CY1113250T1 - Προφαρμακα φωσφοραμιδικου αλκυλιωτη - Google Patents

Προφαρμακα φωσφοραμιδικου αλκυλιωτη

Info

Publication number
CY1113250T1
CY1113250T1 CY20121100999T CY121100999T CY1113250T1 CY 1113250 T1 CY1113250 T1 CY 1113250T1 CY 20121100999 T CY20121100999 T CY 20121100999T CY 121100999 T CY121100999 T CY 121100999T CY 1113250 T1 CY1113250 T1 CY 1113250T1
Authority
CY
Cyprus
Prior art keywords
alkyliotic
phosphoramidic
products
alkylated
combination
Prior art date
Application number
CY20121100999T
Other languages
English (en)
Inventor
Mark Matteucci
Jian-Xin Duan
Hailong Jiao
Jacob Kaizerman
Original Assignee
Threshold Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Threshold Pharmaceuticals, Inc. filed Critical Threshold Pharmaceuticals, Inc.
Publication of CY1113250T1 publication Critical patent/CY1113250T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
    • C07F9/24—Esteramides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6503—Five-membered rings
    • C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6536—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and sulfur atoms with or without oxygen atoms, as the only ring hetero atoms
    • C07F9/6539—Five-membered rings
    • C07F9/65392—Five-membered rings containing two nitrogen atoms
    • C07F9/65397—Five-membered rings containing two nitrogen atoms having the two nitrogen atoms in positions 1 and 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/243—Platinum; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Obesity (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Oncology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Biomedical Technology (AREA)
  • Transplantation (AREA)
  • Emergency Medicine (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Τα προφάρμακα φωσφοραμιδικού αλκυλιωτή μπορούν να χρησιμoποιηθούν για τη θεραπεία του καρκίνου όταν χορηγούνται μόνα ή σε συνδυασμό με ένα ή περισσότερα αντινεοπλαστικά μέσα.
CY20121100999T 2005-06-29 2012-10-23 Προφαρμακα φωσφοραμιδικου αλκυλιωτη CY1113250T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US69575505P 2005-06-29 2005-06-29
EP06786161A EP1896040B1 (en) 2005-06-29 2006-06-29 Phosphoramidate alkylator prodrugs

Publications (1)

Publication Number Publication Date
CY1113250T1 true CY1113250T1 (el) 2016-04-13

Family

ID=37596083

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20121100999T CY1113250T1 (el) 2005-06-29 2012-10-23 Προφαρμακα φωσφοραμιδικου αλκυλιωτη

Country Status (24)

Country Link
US (4) US8003625B2 (el)
EP (2) EP1896040B1 (el)
JP (2) JP5180824B2 (el)
KR (1) KR101198571B1 (el)
CN (2) CN101501054B (el)
AU (2) AU2006263433B8 (el)
BR (1) BRPI0612845A8 (el)
CA (1) CA2613312C (el)
CY (1) CY1113250T1 (el)
DK (1) DK1896040T3 (el)
ES (2) ES2389532T3 (el)
HK (1) HK1113754A1 (el)
HR (1) HRP20120803T1 (el)
IL (1) IL188236A (el)
NO (1) NO334420B1 (el)
NZ (1) NZ565378A (el)
PL (1) PL1896040T3 (el)
PT (1) PT1896040E (el)
RS (1) RS52505B (el)
RU (1) RU2414475C2 (el)
SI (1) SI1896040T1 (el)
TW (1) TWI384989B (el)
WO (1) WO2007002931A2 (el)
ZA (1) ZA200800314B (el)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2613312C (en) * 2005-06-29 2014-10-14 Threshold Pharmaceuticals, Inc. Phosphoramidate alkylator prodrugs
EP2114157B1 (en) * 2006-12-26 2021-05-26 ImmunoGenesis, Inc. Phosphoramidate alkylator prodrug for the treatment of cancer
WO2008124691A1 (en) 2007-04-05 2008-10-16 Threshold Pharmaceuticals, Inc. Glufosfamide combination therapy
WO2009018163A1 (en) * 2007-07-27 2009-02-05 Threshold Pharmaceuticals, Inc. Hypoxia activated prodrugs of anthracyclines
UA104579C2 (uk) 2007-12-10 2014-02-25 Байокрист Фармасьютикалз, Инк. Спосіб лікування раку кровотворної системи із застосуванням фородезину у комбінації з ритуксимабом
EP2350053B1 (en) 2008-10-17 2013-12-11 Whitehead Institute For Biomedical Research Modulators of MTOR Complexes
EP2350664B1 (en) * 2008-10-21 2021-05-19 ImmunoGenesis, Inc. Treatment of cancer using the hypoxia activated prodrug th-302 in combination with docetaxel or pemetrexed
AU2011276590A1 (en) * 2010-06-28 2013-01-31 Threshold Pharmaceuticals, Inc. Treatment of blood cancer
KR20130045341A (ko) * 2010-07-12 2013-05-03 쓰레솔드 파마슈티컬스, 인코포레이티드 암 치료를 위한 저산소증 활성 프로드러그와 항혈관형성제의 투여
CN103458896B (zh) * 2011-04-01 2016-02-10 施瑞修德制药公司 用于治疗癌症的方法
WO2012142520A2 (en) * 2011-04-15 2012-10-18 Threshold Pharmaceuticals, Inc. Unit dose form for oral administration
US9402820B2 (en) * 2011-04-22 2016-08-02 The United States Of America As Represented By The Secretary, Department Of Health And Human Services Use of pyruvate or succinate to enhance the efficacy of a hypoxia activated prodrug for the treatment of tumors
CN102850397B (zh) * 2011-06-29 2015-02-18 北京大学 多靶点抗肿瘤化合物及其制备方法和应用
CN102924507A (zh) * 2011-11-10 2013-02-13 安徽四维药业有限公司 一种抗肿瘤化合物及其制备方法与应用、药物组合物
US9254299B2 (en) 2011-12-22 2016-02-09 Threshold Pharmaceuticals, Inc. Administration of hypoxia activated prodrugs in combination with Chk1 inhibitors for treating cancer
JP2015500884A (ja) * 2011-12-22 2015-01-08 スレッショルド ファーマシューティカルズ，インコーポレイテッド 癌を治療するための低酸素活性化プロドラッグおよびｍＴＯＲ阻害剤
US20160045522A1 (en) * 2012-02-21 2016-02-18 Threshold Pharmaceuticals, Inc. Treatment of Cancer
US9879003B2 (en) 2012-04-11 2018-01-30 Dana-Farber Cancer Institute, Inc. Host targeted inhibitors of dengue virus and other viruses
KR20150027155A (ko) * 2012-07-03 2015-03-11 브리스톨-마이어스 스큅 컴퍼니 바이러스 감염의 치료를 위한 뉴클레오시드 화합물의 부분입체이성질체적으로 풍부한 포스포르아미데이트 유도체의 제조 방법
US9278124B2 (en) 2012-10-16 2016-03-08 Halozyme, Inc. Hypoxia and hyaluronan and markers thereof for diagnosis and monitoring of diseases and conditions and related methods
WO2014063054A1 (en) 2012-10-19 2014-04-24 Dana-Farber Cancer Institute, Inc. Bone marrow on x chromosome kinase (bmx) inhibitors and uses thereof
JP5922791B2 (ja) 2012-10-29 2016-05-24 京セラ株式会社 弾性表面波センサ
WO2015013448A1 (en) 2013-07-26 2015-01-29 Threshold Pharmaceuticals, Inc. Treatment of pancreatic cancer with a combination of a hypoxia-acti vated prodrug and a taxane
WO2015025283A2 (en) 2013-08-20 2015-02-26 Stichting Maastricht Radiation Oncology "Maastro-Clinic" Dual action carbonic anhydrase inhibitors
WO2015051921A1 (en) 2013-10-10 2015-04-16 Merck Patent Gmbh Synthesis of 1-alkyl-2-amino-imidazol-5-carboxylic acid ester via calpha-substituted n-alkyl-glycine ester derivatives
WO2015069489A1 (en) 2013-11-06 2015-05-14 Merck Patent Gmbh Predictive biomarker for hypoxia-activated prodrug therapy
CN104628772A (zh) * 2013-11-07 2015-05-20 四川恒康发展有限责任公司 一种抗肿瘤前药及其激活剂、组合物和应用
CN114404427A (zh) * 2014-02-13 2022-04-29 配体药物公司 前药化合物及其用途
US10131683B2 (en) 2014-07-17 2018-11-20 Molecular Templates, Inc. TH-302 solid forms and methods related thereto
KR102189066B1 (ko) 2015-03-10 2020-12-09 아센타위츠 파마슈티컬즈 리미티드 Dna 알킬화제
KR102001910B1 (ko) 2015-04-02 2019-07-19 아센타위츠 파마슈티컬즈 리미티드 항암제의 나이트로벤질 유도체
PL412787A1 (pl) 2015-06-22 2017-01-02 Magdalena Król Oparty na makrofagach celowany system dostarczania związków związanych z ferrytyną
CN105037427B (zh) * 2015-06-22 2017-05-31 石家庄学院 丹参酮iia亚乙基亚胺磷酸酯衍生物及其制备方法与应用
US20180169064A1 (en) * 2015-06-24 2018-06-21 Threshold Pharmaceuticals, Inc. Aziridine containing dna alkylating agents
JP6695360B2 (ja) * 2015-11-16 2020-05-20 アセンタウィッツ ファーマシューティカルズ リミテッド （ｒ）−および（ｓ）−１−（３−（３−ｎ，ｎ−ジメチルアミノカルボニル）フェノキシル−４−ニトロフェニル）−１−エチル−ｎ，ｎ’−ビス（エチレン）ホスホルアミデート、組成物ならびにその使用方法および製造方法
EP3442979A4 (en) * 2016-04-04 2019-12-18 Rutgers, the State University of New Jersey topoisomerase poisons
KR102579648B1 (ko) 2017-01-06 2023-09-18 리부스 파마슈티칼스, 인크. 신규한 페닐 유도체
CN111788196A (zh) 2018-01-09 2020-10-16 配体药物公司 缩醛化合物及其治疗用途
WO2019238886A1 (en) 2018-06-13 2019-12-19 University Of Dundee Bifunctional molecules for targeting usp14
EP3807272A1 (en) 2018-06-13 2021-04-21 Amphista Therapeutics Ltd Bifunctional molecules for targeting rpn11
WO2019238816A1 (en) 2018-06-13 2019-12-19 University Of Dundee Bifunctional molecules for targeting uchl5
CN110746459A (zh) * 2018-07-24 2020-02-04 上海喀露蓝科技有限公司 一种艾伏磷酰胺的制备方法
EP3650046A1 (en) 2018-11-08 2020-05-13 Cellis AG Mesenchymal stem cell based targeted active ingredient delivery system
CN109705187B (zh) * 2019-01-29 2021-08-20 石家庄学院 一种雷公藤红素衍生物及其制备方法与应用
CN112755001B (zh) * 2019-11-01 2022-04-12 深圳艾欣达伟医药科技有限公司 口服给药的固体剂型药物
US20230174624A1 (en) 2020-03-18 2023-06-08 Cellis Ag Ferritin variants with increased stability, complexation ability and transferrin receptor affinity
CA3212386A1 (en) 2021-03-18 2022-09-22 Alessandro ARCOVITO Ferritin variants with increased stability and complexation ability
WO2023025312A1 (zh) 2021-08-27 2023-03-02 深圳艾欣达伟医药科技有限公司 使用th-302治疗parp抑制剂耐药的患者
WO2023025291A1 (zh) 2021-08-27 2023-03-02 深圳艾欣达伟医药科技有限公司 冻干制剂溶液及冻干制剂、方法和用途
WO2024056413A1 (en) 2022-09-13 2024-03-21 Cellis Ag Isolated targeted delivery system for the treatment of glioma
WO2024112663A1 (en) 2022-11-21 2024-05-30 Rivus Pharmaceuticals, Inc. Deuterium enriched phenyl derivatives for treating mitochondriarelated disorders or conditions
WO2024133541A1 (en) 2022-12-20 2024-06-27 Cellis Sp. Z O.O. [Ltd.] Isolated targeted delivery system for the treatment of ovarian cancer

Family Cites Families (87)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3652579A (en) 1969-06-26 1972-03-28 Hoffmann La Roche 1-methyl-2-substituted 5-nitroimidazoles
DE2229248C3 (de) 1971-07-30 1980-03-27 Gruppo Lepetit S.P.A., Mailand (Italien) 5-Iminomethyl-2-nitroimidazoI-Derivate und Verfahren zu deren Herstellung
US4921963A (en) 1987-04-13 1990-05-01 British Columbia Cancer Foundation Platinum complexes with one radiosensitizing ligand
JPH0819111B2 (ja) 1987-10-22 1996-02-28 ポーラ化成工業株式会社 ２―ニトロイミダゾール誘導体及びこれを有効成分とする放射線増感剤
US5190929A (en) 1988-05-25 1993-03-02 Research Corporation Technologies, Inc. Cyclophosphamide analogs useful as anti-tumor agents
US5403932A (en) 1988-05-25 1995-04-04 Research Corporation Technologies, Inc. Phosphoramidates useful as antitumor agents
US4908356A (en) 1988-05-25 1990-03-13 Research Corporation Technologies, Inc. Aldophosphamide derivatives useful as antitumor agents
DE3835772A1 (de) 1988-10-20 1990-04-26 Deutsches Krebsforsch Tumorhemmende saccharid-konjugate
JP2626727B2 (ja) 1990-01-26 1997-07-02 ポーラ化成工業株式会社 ２―ニトロイミダゾール誘導体、その製造法及びこれを有効成分とする放射線増感剤
HU9201539D0 (en) 1990-09-11 1992-08-28 Kortec Ag Method and device for gasifying gasifiable materials and/or transforming gas as well as heat exchanger of high temperature for executing said method
US5233031A (en) 1991-09-23 1993-08-03 University Of Rochester Phosphoramidate analogs of 2'-deoxyuridine
DE69233669T2 (de) 1991-10-23 2007-10-25 Cancer Research Technology Ltd. Bakterielle nitroreduktase zur reduzierung von cb 1954 und analogen davon in eine zytotoxische form
US5750782A (en) 1992-11-27 1998-05-12 Cancer Research Campaign Technology Limited Nitroaniline derivatives and their use as anti-tumour agents
US5306727A (en) 1993-04-30 1994-04-26 Research Corporation Technologies, Inc. Phosphoramidates useful as antitumor agents
JPH08510469A (ja) 1993-05-25 1996-11-05 オークランド ユニサービシーズ リミテッド ニトロベンジルマスタード四級塩およびその低酸素選択性細胞毒剤としての利用
ATE194920T1 (de) 1993-09-22 2000-08-15 Hoechst Ag Pro-prodrugs, ihre herstellung und anwendung
JPH07309761A (ja) * 1994-05-20 1995-11-28 Kyowa Hakko Kogyo Co Ltd デュオカルマイシン誘導体の安定化法
US5659061A (en) 1995-04-20 1997-08-19 Drug Innovation & Design, Inc. Tumor protease activated prodrugs of phosphoramide mustard analogs with toxification and detoxification functionalities
GB9516943D0 (en) 1995-08-18 1995-10-18 Cancer Soc Auckland Div Nz Inc Novel cyclopropylindoles and their secoprecursors,and their use as prodrugs
US6218519B1 (en) 1996-04-12 2001-04-17 Pro-Neuron, Inc. Compounds and methods for the selective treatment of cancer and bacterial infections
US5728271A (en) 1996-05-20 1998-03-17 Rti Resource Transforms International Ltd. Energy efficient liquefaction of biomaterials by thermolysis
CA2255922C (en) 1996-05-20 2009-07-07 Jan Piskorz Energy efficient liquefaction of biomaterials by thermolysis
US6130237A (en) 1996-09-12 2000-10-10 Cancer Research Campaign Technology Limited Condensed N-aclyindoles as antitumor agents
US6251933B1 (en) 1996-12-13 2001-06-26 The Cancer Research Campaign Technology Limited Seco precursors of cyclopropylindolines and their use as prodrugs
DE19720312A1 (de) 1997-05-15 1998-11-19 Hoechst Ag Zubereitung mit erhöhter in vivo Verträglichkeit
US6017948A (en) 1998-10-30 2000-01-25 Supergen, Inc. Water-miscible pharmaceutical compositions
US7914994B2 (en) 1998-12-24 2011-03-29 Cepheid Method for separating an analyte from a sample
US6240925B1 (en) 1999-03-23 2001-06-05 Cynosure, Inc. Photothermal vascular targeting with bioreductive agents
GB9909612D0 (en) 1999-04-26 1999-06-23 Cancer Res Campaign Tech N-protected amines and their use as prodrugs
WO2000071134A1 (en) 1999-05-24 2000-11-30 Southern Research Institute Isophosphoramide mustard analogs and use thereof
EP1191923A4 (en) 1999-06-11 2004-05-06 Henceforth Hibernia Inc ANTIOXIDANT COMPOSITIONS FOR PROPHYLACTIC, THERAPEUTIC AND INDUSTRIAL USE IMPROVED BY STABILIZED ATOMIC HYDROGEN, AND / OR FREE ELECTRONS AND METHODS OF PREPARING AND USING SAME
AU5935600A (en) * 1999-07-14 2001-01-30 Richard F. Borch Phosphoramide compounds
ATE317846T1 (de) 2000-03-31 2006-03-15 Purdue Research Foundation Phosphoramidat-prodrugs
US20030091574A1 (en) 2001-03-23 2003-05-15 Gevas Philip C. Combination treatment of pancreatic cancer
EP1243276A1 (en) 2001-03-23 2002-09-25 Franciscus Marinus Hendrikus De Groot Elongated and multiple spacers containing activatible prodrugs
US6506739B1 (en) * 2001-05-01 2003-01-14 Telik, Inc. Bis-(N,N'-bis-(2-haloethyl)amino)phosphoramidates as antitumor agents
US7087600B2 (en) 2001-05-31 2006-08-08 Medarex, Inc. Peptidyl prodrugs and linkers and stabilizers useful therefor
FR2825926A1 (fr) 2001-06-14 2002-12-20 Sod Conseils Rech Applic Derives d'imidazoles modulant les canaux sodiques
US7091186B2 (en) 2001-09-24 2006-08-15 Seattle Genetics, Inc. p-Amidobenzylethers in drug delivery agents
KR20030067275A (ko) 2002-02-07 2003-08-14 주식회사 하이폭시 니트로이미다졸 및 위상 이성질화 효소 저해제를유효성분으로 포함하는 항암제
US20040009667A1 (en) 2002-02-07 2004-01-15 Etsuo Iijima Etching method
CA2477163C (en) 2002-02-21 2010-07-27 Institute Of Virology Soluble form of carbonic anhydrase ix (s-ca-ix), assays to detect s-ca ix, and ca ix's coexpression with her-2/neu/c-erbb-2, and ca ix-specific monoclonal antibodies to non-immunodominant epitopes
JP4227771B2 (ja) 2002-07-17 2009-02-18 三菱重工業株式会社 バイオマスのガス化方法
US6833390B2 (en) 2002-07-22 2004-12-21 Bayer Polymers Llc Process for preparing closed-cell water-blown rigid polyurethane foams having improved mechanical properties
DE10237931A1 (de) 2002-08-14 2004-02-26 Endress + Hauser Gmbh + Co. Kg Vorrichtung zur Überwachung eines vorbestimmten Füllstands eines Messmediums in einem Behälter
CN1759118B (zh) 2003-01-09 2010-12-08 美国辉瑞有限公司 作为激酶抑制剂的二氮杂*并吲哚衍生物
GB0306907D0 (en) 2003-03-26 2003-04-30 Angiogene Pharm Ltd Boireductively-activated prodrugs
GB0306908D0 (en) 2003-03-26 2003-04-30 Angiogene Pharm Ltd Bioreductively activated stilbene prodrugs
ZA200507752B (en) * 2003-03-28 2007-01-31 Threshold Pharmaceuticals Inc Compositions and methods for treating cancer
US6855695B2 (en) 2003-06-13 2005-02-15 Vion Pharmaceuticals, Inc. Water-soluble SHPs as novel alkylating agents
US7340059B2 (en) 2003-06-17 2008-03-04 Intel Corporation Programmable scrambler and De-scrambler for digital telephony equipment
JP2005041733A (ja) 2003-07-28 2005-02-17 National Institute Of Advanced Industrial & Technology バイオマスによる水素製造法
US8318683B2 (en) 2004-02-06 2012-11-27 Threshold Pharmaceuticals, Inc. Anti-cancer therapies
US7432106B2 (en) 2004-03-24 2008-10-07 Applied Biosystems Inc. Liquid processing device including gas trap, and system and method
EP1743038A4 (en) 2004-05-04 2007-11-21 Bayer Healthcare MN / CA IX / CA9 AND KIDNEY CANCER PROGNOSIS
IL162713A (en) 2004-06-24 2011-04-28 Desalitech Ltd Apparatus and methods for continuous desalination in closed circuit without containers
WO2006015263A2 (en) 2004-07-29 2006-02-09 Threshold Pharmaceuticals, Inc. Lonidamine analogs
TW200605885A (en) 2004-07-29 2006-02-16 Threshold Pharmaceuticals Inc Multicyclic lonidamine analogs
MX2007006102A (es) 2004-11-22 2007-07-11 Threshold Pharmaceuticals Inc Agentes anti-cancer de union a tubulina y profarmacos de los mismos.
US20070117784A1 (en) 2005-03-04 2007-05-24 Novacea, Inc. Treatment of hyperproliferative diseases with anthraquinones
CA2613312C (en) 2005-06-29 2014-10-14 Threshold Pharmaceuticals, Inc. Phosphoramidate alkylator prodrugs
CA2624707A1 (en) 2005-10-03 2007-04-12 Genetix Pharmaceuticals, Inc. Method for selectively depleting hypoxic cells
WO2008011588A2 (en) 2006-07-20 2008-01-24 Threshold Pharmaceuticals, Inc. Glycoconjugates of phosphoramidate alkylators for treatment of cancer
WO2008033041A1 (en) 2006-09-11 2008-03-20 Auckland Uniservices Limited Cancer treatment
JP2008069017A (ja) 2006-09-12 2008-03-27 Matsushita Electric Ind Co Ltd 水素製造方法
US7807454B2 (en) 2006-10-18 2010-10-05 The Regents Of The University Of California Microfluidic magnetophoretic device and methods for using the same
WO2008076826A1 (en) 2006-12-13 2008-06-26 Threshold Pharmaceuticals, Inc. Pyrophosphoramide alkylators
EP2114157B1 (en) 2006-12-26 2021-05-26 ImmunoGenesis, Inc. Phosphoramidate alkylator prodrug for the treatment of cancer
JP5174411B2 (ja) 2007-09-28 2013-04-03 独立行政法人石油天然ガス・金属鉱物資源機構 管式リフォーマーの有効熱利用方法
US8216607B2 (en) 2008-03-17 2012-07-10 Roger Williams Hospital Combination of ceramide and gemcitabine for inducing cell death and uses thereof in treating cancer
CN104043125B (zh) 2008-04-10 2018-01-12 弗吉尼亚州立邦联大学 诱导肿瘤缺氧以治疗癌症
AU2009258124C1 (en) 2008-06-11 2016-01-07 Genentech, Inc. Diazacarbazoles and methods of use
JP4665021B2 (ja) 2008-09-03 2011-04-06 三菱重工業株式会社 バイオマスのガス化方法
EP2350664B1 (en) 2008-10-21 2021-05-19 ImmunoGenesis, Inc. Treatment of cancer using the hypoxia activated prodrug th-302 in combination with docetaxel or pemetrexed
EP2409130B1 (en) 2009-03-20 2013-12-04 Pbs Biotech, Inc. Automatable aseptic sample withdrawal system
EP2427174A4 (en) 2009-05-04 2014-01-15 Santen Pharmaceutical Co Ltd HEMMER OF THE MTOR SIGNAL PATH FOR THE TREATMENT OF EYE TROUBLE
WO2011057222A1 (en) 2009-11-06 2011-05-12 Infinity Pharmaceuticals, Inc. Oral formulations of a hedgehog pathway inhibitor
JP5659536B2 (ja) 2010-03-31 2015-01-28 新日鐵住金株式会社 タール含有ガスの改質用触媒及びその製造方法、並びにタール含有ガスの改質方法
AU2011276590A1 (en) 2010-06-28 2013-01-31 Threshold Pharmaceuticals, Inc. Treatment of blood cancer
KR20130045341A (ko) 2010-07-12 2013-05-03 쓰레솔드 파마슈티컬스, 인코포레이티드 암 치료를 위한 저산소증 활성 프로드러그와 항혈관형성제의 투여
US10357577B2 (en) 2010-07-16 2019-07-23 Auckland Uniservices Limited Bacterial nitroreductase enzymes and methods relating thereto
CN103458896B (zh) 2011-04-01 2016-02-10 施瑞修德制药公司 用于治疗癌症的方法
WO2012142520A2 (en) 2011-04-15 2012-10-18 Threshold Pharmaceuticals, Inc. Unit dose form for oral administration
JP5805989B2 (ja) 2011-04-26 2015-11-10 大塚電子株式会社 電気泳動移動度測定用セル並びにそれを用いた測定装置及び測定方法
US20150005399A1 (en) 2011-12-20 2015-01-01 Masayasu Sakai Method and device for producing synthetic gas and method and device for synthesizing liquid fuel
JP2015500884A (ja) 2011-12-22 2015-01-08 スレッショルド ファーマシューティカルズ，インコーポレイテッド 癌を治療するための低酸素活性化プロドラッグおよびｍＴＯＲ阻害剤
JP2015511226A (ja) 2012-01-31 2015-04-16 スレッショルド ファーマシューティカルズ，インコーポレイテッド 低酸素活性化プロドラッグ療法のための予測バイオマーカー

Also Published As

Publication number Publication date
NO20080442L (no) 2008-03-31
JP2009502743A (ja) 2009-01-29
US20140170240A1 (en) 2014-06-19
JP5781007B2 (ja) 2015-09-16
AU2011202075A8 (en) 2013-05-30
AU2011202075A1 (en) 2011-05-26
RS52505B (en) 2013-04-30
US8003625B2 (en) 2011-08-23
EP2336141B1 (en) 2016-03-30
JP2012153722A (ja) 2012-08-16
CA2613312A1 (en) 2007-01-04
EP1896040B1 (en) 2012-08-01
HK1113754A1 (en) 2008-10-17
PT1896040E (pt) 2012-09-27
CA2613312C (en) 2014-10-14
AU2006263433B8 (en) 2011-06-09
DK1896040T3 (da) 2012-09-03
NO334420B1 (no) 2014-03-03
RU2414475C2 (ru) 2011-03-20
EP1896040A4 (en) 2010-02-10
ES2389532T3 (es) 2012-10-29
NZ565378A (en) 2011-03-31
KR101198571B1 (ko) 2012-11-07
AU2011202075B8 (en) 2013-05-30
PL1896040T3 (pl) 2012-12-31
US20130303778A1 (en) 2013-11-14
RU2008103195A (ru) 2009-08-10
BRPI0612845A8 (pt) 2018-01-23
CN102746336A (zh) 2012-10-24
CN101501054A (zh) 2009-08-05
US9226932B2 (en) 2016-01-05
EP1896040A2 (en) 2008-03-12
SI1896040T1 (sl) 2012-12-31
TWI384989B (zh) 2013-02-11
US20100137254A1 (en) 2010-06-03
ZA200800314B (en) 2009-09-30
HRP20120803T1 (hr) 2012-11-30
WO2007002931A2 (en) 2007-01-04
EP2336141A2 (en) 2011-06-22
CN102746336B (zh) 2015-08-19
WO2007002931A3 (en) 2009-04-23
IL188236A0 (en) 2008-08-07
JP5180824B2 (ja) 2013-04-10
CN101501054B (zh) 2012-09-05
US8664204B2 (en) 2014-03-04
BRPI0612845A2 (pt) 2010-11-30
US8507464B2 (en) 2013-08-13
AU2006263433A1 (en) 2007-01-04
AU2011202075B2 (en) 2013-01-17
IL188236A (en) 2011-11-30
AU2006263433B2 (en) 2011-06-02
ES2579235T3 (es) 2016-08-08
US20110251159A1 (en) 2011-10-13
EP2336141A3 (en) 2011-09-14
TW200800228A (en) 2008-01-01
KR20080027901A (ko) 2008-03-28

Similar Documents

Publication Publication Date Title
CY1113250T1 (el) Προφαρμακα φωσφοραμιδικου αλκυλιωτη
CY1115852T1 (el) Φαρμακευτικες συνθεσεις
CY1122168T1 (el) Φαρμακοτεχνικες μορφες παραγωγων δεσιταβινης
CY1120523T1 (el) Συνδυαστικη θεραπεια με υαλουρονιδαση και στοχευμενο προς τον ογκο ταξανιο
CY1117445T1 (el) Παραγωγα φωσφοραμιδικου της 5-φθορο-2´-δεοξυουριδινης για χρηση στην θεραπεια καρκινου
USD677820S1 (en) Light fixture
CY1119676T1 (el) Συνθεσεις και μεθοδοι για τη θεραπεια του καρκινου
CY1122523T1 (el) Πεπτιδια και πεπτιδομιμητικα σε συνδυαστικες χρησεις και αγωγες για υποπληθυσμους πασχοντων απο καρκινο
ZA200709011B (en) Phosphoramidate derivatives of nucleoside compounds for use in the treatment of cancer
EA200970737A1 (ru) Оксабициклогептаны и оксабициклогептены, их получение и применение
BR112015000818A2 (pt) método de fornecimento de luz de horticultura a uma cultura em um ambiente de horticultura; dispositivo de iluminação para uso em um ambiente de horticultura; e aplicação de horticultura
CL2016003260A1 (es) Profármacos de gemcitabina
CY1119419T1 (el) C1-inh συνθεσεις για χρηση στην προληψη και αγωγη κληρονομικου αγγειοοιδηματος (ηαε)
CL2008001124A1 (es) Formulacion farmaceutica que comprende al menos un derivado de acido lipoico y un reactivo formador de par ionico, util en el tratamiento del cancer.
MX2015015239A (es) Composiciones y metodos.
ECSP10010527A (es) Terapia de combinacion con antagonistas de c-met y egfr
AU319022S (en) Embossed absorbent article
AR095072A1 (es) Conjugados antibióticos
PA8604401A1 (es) Productos aril-heteroaromaticos, composiciones que los contienen y su utilizacion.
TR201902884T4 (tr) Mmp akti̇f vasküler bozucu ajanlar.
PA8624401A1 (es) Procesos para la preparacion de haluros de aril- y heteroaril-alquilsulfonilo
AR105177A2 (es) Forma cristalina de ácido 8-ciano-1-ciclopropil-7-(1s,6s-2,8-diazabiciclo-(4.3.0)nonan-8-il)-6-flúor-1,4-dihidro-4-oxo-3-quinolincarboxílico
CY1114056T1 (el) Εγγραφο ασφαλειας και/ή αξιας με ενα συστημα επαφης ημιαγωγων τυπου ιι
BR112016006348A2 (pt) tripeptídeos anti-inflamatórios
BR112018001200A2 (pt) sistemas de poliolefina retardantes de chamas