CY1118867T1 - Καθαρισμος τριφωσφορυλιωμενων ολιγονουκλεοτιδιων με τη χρησιμοποιηση ετικετων συλληψης - Google Patents

Καθαρισμος τριφωσφορυλιωμενων ολιγονουκλεοτιδιων με τη χρησιμοποιηση ετικετων συλληψης

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Publication number
CY1118867T1
CY1118867T1 CY20171100440T CY171100440T CY1118867T1 CY 1118867 T1 CY1118867 T1 CY 1118867T1 CY 20171100440 T CY20171100440 T CY 20171100440T CY 171100440 T CY171100440 T CY 171100440T CY 1118867 T1 CY1118867 T1 CY 1118867T1
Authority
CY
Cyprus
Prior art keywords
purification
capture labels
oligonucleotides
triphosphorylated
triphosphorylated oligonucleotides
Prior art date
Application number
CY20171100440T
Other languages
English (en)
Inventor
Janos Ludwig
Marion Goldeck
Brian Sproat
Original Assignee
Rheinische Friedrich-Wilhelms-Universität Bonn
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rheinische Friedrich-Wilhelms-Universität Bonn filed Critical Rheinische Friedrich-Wilhelms-Universität Bonn
Publication of CY1118867T1 publication Critical patent/CY1118867T1/el

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C07H1/02—Phosphorylation
    • C07H1/04—Introducing polyphosphoric acid radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C07H1/02—Phosphorylation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2330/00—Production
    • C12N2330/30—Production chemically synthesised

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Η παρούσα εφεύρεση αναφέρεται σε μια μέθοδο παρασκευής τροποποιημένων με τριφωσφορικό ολιγονουκλεοτιδίων με τη χρησιμοποίηση μιας ετικέτας σύλληψης. Η μέθοδος επιτρέπει τη σύνθεση και καθαρισμό τροποποιημένων με τριφωσφορικό ολιγονουκλεοτιδίων σε υψηλή απόδοση και καθαρότητα κατάλληλων για φαρμακευτικές εφαρμογές.
CY20171100440T 2011-03-28 2017-04-13 Καθαρισμος τριφωσφορυλιωμενων ολιγονουκλεοτιδιων με τη χρησιμοποιηση ετικετων συλληψης CY1118867T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11160032A EP2508530A1 (en) 2011-03-28 2011-03-28 Purification of triphosphorylated oligonucleotides using capture tags
PCT/EP2012/055520 WO2012130886A1 (en) 2011-03-28 2012-03-28 Purification of triphosphorylated oligonucleotides using capture tags
EP12710950.2A EP2691410B1 (en) 2011-03-28 2012-03-28 Purification of triphosphorylated oligonucleotides using capture tags

Publications (1)

Publication Number Publication Date
CY1118867T1 true CY1118867T1 (el) 2018-01-10

Family

ID=44453820

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20171100440T CY1118867T1 (el) 2011-03-28 2017-04-13 Καθαρισμος τριφωσφορυλιωμενων ολιγονουκλεοτιδιων με τη χρησιμοποιηση ετικετων συλληψης

Country Status (17)

Country Link
US (2) US9399658B2 (el)
EP (3) EP2508530A1 (el)
JP (2) JP5981985B2 (el)
CN (2) CN106699829A (el)
AU (2) AU2012234296B2 (el)
CA (1) CA2830980C (el)
CY (1) CY1118867T1 (el)
DK (1) DK2691410T3 (el)
ES (1) ES2623002T3 (el)
HR (1) HRP20170577T1 (el)
HU (1) HUE033843T2 (el)
LT (1) LT2691410T (el)
PL (1) PL2691410T3 (el)
PT (1) PT2691410T (el)
RS (1) RS55912B1 (el)
SI (1) SI2691410T1 (el)
WO (1) WO2012130886A1 (el)

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EP2508530A1 (en) * 2011-03-28 2012-10-10 Rheinische Friedrich-Wilhelms-Universität Bonn Purification of triphosphorylated oligonucleotides using capture tags
EP2712870A1 (en) * 2012-09-27 2014-04-02 Rheinische Friedrich-Wilhelms-Universität Bonn Novel RIG-I ligands and methods for producing them
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CN111032669B (zh) 2017-08-18 2024-03-29 安捷伦科技有限公司 用于亲和纯化寡核苷酸的原酸酯组合物
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US11649457B2 (en) 2020-12-09 2023-05-16 Yale University Methods for treating SARS-CoV-2 infection

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