DD218096A5 - Verfahren zur herstellung von n-(3-triflourmethylphenyl)-n-propargyl-piperazin - Google Patents

Verfahren zur herstellung von n-(3-triflourmethylphenyl)-n-propargyl-piperazin Download PDF

Info

Publication number
DD218096A5
DD218096A5 DD84260319A DD26031984A DD218096A5 DD 218096 A5 DD218096 A5 DD 218096A5 DD 84260319 A DD84260319 A DD 84260319A DD 26031984 A DD26031984 A DD 26031984A DD 218096 A5 DD218096 A5 DD 218096A5
Authority
DD
German Democratic Republic
Prior art keywords
compound
formula
propargyl
piperazine
reaction
Prior art date
Application number
DD84260319A
Other languages
German (de)
English (en)
Inventor
Rolf Banholzer
Herbert Merz
Klaus Stockhaus
Hans Jennewein
Original Assignee
Boehringer Ingelheim Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Kg filed Critical Boehringer Ingelheim Kg
Publication of DD218096A5 publication Critical patent/DD218096A5/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C07D295/027Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
    • C07D295/033Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to carbocyclic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/06Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
    • C07D295/073Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D241/00Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/06Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
    • C07D241/08Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pyridine Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Hydrogenated Pyridines (AREA)
DD84260319A 1983-02-28 1984-02-24 Verfahren zur herstellung von n-(3-triflourmethylphenyl)-n-propargyl-piperazin DD218096A5 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19833306964 DE3306964A1 (de) 1983-02-28 1983-02-28 Neues n-arylpiperazin und verfahren zu seiner herstellung

Publications (1)

Publication Number Publication Date
DD218096A5 true DD218096A5 (de) 1985-01-30

Family

ID=6192038

Family Applications (1)

Application Number Title Priority Date Filing Date
DD84260319A DD218096A5 (de) 1983-02-28 1984-02-24 Verfahren zur herstellung von n-(3-triflourmethylphenyl)-n-propargyl-piperazin

Country Status (25)

Country Link
US (1) US4699910A (es)
EP (1) EP0117531B1 (es)
JP (1) JPS59210074A (es)
KR (1) KR910005413B1 (es)
AT (1) ATE22289T1 (es)
AU (1) AU562643B2 (es)
CA (1) CA1240327A (es)
CS (1) CS240997B2 (es)
DD (1) DD218096A5 (es)
DE (2) DE3306964A1 (es)
DK (1) DK158729C (es)
ES (7) ES8504754A1 (es)
FI (1) FI77658C (es)
GB (1) GB2135997B (es)
GR (1) GR79822B (es)
HU (1) HU190546B (es)
IE (1) IE56938B1 (es)
IL (1) IL71068A (es)
NO (1) NO158803C (es)
NZ (1) NZ207289A (es)
PH (1) PH21982A (es)
PL (1) PL141275B1 (es)
PT (1) PT78155B (es)
SU (1) SU1223844A3 (es)
ZA (1) ZA841418B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH03176457A (ja) * 1989-12-04 1991-07-31 Nippon Paint Co Ltd 新規プロパルギル化合物、その製法ならびに該化合物を含む被覆材
JPH05255089A (ja) * 1991-12-18 1993-10-05 Sanwa Kagaku Kenkyusho Co Ltd 抗ウイルス剤
US5661163A (en) * 1995-06-07 1997-08-26 Merck & Co., Inc. Alpha-1a adrenergic receptor antagonists
USRE46117E1 (en) 1999-12-22 2016-08-23 Teva Pharmaceuticals International Gmbh Modulators of dopamine neurotransmission
EA027748B1 (ru) 2012-04-04 2017-08-31 Тева Фармасьютикалз Интернэшнл Гмбх Применение придопидина в комбинации с тетрабеназином для лечения двигательных нарушений и ожирения

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2993899A (en) * 1958-03-31 1961-07-25 Miles Lab Acetylenically unsaturated piperazine derivatives
NL6607959A (es) * 1965-06-10 1966-12-12
DE1545561A1 (de) * 1965-08-23 1969-12-11 Acraf Verfahren zur Herstellung von pharmakologisch aktiven N,N-disubstituierten 1-Aryl-3-aminopropinen
FR2187311B1 (es) * 1972-06-02 1975-06-20 Bouchara Emile
GB1560271A (en) * 1977-01-14 1980-02-06 Joullie International Sa Therapeutically useful m-trifluoromethylphenylpiperazine derivatives
US4180574A (en) * 1978-12-26 1979-12-25 Abbott Laboratories Certain ovicidal piperazines
US4518712A (en) * 1980-06-30 1985-05-21 Taiho Pharmaceutical Company Limited Piperazine derivative and analgesic composition containing the same

Also Published As

Publication number Publication date
CS127484A2 (en) 1985-06-13
GR79822B (es) 1984-10-31
EP0117531A1 (de) 1984-09-05
NO840732L (no) 1984-08-29
IL71068A (en) 1988-05-31
ES8601173A1 (es) 1985-10-16
NO158803C (no) 1988-11-09
ES8603446A1 (es) 1985-12-16
ES530073A0 (es) 1985-04-16
AU2508584A (en) 1984-09-06
PL141275B1 (en) 1987-07-31
ES8603447A1 (es) 1985-12-16
GB8405113D0 (en) 1984-04-04
KR910005413B1 (ko) 1991-07-29
EP0117531B1 (de) 1986-09-17
DE3306964A1 (de) 1984-09-06
ES536415A0 (es) 1985-12-16
ATE22289T1 (de) 1986-10-15
ES536412A0 (es) 1985-10-16
ES8603444A1 (es) 1985-12-16
ES536411A0 (es) 1985-10-16
JPS59210074A (ja) 1984-11-28
DK102084D0 (da) 1984-02-24
JPH056545B2 (es) 1993-01-26
NO158803B (no) 1988-07-25
ES8504754A1 (es) 1985-04-16
ES536416A0 (es) 1985-12-16
GB2135997A (en) 1984-09-12
SU1223844A3 (ru) 1986-04-07
DK158729C (da) 1990-11-19
PH21982A (en) 1988-05-02
FI77658C (fi) 1989-04-10
IE840460L (en) 1984-08-28
ES536413A0 (es) 1985-12-16
ES8601174A1 (es) 1985-10-16
IL71068A0 (en) 1984-05-31
DK158729B (da) 1990-07-09
IE56938B1 (en) 1992-02-12
HU190546B (en) 1986-09-29
AU562643B2 (en) 1987-06-18
FI77658B (fi) 1988-12-30
ES8603445A1 (es) 1985-12-16
DK102084A (da) 1984-08-29
US4699910A (en) 1987-10-13
DE3460733D1 (en) 1986-10-23
KR840007875A (ko) 1984-12-11
GB2135997B (en) 1986-02-19
CS240997B2 (en) 1986-03-13
PL246418A1 (en) 1985-07-02
PT78155B (de) 1986-07-17
NZ207289A (en) 1986-07-11
FI840743A (fi) 1984-08-29
ZA841418B (en) 1985-11-27
FI840743A0 (fi) 1984-02-23
CA1240327A (en) 1988-08-09
ES536414A0 (es) 1985-12-16
PT78155A (de) 1984-03-01

Similar Documents

Publication Publication Date Title
DE1543715A1 (de) Verfahren zur Herstellung von basischen Derivaten von Phthalanen und Isochromanen
EP1778691A1 (de) Hydrate und polymorphe des 4-[[(7r)-8-cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-4-6-oxo-2-piperidinyl|]amino]-3-methoxy-n-(1-methyl-4-piperidinyl)-benzamid, verfahren zu deren herstellung und deren verwendung als arzneimittel
DE3336024A1 (de) 4-amino-l-benzyl-pyrrolidinone und ihre saeureadditionssalze, verfahren zu ihrer herstellung und arzneimittel
EP0163260B1 (de) Neue substituierte Pyrrolidinone, Verfahren zu ihrer Herstellung und Arzneimittel
DE3334757A1 (de) Piperazinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneipraeparate
DE2037852B2 (de) Neue Piperazinderivate und Verfahren zu ihrer Herstellung
DE2702537A1 (de) Neue piperazinderivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel
EP0132811B1 (de) In 1-Stellung substituierte 4-Hydroxymethyl-pyrrolidinone, Verfahren zu ihrer Herstellung, pharmazeutische Zusammensetzungen und Zwischenprodukte
EP0075752A2 (de) Substituierte 2-Phenyl-2-(pyridyloxy)-ethylamine und isostere Verbindungen, Verfahren zu ihrer Herstellung und Verwendung
DD218096A5 (de) Verfahren zur herstellung von n-(3-triflourmethylphenyl)-n-propargyl-piperazin
DE2514914A1 (de) Verfahren zur herstellung tertiaerer amine
WO1991009834A1 (de) o-HYDROXY-β-(1-NAPHTHYL)-PROPIOPHENONDERIVATE, VERFAHREN ZU IHRER HERSTELLUNG UND DIESE VERBINDUNGEN ENTHALTENDE ARZNEIMITTEL
DE1950351C3 (de) l-(2-Cyano-5-methylphenoxy)-2-hydroxy-3-aIkylaminopropane, Verfahren zu ihrer Herstellung sowie diese enthaltende Arzneimittel
EP0297435B1 (de) Aminopropanolderivate von 3-(3'-Hydroxyphenyl)-1-propanon-Verbindungen, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
DE2705896A1 (de) 2,5-disubstituierte benzamide und verfahren zu ihrer herstellung
DE1951614C3 (de) Substituierte Benzylalkohol, deren physiologisch verträgliche Salze, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
AT311350B (de) Verfahren zur Herstellung von neuen 1,2,3,6,-Tetrahydro-4-pyridylmethyl-carbonsäureestern, deren Säureadditionssalzen und quaternären Ammoniumverbindungen
AT368146B (de) Verfahren zur herstellung neuer 2-anilinooxazoline
DE2114893A1 (de) Neue basisch substituierte Thiolcarbamidsäure-alkylester und Verfahren zu deren Herstellung
EP0296592B1 (de) Aminopropanolderivate von 3-(2-Hydroxyphenyl)-1-propanon-Verbindungen, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
DE2158959A1 (de) Neue Imidazohdinonderivate und Verfahren zu ihrer Herstellung
DE3151123A1 (de) 1,4-disubstituierte piperazinderivate, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zubereitungen
DE1543928C (de) Amino dihalogen phenyl ethanolamine, Verfahren zu ihrer Herstellung sowie diese enthaltende Arzneimittel
DE2423896A1 (de) Neue 1- eckige klammer auf n-(p-fluorbenzoylpropyl)-4-piperidyl eckige klammer zu -harnstoffe und verfahren zu ihrer herstellung
EP0031456A1 (de) Neue substituierte 4-Amino-2,6-diaryl-tetrahydrothiopyrane, deren Säureadditionssalze, Verfahren zu ihrer Herstellung und pharmazeutische Zusammensetzungen

Legal Events

Date Code Title Description
ENJ Ceased due to non-payment of renewal fee