CY1121812T1 - Φαρμακοτεχνικη μορφη ταχειας διαλυτοποιησης η οποια περιλαμβανει σινακαλσετη hcl - Google Patents

Φαρμακοτεχνικη μορφη ταχειας διαλυτοποιησης η οποια περιλαμβανει σινακαλσετη hcl

Info

Publication number
CY1121812T1
CY1121812T1 CY20191100734T CY191100734T CY1121812T1 CY 1121812 T1 CY1121812 T1 CY 1121812T1 CY 20191100734 T CY20191100734 T CY 20191100734T CY 191100734 T CY191100734 T CY 191100734T CY 1121812 T1 CY1121812 T1 CY 1121812T1
Authority
CY
Cyprus
Prior art keywords
sinacalcet
hcl
form containing
pharmaceutical form
rapid dissolving
Prior art date
Application number
CY20191100734T
Other languages
English (en)
Inventor
Francisco J. ÁLVAREZ
Tzuchi R. Ju
Hung-Ren H. Lin
Glen Cary Lawrence
Original Assignee
Amgen Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34434844&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1121812(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Amgen Inc. filed Critical Amgen Inc.
Publication of CY1121812T1 publication Critical patent/CY1121812T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
    • A61P5/20—Drugs for disorders of the endocrine system of the parathyroid hormones for decreasing, blocking or antagonising the activity of PTH

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Rheumatology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Η παρούσα εφεύρεση σχετίζεται με μία φαρμακευτική σύνθεση η οποία περιλαμβάνει μία θεραπευτικώς αποτελεσματική ποσότητα μιας δραστικής στον υποδοχέα ασβεστίου ένωσης και τουλάχιστον ένα φαρμακευτικώς αποδεκτό έκδοχο, όπου η σύνθεση έχει ένα προφίλ ελεγχόμενης διαλυτοποίησης. Η παρούσα εφεύρεση περαιτέρω σχετίζεται με μία μέθοδο παραγωγής της φαρμακευτικής σύνθεσης, καθώς επίσης με μία μέθοδο αντιμετώπισης μίας νόσου χρησιμοποιώντας τη φαρμακευτική σύνθεση.
CY20191100734T 2003-09-12 2019-07-10 Φαρμακοτεχνικη μορφη ταχειας διαλυτοποιησης η οποια περιλαμβανει σινακαλσετη hcl CY1121812T1 (el)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US50221903P 2003-09-12 2003-09-12
EP10014567A EP2316442A1 (en) 2003-09-12 2004-09-10 Rapid dissolution formulation of a calcium receptor-active compound
EP04781429.8A EP1663182B2 (en) 2003-09-12 2004-09-10 RAPID DISSOLUTION FORMULATION OF CINACALCET HCl
EP17185704.8A EP3260117B8 (en) 2003-09-12 2004-09-10 Rapid dissolution formulation comprising cinacalcet hcl
EP14163366.9A EP2821067B1 (en) 2003-09-12 2004-09-10 Rapid dissolution formulation of cinacalcet
PCT/US2004/026732 WO2005034928A1 (en) 2003-09-12 2004-09-10 Rapid dissolution formulation of a calcium receptor-active compound

Publications (1)

Publication Number Publication Date
CY1121812T1 true CY1121812T1 (el) 2020-07-31

Family

ID=34434844

Family Applications (5)

Application Number Title Priority Date Filing Date
CY20171101211T CY1119609T1 (el) 2003-09-12 2017-11-20 Ταχειας διαλυτοποιησης σκευασμα σινακαλσετης
CY20191100682T CY1122259T1 (el) 2003-09-12 2019-06-28 Φαρμακοτεχνικη μορφη ταχειας διαλυτοποιησης η οποια περιλαμβανει σινακαλσετη hcl
CY20191100735T CY1121814T1 (el) 2003-09-12 2019-07-10 Φαρμακοτεχνικη μορφη ταχειας διαλυτοποιησης της σινακαλσετης hcl
CY20191100734T CY1121812T1 (el) 2003-09-12 2019-07-10 Φαρμακοτεχνικη μορφη ταχειας διαλυτοποιησης η οποια περιλαμβανει σινακαλσετη hcl
CY20191100767T CY1121820T1 (el) 2003-09-12 2019-07-18 Φαρμακοτεχνικη μορφη ταχειας διααυτοποιησης σινακαλσετης hcl

Family Applications Before (3)

Application Number Title Priority Date Filing Date
CY20171101211T CY1119609T1 (el) 2003-09-12 2017-11-20 Ταχειας διαλυτοποιησης σκευασμα σινακαλσετης
CY20191100682T CY1122259T1 (el) 2003-09-12 2019-06-28 Φαρμακοτεχνικη μορφη ταχειας διαλυτοποιησης η οποια περιλαμβανει σινακαλσετη hcl
CY20191100735T CY1121814T1 (el) 2003-09-12 2019-07-10 Φαρμακοτεχνικη μορφη ταχειας διαλυτοποιησης της σινακαλσετης hcl

Family Applications After (1)

Application Number Title Priority Date Filing Date
CY20191100767T CY1121820T1 (el) 2003-09-12 2019-07-18 Φαρμακοτεχνικη μορφη ταχειας διααυτοποιησης σινακαλσετης hcl

Country Status (30)

Country Link
US (7) US7829595B2 (el)
EP (8) EP2316442A1 (el)
JP (3) JP5026077B2 (el)
KR (1) KR101332058B1 (el)
CN (1) CN1946382B (el)
AR (1) AR045637A1 (el)
AU (1) AU2004279318C1 (el)
BR (2) BR122018013029B1 (el)
CA (1) CA2536487C (el)
CY (5) CY1119609T1 (el)
DE (1) DE19164145T1 (el)
DK (6) DK3260117T3 (el)
EA (1) EA013425B1 (el)
ES (7) ES2401769T5 (el)
HR (1) HRP20130114T4 (el)
HU (5) HUE035596T2 (el)
IL (1) IL173737A (el)
IS (1) IS3027B (el)
MX (1) MXPA06002616A (el)
MY (1) MY142046A (el)
NO (1) NO335739B1 (el)
NZ (1) NZ545498A (el)
PL (6) PL3395339T3 (el)
PT (6) PT2821067T (el)
SG (1) SG146608A1 (el)
SI (6) SI1663182T2 (el)
TR (4) TR201910177T4 (el)
TW (1) TWI344363B (el)
WO (1) WO2005034928A1 (el)
ZA (1) ZA200602710B (el)

Families Citing this family (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100074949A1 (en) * 2008-08-13 2010-03-25 William Rowe Pharmaceutical composition and administration thereof
NZ545498A (en) * 2003-09-12 2010-04-30 Amgen Inc Rapid dissolution formulation of a calcium receptor-active compound
DK1773816T3 (en) 2004-06-24 2015-01-26 Vertex Pharma Modulators of ATP-binding cassette transporters
JP4773436B2 (ja) * 2005-05-16 2011-09-14 テバ ファーマシューティカル インダストリーズ リミティド シナカルセト塩酸塩の調製方法
KR20080007376A (ko) * 2005-05-23 2008-01-18 테바 파마슈티컬 인더스트리즈 리미티드 무정형 시나칼셋 염산염 및 이의 제조
ATE445587T1 (de) * 2005-05-23 2009-10-15 Teva Pharma Verfahren zur herstellung von cinacalcet hydrochlorid kristallform i
DK1884242T3 (da) 2005-05-26 2013-05-06 Dainippon Sumitomo Pharma Co Farmaceutisk sammensætning omfattende lurasidon
US8486381B2 (en) 2005-09-02 2013-07-16 Amgen Inc. Methods of modulating intestinal fluid balance
JP2009516655A (ja) * 2005-11-22 2009-04-23 テバ ファーマシューティカル インダストリーズ リミティド シナカルセット塩酸塩の結晶形フォーム（Ｆｏｒｍ）、およびそれらの調製方法
JP5409010B2 (ja) 2005-12-28 2014-02-05 バーテックス ファーマシューティカルズ インコーポレイテッド Ｎ−［２，４−ビス（１，１−ジメチルエチル）−５−ヒドロキシフェニル］−１，４−ジヒドロ−４−オキソキノリン−３−カルボキサミドの固体形態
CA2882048C (en) 2006-02-03 2020-03-24 Proventiv Therapeutics, Llc Treating vitamin d insufficiency and deficiency with 25-hydroxyvitamin d2 and 25-hydroxyvitamin d3
JP5309014B2 (ja) * 2006-03-23 2013-10-09 アムジエン・インコーポレーテツド シナカルセットの多形体の製造および使用のための方法および組成物
TW200811082A (en) * 2006-04-27 2008-03-01 Teva Pharma Process for the preparation of cinacalcet base
MX2008013684A (es) * 2006-04-27 2008-11-06 Teva Pharma Proceso para la preparacion de base de cinacalcet.
PL2679228T3 (pl) 2006-06-21 2018-07-31 Opko Ireland Global Holdings, Ltd. Terapia z użyciem środka do uzupełniania witaminy D i środka do zastępowania hormonami witaminy D
WO2008000422A1 (en) * 2006-06-27 2008-01-03 Sandoz Ag Amorphous form of cinacalcet
CA2662315A1 (en) * 2006-09-01 2008-03-06 Teva Pharmaceutical Industries Ltd. Solid composites of a calcium receptor-active compound
US20080146845A1 (en) * 2006-11-20 2008-06-19 Boaz Gome Process for preparing Cinacalcet
WO2008064202A2 (en) * 2006-11-20 2008-05-29 Dr. Reddy's Labortories, Ltd. Modified-release formulations of calcium receptor-active compounds
TW201718635A (zh) 2007-03-06 2017-06-01 安美基公司 變異之活動素受體多肽及其用途
US20080261926A1 (en) * 2007-04-02 2008-10-23 Liu Julie F Pharmaceutical Calcimimetics
ES2403107T3 (es) 2007-04-25 2013-05-14 Cytochroma Inc. Método de tratamiento de insuficiencia y deficiencia de vitamina D
EP3542792B1 (en) 2007-04-25 2023-06-28 EirGen Pharma Ltd. Controlled release 25-hydroxyvitamin d
EP2170805B1 (en) * 2007-06-21 2016-03-16 Amgen Inc. Methods of synthesizing cinacalcet and salts thereof
US20090093652A1 (en) * 2007-08-16 2009-04-09 Michal Rafilovich Crystalline forms cinacalcet fumarate and cinacalcet succinate and processes for preparation thereof
WO2010071689A2 (en) * 2008-05-05 2010-06-24 Medichem, S.A. Process for controlling the particle size of a 3-(trifluoromethyl)phenyl]-1-aminopropane derivative
US20100256184A1 (en) * 2008-08-13 2010-10-07 Vertex Pharmaceuticals Incorporated Pharmaceutical composition and administrations thereof
EP2334284B1 (de) * 2008-09-25 2012-08-08 Ratiopharm GmbH Kompaktiertes cinacalcet
WO2010086129A1 (en) 2009-01-27 2010-08-05 Rathiopharm Gmbh Inclusion complex comprising cinacalcet and cyclodextrin
NZ624460A (en) 2009-03-20 2015-12-24 Vertex Pharma Process for making modulators of cystic fibrosis transmembrane conductance regulator
CA2762137A1 (en) 2009-05-27 2010-12-02 Leo Pharma A/S Novel calcium sensing receptor modulating compounds and pharmaceutical use thereof
US8785494B2 (en) 2009-05-27 2014-07-22 Leo-Pharma A/S Calcium sensing receptor modulating compounds and pharmaceutical use thereof
EP2314286A1 (de) 2009-10-21 2011-04-27 Ratiopharm GmbH Schmelzgranuliertes Cinacalcet
HUE048464T2 (hu) 2010-03-29 2020-07-28 Opko Ireland Global Holdings Ltd Módszerek és készítmények mellékpajzsmirigy szintjének csökkentésére
CN109745313A (zh) 2010-08-11 2019-05-14 德雷克塞尔大学 治疗帕金森病中运动障碍的d3多巴胺受体激动剂
WO2012071535A2 (en) * 2010-11-23 2012-05-31 Amgen Inc Pediatric formulation
US20130267516A1 (en) 2010-11-26 2013-10-10 Leo Pharma A/S Substituted cyclopentyl-azines as casr-active compounds
RU2013128973A (ru) 2010-11-26 2015-01-10 Лео Фарма А/С Соединения, активные в отношении кальций-чувствительных рецепторов
US20130244995A1 (en) 2010-11-26 2013-09-19 Leo Pharma A/S Calcium-sensing receptor-active compounds
US20130261132A1 (en) 2010-11-26 2013-10-03 Leo Pharma A/S Calcium-sensing receptor-active compounds
EP2793925B1 (en) * 2011-12-19 2019-03-20 Amgen Inc. Variant activin receptor polypeptides, alone or in combination with chemotherapy, and uses thereof
WO2013107503A1 (en) 2012-01-17 2013-07-25 Zentiva Saglik Urunleri San. Ve Tic. A.S. Method for producing cinacalcet compositions for direct tableting
CN104470518A (zh) 2012-02-27 2015-03-25 沃泰克斯药物股份有限公司 药物组合物及其施用
CN102885792A (zh) * 2012-10-12 2013-01-23 华润赛科药业有限责任公司 盐酸西那卡塞的口服固体速释制剂
EP2730279B1 (en) * 2012-11-09 2015-07-22 K.H.S. Pharma Holding GmbH Immediate release formulations of cinacalcet
EP2919903B1 (en) 2012-11-14 2020-07-22 W.R. Grace & CO. - CONN. Compositions containing a biologically active material and a non-ordered inorganic oxide
ES2737756T3 (es) 2012-12-21 2020-01-15 Synthon Bv Composición de comprimido que comprende clorhidrato de cinacalcet
JP2016508504A (ja) 2013-02-01 2016-03-22 サンタ マリア バイオセラピューティクス インコーポレイテッド 対象に対する抗アクチビン−ａ化合物の投与
KR101847947B1 (ko) 2013-03-15 2018-05-28 옵코 아이피 홀딩스 Ⅱ 인코포레이티드 안정화되고 변형된 비타민 ｄ 방출 제형
WO2014207691A1 (en) 2013-06-26 2014-12-31 Jubilant Life Sciences Limited Disintegrant free composition of cinacalcet
EP3116487A1 (en) * 2014-03-14 2017-01-18 Abdi Ibrahim Ilac Sanayi ve Ticaret Anonim Sirketi Pharmaceutical composition of cinacalcet
WO2015150944A1 (en) 2014-03-29 2015-10-08 Wockhardt Limited Solid oral pharmaceutical compositions comprising cinacalcet or a salt thereof
CA2957240A1 (en) 2014-08-07 2016-02-11 Opko Ireland Global Holdings, Ltd. Adjunctive therapy with 25-hydroxyvitamin d
CA2963945C (en) 2014-10-07 2023-01-10 Vertex Pharmaceuticals Incorporated Co-crystals of modulators of cystic fibrosis transmembrane conductance regulator
CN104721164B (zh) * 2015-03-25 2017-07-07 河北仁合益康药业有限公司 一种盐酸西那卡塞薄膜衣片组合物
JP7032322B2 (ja) 2016-03-28 2022-03-08 オプコ アイルランド グローバル ホールディングス リミテッド ビタミンｄ治療法
WO2017170858A1 (ja) 2016-03-31 2017-10-05 大日本住友製薬株式会社 溶出性に優れた経口製剤
EP3668493A4 (en) * 2017-08-16 2021-08-25 Unichem Laboratories Ltd PHARMACEUTICAL COMPOSITIONS WITH CINACALCET HYDROCHLORIDE AND ONE OR MORE BINDERS
US20210030671A1 (en) 2018-03-30 2021-02-04 Ftf Pharma Private Limited Liquid dosage forms of cinacalcet or salt thereof
US10920483B2 (en) 2018-10-25 2021-02-16 Mark Mutchnik Window seal for preventing water penetration
RU2750761C2 (ru) * 2019-09-17 2021-07-02 Общество с ограниченной ответственностью "АМЕДАРТ" Ядро таблетки, содержащей цинакальцета гидрохлорид
CN115666534A (zh) * 2020-02-29 2023-01-31 肯法姆股份有限公司 包含哌甲酯前药的组合物、其制备和使用方法
CN112546010A (zh) * 2020-12-02 2021-03-26 普莱赛思(天津)生命科技有限公司 一种肾病药物组合物及其制备方法

Family Cites Families (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4517179A (en) 1983-04-29 1985-05-14 Pennwalt Corporation Rapid dissolving, uniform drug compositions and their preparation
IL88150A0 (en) 1987-11-02 1989-06-30 Merck & Co Inc Pharmaceutical tablet compositions containing phthalizine acetic acid compounds
EP0357815A1 (de) 1988-09-06 1990-03-14 Siemens Aktiengesellschaft Schaltbare Konstantstromquelle mit I2L-Gattern
KR900701255A (ko) 1988-11-30 1990-12-01 스테이너 브이.캔스타드 서방성 딜티아젬 제제
NZ231897A (en) 1988-12-30 1992-09-25 Monsanto Co Dry water-soluble granular composition comprising glyphosate and a liquid surfactant
US5126145A (en) 1989-04-13 1992-06-30 Upsher Smith Laboratories Inc Controlled release tablet containing water soluble medicament
US4931286A (en) 1989-04-19 1990-06-05 Aqualon Company High gloss cellulose tablet coating
DD299322A5 (de) * 1989-09-21 1992-04-09 Maschinenfabrik Rieter Ag,Ch Verfahren und vorrichtung zur feinreinigung von textilfasern
US5011068A (en) * 1989-12-05 1991-04-30 Progressive Tool & Industries Co. Automotive body framing system
CN1192011C (zh) 1991-08-23 2005-03-09 Nps药物有限公司 对钙受体具活性的芳烷基胺化合物
US6011068A (en) 1991-08-23 2000-01-04 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
US6031003A (en) 1991-08-23 2000-02-29 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
US6001884A (en) 1991-08-23 1999-12-14 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
US6313146B1 (en) 1991-08-23 2001-11-06 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
WO1993004373A1 (en) 1991-08-23 1993-03-04 Nps Pharmaceuticals, Inc. Calcium receptor active molecules
US5162117A (en) 1991-11-22 1992-11-10 Schering Corporation Controlled release flutamide composition
KR100296899B1 (ko) 1993-02-23 2001-10-24 쉘비 칼베르그 모르스 칼슘수용체활성분자
US6210714B1 (en) 1993-11-23 2001-04-03 Euro-Celtique S.A. Immediate release tablet cores of acetaminophen having sustained-release coating
NZ272608A (en) * 1994-07-22 2000-05-26 Lilly Co Eli Inhibiting bone loss by administering a bisphosphonate and a second compound selected from various compounds, including 2-phenyl-3-aroylbenzothienes; bisphosphonate combination salts
BRPI9509411B8 (pt) * 1994-10-21 2021-07-06 Nps Pharma Inc composto modulador de receptor de íon inorgânico e composição farmacêutica
GB9424766D0 (en) 1994-12-07 1995-02-08 Wellcome Found Pharmaceutical composition
GB9501127D0 (en) 1995-01-20 1995-03-08 Wellcome Found Tablet
DE19530575A1 (de) 1995-08-19 1997-02-20 Gruenenthal Gmbh Schnell zerfallende Arzneiform von Tramadol oder einem Tramadolsalz
ES2201300T3 (es) 1996-05-01 2004-03-16 Nps Pharmaceuticals, Inc. Compuestos activos frente a receptores de iones inorganicos.
US5837292A (en) 1996-07-03 1998-11-17 Yamanouchi Europe B.V. Granulate for the preparation of fast-disintegrating and fast-dissolving compositions containing a high amount of drug
EP0933354B1 (en) 1996-07-08 2011-03-30 Kyowa Hakko Kirin Co., Ltd. Calcium receptor-active compounds
DE19637082A1 (de) 1996-09-12 1998-03-19 Boehringer Mannheim Gmbh Schnellzerfallende Pellets
TW483881B (en) 1996-12-03 2002-04-21 Nps Pharma Inc Calcilytic compounds
IE970588A1 (en) 1997-08-01 2000-08-23 Elan Corp Plc Controlled release pharmaceutical compositions containing tiagabine
WO1999009458A1 (de) 1997-08-13 1999-02-25 OCé PRINTING SYSTEMS GMBH Druck- oder kopiergerätesystem zum performanceangepassten erstellen einer vorgegebenen blattfolge von monochrom und/oder farbig bedruckten einzelblättern
NZ507271A (en) 1998-03-06 2003-03-28 Eurand Internat S Fast disintegrating tablets
US6525084B2 (en) 1998-07-23 2003-02-25 Novo Nordisk A/S Stable pharmaceutical formulation
JP2002527414A (ja) 1998-10-14 2002-08-27 オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド １，２−ジ置換シクロプロパン
UA74775C2 (en) 1998-11-23 2006-02-15 Monsanto Ci High concentrated aqueous composition of the monoethanolammonium salt of n-phosphonomethylglycine and a method to control undesired plants
UA74141C2 (uk) 1998-12-09 2005-11-15 Дж.Д. Сірл Енд Ко. Фармацевтична композиція на основі тонкоподрібненого еплеренону (варіанти), спосіб її одержання та спосіб лікування розладів, опосередкованих альдостероном (варіанти)
US6248363B1 (en) 1999-11-23 2001-06-19 Lipocine, Inc. Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
US6447809B1 (en) * 1999-05-11 2002-09-10 Metagenics, Inc. Composition for promoting healthy bone structure
US6733780B1 (en) 1999-10-19 2004-05-11 Genzyme Corporation Direct compression polymer tablet core
FR2800735B1 (fr) 1999-11-09 2002-02-01 Centre Nat Rech Scient Nouvelles aralkyle-1,2-diamines possedant une activite calcimimetique et leur mode de preparation
KR20020082473A (ko) 1999-12-22 2002-10-31 파마시아 코포레이션 시클로옥시게나제-2 억제제의 지속-방출 조제물
GB0001621D0 (en) * 2000-01-26 2000-03-15 Astrazeneca Ab Pharmaceutical compositions
AU5066101A (en) 2000-04-13 2001-10-30 Synthon B.V. Modified release formulations containing a hypnotic agent
US6419954B1 (en) * 2000-05-19 2002-07-16 Yamanouchi Pharmaceutical Co., Ltd. Tablets and methods for modified release of hydrophilic and other active agents
FR2809396B1 (fr) 2000-05-24 2005-10-14 Centre Nat Rech Scient Nouvelles molecules possedant une activite calcimimetique et leur mode de preparation
US6656492B2 (en) * 2000-06-30 2003-12-02 Yamanouchi Pharmaceutical Co., Ltd. Quick disintegrating tablet in buccal cavity and manufacturing method thereof
JP2002167327A (ja) * 2000-09-22 2002-06-11 Takeda Chem Ind Ltd 固形製剤
US20040034039A1 (en) 2000-09-22 2004-02-19 Yoshinori Nakano Solid preparations
US7049283B2 (en) * 2000-12-06 2006-05-23 Novartis Ag Pharmaceutical compositions for the oral delivery of pharmacologically active agents
IN191028B (el) 2001-05-17 2003-09-13 Sun Pharmaceutical Ind Ltd
CA2448864C (en) 2001-06-22 2008-04-22 Pfizer Products Inc. Pharmaceutical compositions containing a solid dispersion of a poorly-soluble drug in a matrix and a solubility-enhancing polymer
EP1321142A1 (en) 2001-12-21 2003-06-25 Novartis AG Solid pharmaceutical composition for oral administration of Tegaserod
WO2003086343A2 (en) 2002-04-05 2003-10-23 Cadila Healthcare Limited Fast disintegrating oral dosage forms
US20050147670A1 (en) * 2002-05-29 2005-07-07 Impax Laboratories Inc. Oral disintegrating dosage forms
US20040082588A1 (en) 2002-09-30 2004-04-29 Schering Corporation Methods for treating disorders of calcium homeostasis
GB0230015D0 (en) 2002-12-23 2003-01-29 Novartis Ag Organic compounds
NZ545498A (en) 2003-09-12 2010-04-30 Amgen Inc Rapid dissolution formulation of a calcium receptor-active compound
DE602005025977D1 (de) 2004-08-23 2011-03-03 Teva Pharma Kristalline form des ibandronat-natriums und herstellungsverfahren dafür
NL1028867C2 (nl) 2005-04-26 2006-10-27 Xycarb Ceramics B V Inrichting voor het ondersteunen van een substraat alsmede een werkwijze voor het vervaardigen van een dergelijke inrichting.
EP2252901A4 (en) 2008-03-11 2012-01-25 Univ Western Ontario SYSTEM AND METHOD FOR MAGNETIC RESONANCE IMAGING

Also Published As

Publication number Publication date
PL2821067T3 (pl) 2018-02-28
CA2536487C (en) 2011-10-25
EP2821067B1 (en) 2017-10-25
SI3395339T1 (sl) 2019-08-30
ES2734057T3 (es) 2019-12-04
KR101332058B1 (ko) 2013-11-22
MXPA06002616A (es) 2006-06-05
EP1663182B1 (en) 2013-01-16
EP3578175A1 (en) 2019-12-11
BR122018013029B1 (pt) 2022-04-12
SI3260117T1 (sl) 2019-08-30
EP3395339A1 (en) 2018-10-31
CY1121820T1 (el) 2020-07-31
ES2401769T5 (es) 2020-07-01
HRP20130114T4 (hr) 2019-12-27
HUE043958T2 (hu) 2019-09-30
PT3395340T (pt) 2019-07-15
DK3260117T3 (da) 2019-07-01
HUE045411T2 (hu) 2019-12-30
CY1121814T1 (el) 2020-07-31
CN1946382B (zh) 2010-12-08
JP2012197280A (ja) 2012-10-18
DE19164145T1 (de) 2021-04-29
US9375405B2 (en) 2016-06-28
PL3395339T3 (pl) 2019-09-30
HUE044822T2 (hu) 2019-11-28
ES2735216T3 (es) 2019-12-17
SI2821067T1 (en) 2018-03-30
IL173737A0 (en) 2006-07-05
AR045637A1 (es) 2005-11-02
US20210052518A1 (en) 2021-02-25
PT3395338T (pt) 2019-07-23
TR201909267T4 (tr) 2019-07-22
SG146608A1 (en) 2008-10-30
EP3260117B8 (en) 2019-11-27
IL173737A (en) 2012-04-30
EP3260117B1 (en) 2019-04-17
DK3395339T3 (da) 2019-07-22
ES2655435T3 (es) 2018-02-20
BRPI0414254A (pt) 2006-11-07
JP2007505108A (ja) 2007-03-08
US20050147669A1 (en) 2005-07-07
AU2004279318C1 (en) 2020-06-25
JP5940120B2 (ja) 2016-06-29
US20110136915A1 (en) 2011-06-09
CN1946382A (zh) 2007-04-11
PT1663182E (pt) 2013-03-14
EP3395340B8 (en) 2019-12-11
SI1663182T1 (sl) 2013-05-31
PL1663182T5 (pl) 2020-07-27
ES2737348T3 (es) 2020-01-13
ZA200602710B (en) 2007-04-25
TW200518743A (en) 2005-06-16
TR201910177T4 (tr) 2019-08-21
DK1663182T3 (da) 2013-04-15
EP3395340A1 (en) 2018-10-31
JP2015007089A (ja) 2015-01-15
US20160338975A1 (en) 2016-11-24
SI1663182T2 (sl) 2020-02-28
JP5026077B2 (ja) 2012-09-12
EP1663182B2 (en) 2019-11-20
DK1663182T4 (da) 2020-02-17
CY1119609T1 (el) 2018-04-04
AU2004279318B2 (en) 2010-02-25
ES2401769T3 (es) 2013-04-24
US7829595B2 (en) 2010-11-09
NZ545498A (en) 2010-04-30
DK2821067T3 (en) 2017-12-04
HRP20130114T1 (en) 2013-03-31
PT3260117T (pt) 2019-07-04
TR201910447T4 (tr) 2019-08-21
CY1122259T1 (el) 2020-11-25
SI3395338T1 (sl) 2019-08-30
EP3395338A1 (en) 2018-10-31
PL3260117T3 (pl) 2019-10-31
US20200222340A1 (en) 2020-07-16
CA2536487A1 (en) 2005-04-21
KR20070017460A (ko) 2007-02-12
EA200600566A1 (ru) 2006-08-25
EP3395340B1 (en) 2019-04-17
EP3395339B8 (en) 2019-12-11
HUE044279T2 (hu) 2019-10-28
EP3578175B1 (en) 2022-11-30
US20190117592A1 (en) 2019-04-25
BRPI0414254B1 (pt) 2021-03-02
JP5849015B2 (ja) 2016-01-27
IS8324A (is) 2006-02-23
MY142046A (en) 2010-08-30
EP3395338B1 (en) 2019-05-01
ES2812198T1 (es) 2021-03-16
PT3395339T (pt) 2019-07-15
NO20061640L (no) 2006-06-12
EP2821067A1 (en) 2015-01-07
DK3395338T3 (da) 2019-07-22
BRPI0414254B8 (pt) 2021-05-25
EP2316442A1 (en) 2011-05-04
SI3395340T1 (sl) 2019-08-30
IS3027B (is) 2021-03-15
EP1663182A1 (en) 2006-06-07
ES2735226T3 (es) 2019-12-17
PL3395340T3 (pl) 2019-10-31
EP3395339B1 (en) 2019-04-17
TWI344363B (en) 2011-07-01
AU2004279318A1 (en) 2005-04-21
PL3395338T3 (pl) 2019-10-31
NO335739B1 (no) 2015-02-02
WO2005034928A1 (en) 2005-04-21
US20180243238A1 (en) 2018-08-30
EP3260117A1 (en) 2017-12-27
HUE035596T2 (en) 2018-05-28
DK3395340T3 (da) 2019-07-15
TR201910180T4 (tr) 2019-07-22
PT2821067T (pt) 2017-12-01
EA013425B1 (ru) 2010-04-30
PL1663182T3 (pl) 2013-06-28

Similar Documents

Publication Publication Date Title
CY1121812T1 (el) Φαρμακοτεχνικη μορφη ταχειας διαλυτοποιησης η οποια περιλαμβανει σινακαλσετη hcl
CY1121877T1 (el) Φαρμακευτικη συνθεση η οποια περιλαμβανει πιμοβενδανη
CY1121330T1 (el) Συνθεσεις που περιλαμβανουν αζελαστινη και μεθοδοι χρησης αυτων
CY1117470T1 (el) Στερεα δοσολογικα σκευασματα με βελτιωμενη ενδοστοματικη προσροφηση
CY1105648T1 (el) Filbanserin για την θεραπεια εξτραπυραμιδικων διαταραχων κινησης
AR037930A1 (es) Formulaciones de acitromicina directamente compresibles
CY1111797T1 (el) Τοπικη φαρμακοτεχνικη μορφη ιβερμεκτινης για την θεραπεια δερματολογικων καταστασεων
CY1109880T1 (el) ΑΝΤΑΓΩΝΙΣΤΗΣ CaSR
NO20084065L (no) Hurtig frigivelses paracetamol tabletter
CY1106478T1 (el) Μεθοδος για την παραγωγη αμορφης επιβραδυντικης μητρας μη διαλυτης στο υδωρ
NO20060149L (no) Farmasoytiske forbindelser av atorvastatin
ECSP034826A (es) Método para fabricar una composición farmacéutica de dosis baja
CY1109013T1 (el) Νεα 4,4΄-διθειοδις-(3-αμινοβουτανιο-1-σουλφονικα) παραγωγα και συνθεσεις που τα περιεχουν
AR044775A1 (es) Composiciones farmaceuticas de atorvastatina
BR0315462A (pt) Composto, composição farmacêutica, uso de um composto, método para o tratamento de um sujeito que sofre de uma condição patológica ou de doença susceptìvel de alìvio por antagonismo de receptores de ltd4 e produto de combinação
DE60215313D1 (de) Indolderivate und deren verwendung als gnrh antagonisten
CY1113703T1 (el) Ταχειας διαλυσης φαρμακοτεχνικη μορφη της σινακαλσετης hci
AR039162A1 (es) Formulaciones de venlafaxina de liberacion extendida
TW200509984A (en) Injectable dosage form of flupirtine
SE0000303D0 (sv) Novel compounds
BRPI0507985A (pt) derivados de piperazina uréia para o tratamento de endometriose
CY1106129T1 (el) Κιταλοπραμη για την αγωγη της υψηλης πιεσεως του αιματος
CR7754A (es) Derivados de 4-piridil-metil-ftalazina para la fabricacion de un medicamento para el tratamiento de sindromes mielodisplasticos
AR030660A1 (es) Composicion farmaceutica para la prevencion o el tratamiento de una enfermedad asociada con un exceso de la produccion de il-12
CY1106385T1 (el) Χρηση παραγωγων της εποθειλονης για τη θepαπεια του υπepπαραθυρεοειδισμου