CY1117302T1 - Αντισωματα αντι-mif - Google Patents
Αντισωματα αντι-mifInfo
- Publication number
- CY1117302T1 CY1117302T1 CY20151100250T CY151100250T CY1117302T1 CY 1117302 T1 CY1117302 T1 CY 1117302T1 CY 20151100250 T CY20151100250 T CY 20151100250T CY 151100250 T CY151100250 T CY 151100250T CY 1117302 T1 CY1117302 T1 CY 1117302T1
- Authority
- CY
- Cyprus
- Prior art keywords
- mif
- antibodies
- relates
- antigen
- binding fragments
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Cardiology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Oncology (AREA)
- Urology & Nephrology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Vascular Medicine (AREA)
- Dermatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Hematology (AREA)
- Communicable Diseases (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Ophthalmology & Optometry (AREA)
- Peptides Or Proteins (AREA)
Abstract
Η παρούσα εφεύρεση αναφέρεται σε μονοκλωνικά αντισώματα και τμήματα αυτών δέσμευσης με αντιγόνο που δεσμεύονται ειδικά με το C-άκρο ή την κεντρική περιοχή του παράγοντα αναστολής της μετανάστευσης μακροφάγων (MIF). Τα εν λόγω αντισώματα αντι-MIF και τα τμήματα αυτών δέσμευσης με αντιγόνο επιπλέον αναστέλλουν τη βιολογική λειτουργία του ανθρωπίνου MIF. Η αίτηση αναφέρεται επίσης σε απομονωμένες ανοσοσφαιρίνες βαριάς και ελαφριάς αλυσίδας που προέρχονται από αντισώματα αντι-MIF και μόρια νουκλεϊνικών οξέων που κωδικοποιούν τέτοιες ανοσοσφαιρίνες. Η παρούσα αίτηση αναφέρεται επίσης σε μια μέθοδο ταυτοποίησης αντισωμάτων αντι-MIF, σε φαρμακευτικές συνθέσεις που περιλαμβάνουν τα εν λόγω αντισώματα και μια μέθοδο χρήσης των εν λόγω αντισωμάτων και συνθέσεων για τη θεραπευτική αγωγή διαταραχών σχετικών με τον MIF.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US1898808P | 2008-01-04 | 2008-01-04 | |
US9468508P | 2008-09-05 | 2008-09-05 | |
EP08869976.4A EP2231707B1 (en) | 2008-01-04 | 2008-12-30 | Anti mif antibodies |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1117302T1 true CY1117302T1 (el) | 2017-04-26 |
Family
ID=40535633
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20151100250T CY1117302T1 (el) | 2008-01-04 | 2015-03-13 | Αντισωματα αντι-mif |
Country Status (23)
Country | Link |
---|---|
US (3) | US20090220521A1 (el) |
EP (4) | EP2231707B1 (el) |
JP (1) | JP5502752B2 (el) |
KR (2) | KR20160105943A (el) |
CN (2) | CN103724430B (el) |
AU (1) | AU2008346517B2 (el) |
BR (1) | BRPI0821682A2 (el) |
CA (1) | CA2711029A1 (el) |
CY (1) | CY1117302T1 (el) |
DK (1) | DK2231707T3 (el) |
ES (3) | ES2623653T3 (el) |
HK (1) | HK1147762A1 (el) |
HR (1) | HRP20150224T1 (el) |
IL (1) | IL206715A (el) |
MX (1) | MX2010007406A (el) |
NZ (3) | NZ586600A (el) |
PL (2) | PL3118223T3 (el) |
PT (1) | PT2231707E (el) |
RS (1) | RS53906B1 (el) |
RU (2) | RU2509777C2 (el) |
SI (1) | SI2231707T1 (el) |
WO (1) | WO2009086920A1 (el) |
ZA (1) | ZA201004973B (el) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2008346517B2 (en) * | 2008-01-04 | 2013-12-05 | Baxalta GmbH | Anti MIF antibodies |
US9238689B2 (en) | 2011-07-15 | 2016-01-19 | Morpho Sys AG | Antibodies that are cross-reactive for macrophage migration inhibitory factor (MIF) and D-dopachrome tautomerase (D-DT) |
US9958456B2 (en) | 2011-10-07 | 2018-05-01 | Baxalta Incorporated | OxMIF as a diagnostic marker |
AU2012327159B2 (en) * | 2011-10-07 | 2015-03-26 | Baxalta GmbH | Characterization of CHO-MIF gene and protein, and use thereof |
AU2013202693B2 (en) * | 2012-04-16 | 2015-01-22 | Baxalta GmbH | Combination Therapy of Anti-MIF Antibodies and Chemotherapeutics |
AU2013203957B9 (en) * | 2012-04-16 | 2015-10-15 | Baxalta GmbH | Combination Therapy of Anti-MIF Antibodies and Glucocorticoids |
NZ628459A (en) * | 2012-07-10 | 2016-06-24 | Baxalta Inc | Anti-mif immunohistochemistry |
US20150309012A1 (en) * | 2012-12-07 | 2015-10-29 | Baxter International Inc. | Anti-mif antibody cell migration assay |
US10613100B2 (en) * | 2014-01-03 | 2020-04-07 | Baxalta Incorporated | Anti-MIF immunohistochemistry |
WO2016026956A1 (en) | 2014-08-22 | 2016-02-25 | Baxalta GmbH | Detection of cho-mif contaminations |
EP3277718B1 (en) | 2015-03-31 | 2021-03-24 | Baxalta GmbH | Dosage regimen for anti-mif antibodies |
US20180155419A1 (en) | 2015-05-18 | 2018-06-07 | Baxalta GmbH | Anti-mif antibodies in the treatment of cancers containing mutant tp53 and/or mutant ras |
EP3512880A1 (en) * | 2016-09-15 | 2019-07-24 | Ablynx NV | Immunoglobulin single variable domains directed against macrophage migration inhibitory factor |
CN109868311B (zh) * | 2017-12-01 | 2023-10-20 | 上海市精神卫生中心 | Mif及其预测二代抗精神病药物诱导的代谢不良反应的应用 |
JP2021526820A (ja) * | 2018-06-07 | 2021-10-11 | オンコワン・リサーチ・アンド・ディベロップメント・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | 癌治療のための抗oxMIF/抗CD3抗体 |
EP3757252B1 (en) | 2019-06-28 | 2022-03-30 | Walter Ag | A coated cutting tool |
AU2020397229A1 (en) | 2019-12-06 | 2022-06-30 | Oncoone Research & Development Gmbh | Anti-oxMIF/anti-CD3 bispecific antibody constructs |
US20230365671A1 (en) * | 2020-10-02 | 2023-11-16 | Oncoone Research & Development Gmbh | IMPROVED ANTI-oxMIF ANTIBODIES WITH REDUCED AGGREGATION POTENTIAL AND REDUCED HYDROPHOBICITY |
JP2024505963A (ja) | 2021-02-03 | 2024-02-08 | オンコワン・リサーチ・アンド・ディベロップメント・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | 抗oxMIF放射性免疫コンジュゲート |
IL310958A (en) | 2021-09-03 | 2024-04-01 | Oncoone Res & Development Gmbh | Enhanced Fc-silenced anti-oxMIF antibodies with reduced aggregation potential and reduced hydrophobicity |
WO2023133361A2 (en) * | 2022-01-10 | 2023-07-13 | Phenomic Ai | Anti-cthrc1 fusion proteins and methods of using the same |
CN114573693A (zh) * | 2022-04-25 | 2022-06-03 | 中国人民解放军陆军军医大学 | 一种听觉发育中免疫调节分子mif抗体制备方法 |
CN115814069B (zh) * | 2022-10-31 | 2023-07-21 | 四川大学华西医院 | Mif基因敲除的肿瘤细胞在制备肿瘤疫苗中的用途 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6030615A (en) * | 1993-05-17 | 2000-02-29 | The Picower Institute For Medical Research | Combination method for treating diseases caused by cytokine-mediated toxicity |
US6774227B1 (en) * | 1993-05-17 | 2004-08-10 | Cytokine Pharmasciences, Inc. | Therapeutic uses of factors which inhibit or neutralize MIF activity |
JPH0977799A (ja) * | 1995-09-13 | 1997-03-25 | Sapporo Immuno Diagnostic Lab:Kk | ヒト−マクロファージ遊走阻止因子(ヒト−mif)に対するモノクローナル抗体および該抗体を産生するハイブリドーマ |
RU2236251C2 (ru) * | 1999-02-12 | 2004-09-20 | Дзе Скриппс Рисерч Инститьют | Способы лечения опухолей и метастазов с использованием комбинации антиангиогенной терапии и иммунотерапии |
AU2001238677A1 (en) * | 2000-02-28 | 2001-09-12 | Idec Pharmaceuticals Corporation | Method for preparing anti-mif antibodies |
AR045563A1 (es) * | 2003-09-10 | 2005-11-02 | Warner Lambert Co | Anticuerpos dirigidos a m-csf |
CN100457895C (zh) * | 2006-05-24 | 2009-02-04 | 中国科学院生物物理研究所 | 鼠抗人巨噬细胞迁移抑制因子单克隆抗体及其应用 |
AU2008346517B2 (en) * | 2008-01-04 | 2013-12-05 | Baxalta GmbH | Anti MIF antibodies |
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2008
- 2008-12-30 AU AU2008346517A patent/AU2008346517B2/en active Active
- 2008-12-30 NZ NZ586600A patent/NZ586600A/en unknown
- 2008-12-30 EP EP08869976.4A patent/EP2231707B1/en active Active
- 2008-12-30 RU RU2010132647/10A patent/RU2509777C2/ru active
- 2008-12-30 SI SI200831400T patent/SI2231707T1/sl unknown
- 2008-12-30 KR KR1020167023984A patent/KR20160105943A/ko not_active Application Discontinuation
- 2008-12-30 US US12/346,309 patent/US20090220521A1/en not_active Abandoned
- 2008-12-30 PL PL16183733T patent/PL3118223T3/pl unknown
- 2008-12-30 DK DK08869976.4T patent/DK2231707T3/en active
- 2008-12-30 NZ NZ611117A patent/NZ611117A/en unknown
- 2008-12-30 WO PCT/EP2008/011146 patent/WO2009086920A1/en active Application Filing
- 2008-12-30 CA CA2711029A patent/CA2711029A1/en not_active Abandoned
- 2008-12-30 PL PL08869976T patent/PL2231707T3/pl unknown
- 2008-12-30 NZ NZ596409A patent/NZ596409A/xx unknown
- 2008-12-30 EP EP14163839.5A patent/EP2754671B1/en active Active
- 2008-12-30 ES ES14163839.5T patent/ES2623653T3/es active Active
- 2008-12-30 CN CN201410037650.3A patent/CN103724430B/zh active Active
- 2008-12-30 CN CN200880127872.7A patent/CN101983207B/zh active Active
- 2008-12-30 ES ES16183733T patent/ES2791333T3/es active Active
- 2008-12-30 PT PT08869976T patent/PT2231707E/pt unknown
- 2008-12-30 RS RS20150197A patent/RS53906B1/en unknown
- 2008-12-30 EP EP16183733.1A patent/EP3118223B8/en active Active
- 2008-12-30 MX MX2010007406A patent/MX2010007406A/es active IP Right Grant
- 2008-12-30 BR BRPI0821682-7A patent/BRPI0821682A2/pt not_active IP Right Cessation
- 2008-12-30 EP EP20120189220 patent/EP2548890A1/en not_active Withdrawn
- 2008-12-30 KR KR1020107017306A patent/KR101654678B1/ko active IP Right Grant
- 2008-12-30 JP JP2010541032A patent/JP5502752B2/ja active Active
- 2008-12-30 ES ES08869976.4T patent/ES2531629T3/es active Active
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2010
- 2010-04-26 US US12/767,635 patent/US8668909B2/en active Active
- 2010-06-30 IL IL206715A patent/IL206715A/en active IP Right Grant
- 2010-07-14 ZA ZA2010/04973A patent/ZA201004973B/en unknown
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2011
- 2011-02-21 HK HK11101702.4A patent/HK1147762A1/xx unknown
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2013
- 2013-12-03 RU RU2013153592/10A patent/RU2013153592A/ru not_active Application Discontinuation
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2014
- 2014-01-17 US US14/157,967 patent/US20150023978A1/en not_active Abandoned
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2015
- 2015-02-26 HR HRP20150224TT patent/HRP20150224T1/hr unknown
- 2015-03-13 CY CY20151100250T patent/CY1117302T1/el unknown
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