CY1121411T1 - Σταθερες φαρμακοτεχνικες μορφες πολυπεπτιδιων και χρησεις αυτων - Google Patents
Σταθερες φαρμακοτεχνικες μορφες πολυπεπτιδιων και χρησεις αυτωνInfo
- Publication number
- CY1121411T1 CY1121411T1 CY20191100137T CY191100137T CY1121411T1 CY 1121411 T1 CY1121411 T1 CY 1121411T1 CY 20191100137 T CY20191100137 T CY 20191100137T CY 191100137 T CY191100137 T CY 191100137T CY 1121411 T1 CY1121411 T1 CY 1121411T1
- Authority
- CY
- Cyprus
- Prior art keywords
- formulations
- formulation
- tween
- polypeptides
- pharmaceutical
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39591—Stabilisation, fragmentation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Physical Education & Sports Medicine (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Inorganic Chemistry (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Dermatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
Abstract
Παρέχονται φαρμακοτεχνικές μορφές οι οποίες περιέχουν μονές μεταβλητές περιοχές με καλή διαλυτότητα και καλή σταθερότητα κάτω από διαφορετικές συνθήκες αποθήκευσης, μεταφοράς και συνθήκες τάσης. Οι φαρμακοτεχνικές μορφές είναι χρήσιμες ως φαρμακευτική φαρμακοτεχνική μορφή. Η φαρμακοτεχνική μορφή αποτελείται από έναν υδατικό φορέα με pΗ 5.5 έως 8.0, ένα ρυθμιστικό που επιλέγεται από την ομάδα που αποτελείται από ιστιδίνη με pΗ 6.0-6.5, hepes με pΗ 7.0-8.0, MES με pΗ 6.0, ηλεκτρικό με pΗ 6.0-6.5 και οξικό με pΗ 5,5-6.0, ένα έκδοχο, και/ή ένα επιφανειοδραστικό που επιλέγεται από Tween 80, Tween 20 και πολοξαμερή. Η φαρμακοτεχνική μορφή χαρακτηρίζεται περαιτέρω από το ότι έχει συγκέντρωση ανόργανου άλατος 150 mM ή χαμηλότερη. Η εφεύρεση περαιτέρω αφορά περιέκτες και φαρμακευτικές μονάδες που αποτελούνται από τέτοιες φαρμακοτεχνικές μορφές και μεθόδους για την παρασκευή και προφυλακτικές και θεραπευτικές χρήσεις των φαρμακοτεχνικών μορφών και φαρμακευτικών μονάδων της εφεύρεσης.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US27581609P | 2009-09-03 | 2009-09-03 | |
US28450209P | 2009-12-18 | 2009-12-18 | |
EP10747896.8A EP2473528B1 (en) | 2009-09-03 | 2010-09-03 | Stable formulations of polypeptides and uses thereof |
PCT/EP2010/062975 WO2011026948A1 (en) | 2009-09-03 | 2010-09-03 | Stable formulations of polypeptides and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1121411T1 true CY1121411T1 (el) | 2020-05-29 |
Family
ID=42797362
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20191100137T CY1121411T1 (el) | 2009-09-03 | 2019-01-31 | Σταθερες φαρμακοτεχνικες μορφες πολυπεπτιδιων και χρησεις αυτων |
Country Status (12)
Country | Link |
---|---|
US (2) | US20120244158A1 (el) |
EP (5) | EP2805731B1 (el) |
CY (1) | CY1121411T1 (el) |
DK (2) | DK2473527T3 (el) |
ES (3) | ES2531083T3 (el) |
HK (1) | HK1204284A1 (el) |
HR (1) | HRP20190137T1 (el) |
LT (1) | LT2805731T (el) |
PL (2) | PL2473528T3 (el) |
PT (3) | PT2473527T (el) |
SI (1) | SI2805731T1 (el) |
WO (2) | WO2011026948A1 (el) |
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US10005830B2 (en) | 2009-03-05 | 2018-06-26 | Ablynx N.V. | Antigen binding dimer-complexes, methods of making/avoiding and uses thereof |
US9265834B2 (en) | 2009-03-05 | 2016-02-23 | Ablynx N.V. | Stable formulations of polypeptides and uses thereof |
AU2010233658B2 (en) | 2009-04-10 | 2013-11-28 | Ablynx Nv | Improved amino acid sequences directed against IL-6R and polypeptides comprising the same for the treatment of IL-6R related diseases and disorders |
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WO2008142165A1 (en) | 2007-05-24 | 2008-11-27 | Ablynx N.V. | Amino acid sequences directed against growth factor receptors and polypeptides comprising the same for the treatment of diseases and disorders associated with growth factors and their receptors |
WO2009068630A1 (en) | 2007-11-27 | 2009-06-04 | Ablynx N.V. | Immunoglobulin constructs |
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CA2712432C (en) | 2008-01-29 | 2018-09-25 | Ablynx N.V. | Methods to stabilize single variable domains |
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CA2717015A1 (en) * | 2008-03-05 | 2009-09-11 | Ablynx Nv | Novel antigen binding dimer-complexes, methods of making and uses thereof |
CA2718081A1 (en) * | 2008-03-21 | 2009-09-24 | Ablynx Nv | Von willebrand factor specific binders and methods of use therefor |
EP4104821A1 (en) * | 2008-10-29 | 2022-12-21 | Ablynx N.V. | Formulations of single domain antigen binding molecules |
CA2744055A1 (en) * | 2008-11-26 | 2010-06-03 | Glaxo Group Limited | Polypeptides, antibody variable domains & antagonists |
DK2387583T3 (en) * | 2009-01-14 | 2019-01-14 | Ablynx Nv | PULMONAL ADMINISTRATION OF VARIABLE IMMUNGLOBULIN SINGLE DOMAINS AND CONSTRUCTIONS THEREOF. |
RU2650594C1 (ru) * | 2009-01-29 | 2018-04-17 | Медиммун, Ллк | Человеческие анти-il-6 антитела с пролонгированным периодом выведения in vivo и их применение при лечении онкологических, аутоиммунных заболеваний и воспалительных заболеваний |
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US9265834B2 (en) | 2009-03-05 | 2016-02-23 | Ablynx N.V. | Stable formulations of polypeptides and uses thereof |
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-
2010
- 2010-09-03 DK DK10747895.0T patent/DK2473527T3/en active
- 2010-09-03 EP EP14171120.0A patent/EP2805731B1/en active Active
- 2010-09-03 LT LTEP14171120.0T patent/LT2805731T/lt unknown
- 2010-09-03 EP EP10747895.0A patent/EP2473527B1/en active Active
- 2010-09-03 ES ES10747896T patent/ES2531083T3/es active Active
- 2010-09-03 WO PCT/EP2010/062975 patent/WO2011026948A1/en active Application Filing
- 2010-09-03 SI SI201031846T patent/SI2805731T1/sl unknown
- 2010-09-03 DK DK10747896T patent/DK2473528T3/en active
- 2010-09-03 US US13/393,636 patent/US20120244158A1/en not_active Abandoned
- 2010-09-03 ES ES18185772T patent/ES2831323T3/es active Active
- 2010-09-03 PT PT107478950T patent/PT2473527T/pt unknown
- 2010-09-03 PL PL10747896T patent/PL2473528T3/pl unknown
- 2010-09-03 PL PL18185772T patent/PL3438126T3/pl unknown
- 2010-09-03 ES ES10747895.0T patent/ES2617180T3/es active Active
- 2010-09-03 WO PCT/EP2010/062972 patent/WO2011026945A1/en active Application Filing
- 2010-09-03 PT PT181857723T patent/PT3438126T/pt unknown
- 2010-09-03 EP EP10747896.8A patent/EP2473528B1/en active Active
- 2010-09-03 EP EP18185772.3A patent/EP3438126B1/en active Active
- 2010-09-03 EP EP20176028.7A patent/EP3725330A1/en active Pending
- 2010-09-03 PT PT10747896T patent/PT2473528E/pt unknown
- 2010-09-03 US US13/393,679 patent/US9884117B2/en active Active
-
2015
- 2015-05-22 HK HK15104885.3A patent/HK1204284A1/xx not_active IP Right Cessation
-
2019
- 2019-01-21 HR HRP20190137TT patent/HRP20190137T1/hr unknown
- 2019-01-31 CY CY20191100137T patent/CY1121411T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
PT2473528E (pt) | 2015-03-04 |
LT2805731T (lt) | 2019-02-11 |
WO2011026945A1 (en) | 2011-03-10 |
ES2617180T3 (es) | 2017-06-15 |
PT2473527T (pt) | 2017-02-27 |
ES2831323T3 (es) | 2021-06-08 |
EP2473527B1 (en) | 2016-11-30 |
EP3438126A1 (en) | 2019-02-06 |
EP3438126B1 (en) | 2020-08-19 |
EP2805731B1 (en) | 2018-10-31 |
EP2805731A2 (en) | 2014-11-26 |
DK2473527T3 (en) | 2017-03-06 |
US20120201812A1 (en) | 2012-08-09 |
EP2473528B1 (en) | 2014-12-03 |
ES2531083T3 (es) | 2015-03-10 |
EP2805731A3 (en) | 2015-04-01 |
HRP20190137T1 (hr) | 2019-03-22 |
EP2473527A1 (en) | 2012-07-11 |
PT3438126T (pt) | 2020-11-09 |
EP2473528A1 (en) | 2012-07-11 |
PL2473528T3 (pl) | 2015-05-29 |
EP3725330A1 (en) | 2020-10-21 |
US20120244158A1 (en) | 2012-09-27 |
SI2805731T1 (sl) | 2019-02-28 |
US9884117B2 (en) | 2018-02-06 |
HK1204284A1 (en) | 2015-11-13 |
PL3438126T3 (pl) | 2021-03-08 |
DK2473528T3 (en) | 2015-03-02 |
WO2011026948A1 (en) | 2011-03-10 |
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