CY1119218T1 - Αναστολεις διυδροπυριδοφθαλαζινονης της πολυμερασης της πολυαδενοσφωσφορικης ριβοζης (parp) - Google Patents

Αναστολεις διυδροπυριδοφθαλαζινονης της πολυμερασης της πολυαδενοσφωσφορικης ριβοζης (parp)

Info

Publication number
CY1119218T1
CY1119218T1 CY20171100578T CY171100578T CY1119218T1 CY 1119218 T1 CY1119218 T1 CY 1119218T1 CY 20171100578 T CY20171100578 T CY 20171100578T CY 171100578 T CY171100578 T CY 171100578T CY 1119218 T1 CY1119218 T1 CY 1119218T1
Authority
CY
Cyprus
Prior art keywords
polymadene
phosphorosis
diahydrodyphythrophalazinone
parp
polymerase
Prior art date
Application number
CY20171100578T
Other languages
English (en)
Inventor
Bing Wang
Daniel Chu
Original Assignee
Medivation Technologies, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medivation Technologies, Inc. filed Critical Medivation Technologies, Inc.
Publication of CY1119218T1 publication Critical patent/CY1119218T1/el

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/28—Compounds containing heavy metals
    • A61K31/282—Platinum compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61N2005/1092—Details
    • A61N2005/1098—Enhancing the effect of the particle by an injected agent or implanted device

Abstract

Η εφεύρεση παρέχει μια ένωση του τύπου:
CY20171100578T 2008-08-06 2017-05-31 Αναστολεις διυδροπυριδοφθαλαζινονης της πολυμερασης της πολυαδενοσφωσφορικης ριβοζης (parp) CY1119218T1 (el)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US8668708P 2008-08-06 2008-08-06
US15103609P 2009-02-09 2009-02-09
US17308809P 2009-04-27 2009-04-27
EP09805360.6A EP2326650B9 (en) 2008-08-06 2009-07-27 Dihydropyridophthalazinone inhibitors of poly(adp-ribose)polymerase (parp)

Publications (1)

Publication Number Publication Date
CY1119218T1 true CY1119218T1 (el) 2018-02-14

Family

ID=41129519

Family Applications (3)

Application Number Title Priority Date Filing Date
CY20141100240T CY1115022T1 (el) 2008-08-06 2014-03-28 Αναστολεις πολυ (adp-ριβοζης)πολυμερασης (parp) του τυπου διυδροπυριδοφθαλαζινονης
CY20171100578T CY1119218T1 (el) 2008-08-06 2017-05-31 Αναστολεις διυδροπυριδοφθαλαζινονης της πολυμερασης της πολυαδενοσφωσφορικης ριβοζης (parp)
CY2019044C CY2019044I1 (el) 2008-08-06 2019-11-28 Αναστολεις διυδροπυριδοφθαλαζινονης της πολυμερασης της πολυαδενοσφωσφορικης ριβοζης (parp)

Family Applications Before (1)

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CY20141100240T CY1115022T1 (el) 2008-08-06 2014-03-28 Αναστολεις πολυ (adp-ριβοζης)πολυμερασης (parp) του τυπου διυδροπυριδοφθαλαζινονης

Family Applications After (1)

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CY2019044C CY2019044I1 (el) 2008-08-06 2019-11-28 Αναστολεις διυδροπυριδοφθαλαζινονης της πολυμερασης της πολυαδενοσφωσφορικης ριβοζης (parp)

Country Status (31)

Country Link
US (7) US8012976B2 (el)
EP (3) EP2767537B1 (el)
JP (3) JP5984389B2 (el)
KR (1) KR101846029B1 (el)
CN (3) CN103896942A (el)
AR (1) AR072970A1 (el)
AU (1) AU2009279944B2 (el)
BR (1) BRPI0917119B1 (el)
CA (1) CA2732797C (el)
CY (3) CY1115022T1 (el)
DK (2) DK2326650T3 (el)
ES (2) ES2625817T3 (el)
FR (1) FR19C1071I2 (el)
GB (1) GB2462361A (el)
HK (2) HK1157755A1 (el)
HR (1) HRP20170982T1 (el)
HU (2) HUE035295T2 (el)
IL (1) IL211070A (el)
LT (2) LT2767537T (el)
LU (1) LUC00140I2 (el)
MX (1) MX2011001328A (el)
NL (1) NL301021I2 (el)
NO (1) NO2019042I1 (el)
NZ (1) NZ591166A (el)
PL (2) PL2767537T3 (el)
PT (2) PT2326650E (el)
SG (2) SG193842A1 (el)
SI (2) SI2767537T1 (el)
TW (2) TWI448464B (el)
WO (1) WO2010017055A2 (el)
ZA (1) ZA201100897B (el)

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