CY1121724T1 - Ενωσεις για την αντιμετωπιση καρκινου - Google Patents

Ενωσεις για την αντιμετωπιση καρκινου

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Publication number
CY1121724T1
CY1121724T1 CY20191100320T CY191100320T CY1121724T1 CY 1121724 T1 CY1121724 T1 CY 1121724T1 CY 20191100320 T CY20191100320 T CY 20191100320T CY 191100320 T CY191100320 T CY 191100320T CY 1121724 T1 CY1121724 T1 CY 1121724T1
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Cyprus
Prior art keywords
compounds
cancer
treatment
optional
disclosed
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CY20191100320T
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English (en)
Inventor
Duane D. Miller
Wei Li
Zhao Wang
Yan Lu
Jianjun Chen
James T. Dalton
Chien-Ming Li
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University Of Tennessee Research Foundation
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Application filed by University Of Tennessee Research Foundation filed Critical University Of Tennessee Research Foundation
Publication of CY1121724T1 publication Critical patent/CY1121724T1/el

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    • C07D277/06—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/42—Oxazoles
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    • A61K31/425—Thiazoles
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    • C07D263/14—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with radicals substituted by oxygen atoms
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    • C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Ενώσεις σύμφωνα με τον τύπο (I) γνωστοποιούνται, (I), όπου Q είναι S, Ν, ή O˙ Χ είναι προαιρετικό, και μπορεί να είναι O=, S=, =Ν-ΝΗ2, =Ν-ΟΗ, ή -ΟΗ˙ Υ είναι προαιρετικό και μπορεί να είναι -Ν(Η)-, Ο, ή C1 έως C20 υδρογονάνθρακας˙ και R1 και R2 είναι το καθένα ανεξάρτητα υποκατεστημένα ή μη-υποκατεστημένα ενός-, συγχωνευμένων- ή πολλαπλών- δακτυλίων αρυλικά ή (ετερο)κυκλικά συστήματα δακτυλίων. Μέθοδοι παρασκευής αυτών των ενώσεων, φαρμακευτικές συνθέσεις οι οποίες περιέχουν τις ενώσεις, και η χρήση τους, ειδικότερα για αντιμετώπιση ή πρόληψη καρκίνου, επίσης γνωστοποιούνται.
CY20191100320T 2008-06-16 2019-03-18 Ενωσεις για την αντιμετωπιση καρκινου CY1121724T1 (el)

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US6187508P 2008-06-16 2008-06-16
PCT/US2009/047572 WO2010074776A2 (en) 2008-06-16 2009-06-16 Compounds for the treatment of cancer

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