol substitues par des bases, leur procede de preparation et leurs applications
FR7638400A FR2335216A1 (fr) 1975-12-19 1976-12-20 Nouveaux derives d'indol substitues par des bases, leur procede de preparation et leurs applications
GB53124/76A GB1566307A (en) 1975-12-19 1976-12-20 Indole derivatives of amides and amino esters and process for their manufacture

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19752557342 DE2557342A1 (de) 1975-12-19 1975-12-19 Basisch substituierte indolderivate und verfahren zu ihrer herstellung

Publications (1)

Publication Number Publication Date
DE2557342A1 true DE2557342A1 (de) 1977-06-30

Family

ID=5964905

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19752557342 Withdrawn DE2557342A1 (de) 1975-12-19 1975-12-19 Basisch substituierte indolderivate und verfahren zu ihrer herstellung

Country Status (11)

Country Link
JP (1) JPS5277060A (da)
AT (1) ATA936276A (da)
BE (1) BE849626A (da)
CA (1) CA1079739A (da)
DE (1) DE2557342A1 (da)
DK (1) DK571376A (da)
FR (1) FR2335216A1 (da)
GB (1) GB1566307A (da)
IT (1) IT1065683B (da)
LU (1) LU76427A1 (da)
NL (1) NL7614050A (da)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2152049A (en) * 1983-12-23 1985-07-31 Sandoz Ltd Benzoic acid derivative
US7781436B2 (en) 2005-07-29 2010-08-24 Hoffmann-La Roche Inc. Indol-3-y-carbonyl-piperidin and piperazin-derivatives
US8304413B2 (en) 2008-06-03 2012-11-06 Intermune, Inc. Compounds and methods for treating inflammatory and fibrotic disorders
US8741936B2 (en) 2005-05-10 2014-06-03 Intermune, Inc. Method of modulating stress-activated protein kinase system
US9359379B2 (en) 2012-10-02 2016-06-07 Intermune, Inc. Anti-fibrotic pyridinones
US10233195B2 (en) 2014-04-02 2019-03-19 Intermune, Inc. Anti-fibrotic pyridinones

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5936675A (ja) * 1982-07-13 1984-02-28 サンド・アクチエンゲゼルシヤフト 二環性複素環式カルボン酸アザビシクロアルキルエステルまたはアミド
US4861880A (en) * 1982-09-20 1989-08-29 Pfizer Inc. 1-phenyl-2(1H,3H)-indolone psycho-therapeutic agents
US4476307A (en) * 1982-09-20 1984-10-09 Pfizer Inc. Heteroylidene indolone compounds
US4879391A (en) * 1982-09-20 1989-11-07 Pfizer Inc. 1-Phenyl-2(1H,3H)-indolone psychotherapeutic agents
US4977178A (en) * 1982-09-20 1990-12-11 Pfizer Inc. Method of treating anxiety and depression with 1-phenyl-2(1H,3H)-indolone psycho-therapeutic agents
JPS6084281A (ja) * 1983-09-14 1985-05-13 Yoshitomi Pharmaceut Ind Ltd ３−インド−ルカルボキサミド類
US5852014A (en) * 1992-03-12 1998-12-22 Smithkline Beecham P.L.C. Condensed indole derivatives as 5HT4 -receptor antagonists
ES2219813T3 (es) * 1992-03-12 2004-12-01 Smithkline Beecham Plc N-(1-nbutil-4-piperidinil)metil-3,4-dihidro-2h-1,3-oxazino-3,2-a-indol-10-carboxamida, o una de sus sales farmaceuticamente aceptables.
ATE206701T1 (de) * 1996-04-19 2001-10-15 American Home Prod Östrogene verbindungen
US6069153A (en) * 1998-05-12 2000-05-30 American Home Products Corporation Indenoindoles and benzocarbazoles as estrogenic agents
US6479535B1 (en) 1998-05-15 2002-11-12 Wyeth 2-phenyl-1-[4-(2-aminoethoxy)-benzyl]-indole and estrogen formulations
US6159959A (en) * 1999-05-06 2000-12-12 American Home Products Corporation Combined estrogen and antiestrogen therapy
AU2006292429A1 (en) * 2005-09-16 2007-03-29 Serenex, Inc. Carbazole derivatives
EA020332B1 (ru) * 2007-08-10 2014-10-30 Х. Лундбекк А/С Аналоги гетероариламидов

Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2152049A (en) * 1983-12-23 1985-07-31 Sandoz Ltd Benzoic acid derivative
US5001133A (en) * 1983-12-23 1991-03-19 Sandoz Ltd. Benzoic acid derivatives
US9527816B2 (en) 2005-05-10 2016-12-27 Intermune, Inc. Method of modulating stress-activated protein kinase system
US10010536B2 (en) 2005-05-10 2018-07-03 Intermune, Inc. Method of modulating stress-activated protein kinase system
US8741936B2 (en) 2005-05-10 2014-06-03 Intermune, Inc. Method of modulating stress-activated protein kinase system
US7781436B2 (en) 2005-07-29 2010-08-24 Hoffmann-La Roche Inc. Indol-3-y-carbonyl-piperidin and piperazin-derivatives
US8969347B2 (en) 2008-06-03 2015-03-03 Intermune, Inc. Compounds and methods for treating inflammatory and fibrotic disorders
US9290450B2 (en) 2008-06-03 2016-03-22 Intermune, Inc. Compounds and methods for treating inflammatory and fibrotic disorders
USRE47142E1 (en) 2008-06-03 2018-11-27 Intermune, Inc. Compounds and methods for treating inflammatory and fibrotic disorders
US8304413B2 (en) 2008-06-03 2012-11-06 Intermune, Inc. Compounds and methods for treating inflammatory and fibrotic disorders
US9675593B2 (en) 2012-10-02 2017-06-13 Intermune, Inc. Anti-fibrotic pyridinones
US9359379B2 (en) 2012-10-02 2016-06-07 Intermune, Inc. Anti-fibrotic pyridinones
US10376497B2 (en) 2012-10-02 2019-08-13 Intermune, Inc. Anti-fibrotic pyridinones
US10898474B2 (en) 2012-10-02 2021-01-26 Intermune, Inc. Anti-fibrotic pyridinones
US10233195B2 (en) 2014-04-02 2019-03-19 Intermune, Inc. Anti-fibrotic pyridinones
US10544161B2 (en) 2014-04-02 2020-01-28 Intermune, Inc. Anti-fibrotic pyridinones

Also Published As

Publication number Publication date
FR2335216A1 (fr) 1977-07-15
LU76427A1 (da) 1977-07-05
JPS5277060A (en) 1977-06-29
IT1065683B (it) 1985-03-04
GB1566307A (en) 1980-04-30
ATA936276A (de) 1980-02-15
CA1079739A (en) 1980-06-17
NL7614050A (nl) 1977-06-21
BE849626A (fr) 1977-06-20
DK571376A (da) 1977-06-20

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8130 Withdrawal