CA1079739A - Basically substituted indole derivatives and process for their manufacture - Google Patents
Basically substituted indole derivatives and process for their manufactureInfo
- Publication number
- CA1079739A CA1079739A CA268,139A CA268139A CA1079739A CA 1079739 A CA1079739 A CA 1079739A CA 268139 A CA268139 A CA 268139A CA 1079739 A CA1079739 A CA 1079739A
- Authority
- CA
- Canada
- Prior art keywords
- phenyl
- indole
- chloro
- resultant
- carbon atoms
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19752557342 DE2557342A1 (de) | 1975-12-19 | 1975-12-19 | Basisch substituierte indolderivate und verfahren zu ihrer herstellung |
Publications (1)
Publication Number | Publication Date |
---|---|
CA1079739A true CA1079739A (en) | 1980-06-17 |
Family
ID=5964905
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA268,139A Expired CA1079739A (en) | 1975-12-19 | 1976-12-17 | Basically substituted indole derivatives and process for their manufacture |
Country Status (11)
Country | Link |
---|---|
JP (1) | JPS5277060A (da) |
AT (1) | ATA936276A (da) |
BE (1) | BE849626A (da) |
CA (1) | CA1079739A (da) |
DE (1) | DE2557342A1 (da) |
DK (1) | DK571376A (da) |
FR (1) | FR2335216A1 (da) |
GB (1) | GB1566307A (da) |
IT (1) | IT1065683B (da) |
LU (1) | LU76427A1 (da) |
NL (1) | NL7614050A (da) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5936675A (ja) * | 1982-07-13 | 1984-02-28 | サンド・アクチエンゲゼルシヤフト | 二環性複素環式カルボン酸アザビシクロアルキルエステルまたはアミド |
US4861880A (en) * | 1982-09-20 | 1989-08-29 | Pfizer Inc. | 1-phenyl-2(1H,3H)-indolone psycho-therapeutic agents |
US4476307A (en) * | 1982-09-20 | 1984-10-09 | Pfizer Inc. | Heteroylidene indolone compounds |
US4879391A (en) * | 1982-09-20 | 1989-11-07 | Pfizer Inc. | 1-Phenyl-2(1H,3H)-indolone psychotherapeutic agents |
US4977178A (en) * | 1982-09-20 | 1990-12-11 | Pfizer Inc. | Method of treating anxiety and depression with 1-phenyl-2(1H,3H)-indolone psycho-therapeutic agents |
JPS6084281A (ja) * | 1983-09-14 | 1985-05-13 | Yoshitomi Pharmaceut Ind Ltd | 3−インド−ルカルボキサミド類 |
FR2557110B1 (fr) * | 1983-12-23 | 1989-11-24 | Sandoz Sa | Nouveaux derives d'amines cycliques, leur preparation et leur utilisation comme medicaments |
US5852014A (en) * | 1992-03-12 | 1998-12-22 | Smithkline Beecham P.L.C. | Condensed indole derivatives as 5HT4 -receptor antagonists |
ES2219813T3 (es) * | 1992-03-12 | 2004-12-01 | Smithkline Beecham Plc | N-(1-nbutil-4-piperidinil)metil-3,4-dihidro-2h-1,3-oxazino-3,2-a-indol-10-carboxamida, o una de sus sales farmaceuticamente aceptables. |
ATE206701T1 (de) * | 1996-04-19 | 2001-10-15 | American Home Prod | Östrogene verbindungen |
US6069153A (en) * | 1998-05-12 | 2000-05-30 | American Home Products Corporation | Indenoindoles and benzocarbazoles as estrogenic agents |
US6479535B1 (en) | 1998-05-15 | 2002-11-12 | Wyeth | 2-phenyl-1-[4-(2-aminoethoxy)-benzyl]-indole and estrogen formulations |
US6159959A (en) * | 1999-05-06 | 2000-12-12 | American Home Products Corporation | Combined estrogen and antiestrogen therapy |
MX2007014114A (es) | 2005-05-10 | 2008-03-14 | Intermune Inc | Derivados de piridona para modular el sistema de proteina cinasa activada por estres. |
AU2006274884B2 (en) | 2005-07-29 | 2012-04-05 | F. Hoffmann-La Roche Ag | Indol-3-yl-carbonyl-piperidin and piperazin derivatives |
AU2006292429A1 (en) * | 2005-09-16 | 2007-03-29 | Serenex, Inc. | Carbazole derivatives |
EA020332B1 (ru) * | 2007-08-10 | 2014-10-30 | Х. Лундбекк А/С | Аналоги гетероариламидов |
JP5627574B2 (ja) | 2008-06-03 | 2014-11-19 | インターミューン, インコーポレイテッド | 炎症性および線維性疾患を治療するための化合物および方法 |
AR092742A1 (es) | 2012-10-02 | 2015-04-29 | Intermune Inc | Piridinonas antifibroticas |
JP6525437B2 (ja) | 2014-04-02 | 2019-06-05 | インターミューン, インコーポレイテッド | 抗線維性ピリジノン |
-
1975
- 1975-12-19 DE DE19752557342 patent/DE2557342A1/de not_active Withdrawn
-
1976
- 1976-12-17 IT IT30582/76A patent/IT1065683B/it active
- 1976-12-17 CA CA268,139A patent/CA1079739A/en not_active Expired
- 1976-12-17 AT AT936276A patent/ATA936276A/de not_active Application Discontinuation
- 1976-12-17 NL NL7614050A patent/NL7614050A/xx not_active Application Discontinuation
- 1976-12-17 DK DK571376A patent/DK571376A/da not_active Application Discontinuation
- 1976-12-17 LU LU76427A patent/LU76427A1/xx unknown
- 1976-12-18 JP JP51151501A patent/JPS5277060A/ja active Pending
- 1976-12-20 BE BE173447A patent/BE849626A/xx unknown
- 1976-12-20 FR FR7638400A patent/FR2335216A1/fr not_active Withdrawn
- 1976-12-20 GB GB53124/76A patent/GB1566307A/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
FR2335216A1 (fr) | 1977-07-15 |
LU76427A1 (da) | 1977-07-05 |
DE2557342A1 (de) | 1977-06-30 |
JPS5277060A (en) | 1977-06-29 |
IT1065683B (it) | 1985-03-04 |
GB1566307A (en) | 1980-04-30 |
ATA936276A (de) | 1980-02-15 |
NL7614050A (nl) | 1977-06-21 |
BE849626A (fr) | 1977-06-20 |
DK571376A (da) | 1977-06-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MKEX | Expiry |