CY1118447T1 - Fc ΜΕΤΑΛΛΑΓΜΑΤΑ ΑΝΤΙΣΩΜΑΤΩΝ ΜΕ ΑΦΑΙΡΕΘΕΙΣΕΣ ΤΕΛΕΣΤΙΚΕΣ ΛΕΙΤΟΥΡΓΙΕΣ - Google Patents

Fc ΜΕΤΑΛΛΑΓΜΑΤΑ ΑΝΤΙΣΩΜΑΤΩΝ ΜΕ ΑΦΑΙΡΕΘΕΙΣΕΣ ΤΕΛΕΣΤΙΚΕΣ ΛΕΙΤΟΥΡΓΙΕΣ

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Publication number
CY1118447T1
CY1118447T1 CY20171100054T CY171100054T CY1118447T1 CY 1118447 T1 CY1118447 T1 CY 1118447T1 CY 20171100054 T CY20171100054 T CY 20171100054T CY 171100054 T CY171100054 T CY 171100054T CY 1118447 T1 CY1118447 T1 CY 1118447T1
Authority
CY
Cyprus
Prior art keywords
antibody
mutuals
telephone functions
removable telephone
removable
Prior art date
Application number
CY20171100054T
Other languages
English (en)
Inventor
William Strohl
Omid Vafa
Original Assignee
Janssen Biotech, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Biotech, Inc. filed Critical Janssen Biotech, Inc.
Publication of CY1118447T1 publication Critical patent/CY1118447T1/el

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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P19/00—Drugs for skeletal disorders
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/00—Drugs for disorders of the nervous system
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
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    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/71—Decreased effector function due to an Fc-modification
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    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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Abstract

Αντίσωμα και άλλα μόρια που περιέχουν Fc, με παραλλαγές στην Fc περιοχή μειώνουν πρόσδεση σε Fc γάμμα υποδοχείς και προκύπτουσα δραστικότητα και μπορούν να χρησιμοποιηθούν στην θεραπευτική αγωγή διαφόρων ασθενειών και διαταραχών.
CY20171100054T 2009-11-30 2017-01-17 Fc ΜΕΤΑΛΛΑΓΜΑΤΑ ΑΝΤΙΣΩΜΑΤΩΝ ΜΕ ΑΦΑΙΡΕΘΕΙΣΕΣ ΤΕΛΕΣΤΙΚΕΣ ΛΕΙΤΟΥΡΓΙΕΣ CY1118447T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26507909P 2009-11-30 2009-11-30
PCT/US2010/058188 WO2011066501A1 (en) 2009-11-30 2010-11-29 Antibody fc mutants with ablated effector functions

Publications (1)

Publication Number Publication Date
CY1118447T1 true CY1118447T1 (el) 2017-06-28

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CY20171100054T CY1118447T1 (el) 2009-11-30 2017-01-17 Fc ΜΕΤΑΛΛΑΓΜΑΤΑ ΑΝΤΙΣΩΜΑΤΩΝ ΜΕ ΑΦΑΙΡΕΘΕΙΣΕΣ ΤΕΛΕΣΤΙΚΕΣ ΛΕΙΤΟΥΡΓΙΕΣ

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US (3) US8961967B2 (el)
EP (2) EP3141260B1 (el)
JP (3) JP5784624B2 (el)
KR (1) KR101791430B1 (el)
CN (1) CN102711810B (el)
AU (1) AU2010324684B2 (el)
BR (1) BR112012013038A2 (el)
CA (1) CA2782218C (el)
CY (1) CY1118447T1 (el)
DK (1) DK2506871T3 (el)
EA (2) EA201890907A1 (el)
ES (2) ES2751549T3 (el)
HR (1) HRP20161542T1 (el)
HU (1) HUE032872T2 (el)
IL (2) IL219864A (el)
LT (1) LT2506871T (el)
ME (1) ME02568B (el)
MX (1) MX2012006243A (el)
PL (1) PL2506871T3 (el)
PT (1) PT2506871T (el)
RS (1) RS55460B1 (el)
SI (1) SI2506871T1 (el)
SM (1) SMT201600387B (el)
WO (1) WO2011066501A1 (el)

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