CY1124810T1 - Συνδυαστικη θεραπεια για τη θεραπευτικη αντιμετωπιση του καρκινου - Google Patents

Συνδυαστικη θεραπεια για τη θεραπευτικη αντιμετωπιση του καρκινου

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Publication number
CY1124810T1
CY1124810T1 CY20211101103T CY211101103T CY1124810T1 CY 1124810 T1 CY1124810 T1 CY 1124810T1 CY 20211101103 T CY20211101103 T CY 20211101103T CY 211101103 T CY211101103 T CY 211101103T CY 1124810 T1 CY1124810 T1 CY 1124810T1
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CY
Cyprus
Prior art keywords
agent
pharmaceutically acceptable
acceptable salt
cancer
treatment
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CY20211101103T
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English (en)
Inventor
Yan Chen
Xizhong Huang
Sunkyu Kim
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Novartis Ag
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=51355593&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1124810(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of CY1124810T1 publication Critical patent/CY1124810T1/el

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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
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    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
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    • A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • A61K31/5685—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone having an oxo group in position 17, e.g. androsterone
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Abstract

Η παρούσα γνωστοποίηση σχετίζεται με φαρμακευτικό συνδυασμό ο οποίος περιέχει (1) έναν πρώτο παράγοντα, ο οποίος είναι ένας αναστολέας CDK, ή ένα φαρμακευτικώς αποδεκτό άλας αυτού, και (2) έναν δεύτερο παράγοντα, ο οποίος είναι ένας αντι-ορμονικός παράγοντας, ή ένα φαρμακευτικώς αποδεκτό άλας αυτού. Η παρούσα γνωστοποίηση αναφέρεται, επίσης, σε έναν φαρμακευτικό συνδυασμό ο οποίος περιέχει (1) έναν πρώτο παράγοντα, ο οποίος είναι ένας αναστολέας CDK, ή ένα φαρμακευτικώς αποδεκτό άλας αυτού, (2) έναν δεύτερο παράγοντα, ο οποίος είναι ένας αντι-ορμονικός παράγοντας, ή ένα φαρμακευτικώς αποδεκτό άλας αυτού, και (3)έναν τρίτο παράγοντα, ο οποίος ρυθμίζει το μονοπάτι PI3K/Akt/mTOR, ή ένα φαρμακευτικώς αποδεκτό άλας αυτού.
CY20211101103T 2013-08-14 2021-12-15 Συνδυαστικη θεραπεια για τη θεραπευτικη αντιμετωπιση του καρκινου CY1124810T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361865804P 2013-08-14 2013-08-14
US201361894029P 2013-10-22 2013-10-22
PCT/IB2014/063782 WO2015022609A1 (en) 2013-08-14 2014-08-07 Combination therapy for the treatment of cancer

Publications (1)

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CY1124810T1 true CY1124810T1 (el) 2022-11-25

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Country Status (20)

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US (7) US20160184311A1 (el)
EP (2) EP4005573A1 (el)
JP (2) JP2016528246A (el)
KR (3) KR102318306B1 (el)
CN (2) CN110368497B (el)
AU (3) AU2014307633A1 (el)
BR (1) BR112016002465B1 (el)
CA (1) CA2918190C (el)
CY (1) CY1124810T1 (el)
DK (1) DK3033086T3 (el)
ES (1) ES2900829T3 (el)
HR (1) HRP20211879T1 (el)
HU (1) HUE057061T2 (el)
LT (1) LT3033086T (el)
MX (2) MX2020002150A (el)
PL (1) PL3033086T3 (el)
PT (1) PT3033086T (el)
RU (1) RU2680714C2 (el)
SI (1) SI3033086T1 (el)
WO (1) WO2015022609A1 (el)

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