CY1125429T1 - Μουτεϊνες ιντερλευκινης-21 και μεθοδοι θεραπευτικης αγωγης - Google Patents
Μουτεϊνες ιντερλευκινης-21 και μεθοδοι θεραπευτικης αγωγηςInfo
- Publication number
- CY1125429T1 CY1125429T1 CY20221100274T CY221100274T CY1125429T1 CY 1125429 T1 CY1125429 T1 CY 1125429T1 CY 20221100274 T CY20221100274 T CY 20221100274T CY 221100274 T CY221100274 T CY 221100274T CY 1125429 T1 CY1125429 T1 CY 1125429T1
- Authority
- CY
- Cyprus
- Prior art keywords
- methods
- muteins
- interleukin
- therapeutic treatment
- treating
- Prior art date
Links
- 108010074108 interleukin-21 Proteins 0.000 title abstract 3
- 102100030704 Interleukin-21 Human genes 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
- 102000037865 fusion proteins Human genes 0.000 abstract 2
- 108020001507 fusion proteins Proteins 0.000 abstract 2
- 102100023990 60S ribosomal protein L17 Human genes 0.000 abstract 1
- 101710089372 Programmed cell death protein 1 Proteins 0.000 abstract 1
- 102000025171 antigen binding proteins Human genes 0.000 abstract 1
- 108091000831 antigen binding proteins Proteins 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
- A61K47/6813—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin the drug being a peptidic cytokine, e.g. an interleukin or interferon
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/10041—Use of virus, viral particle or viral elements as a vector
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Toxicology (AREA)
- Cell Biology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Στο παρόν παρέχονται μουτεΐνες IL-21 και πρωτεΐνες σύντηξης που τις περιλαμβάνουν για χρήση σε μεθόδους θεραπευτικής αγωγής μιας ασθένειας. Σχετικά συζεύγματα, νουκλεϊνικά οξέα, φορείς, κύτταρα ξενιστές, φαρμακευτικές συνθέσεις και κιτ παρέχονται επίσης στο παρόν. Μέθοδοι παρασκευής των μουτεϊνών IL-21 και πρωτεϊνών σύντηξης που τις περιλαμβάνουν, καθώς και μέθοδοι θεραπευτικής αγωγής ενός υποκειμένου που το έχει ανάγκη, παρέχονται από την παρούσα αποκάλυψη. Περαιτέρω παρέχονται πρωτεΐνες δέσμευσης αντιγόνου PD-1.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762540692P | 2017-08-03 | 2017-08-03 | |
US201862616733P | 2018-01-12 | 2018-01-12 | |
PCT/US2018/045105 WO2019028316A1 (en) | 2017-08-03 | 2018-08-03 | INTERLEUKIN-21 MUTÉINS AND METHODS OF TREATMENT |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1125429T1 true CY1125429T1 (el) | 2024-02-16 |
Family
ID=63350603
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20221100274T CY1125429T1 (el) | 2017-08-03 | 2022-04-12 | Μουτεϊνες ιντερλευκινης-21 και μεθοδοι θεραπευτικης αγωγης |
Country Status (33)
Country | Link |
---|---|
US (2) | US11541103B2 (el) |
EP (2) | EP3661954B1 (el) |
JP (2) | JP7079171B2 (el) |
KR (2) | KR20220092652A (el) |
CN (2) | CN111164100B (el) |
AU (2) | AU2018311079B2 (el) |
BR (2) | BR112020002013B1 (el) |
CA (1) | CA3071376A1 (el) |
CL (2) | CL2020000252A1 (el) |
CO (1) | CO2020001113A2 (el) |
CR (1) | CR20200099A (el) |
CY (1) | CY1125429T1 (el) |
DK (1) | DK3661954T3 (el) |
ES (1) | ES2910969T3 (el) |
HR (1) | HRP20220404T1 (el) |
HU (1) | HUE058233T2 (el) |
IL (1) | IL272137A (el) |
JO (1) | JOP20200020B1 (el) |
LT (1) | LT3661954T (el) |
MA (1) | MA56289B1 (el) |
MX (2) | MX2020001328A (el) |
MY (1) | MY195974A (el) |
PH (1) | PH12020500231A1 (el) |
PL (1) | PL3661954T3 (el) |
PT (1) | PT3661954T (el) |
RS (1) | RS63101B1 (el) |
SA (1) | SA520411230B1 (el) |
SG (1) | SG11202000821SA (el) |
SI (1) | SI3661954T1 (el) |
TN (1) | TN2020000015A1 (el) |
TW (2) | TWI798245B (el) |
UY (1) | UY37829A (el) |
WO (1) | WO2019028316A1 (el) |
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CA3072099A1 (en) * | 2017-08-11 | 2019-02-14 | Research Development Foundation | Engineered antibody fc variants for enhanced serum half life |
JP6630026B1 (ja) * | 2018-04-27 | 2020-01-15 | 隆代 大田 | 免疫チェックポイント阻害剤によるがん治療の効果を評価するためのバイオマーカー |
US20210163562A1 (en) * | 2018-07-25 | 2021-06-03 | AskGene Pharma, Inc. | Novel IL-21 Prodrugs and Methods of Use Thereof |
JP2022514702A (ja) * | 2018-12-21 | 2022-02-14 | オーエスイー・イミュノセラピューティクス | 二機能性抗pd-1/il-7分子 |
SG11202111672RA (en) * | 2019-04-30 | 2021-11-29 | Target Discovery Merger Sub Ii Llc | Cancer associated antibody compositions and methods of use |
AU2020380379A1 (en) * | 2019-11-08 | 2022-05-26 | Amgen Inc. | Engineering charge pair mutations for pairing of hetero-IgG molecules |
WO2021092719A1 (zh) * | 2019-11-11 | 2021-05-20 | 王盛典 | 一种靶向抗原特异性t细胞诱导其向记忆干性细胞分化的融合蛋白 |
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WO2022258678A1 (en) | 2021-06-09 | 2022-12-15 | Innate Pharma | Multispecific proteins binding to nkp30, a cytokine receptor, a tumour antigen and cd16a |
EP4352098A1 (en) | 2021-06-09 | 2024-04-17 | Innate Pharma | Multispecific proteins binding to nkp46, a cytokine receptor, a tumour antigen and cd16a |
AU2022324624A1 (en) * | 2021-08-06 | 2024-02-08 | Amgen Inc. | Isolation of therapeutic protein |
AU2022350320A1 (en) * | 2021-09-24 | 2024-04-11 | Bionsystems Inc | Fusion protein dimer including pd-1 and il-21, and use thereof |
US20230136331A1 (en) * | 2021-09-30 | 2023-05-04 | Ildong Pharmaceutical Co., Ltd. | Immunocytokine containing il-21r mutein |
WO2023205738A2 (en) * | 2022-04-20 | 2023-10-26 | Neptune Biosciences Llc | Orthogonal il-21 receptor/cytokine systems |
WO2023215829A1 (en) * | 2022-05-05 | 2023-11-09 | Amgen Inc. | Heteromultimer binding dll3 and cd3 |
KR20230157760A (ko) * | 2022-05-10 | 2023-11-17 | 아주대학교산학협력단 | 인터루킨21 변이체, 이를 포함하는 융합단백질 및 이의 용도 |
TW202409068A (zh) * | 2022-06-29 | 2024-03-01 | 大陸商北京星奇原生物科技有限公司 | Il—21多肽和使用方法 |
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