CY1119435T1 - Σκευασμα για αντισωμα εναντι- αλφα4βητα7 - Google Patents
Σκευασμα για αντισωμα εναντι- αλφα4βητα7Info
- Publication number
- CY1119435T1 CY1119435T1 CY20171101056T CY171101056T CY1119435T1 CY 1119435 T1 CY1119435 T1 CY 1119435T1 CY 20171101056 T CY20171101056 T CY 20171101056T CY 171101056 T CY171101056 T CY 171101056T CY 1119435 T1 CY1119435 T1 CY 1119435T1
- Authority
- CY
- Cyprus
- Prior art keywords
- antibody
- formulations
- vivo
- degradation
- exhibit
- Prior art date
Links
- 239000000203 mixture Substances 0.000 abstract 3
- 238000009472 formulation Methods 0.000 abstract 2
- 238000004220 aggregation Methods 0.000 abstract 1
- 230000002776 aggregation Effects 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 230000015556 catabolic process Effects 0.000 abstract 1
- 238000006731 degradation reaction Methods 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39591—Stabilisation, fragmentation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Abstract
Περιγράφονται σκευάσματα αντισώματος που περιλαμβάνουν ένα μίγμα από ένα μη-αναγωγικό σάκχαρο, ένα αντίσωμα έναντι-α4β7 και τουλάχιστον ένα αμινοξύ. Τα αποκαλυπτόμενα σκευάσματα έχουν βελτιωμένη σταθερότητα, μειωμένο σχηματισμό συσσωματωμάτων και μπορούν να επιβραδύνουν την αποδόμηση του αντισώματος έναντι α4β7 εντός αυτών, ή επιδεικνύουν οποιουσδήποτε συνδυασμούς αυτών. Η παρούσα εφεύρεση περαιτέρω παρέχει ένα ασφαλές σχήμα δοσολογίας αυτών των σκευασμάτων αντισώματος, το οποίο ακολουθείται εύκολα και το οποίο έχει ως αποτέλεσμα μία θεραπευτικά αποτελεσματική ποσότητα του αντισώματος έναντι-α4β7 in vivo.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161481533P | 2011-05-02 | 2011-05-02 | |
US201161550545P | 2011-10-24 | 2011-10-24 | |
US201261585859P | 2012-01-12 | 2012-01-12 | |
PCT/US2012/036072 WO2012151248A2 (en) | 2011-05-02 | 2012-05-02 | FORMULATION FOR ANTI-α4β7 ANTIBODY |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1119435T1 true CY1119435T1 (el) | 2018-03-07 |
Family
ID=46085207
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20171101056T CY1119435T1 (el) | 2011-05-02 | 2017-10-11 | Σκευασμα για αντισωμα εναντι- αλφα4βητα7 |
Country Status (40)
Country | Link |
---|---|
US (12) | US9764033B2 (el) |
EP (3) | EP3329965A3 (el) |
JP (6) | JP6190360B2 (el) |
KR (7) | KR102465394B1 (el) |
CN (4) | CN108079291B (el) |
AR (1) | AR086237A1 (el) |
AU (6) | AU2012250873B2 (el) |
BR (1) | BR112013028424A2 (el) |
CA (2) | CA3028209C (el) |
CL (2) | CL2013003146A1 (el) |
CO (1) | CO6801647A2 (el) |
CR (1) | CR20130677A (el) |
CY (1) | CY1119435T1 (el) |
DK (1) | DK2704798T3 (el) |
DO (1) | DOP2013000253A (el) |
EA (1) | EA032729B1 (el) |
EC (2) | ECSP13013050A (el) |
ES (1) | ES2645187T3 (el) |
GE (1) | GEP201706734B (el) |
HK (2) | HK1249466A1 (el) |
HR (1) | HRP20171432T1 (el) |
HU (1) | HUE036663T2 (el) |
IL (5) | IL296847A (el) |
LT (1) | LT2704798T (el) |
MA (1) | MA35136B1 (el) |
ME (1) | ME02859B (el) |
MX (3) | MX348814B (el) |
MY (2) | MY183471A (el) |
PE (2) | PE20190405A1 (el) |
PH (2) | PH12018500030A1 (el) |
PL (1) | PL2704798T3 (el) |
PT (1) | PT2704798T (el) |
RS (1) | RS56397B1 (el) |
SG (1) | SG194652A1 (el) |
SI (1) | SI2704798T1 (el) |
TW (3) | TWI664980B (el) |
UA (2) | UA116189C2 (el) |
UY (1) | UY34053A (el) |
WO (1) | WO2012151248A2 (el) |
ZA (3) | ZA201308069B (el) |
Families Citing this family (63)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2600901B1 (en) | 2010-08-06 | 2019-03-27 | ModernaTX, Inc. | A pharmaceutical formulation comprising engineered nucleic acids and medical use thereof |
ES2737960T3 (es) | 2010-10-01 | 2020-01-17 | Modernatx Inc | Nucleósidos, nucleótidos y ácidos nucleicos modificados y sus usos |
AU2012236099A1 (en) | 2011-03-31 | 2013-10-03 | Moderna Therapeutics, Inc. | Delivery and formulation of engineered nucleic acids |
CN107998388B (zh) | 2011-05-02 | 2023-07-14 | 千禧制药公司 | 抗α4β7抗体的制剂 |
UA116189C2 (uk) * | 2011-05-02 | 2018-02-26 | Мілленніум Фармасьютікалз, Інк. | КОМПОЗИЦІЯ АНТИ-α4β7 АНТИТІЛА |
US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
EP3682905B1 (en) | 2011-10-03 | 2021-12-01 | ModernaTX, Inc. | Modified nucleosides, nucleotides, and nucleic acids, and uses thereof |
EP2791160B1 (en) | 2011-12-16 | 2022-03-02 | ModernaTX, Inc. | Modified mrna compositions |
AU2013243948A1 (en) | 2012-04-02 | 2014-10-30 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of proteins associated with human disease |
US9303079B2 (en) | 2012-04-02 | 2016-04-05 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
EP4074834A1 (en) | 2012-11-26 | 2022-10-19 | ModernaTX, Inc. | Terminally modified rna |
US8980864B2 (en) | 2013-03-15 | 2015-03-17 | Moderna Therapeutics, Inc. | Compositions and methods of altering cholesterol levels |
AU2014228172B2 (en) * | 2013-03-15 | 2018-12-06 | Abbvie Deutschland Gmbh & Co.Kg | Anti-EGFR antibody drug conjugate formulations |
WO2015048744A2 (en) | 2013-09-30 | 2015-04-02 | Moderna Therapeutics, Inc. | Polynucleotides encoding immune modulating polypeptides |
CA2926218A1 (en) | 2013-10-03 | 2015-04-09 | Moderna Therapeutics, Inc. | Polynucleotides encoding low density lipoprotein receptor |
CN106456784A (zh) * | 2014-04-16 | 2017-02-22 | 拜康有限公司 | 包含摩尔过量的山梨醇的稳定蛋白质制剂 |
KR102642382B1 (ko) * | 2014-10-06 | 2024-02-29 | 케모센트릭스, 인크. | C-c 케모카인 수용체 타입 9 (ccr9)의 억제제 및 항-알파4베타7 인테그린 차단 항체의 조합 요법 |
WO2016086147A1 (en) | 2014-11-26 | 2016-06-02 | Millennium Pharmaceuticals, Inc. | Vedolizumab for the treatment of fistulizing crohn's disease |
EP3237004B1 (en) | 2014-12-24 | 2024-05-08 | Takeda Pharmaceutical Company Limited | Predicting outcome of treatment with an anti-alpha4 beta7 integrin antibody |
MA41636A (fr) * | 2015-03-06 | 2018-01-09 | Millennium Pharm Inc | Méthode de traitement de la cholangite sclérosante primitive |
SG11201800864XA (en) * | 2015-08-11 | 2018-03-28 | Univ Osaka | Antibody |
WO2017087735A1 (en) * | 2015-11-18 | 2017-05-26 | Millennium Pharmaceuticals, Inc. | Method for treating crohn's disease |
USD866757S1 (en) | 2016-03-11 | 2019-11-12 | Millennium Pharmaceuticals, Inc. | Autoinjector |
CN116327920A (zh) * | 2016-03-14 | 2023-06-27 | 千禧制药公司 | 预防移植物抗宿主疾病的方法 |
WO2017160700A1 (en) * | 2016-03-14 | 2017-09-21 | Millennium Pharmaceuticals, Inc. | Methods of treating or preventing graft versus host disease |
WO2017158393A1 (en) * | 2016-03-18 | 2017-09-21 | Oslo University Hospital Hf | Methods of treating graft-versus-host disease |
TW201735949A (zh) | 2016-03-24 | 2017-10-16 | 千禧製藥公司 | 治療抗ctla4及抗pd-1組合治療中的胃腸道免疫相關不良事件之方法 |
WO2017165778A1 (en) | 2016-03-24 | 2017-09-28 | Millennium Pharmaceuticals, Inc. | Methods of treating gastrointestinal immune-related adverse events in immune oncology treatments |
EP3443346B1 (en) * | 2016-04-13 | 2023-08-30 | Medimmune, LLC | Use of amino acids as stabilizing compounds in pharmaceutical compositions containing high concentrations of protein-based therapeutic agents |
WO2017192867A1 (en) | 2016-05-04 | 2017-11-09 | Millennium Pharmaceuticals, Inc. | Triple combination therapy for treating inflammatory bowel disease |
JP7202893B2 (ja) * | 2016-06-12 | 2023-01-12 | 武田薬品工業株式会社 | 炎症性腸疾患を治療する方法 |
IL265665B1 (en) * | 2016-10-07 | 2024-03-01 | Regeneron Pharma | A stable protein at room temperature that has been lyophilized |
WO2018104893A1 (en) | 2016-12-06 | 2018-06-14 | Glaxosmithkline Intellectual Property Development Limited | Alpha4-beta7 antibodies with incrased fcrn binding and/or half-life |
HUE058664T2 (hu) * | 2016-12-23 | 2022-09-28 | Immunogen Inc | ADAM9-et célzó immunkonjugátumok és eljárások azok felhasználására |
WO2018200818A2 (en) * | 2017-04-28 | 2018-11-01 | Millennium Pharmaceuticals, Inc. | Method of treating pediatric disorders |
CA3063324A1 (en) | 2017-05-16 | 2018-11-22 | Bhami's Research Laboratory, Pvt. Ltd. | High concentration protein formulations with reduced viscosity |
AU2018274749A1 (en) * | 2017-05-26 | 2019-12-19 | Millennium Pharmaceuticals, Inc. | Methods for the treatment of chronic pouchitis |
TWI762706B (zh) | 2017-08-24 | 2022-05-01 | 丹麥商諾佛 儂迪克股份有限公司 | Glp-1組成物及其用途 |
TWI648098B (zh) | 2017-11-14 | 2019-01-21 | 亞智科技股份有限公司 | 氣液混合機構、製程設備及氣液混合方法 |
US20210031012A1 (en) | 2018-01-26 | 2021-02-04 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with a pde4 inhibitor |
AU2019251452A1 (en) * | 2018-04-10 | 2020-11-26 | Dr. Reddy's Laboratories Limited | Stable antibody formulation |
US20210401982A1 (en) * | 2018-04-10 | 2021-12-30 | Dr. Reddy's Laboratories Limited | Stable formulations of therapeutic antibody |
WO2019198100A1 (en) * | 2018-04-10 | 2019-10-17 | Dr. Reddy's Laboratories Limited | Antibody formulation |
US20220257600A1 (en) | 2018-06-20 | 2022-08-18 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with a jak or other kinase inhibitor |
WO2019246312A1 (en) | 2018-06-20 | 2019-12-26 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with an immunomodulator |
EP3810268A1 (en) | 2018-06-20 | 2021-04-28 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with an il-12/il-23 inhibitor |
EP3810085A1 (en) | 2018-06-20 | 2021-04-28 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with an integrin inhibitor |
WO2019246317A1 (en) | 2018-06-20 | 2019-12-26 | Progenity, Inc. | Treatment of a disease or condition in a tissue originating from the endoderm |
EP3810095A1 (en) | 2018-06-20 | 2021-04-28 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with a tnf inhibitor |
CN109239335A (zh) * | 2018-09-11 | 2019-01-18 | 广州万孚生物技术股份有限公司 | 联检试纸条及其制备方法 |
WO2020123241A1 (en) * | 2018-12-10 | 2020-06-18 | Clear Creek Bio, Inc. | Multiphasic dosing regimens for treating cancer |
MX2021009851A (es) | 2019-02-18 | 2021-09-10 | Lilly Co Eli | Formulacion de anticuerpos terapeuticos. |
AR119270A1 (es) * | 2019-06-10 | 2021-12-09 | Millennium Pharm Inc | MÉTODOS PARA PRODUCIR UN ANTICUERPO ANTI-a4b7 |
WO2020252082A1 (en) * | 2019-06-10 | 2020-12-17 | Millennium Pharmaceuticals, Inc. | Cell culture methods and compositions for antibody production |
US10792360B1 (en) | 2019-11-21 | 2020-10-06 | Chemocentryx, Inc. | Compositions and methods for treating inflammatory bowel disease using CCR9 inhibitor and anti-TNF-alpha blocking antibodies |
WO2021144476A1 (en) | 2020-02-18 | 2021-07-22 | Novo Nordisk A/S | Pharmaceutical formulations |
CN113577281A (zh) * | 2020-04-30 | 2021-11-02 | 中国科学院分子细胞科学卓越创新中心 | 调控整合素β亚基的试剂和方法 |
AR122983A1 (es) | 2020-07-16 | 2022-10-19 | Abbvie Inc | ANTICUERPOS ANTI-a4b7 |
US20240100158A1 (en) * | 2021-01-20 | 2024-03-28 | Dr. Reddy’S Laboratories Limited | Freeze dried antibody formulations and methods thereof |
EP4333878A1 (en) * | 2021-05-07 | 2024-03-13 | Dr. Reddy's Laboratories Limited | A method of improving stability of an antibody formulation |
CN113813377A (zh) * | 2021-09-07 | 2021-12-21 | 杭州远大生物制药有限公司 | 抗α4β7抗体制剂及其应用 |
Family Cites Families (79)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
GB8422238D0 (en) | 1984-09-03 | 1984-10-10 | Neuberger M S | Chimeric proteins |
US4699880A (en) | 1984-09-25 | 1987-10-13 | Immunomedics, Inc. | Method of producing monoclonal anti-idiotype antibody |
GB8601597D0 (en) | 1986-01-23 | 1986-02-26 | Wilson R H | Nucleotide sequences |
US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
IL85035A0 (en) | 1987-01-08 | 1988-06-30 | Int Genetic Eng | Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same |
WO1988007089A1 (en) | 1987-03-18 | 1988-09-22 | Medical Research Council | Altered antibodies |
US5258498A (en) | 1987-05-21 | 1993-11-02 | Creative Biomolecules, Inc. | Polypeptide linkers for production of biosynthetic proteins |
EP0303463B1 (en) | 1987-08-11 | 1994-11-30 | The Board Of Trustees Of The Leland Stanford Junior University | Method to control leukocyte extravasation |
US5403919A (en) | 1987-08-11 | 1995-04-04 | Board Of Trustees Of The Leland Stanford Junior University Stanford University | Method to control leukocyte extravasation |
US5538724A (en) | 1987-08-11 | 1996-07-23 | The Board Of Trustees For The Leland Stanford Junior Univ. | Method of control leukocyte extravasation |
US5336603A (en) | 1987-10-02 | 1994-08-09 | Genentech, Inc. | CD4 adheson variants |
US5223392A (en) | 1988-01-25 | 1993-06-29 | Exocell, Inc. | Monoclonal antibodies against glycated albumin, hybrid cell lines producing these antibodies, and use therefore |
JP3095168B2 (ja) | 1988-02-05 | 2000-10-03 | エル. モリソン,シェリー | ドメイン‐変性不変部を有する抗体 |
WO1990007321A2 (en) | 1988-12-23 | 1990-07-12 | The Board Of Trustees Of The Leland Stanford Junior University | Lymphocyte receptor homing sequences and their uses |
US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
IL162181A (en) | 1988-12-28 | 2006-04-10 | Pdl Biopharma Inc | A method of producing humanized immunoglubulin, and polynucleotides encoding the same |
US5225538A (en) | 1989-02-23 | 1993-07-06 | Genentech, Inc. | Lymphocyte homing receptor/immunoglobulin fusion proteins |
DE3920358A1 (de) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
IL113261A (en) | 1989-09-01 | 1996-10-16 | Hutchinson Fred Cancer Res | Repression by peptides of lymphocyte binding to vascular endothelium by interaction of extracellular uterine capacitor with connective tissue, and pharmaceutical preparations containing |
US5730978A (en) | 1989-09-01 | 1998-03-24 | Fred Hutchinson Cancer Research Center | Inhibition of lymphocyte adherence with α4β1-specific antibodies |
GB8928874D0 (en) | 1989-12-21 | 1990-02-28 | Celltech Ltd | Humanised antibodies |
US5859205A (en) * | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
CZ282603B6 (cs) | 1991-03-06 | 1997-08-13 | Merck Patent Gesellschaft Mit Beschränkter Haftun G | Humanizované a chimerické monoklonální protilátky |
US5665595A (en) | 1991-06-07 | 1997-09-09 | Dowelanco | Immunoglobulins against insect tissue |
JP4124480B2 (ja) | 1991-06-14 | 2008-07-23 | ジェネンテック・インコーポレーテッド | 免疫グロブリン変異体 |
GB9115364D0 (en) | 1991-07-16 | 1991-08-28 | Wellcome Found | Antibody |
ATE297465T1 (de) | 1991-11-25 | 2005-06-15 | Enzon Inc | Verfahren zur herstellung von multivalenten antigenbindenden proteinen |
US5871734A (en) | 1992-01-13 | 1999-02-16 | Biogen, Inc. | Treatment for asthma with VLA-4 blocking agents |
US5932214A (en) * | 1994-08-11 | 1999-08-03 | Biogen, Inc. | Treatment for inflammatory bowel disease with VLA-4 blockers |
EP0625912B1 (en) | 1992-02-12 | 1997-04-16 | Biogen, Inc. | Treatment for inflammatory bowel disease |
WO1993023526A1 (en) | 1992-05-21 | 1993-11-25 | Center For Blood Research, Inc. | A NOVEL RECEPTOR FOR α4 INTEGRINS AND METHODS BASED THEREON |
WO1994012214A1 (en) | 1992-12-01 | 1994-06-09 | Protein Design Labs, Inc. | Humanized antibodies reactive with cd18 |
AU5675794A (en) | 1992-12-15 | 1994-07-04 | Board Of Trustees Of The Leland Stanford Junior University | Mucosal vascular addressin, dna and expression |
SG44845A1 (en) | 1993-01-12 | 1997-12-19 | Biogen Inc | Recombitant anti-vla4 antibody molecules |
ES2114183T5 (es) | 1993-02-09 | 2006-06-16 | Biogen Idec Ma, Inc. | Anticuerpo para el tratamiento de la diabetes dependiente de la insulina. |
US6017695A (en) | 1993-03-26 | 2000-01-25 | Becton Dickinson And Company | Nucleic acids encoding human cell adhesion molecule |
JPH06303990A (ja) | 1993-04-24 | 1994-11-01 | Kanebo Ltd | モノクローナル抗体、それを産生するハイブリドーマおよび該抗体の製造方法 |
EP0714409A1 (en) | 1993-06-16 | 1996-06-05 | Celltech Therapeutics Limited | Antibodies |
ES2270425T3 (es) | 1994-01-25 | 2007-04-01 | Elan Pharmaceuticals, Inc. | Anticuerpos humanizados contra la molecula de adhesion leucocitaria vla-4. |
US5840299A (en) | 1994-01-25 | 1998-11-24 | Athena Neurosciences, Inc. | Humanized antibodies against leukocyte adhesion molecule VLA-4 |
US5594120A (en) | 1994-02-18 | 1997-01-14 | Brigham And Women's Hospital, Inc. | Integrin alpha subunit |
US5610281A (en) | 1994-05-03 | 1997-03-11 | Brigham & Women's Hospital, Inc. | Antibodies for modulating heterotypic E-cadherin interactions with human T lymphocytes |
GB2292079B (en) | 1994-08-12 | 1998-07-15 | Flexpharm Ltd | Coated prednisolone preparation for the treatment of inflamatory bowel disease |
US5624321A (en) | 1994-12-23 | 1997-04-29 | Snyder; Stephen D. | Spring-actuated swing device |
DK0808367T3 (da) | 1995-02-10 | 2007-11-05 | Millennium Pharm Inc | Vaskulære slimhindeaddressiner samt anvendelse deraf |
US6551593B1 (en) | 1995-02-10 | 2003-04-22 | Millennium Pharmaceuticals, Inc. | Treatment of Inflammatory bowel disease by inhibiting binding and/or signalling through α 4 β 7 and its ligands and madcam |
US7803904B2 (en) | 1995-09-01 | 2010-09-28 | Millennium Pharmaceuticals, Inc. | Mucosal vascular addressing and uses thereof |
US7750137B2 (en) | 1995-09-01 | 2010-07-06 | Millennium Pharmaceuticals, Inc. | Mucosal vascular addressins |
US6267958B1 (en) * | 1995-07-27 | 2001-07-31 | Genentech, Inc. | Protein formulation |
US6037324A (en) | 1996-01-04 | 2000-03-14 | Leukosite, Inc. | Inhibitors of MAdCAM-1-mediated interactions and methods of use therefor |
US6015662A (en) | 1996-01-23 | 2000-01-18 | Abbott Laboratories | Reagents for use as calibrators and controls |
US7147851B1 (en) | 1996-08-15 | 2006-12-12 | Millennium Pharmaceuticals, Inc. | Humanized immunoglobulin reactive with α4β7 integrin |
EP0852951A1 (de) * | 1996-11-19 | 1998-07-15 | Roche Diagnostics GmbH | Stabile lyophilisierte pharmazeutische Zubereitungen von mono- oder polyklonalen Antikörpern |
US20010046496A1 (en) * | 2000-04-14 | 2001-11-29 | Brettman Lee R. | Method of administering an antibody |
JP4317010B2 (ja) | 2001-07-25 | 2009-08-19 | ピーディーエル バイオファーマ,インコーポレイティド | IgG抗体の安定な凍結乾燥医薬製剤 |
US7053202B2 (en) | 2001-10-19 | 2006-05-30 | Millennium Pharmaceuticals, Inc. | Immunoglobulin DNA cassette molecules, monobody constructs, methods of production, and methods of use therefor |
DE10163459A1 (de) | 2001-12-21 | 2003-07-03 | Merck Patent Gmbh | Lyophilisierte Zubereitung enthaltend Antikörper gegen EGF-Rezeptor |
BR0307975A (pt) | 2002-02-25 | 2005-01-11 | Elan Pharm Inc | Métodos para reduzir cronicamente a inflamação patológica em um paciente e para determinar a eficácia de um regime de administração crÈnica para tratar inflamação patológica em um indivìduo, composição e terapia combinada para tratamento crÈnico de inflamação patológica em um paciente e uso de um inibidor de alfa-4-integrina |
CA2485681C (en) | 2002-05-24 | 2012-10-16 | Millennium Pharmaceuticals, Inc. | Ccr9 inhibitors and methods of use thereof |
EP2256116A3 (en) | 2002-11-18 | 2011-11-16 | ChemoCentryx, Inc. | Aryl sulfonamides |
US20040191243A1 (en) | 2002-12-13 | 2004-09-30 | Bei Chen | System and method for stabilizing antibodies with histidine |
RU2332986C2 (ru) * | 2003-04-04 | 2008-09-10 | Дженентек, Инк. | Высококонцентрированные композиции антител и белков |
SI3530673T1 (sl) * | 2004-09-03 | 2022-08-31 | Genentech, Inc. | Humanizirani antagonisti proti beta7 in njihove uporabe |
EP1948691A1 (en) * | 2005-11-17 | 2008-07-30 | Millennium Pharmaceuticals, Inc. | HUMANIZED IMMUNOGLOBULIN REACTIVE WITH a4ß7INTEGRIN |
EP1977763A4 (en) | 2005-12-28 | 2010-06-02 | Chugai Pharmaceutical Co Ltd | STABILIZER PREPARATION CONTAINING ANTIBODIES |
CA2638811A1 (en) * | 2006-02-03 | 2007-08-16 | Medimmune, Llc | Protein formulations |
EA018301B1 (ru) | 2006-04-21 | 2013-07-30 | Новартис Аг | Фармацевтические композиции, содержащие антагонистическое моноклональное антитело к cd40, и их применение |
US20080112953A1 (en) | 2006-10-06 | 2008-05-15 | Amgen Inc. | Stable formulations |
EP2094247B1 (en) | 2006-10-20 | 2022-06-29 | Amgen Inc. | Stable polypeptide formulations |
EP2109480B1 (en) | 2006-12-07 | 2017-06-28 | The Government of the United States of America as Represented by the Secretary of the Department of Health and Human Services | Use of antagonists of the interaction between hiv gp120 and alpha4beta7 integrin |
CA2671968A1 (en) | 2006-12-11 | 2008-06-19 | F. Hoffmann-La Roche Ag | Abeta antibody parenteral formulation |
UA107557C2 (xx) | 2007-07-06 | 2015-01-26 | Композиція антитіла офатумумабу | |
SG183709A1 (en) * | 2007-08-08 | 2012-09-27 | Abbott Lab | Compositions and methods for crystallizing antibodies |
AR075715A1 (es) | 2009-03-05 | 2011-04-20 | Novartis Ag | Formulacion de anticuerpo liofilizado |
EP2408816B1 (en) | 2009-03-20 | 2019-09-04 | Amgen Inc. | Alpha-4-beta-7 heterodimer specific antagonist antibody |
UA116189C2 (uk) * | 2011-05-02 | 2018-02-26 | Мілленніум Фармасьютікалз, Інк. | КОМПОЗИЦІЯ АНТИ-α4β7 АНТИТІЛА |
-
2012
- 2012-02-05 UA UAA201313899A patent/UA116189C2/uk unknown
- 2012-05-02 KR KR1020217020871A patent/KR102465394B1/ko active IP Right Grant
- 2012-05-02 ME MEP-2017-228A patent/ME02859B/me unknown
- 2012-05-02 UY UY0001034053A patent/UY34053A/es not_active Application Discontinuation
- 2012-05-02 TW TW107138209A patent/TWI664980B/zh active
- 2012-05-02 IL IL296847A patent/IL296847A/en unknown
- 2012-05-02 CA CA3028209A patent/CA3028209C/en active Active
- 2012-05-02 JP JP2014509378A patent/JP6190360B2/ja active Active
- 2012-05-02 AR ARP120101539A patent/AR086237A1/es not_active Application Discontinuation
- 2012-05-02 PE PE2018001579A patent/PE20190405A1/es unknown
- 2012-05-02 HU HUE12721093A patent/HUE036663T2/hu unknown
- 2012-05-02 SI SI201231073T patent/SI2704798T1/sl unknown
- 2012-05-02 IL IL296838A patent/IL296838A/en unknown
- 2012-05-02 UA UAA201707804A patent/UA126545C2/uk unknown
- 2012-05-02 CN CN201711161579.XA patent/CN108079291B/zh active Active
- 2012-05-02 BR BR112013028424-2A patent/BR112013028424A2/pt active Search and Examination
- 2012-05-02 US US14/114,832 patent/US9764033B2/en active Active
- 2012-05-02 KR KR1020187033652A patent/KR102096484B1/ko active IP Right Grant
- 2012-05-02 TW TW101115712A patent/TWI556828B/zh active
- 2012-05-02 EP EP18150968.8A patent/EP3329965A3/en active Pending
- 2012-05-02 SG SG2013079686A patent/SG194652A1/en unknown
- 2012-05-02 LT LTEP12721093.8T patent/LT2704798T/lt unknown
- 2012-05-02 PL PL12721093T patent/PL2704798T3/pl unknown
- 2012-05-02 GE GEAP201213304A patent/GEP201706734B/en unknown
- 2012-05-02 MY MYPI2016001847A patent/MY183471A/en unknown
- 2012-05-02 WO PCT/US2012/036072 patent/WO2012151248A2/en active Application Filing
- 2012-05-02 IL IL275038A patent/IL275038B2/en unknown
- 2012-05-02 EP EP12721093.8A patent/EP2704798B1/en active Active
- 2012-05-02 PE PE2013002431A patent/PE20141175A1/es active IP Right Grant
- 2012-05-02 AU AU2012250873A patent/AU2012250873B2/en active Active
- 2012-05-02 TW TW105130046A patent/TWI664978B/zh active
- 2012-05-02 ES ES12721093.8T patent/ES2645187T3/es active Active
- 2012-05-02 MX MX2013012724A patent/MX348814B/es active IP Right Grant
- 2012-05-02 CN CN201711310404.0A patent/CN108129565B/zh active Active
- 2012-05-02 KR KR1020227038842A patent/KR20220154834A/ko not_active Application Discontinuation
- 2012-05-02 KR KR1020187012689A patent/KR101923378B1/ko active Application Filing
- 2012-05-02 MY MYPI2013003922A patent/MY172735A/en unknown
- 2012-05-02 KR KR1020207008950A patent/KR102275603B1/ko active IP Right Grant
- 2012-05-02 US US13/462,414 patent/US20120282249A1/en not_active Abandoned
- 2012-05-02 KR KR1020177027571A patent/KR101923371B1/ko active IP Right Grant
- 2012-05-02 EP EP17180246.5A patent/EP3263178A1/en active Pending
- 2012-05-02 CN CN201280030450.4A patent/CN103608071B/zh active Active
- 2012-05-02 CA CA2834867A patent/CA2834867C/en active Active
- 2012-05-02 CN CN201711309462.1A patent/CN108187042A/zh active Pending
- 2012-05-02 DK DK12721093.8T patent/DK2704798T3/en active
- 2012-05-02 EA EA201391614A patent/EA032729B1/ru not_active IP Right Cessation
- 2012-05-02 RS RS20171014A patent/RS56397B1/sr unknown
- 2012-05-02 MX MX2016012776A patent/MX356827B/es unknown
- 2012-05-02 PT PT127210938T patent/PT2704798T/pt unknown
- 2012-05-02 KR KR1020137031382A patent/KR20140145953A/ko active Application Filing
-
2013
- 2013-10-28 IL IL229104A patent/IL229104A0/en unknown
- 2013-10-29 ZA ZA2013/08069A patent/ZA201308069B/en unknown
- 2013-10-30 CL CL2013003146A patent/CL2013003146A1/es unknown
- 2013-10-30 DO DO2013000253A patent/DOP2013000253A/es unknown
- 2013-10-31 MX MX2021006723A patent/MX2021006723A/es unknown
- 2013-11-01 CO CO13259825A patent/CO6801647A2/es not_active Application Discontinuation
- 2013-11-26 MA MA36501A patent/MA35136B1/fr unknown
- 2013-11-26 EC ECSP13013050 patent/ECSP13013050A/es unknown
- 2013-12-19 CR CR20130677A patent/CR20130677A/es unknown
-
2016
- 2016-07-20 US US15/215,012 patent/US9663579B2/en active Active
- 2016-07-20 US US15/215,000 patent/US10004808B2/en active Active
- 2016-07-20 US US15/214,993 patent/US10143752B2/en active Active
- 2016-09-19 AU AU2016231469A patent/AU2016231469B2/en active Active
-
2017
- 2017-04-05 CL CL2017000830A patent/CL2017000830A1/es unknown
- 2017-05-02 JP JP2017091845A patent/JP6534415B2/ja active Active
- 2017-08-16 US US15/678,744 patent/US20190076532A1/en not_active Abandoned
- 2017-09-22 HR HRP20171432TT patent/HRP20171432T1/hr unknown
- 2017-10-11 CY CY20171101056T patent/CY1119435T1/el unknown
- 2017-10-20 ZA ZA2017/07158A patent/ZA201707158B/en unknown
-
2018
- 2018-01-03 PH PH12018500030A patent/PH12018500030A1/en unknown
- 2018-03-20 US US15/927,032 patent/US20180207279A1/en not_active Abandoned
- 2018-06-21 HK HK18107977.2A patent/HK1249466A1/zh unknown
- 2018-06-21 US US16/015,167 patent/US20180289811A1/en not_active Abandoned
- 2018-07-10 JP JP2018130978A patent/JP6473845B2/ja active Active
- 2018-10-18 ZA ZA2018/06946A patent/ZA201806946B/en unknown
- 2018-11-27 HK HK18115181.7A patent/HK1256106A1/zh unknown
- 2018-12-03 US US16/208,294 patent/US20190231878A1/en active Pending
- 2018-12-11 AU AU2018278866A patent/AU2018278866B2/en active Active
-
2019
- 2019-03-20 AU AU2019201926A patent/AU2019201926A1/en not_active Abandoned
- 2019-04-10 JP JP2019074688A patent/JP6878489B2/ja active Active
- 2019-06-26 IL IL267668A patent/IL267668B/en active IP Right Grant
- 2019-12-23 US US16/726,092 patent/US20200206353A1/en active Pending
-
2020
- 2020-01-15 US US16/743,813 patent/US20210052733A1/en active Pending
- 2020-02-13 PH PH12020500336A patent/PH12020500336A1/en unknown
- 2020-10-08 AU AU2020250249A patent/AU2020250249B2/en active Active
-
2021
- 2021-04-28 JP JP2021075479A patent/JP7258941B2/ja active Active
-
2022
- 2022-02-22 US US17/652,090 patent/US20220370617A1/en active Pending
- 2022-04-29 EC ECSENADI202234515A patent/ECSP22034515A/es unknown
- 2022-09-15 AU AU2022231726A patent/AU2022231726A1/en active Pending
-
2023
- 2023-04-05 JP JP2023061100A patent/JP2023076616A/ja active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CY1119435T1 (el) | Σκευασμα για αντισωμα εναντι- αλφα4βητα7 | |
CY1119436T1 (el) | Σκευασμα για αντισωμα εναντι- 4 7 | |
CY1122483T1 (el) | Λυοφιλοποιημενες παρασκευες μελφαλανης φλουφεναμιδης | |
CY1122786T1 (el) | Δοσολογικα σχηματα για ενωσεις κατηγοριας εχινοκανδινης | |
CY1122181T1 (el) | Φαρμακοτεχνικη μορφη αντισωματος | |
CY1122730T1 (el) | 1,2,4-τριαζολες ως διαμορφωτες πυρηνικης μεταφορας και χρησεις αυτων | |
CY1122953T1 (el) | Ενα καινοτομο συμπλοκο που περιλαμβανει ενα κυτταροδιεισδυτικο πεπτιδιο, ενα φορτιο και εναν tlr πεπτιδικο αγωνιστη για την αντιμετωπιση του ορθοκολικου καρκινου | |
CY1121150T1 (el) | Νευροδραστικα 19-αλκοξυ-17-υποκατεστημενα στεροειδη, χρησιμα σε μεθοδους θεραπειας | |
CY1123657T1 (el) | Σταθερη φαρμακοτεχνικη μορφη anti-ifnar1 | |
CY1122329T1 (el) | Anti-siglec-8 αντισωματα και μeθοδοι χρhσεως αυτων | |
BR112016012506A2 (pt) | Combinações farmacêuticas, seus usos, e uso de um portador de dados | |
MX2022006107A (es) | Metodos y composiciones para dosificacion en terapia celular adoptiva. | |
CY1118373T1 (el) | Υψηλης συγκεντρωσης υγρες μορφοποιησεις anti-tnfa αντισωματος | |
MX2021008224A (es) | Combinacion de vacunacion e inhibicion de la trayectoria pd-1. | |
BR112014021325A2 (pt) | Formulação farmacêutica líquida e formulação liofilizada | |
EA201691059A1 (ru) | Соединения-пептидомиметики и содержащие их конъюгаты антитело-лекарственное средство | |
MX2021000898A (es) | Inhibidores de pcsk9 para usarse en el tratamiento de pacientes con hipercolesterolemia familiar heterocigota (hfhe). | |
AR092177A1 (es) | Metodos para tratar o prevenir asma administrando un antagonista de il-4r | |
BR112012029912A2 (pt) | vácinas de combinação de nanotransportadores sintéticos | |
EA201890454A1 (ru) | Пирролопиримидиновые нуклеозиды и их аналоги, которые можно использовать в качестве противовирусных средств | |
TN2015000402A1 (fr) | Methods for treating crohn's disease using an anti-il23 antibody | |
BR112015020139A2 (pt) | compostos terapêuticos e usos dos mesmos | |
EA201790239A1 (ru) | Молекула-носитель для антигенов | |
EA201391515A1 (ru) | Инактивированная вакцина вируса денге | |
EA201591581A1 (ru) | Способы лечения псориаза при помощи анти-il-23 антитела |