CY1115302T1 - Ενωση οξαζολιου και φαρμακευτικη συνθεση - Google Patents

Ενωση οξαζολιου και φαρμακευτικη συνθεση

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Publication number
CY1115302T1
CY1115302T1 CY20141100485T CY141100485T CY1115302T1 CY 1115302 T1 CY1115302 T1 CY 1115302T1 CY 20141100485 T CY20141100485 T CY 20141100485T CY 141100485 T CY141100485 T CY 141100485T CY 1115302 T1 CY1115302 T1 CY 1115302T1
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CY
Cyprus
Prior art keywords
group
oxazoli
union
pharmaceutical composition
substituents
Prior art date
Application number
CY20141100485T
Other languages
English (en)
Inventor
Minoru Okada
Masaya Kato
Norifumi Sato
Tetsuyuki Uno
Hideki Kitagaki
Junpei Haruta
Hidetaka Hiyama
Tomonori Shibata
Original Assignee
Otsuka Pharmaceutical Co., Ltd
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Filing date
Publication date
Application filed by Otsuka Pharmaceutical Co., Ltd filed Critical Otsuka Pharmaceutical Co., Ltd
Publication of CY1115302T1 publication Critical patent/CY1115302T1/el

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/421—1,3-Oxazoles, e.g. pemoline, trimethadione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
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    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/04—Phosphoric diester hydrolases (3.1.4)
    • C12Y301/04012—Sphingomyelin phosphodiesterase (3.1.4.12)

Abstract

Η παρούσα εφεύρεση παρέχει ένωση οξαζολίου που αντιπροσωπεύεται με τον Τύπο (1) ή άλας αυτής: όπου το R1 είναι αρύλ ομάδα η οποία μπορεί να έχει έναν ή περισσότερους υποκατάστατες, το R2 είναι αρύλ ομάδα ή περιέχουσα άτομο αζώτου ετεροκυκλική ομάδα, εκάστη των οποίων μπορεί να έχει έναν ή περισσότερους υποκατάστατες και το W είναι δισθενής ομάδα που αντιπροσωπεύεται από -Υ1-Α1- ή -Y2-C(=O)-, όπου το Υ1 είναι μία ομάδα όπως -C(=O)-, το Α1 είναι μία ομάδα όπως κατώτερη αλκυλένο ομάδα και το Υ2 είναι μία ομάδα όπως πιπεραζινοδιύλ ομάδα. Η ένωση οξαζολίου έχει ειδική ανασταλτική δράση έναντι φωσφοδιεστεράσης 4.
CY20141100485T 2005-11-15 2014-07-01 Ενωση οξαζολιου και φαρμακευτικη συνθεση CY1115302T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2005330590 2005-11-15
EP06823467.3A EP1954684B1 (en) 2005-11-15 2006-11-14 Oxazole compound and pharmaceutical composition

Publications (1)

Publication Number Publication Date
CY1115302T1 true CY1115302T1 (el) 2017-01-04

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Country Status (23)

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US (8) USRE46792E1 (el)
EP (1) EP1954684B1 (el)
JP (1) JP5305914B2 (el)
KR (1) KR101439557B1 (el)
CN (1) CN101309912B (el)
AR (3) AR057891A1 (el)
AU (1) AU2006316079B2 (el)
BR (1) BRPI0618589B8 (el)
CA (1) CA2627541C (el)
CY (1) CY1115302T1 (el)
DK (1) DK1954684T3 (el)
ES (1) ES2483992T3 (el)
HK (1) HK1121162A1 (el)
IL (1) IL191008A (el)
MY (1) MY153720A (el)
NO (1) NO341440B1 (el)
PL (1) PL1954684T3 (el)
PT (1) PT1954684E (el)
RU (1) RU2418793C2 (el)
SI (1) SI1954684T1 (el)
TW (1) TWI330639B (el)
WO (1) WO2007058338A2 (el)
ZA (1) ZA200803758B (el)

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BRPI0618589A2 (pt) 2012-07-03
BRPI0618589B1 (pt) 2020-11-17
TW200732332A (en) 2007-09-01
PL1954684T3 (pl) 2014-10-31
AU2006316079B2 (en) 2012-03-29
WO2007058338A3 (en) 2007-07-19
MY153720A (en) 2015-03-13
RU2418793C2 (ru) 2011-05-20
KR101439557B1 (ko) 2014-09-11
PT1954684E (pt) 2014-07-17
US20190070151A1 (en) 2019-03-07
CN101309912A (zh) 2008-11-19
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AU2006316079A1 (en) 2007-05-24
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