CY1121573T1 - Συζευγμα αντισωματος anti-her2-φαρμακου - Google Patents

Συζευγμα αντισωματος anti-her2-φαρμακου

Info

Publication number
CY1121573T1
CY1121573T1 CY20191100406T CY191100406T CY1121573T1 CY 1121573 T1 CY1121573 T1 CY 1121573T1 CY 20191100406 T CY20191100406 T CY 20191100406T CY 191100406 T CY191100406 T CY 191100406T CY 1121573 T1 CY1121573 T1 CY 1121573T1
Authority
CY
Cyprus
Prior art keywords
tumor
her2
binds
conject
drug antibody
Prior art date
Application number
CY20191100406T
Other languages
English (en)
Inventor
Hiroyuki Naito
Yusuke OGITANI
Takeshi Masuda
Takashi Nakada
Masao Yoshida
Shinji Ashida
Koji Morita
Hideki Miyazaki
Yuji Kasuya
Ichiro Hayakawa
Yuki Abe
Original Assignee
Daiichi Sankyo Company, Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=53756672&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1121573(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Daiichi Sankyo Company, Limited filed Critical Daiichi Sankyo Company, Limited
Publication of CY1121573T1 publication Critical patent/CY1121573T1/el

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    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
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Abstract

Ως ένα φάρμακο κατά των όγκων που έχει μια εξαιρετική επίδραση κατά των όγκων και που έχει επίσης και μια εξαιρετική θεραπευτική επίδραση, ένα σύζευγμα αντισώματος-φαρμάκου παρέχεται, το οποίο χαρακτηρίζεται από το γεγονός ότι μια ένωση κατά των όγκων αναπαρίσταται από χημικό τύπο (1) συνδέεται σε ένα αντίσωμα αντι-ΗΕR2 μέσα από ένα συνδέτη έχοντας μια δομή που αναπαρίσταται από χημικό τύπο: -L1-L2-LP-NH-(CH2)n1-La-(CH2)n2-C(=O)- (όπου το αντίσωμα αντι-ΗΕR2 συνδέεται στο τερματικό του L1, και η ένωση κατά των όγκων συνδέεται σε μια ομάδα καρβονυλίου σε μια μερίδα -(CH2)n2-C(=O)- όπου ένα άτομο αζώτου σε μια αμινομάδα που εντοπίζεται στη θέση-1 στην ένωση κατά των όγκων χρησιμεύει ως ένα μέρος σύνδεσης).
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