CY1124764T1 - Υπογλωττια ανθεκτικα σε καταχρηση δισκια που περιεχουν βουπρενορφινη και ναλοξονη - Google Patents
Υπογλωττια ανθεκτικα σε καταχρηση δισκια που περιεχουν βουπρενορφινη και ναλοξονηInfo
- Publication number
- CY1124764T1 CY1124764T1 CY20211100911T CY211100911T CY1124764T1 CY 1124764 T1 CY1124764 T1 CY 1124764T1 CY 20211100911 T CY20211100911 T CY 20211100911T CY 211100911 T CY211100911 T CY 211100911T CY 1124764 T1 CY1124764 T1 CY 1124764T1
- Authority
- CY
- Cyprus
- Prior art keywords
- naloxone
- subglottic
- tablets containing
- abuse resistant
- containing buprenorphine
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4748—Quinolines; Isoquinolines forming part of bridged ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Addiction (AREA)
- Neurosurgery (AREA)
- Organic Chemistry (AREA)
- Emergency Medicine (AREA)
- Zoology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Παρέχεται ένα δισκίο κατάλληλο για υπογλώττια χορήγηση που περιέχει μικροσωματίδια μιας φαρμακολογικώς αποτελεσματικής ποσότητας βουπρενορφίνης, ή ενός φαρμακευτικώς αποδεκτού άλατος αυτής• σωματίδια μιας φαρμακολογικώς αποτελεσματικής ποσότητας ναλοξόνης ή ενός φαρμακευτικώς αποδεκτού άλατος αυτής• έναν διαλυτοποιητή• και σωματίδια ενός ασθενούς οξέος που παρέχεται σε επαρκή ποσότητα ώστε να καθιστά δυνατή την εξασφάλιση μιας τιμής ph μεταξύ περίπου 4,0 και περίπου 6,5 και τη διατήρηση του pH μέσα σε αυτό το εύρος για όχι πάνω από περίπου 3 λεπτά μετά τη χορήγηση σε έναν ασθενή.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161536180P | 2011-09-19 | 2011-09-19 | |
PCT/GB2012/052303 WO2013041851A1 (en) | 2011-09-19 | 2012-09-18 | New abuse-resistant pharmaceutical composition for the treatment of opioid dependence |
EP12775283.0A EP2706986B1 (en) | 2011-09-19 | 2012-09-18 | New abuse-resistant pharmaceutical composition for the treatment of opioid dependence |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1124764T1 true CY1124764T1 (el) | 2022-07-22 |
Family
ID=47046639
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20151100422T CY1116270T1 (el) | 2011-09-19 | 2015-05-13 | Νεα ανθεκτικη στην καταχρηση φαρμακευτικη συνθεση για θεραπεια της εξαρτησης απο οπιοειδη |
CY20211100911T CY1124764T1 (el) | 2011-09-19 | 2021-10-19 | Υπογλωττια ανθεκτικα σε καταχρηση δισκια που περιεχουν βουπρενορφινη και ναλοξονη |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20151100422T CY1116270T1 (el) | 2011-09-19 | 2015-05-13 | Νεα ανθεκτικη στην καταχρηση φαρμακευτικη συνθεση για θεραπεια της εξαρτησης απο οπιοειδη |
Country Status (31)
Country | Link |
---|---|
US (15) | US8940330B2 (el) |
EP (3) | EP2706986B1 (el) |
JP (2) | JP6210988B2 (el) |
KR (1) | KR102078044B1 (el) |
CN (1) | CN103813785B (el) |
AU (1) | AU2012311293B2 (el) |
BR (1) | BR112014006356B1 (el) |
CA (1) | CA2834327C (el) |
CL (1) | CL2014000575A1 (el) |
CO (1) | CO6960541A2 (el) |
CY (2) | CY1116270T1 (el) |
DK (2) | DK2915525T3 (el) |
EA (1) | EA029507B1 (el) |
ES (2) | ES2887104T3 (el) |
HK (2) | HK1193568A1 (el) |
HR (2) | HRP20211539T1 (el) |
HU (1) | HUE056309T2 (el) |
IL (1) | IL230528B (el) |
LT (1) | LT2915525T (el) |
ME (1) | ME02153B (el) |
MX (1) | MX361757B (el) |
MY (1) | MY185284A (el) |
PE (1) | PE20141198A1 (el) |
PL (2) | PL2706986T3 (el) |
PT (2) | PT2706986E (el) |
RS (2) | RS62505B1 (el) |
SG (1) | SG2014009401A (el) |
SI (2) | SI2706986T1 (el) |
SM (1) | SMT201500126B (el) |
WO (1) | WO2013041851A1 (el) |
ZA (1) | ZA201400501B (el) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2012311293B2 (en) | 2011-09-19 | 2014-02-20 | Orexo Ab | New abuse-resistant pharmaceutical composition for the treatment of opioid dependence |
US20140280531A1 (en) * | 2013-03-13 | 2014-09-18 | Xin Liu | Object ranking and recommendations within a social network |
EP2983668A4 (en) * | 2013-04-08 | 2017-01-11 | Virginia Commonwealth University | Compositions to alleviate presystemic metabolism of opioids |
EP2886103A1 (en) * | 2013-12-23 | 2015-06-24 | Hexal AG | Pharmaceutical orodispersible film comprising buprenorphine particles with a particular size |
US10617686B2 (en) * | 2014-07-08 | 2020-04-14 | Hikma Pharmaceuticals Usa Inc. | Liquid naloxone spray |
US10722510B2 (en) | 2014-07-08 | 2020-07-28 | Hikma Pharmaceuticals Usa Inc. | Liquid naloxone spray |
EP3177146A4 (en) * | 2014-07-08 | 2018-01-03 | Insys Pharma, Inc. | Sublingual naloxone spray |
US11135155B2 (en) | 2014-07-08 | 2021-10-05 | Hikma Pharmaceuticals Usa Inc. | Liquid naloxone spray |
NZ731309A (en) | 2014-11-07 | 2022-02-25 | Indivior Uk Ltd | Buprenorphine dosing regimens |
WO2018034920A1 (en) * | 2016-08-17 | 2018-02-22 | Insys Development Company, Inc. | Liquid naloxone spray |
CN110325178B (zh) * | 2016-12-26 | 2022-05-13 | 盐野义制药株式会社 | 改善含量均一性的制剂的制造方法 |
US10646484B2 (en) | 2017-06-16 | 2020-05-12 | Indivior Uk Limited | Methods to treat opioid use disorder |
WO2019064026A1 (en) | 2017-09-29 | 2019-04-04 | Orexo Ab | NEW PHARMACEUTICAL COMPOSITIONS |
BR112020007808A2 (pt) * | 2017-10-20 | 2020-10-20 | Chiesi Farmaceutici S.P.A. | formulações farmacêuticas que compreendem um agonista de receptor de opioide como ingrediente ativo, métodos de fabricação e usos terapêuticos destas |
CN111479592B (zh) * | 2017-11-15 | 2023-05-26 | 加利福尼亚大学董事会 | 阿片样物质使用障碍、阿片样物质戒断症状和慢性疼痛的治疗 |
AU2019236389A1 (en) | 2018-03-11 | 2020-07-30 | Nanologica Ab | Porous silica particles for use in compressed pharmaceutical dosage form |
GB201904767D0 (en) | 2019-04-04 | 2019-05-22 | Orexo Ab | New pharmaceutical compositions |
KR20220003541A (ko) * | 2019-04-18 | 2022-01-10 | 키에시 파르마슈티시 엣스. 피. 에이. | 신생아 오피오이드 금단 증후군 치료를 위한 방법 |
US11571414B2 (en) | 2019-09-06 | 2023-02-07 | Eric Dwayne Ford | Methods of treating respiratory illnesses, alleviating inflammation and visceral pain, and alleviating opioid addiction while suppressing withdrawal symptoms |
MX2022010800A (es) * | 2020-03-11 | 2022-09-27 | Purdue Pharma Lp | Composiciones y metodos para la administracion de naloxona. |
Family Cites Families (97)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1428361A (en) | 1972-02-15 | 1976-03-17 | Grant A | Safeguarded medicinal compositions |
JPS5138412A (en) | 1974-09-24 | 1976-03-31 | Nippon Kayaku Kk | Kokoseizai no seiho |
US4175119A (en) | 1978-01-11 | 1979-11-20 | Porter Garry L | Composition and method to prevent accidental and intentional overdosage with psychoactive drugs |
US4457933A (en) | 1980-01-24 | 1984-07-03 | Bristol-Myers Company | Prevention of analgesic abuse |
AU8533582A (en) | 1981-07-10 | 1984-01-12 | Reckitt & Colman Products Limited | Stable solutions of buprenorphine |
US4459278A (en) | 1983-03-07 | 1984-07-10 | Clear Lake Development Group | Composition and method of immobilizing emetics and method of treating human beings with emetics |
US4529583A (en) | 1983-03-07 | 1985-07-16 | Clear Lake Development Group | Composition and method of immobilizing emetics and method of treating human beings with emetics |
GB8332556D0 (en) | 1983-12-06 | 1984-01-11 | Reckitt & Colmann Prod Ltd | Analgesic compositions |
FR2562313B1 (fr) | 1984-04-03 | 1989-04-07 | Cogema | Procede de decontamination en uranium et en radium de solutions uraniferes acides par addition d'un sel d'aluminium |
GB2162061B (en) | 1984-05-03 | 1988-11-16 | Bibhuti B Bardhan | Controlled time release therapeutic composition having means for counteracting overdosage |
GB8430346D0 (en) | 1984-11-30 | 1985-01-09 | Reckitt & Colmann Prod Ltd | Analgesic compositions |
US4885173A (en) | 1985-05-01 | 1989-12-05 | University Of Utah | Methods and compositions for noninvasive dose-to-effect administration of drugs with cardiovascular or renal vascular activities |
US5288497A (en) | 1985-05-01 | 1994-02-22 | The University Of Utah | Compositions of oral dissolvable medicaments |
FR2582513B1 (fr) | 1985-05-28 | 1988-08-05 | Synthelabo | Compositions pharmaceutiques contenant de l'alfuzosine |
US4755386A (en) | 1986-01-22 | 1988-07-05 | Schering Corporation | Buccal formulation |
US4769372A (en) | 1986-06-18 | 1988-09-06 | The Rockefeller University | Method of treating patients suffering from chronic pain or chronic cough |
GB8728294D0 (en) | 1987-12-03 | 1988-01-06 | Reckitt & Colmann Prod Ltd | Treatment compositions |
SE8800080L (sv) | 1988-01-13 | 1989-07-14 | Kabivitrum Ab | Laekemedelskomposition |
US4981468A (en) | 1989-02-17 | 1991-01-01 | Eli Lilly And Company | Delivery device for orally administered therapeutic agents |
US5069909A (en) | 1990-06-20 | 1991-12-03 | Cygnus Therapeutic Systems | Transdermal administration of buprenorphine |
CA2070061C (en) | 1991-06-07 | 2004-02-10 | Shigeyuki Takama | Physiologically active polypeptide-containing pharmaceutical composition |
US5192802A (en) | 1991-09-25 | 1993-03-09 | Mcneil-Ppc, Inc. | Bioadhesive pharmaceutical carrier |
US5362496A (en) | 1993-08-04 | 1994-11-08 | Pharmetrix Corporation | Method and therapeutic system for smoking cessation |
US5547878A (en) | 1993-11-02 | 1996-08-20 | Kell; Michael | Method of monitoring patient compliance with medications prescriptions |
US5856493A (en) | 1995-02-06 | 1999-01-05 | Smithkline Beecham Corporation | Process for making novel form of paroxeting hydrochloride anhydrate |
US5888534A (en) | 1995-06-13 | 1999-03-30 | Pentech Pharmaceuticals, Inc. | Controlled release of drugs delivered by sublingual or buccal administration |
PT914097E (pt) | 1996-03-12 | 2002-06-28 | Alza Corp | Composicao e forma de dosagem compreendendo antagonista de opioide |
US5795909A (en) | 1996-05-22 | 1998-08-18 | Neuromedica, Inc. | DHA-pharmaceutical agent conjugates of taxanes |
JP2000505090A (ja) | 1996-07-11 | 2000-04-25 | ファーマーク、ニーダーランド、ベスローテン、フェンノートシャップ | インドール選択的セロトニンアゴニストを含む包接錯体 |
US6217000B1 (en) | 1996-10-25 | 2001-04-17 | The Boeing Company | Composite fabrication method and tooling to improve part consolidation |
GB9710726D0 (en) | 1997-05-23 | 1997-07-16 | Nycomed Imaging As | Compound |
WO1998053802A1 (en) | 1997-05-30 | 1998-12-03 | Laboratorios Phoenix U.S.A., Inc. | Multi-layered osmotic device |
WO1999032120A1 (en) | 1997-12-22 | 1999-07-01 | Euro-Celtique, S.A. | A method of preventing abuse of opioid dosage forms |
US6375957B1 (en) | 1997-12-22 | 2002-04-23 | Euro-Celtique, S.A. | Opioid agonist/opioid antagonist/acetaminophen combinations |
ES2138937B1 (es) | 1998-07-07 | 2000-10-01 | Medichem Sa | Polimorfo de maleato de paroxetina y formulaciones farmaceuticas que lo contienen. |
SE9803239D0 (sv) | 1998-09-24 | 1998-09-24 | Diabact Ab | Composition for the treatment of acute pain |
SE9803240D0 (sv) | 1998-09-24 | 1998-09-24 | Diabact Ab | A pharmaceutical composition having a rapid action |
IT1302682B1 (it) | 1998-10-16 | 2000-09-29 | Formenti Farmaceutici Spa | Composizioni farmaceutiche orali contenenti buprenorfina |
US6228469B1 (en) | 1999-09-07 | 2001-05-08 | Corning Incorporated | Protective coating on metal |
US6264981B1 (en) | 1999-10-27 | 2001-07-24 | Anesta Corporation | Oral transmucosal drug dosage using solid solution |
AR031682A1 (es) | 1999-11-19 | 2003-10-01 | Reckitt Benckiser Helthcare Uk | Composiciones farmaceuticas |
US6716449B2 (en) | 2000-02-08 | 2004-04-06 | Euro-Celtique S.A. | Controlled-release compositions containing opioid agonist and antagonist |
BRPI0108380B8 (pt) | 2000-02-08 | 2021-05-25 | Euro Celtique S/A | fórmulas de opióides agonistas resistentes à adulteração, método para diminuir o abuso de um opióide agonista numa fórmula de dosagem oral, método de preparação de uma fórmula de dosagem oral e método de tratamento da dor |
EP1274444B1 (en) | 2000-03-16 | 2013-05-15 | THE McLEAN HOSPITAL CORPORATION | Cdp-choline and uridine for the treatment of alcohol abuse |
GB0026137D0 (en) | 2000-10-25 | 2000-12-13 | Euro Celtique Sa | Transdermal dosage form |
US20020160043A1 (en) | 2001-02-27 | 2002-10-31 | Dennis Coleman | Compositions and method of manufacture for oral dissolvable dosage forms |
US6897123B2 (en) | 2001-03-05 | 2005-05-24 | Agityne Corporation | Bonding of parts with dissimilar thermal expansion coefficients |
WO2002092060A1 (en) | 2001-05-11 | 2002-11-21 | Endo Pharmaceuticals, Inc. | Abuse-resistant controlled-release opioid dosage form |
US20030004177A1 (en) | 2001-05-11 | 2003-01-02 | Endo Pharmaceuticals, Inc. | Abuse-resistant opioid dosage form |
US20030035839A1 (en) | 2001-05-15 | 2003-02-20 | Peirce Management, Llc | Pharmaceutical composition for both intraoral and oral administration |
US20030068356A1 (en) | 2001-07-10 | 2003-04-10 | Pather S. Indiran | Sequential drug delivery systems |
DK1416842T3 (da) | 2001-07-18 | 2009-03-16 | Euro Celtique Sa | Farmaceutiske kombinationer af oxycodon og naloxon |
US20030044458A1 (en) | 2001-08-06 | 2003-03-06 | Curtis Wright | Oral dosage form comprising a therapeutic agent and an adverse-effect agent |
US7144587B2 (en) | 2001-08-06 | 2006-12-05 | Euro-Celtique S.A. | Pharmaceutical formulation containing opioid agonist, opioid antagonist and bittering agent |
US20030068375A1 (en) | 2001-08-06 | 2003-04-10 | Curtis Wright | Pharmaceutical formulation containing gelling agent |
US7141250B2 (en) | 2001-08-06 | 2006-11-28 | Euro-Celtique S.A. | Pharmaceutical formulation containing bittering agent |
WO2003013433A2 (en) | 2001-08-06 | 2003-02-20 | Euro-Celtique S.A. | Sequestered antagonist formulations |
US7842307B2 (en) | 2001-08-06 | 2010-11-30 | Purdue Pharma L.P. | Pharmaceutical formulation containing opioid agonist, opioid antagonist and gelling agent |
US20110033542A1 (en) * | 2009-08-07 | 2011-02-10 | Monosol Rx, Llc | Sublingual and buccal film compositions |
CA2464528A1 (en) | 2001-11-02 | 2003-05-15 | Elan Corporation, Plc | Pharmaceutical composition |
US6472563B1 (en) | 2001-11-09 | 2002-10-29 | Sepracor Inc. | Formoterol tartrate process and polymorph |
US6974818B2 (en) | 2002-03-01 | 2005-12-13 | Euro-Celtique S.A. | 1,2,5-thiadiazol-3-YL-piperazine therapeutic agents useful for treating pain |
US20030191147A1 (en) | 2002-04-09 | 2003-10-09 | Barry Sherman | Opioid antagonist compositions and dosage forms |
WO2004054511A2 (en) | 2002-12-13 | 2004-07-01 | The Regents Of The University Of California | Analgesic combination comprising nalbuphine |
US7524515B2 (en) | 2003-01-10 | 2009-04-28 | Mutual Pharmaceuticals, Inc. | Pharmaceutical safety dosage forms |
AU2004208644B2 (en) | 2003-01-31 | 2009-07-23 | Orexo Ab | A rapid-acting pharmaceutical composition |
US8512727B2 (en) * | 2003-03-03 | 2013-08-20 | Alkermes Pharma Ireland Limited | Nanoparticulate meloxicam formulations |
TWI347201B (en) | 2003-04-21 | 2011-08-21 | Euro Celtique Sa | Pharmaceutical products,uses thereof and methods for preparing the same |
US20050042281A1 (en) | 2003-08-21 | 2005-02-24 | Singh Nikhilesh N. | Compositions for delivering therapeutic agents across the oral mucosa |
EP1750675B1 (en) * | 2004-06-02 | 2008-10-29 | Galephar M/F | Stable oral pharmaceutical compositions of buprenorphine and salt thereof |
US20060051413A1 (en) | 2004-09-08 | 2006-03-09 | Chow Sing S M | Method of enhancing absorptions of transmucosal administration formulations |
FR2883179B1 (fr) | 2005-03-18 | 2009-04-17 | Ethypharm Sa | Comprime enrobe |
MX2007011977A (es) | 2005-03-28 | 2007-12-07 | Orexo Ab | Composiciones farmaceuticas novedosas utiles en el tratamiento del dolor. |
US8021638B2 (en) | 2005-03-31 | 2011-09-20 | Touchstone Research Laboratory, Ltd | Carbon foam and high density carbon foam composite tooling |
US8252328B2 (en) | 2006-01-06 | 2012-08-28 | Acelrx Pharmaceuticals, Inc. | Bioadhesive drug formulations for oral transmucosal delivery |
JP2007321063A (ja) * | 2006-06-01 | 2007-12-13 | Sumitomo Chemical Co Ltd | 樹脂粒子の分離方法 |
US20100233257A1 (en) * | 2006-06-09 | 2010-09-16 | Ethypharm | Low dose sublingual tablets of opioid analgesics and preparation process |
US20070286900A1 (en) | 2006-06-09 | 2007-12-13 | Catherine Herry | Low dose tablets of opioid analgesics and preparation process |
RS54764B1 (sr) | 2006-07-21 | 2016-10-31 | Biodelivery Sciences Int Inc | Sredstvo za transmukozalnu isporuku sa povećanim nakupljanjem |
EP1897543A1 (en) | 2006-08-30 | 2008-03-12 | Euro-Celtique S.A. | Buprenorphine- wafer for drug substitution therapy |
CN1943575A (zh) | 2006-10-24 | 2007-04-11 | 岳振江 | 滥用潜力低的复方盐酸丁丙诺啡盐酸纳洛酮舌下片 |
DK2101740T3 (da) * | 2006-12-04 | 2013-11-18 | Orexo Ab | Nye ikke-misbrugs-farmaceutiske sammensætninger omfattende opioider |
GB2447016A (en) * | 2007-03-01 | 2008-09-03 | Reckitt Benckiser Healthcare | Buprenorphine/naloxone compositions |
GB2447015A (en) | 2007-03-01 | 2008-09-03 | Reckitt Benckiser Healthcare | Analgesic composition comprising a specific ratio of buprenorphine and naltrexone |
US20100098757A1 (en) | 2007-03-15 | 2010-04-22 | Toyo Boseki Kabushiki Kaisha | Process for production of buprenorphine pharmaceutical preparation to be applied to mouth mucosa |
GB2450117A (en) * | 2007-06-13 | 2008-12-17 | Reckitt Benckiser Healthcare | A water- and oxygen-occlusive blister tablet pack |
GB0712535D0 (en) | 2007-06-28 | 2007-08-08 | Airbus Uk Ltd | Method for forming composite components and tool for use therein |
US7968021B2 (en) | 2007-07-31 | 2011-06-28 | The Boeing Company | Coefficient of thermal expansion control structure |
US20090263476A1 (en) | 2008-04-16 | 2009-10-22 | Jobdevairakkam Christopher N | Composition of Rapid Disintegrating Direct Compression Buccal Tablet |
US20090266870A1 (en) | 2008-04-23 | 2009-10-29 | The Boeing Company | Joined composite structures with a graded coefficient of thermal expansion for extreme environment applications |
JP2010043236A (ja) * | 2008-07-17 | 2010-02-25 | Sekisui Chem Co Ltd | タンニン系接着剤、及びそれを用いた木質系複合材料 |
JP2012526840A (ja) | 2009-05-13 | 2012-11-01 | プロテイン デリヴァリー ソリューションズ エルエルシー | 膜貫通送達のための製剤系 |
US8475832B2 (en) * | 2009-08-07 | 2013-07-02 | Rb Pharmaceuticals Limited | Sublingual and buccal film compositions |
US8269514B2 (en) | 2009-08-25 | 2012-09-18 | Formfactor, Inc. | Method and apparatus for multilayer support substrate |
JP5371050B2 (ja) * | 2009-11-06 | 2013-12-18 | 住友精化株式会社 | ジボランの製造方法 |
AU2012311293B2 (en) | 2011-09-19 | 2014-02-20 | Orexo Ab | New abuse-resistant pharmaceutical composition for the treatment of opioid dependence |
AU2013255640B2 (en) | 2012-05-02 | 2017-06-15 | Orexo Ab | New alfentanil composition for the treatment of acute pain |
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