CY1111819T1 - Αντισωμα εναντι epcam και χρησεις αυτου - Google Patents

Αντισωμα εναντι epcam και χρησεις αυτου

Info

Publication number
CY1111819T1
CY1111819T1 CY20111100854T CY111100854T CY1111819T1 CY 1111819 T1 CY1111819 T1 CY 1111819T1 CY 20111100854 T CY20111100854 T CY 20111100854T CY 111100854 T CY111100854 T CY 111100854T CY 1111819 T1 CY1111819 T1 CY 1111819T1
Authority
CY
Cyprus
Prior art keywords
epcam antibody
mouse
entitled
therapeutic
high affinity
Prior art date
Application number
CY20111100854T
Other languages
English (en)
Inventor
Anna Maria Anastasi
Fiorella Petronzelli
Santis Rita De
Saverio Alberti
Original Assignee
Sigma-Tau Industrie Farmaceutiche Riunite S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. filed Critical Sigma-Tau Industrie Farmaceutiche Riunite S.P.A.
Publication of CY1111819T1 publication Critical patent/CY1111819T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77—Internalization into the cell

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Ένα πρωτότυπο αντίσωμα έναντι EpCAM, με τίτλο ST3232/10, ποντικίσιας προέλευσης παρουσιάζει ιδιότητες κατάλληλες τόσο για θεραπευτικές όσο και για διαγνωστικές εφαρμογές. Αυτό παρουσιάζει υψηλή συγγένεια για το φυσικό αντιγόνο και καλή επιλεκτικότητα όγκων.
CY20111100854T 2007-04-04 2011-09-06 Αντισωμα εναντι epcam και χρησεις αυτου CY1111819T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07105628 2007-04-04
EP08759374A EP2142570B1 (en) 2007-04-04 2008-04-02 Anti-epcam antibody and uses thereof

Publications (1)

Publication Number Publication Date
CY1111819T1 true CY1111819T1 (el) 2015-10-07

Family

ID=38458122

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20111100854T CY1111819T1 (el) 2007-04-04 2011-09-06 Αντισωμα εναντι epcam και χρησεις αυτου

Country Status (21)

Country Link
US (1) US8318911B2 (el)
EP (1) EP2142570B1 (el)
JP (1) JP5631733B2 (el)
KR (1) KR101683884B1 (el)
CN (1) CN101970497B (el)
AT (1) ATE512988T1 (el)
AU (1) AU2008235566B2 (el)
BR (1) BRPI0810096A8 (el)
CA (1) CA2682296C (el)
CY (1) CY1111819T1 (el)
DK (1) DK2142570T3 (el)
EA (1) EA023679B1 (el)
ES (1) ES2367675T3 (el)
HR (1) HRP20110620T1 (el)
IL (1) IL201196A0 (el)
MX (1) MX2009010444A (el)
PL (1) PL2142570T3 (el)
PT (1) PT2142570E (el)
RS (1) RS52040B (el)
SI (1) SI2142570T1 (el)
WO (1) WO2008122551A2 (el)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1585974B1 (en) 2003-01-24 2013-02-27 University of Utah Methods of predicting mortality risk by determining telomere length
CN102439171B (zh) 2008-12-22 2017-07-14 犹他大学研究基金会 单色多重定量pcr
GB0909904D0 (en) * 2009-06-09 2009-07-22 Affitech As Product
EP3138581B1 (en) 2011-03-17 2019-01-02 The University of Birmingham Re-directed immunotherapy
CN110763842A (zh) 2011-06-29 2020-02-07 中央研究院 使用表面涂层对生物物质的捕获、纯化和释放
EP2819695B1 (en) * 2012-03-02 2018-06-27 Academia Sinica ANTI-EPITHELIAL CELL ADHESION MOLECULE (EpCAM) ANTIBODIES AND METHODS OF USE THEREOF
US9494500B2 (en) 2012-10-29 2016-11-15 Academia Sinica Collection and concentration system for biologic substance of interest and use thereof
ES2762860T3 (es) 2013-05-22 2020-05-26 Telomere Diagnostics Inc Medidas de abundancia de telómeros cortos
TW201623605A (zh) 2014-04-01 2016-07-01 中央研究院 用於癌症診斷及預後之方法及系統
EP2998026B1 (en) 2014-08-26 2024-01-17 Academia Sinica Collector architecture layout design
BR112017014116A2 (pt) 2014-12-30 2018-03-06 Telomere Diagnostics Inc pcr quantitativo multiplex
US11098131B2 (en) 2015-07-31 2021-08-24 Sutro Biopharma, Inc. Anti-EpCAM antibodies, compositions comprising anti-EpCAM antibodies and methods of making and using anti-EpCAM antibodies
US10107726B2 (en) 2016-03-16 2018-10-23 Cellmax, Ltd. Collection of suspended cells using a transferable membrane
US11046782B2 (en) 2016-03-30 2021-06-29 Musc Foundation For Research Development Methods for treatment and diagnosis of cancer by targeting glycoprotein A repetitions predominant (GARP) and for providing effective immunotherapy alone or in combination
JP2019530431A (ja) 2016-07-26 2019-10-24 テッサ・セラピューティクス・プライベート・リミテッド キメラ抗原受容体
WO2020018964A1 (en) 2018-07-20 2020-01-23 Fred Hutchinson Cancer Research Center Compositions and methods for controlled expression of antigen-specific receptors
EP3897851A2 (en) 2018-12-17 2021-10-27 Revitope Limited Twin immune cell engager
TW202039582A (zh) * 2019-04-22 2020-11-01 大陸商江蘇恆瑞醫藥股份有限公司 抗ＥｐＣＡＭ抗體及其應用
EP3983446A4 (en) * 2019-06-11 2023-04-19 BioAtla, Inc. CONDITIONALLY ACTIVE ANTI-EPCAM ANTIBODIES, ANTIBODY FRAGMENTS, THEIR IMMUNOCONJUGATES AND THEIR USE
CN110950959B (zh) * 2020-02-25 2020-07-03 和铂医药(上海)有限责任公司 靶向EpCAM的抗体及其制备和应用
CN112094350B (zh) * 2020-06-01 2024-01-05 普众发现医药科技(上海)有限公司 可应用于肿瘤细胞捕获的小鼠抗细胞表面糖蛋白cd326的单克隆抗体

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4675187A (en) 1983-05-16 1987-06-23 Bristol-Myers Company BBM-1675, a new antibiotic complex
US5525338A (en) 1992-08-21 1996-06-11 Immunomedics, Inc. Detection and therapy of lesions with biotin/avidin conjugates
IT1245748B (it) 1990-12-21 1994-10-14 Mini Ricerca Scient Tecnolog Preparazione includente anticorpi monoclonali biotinilati, avidina e biotina, per la diagnosi di affezioni tumorali e suo impiego
US5578287A (en) 1992-06-09 1996-11-26 Neorx Corporation Three-step pretargeting methods using improved biotin-active agent
JP3427871B2 (ja) 1996-06-24 2003-07-22 戸田工業株式会社 コバルト被着型針状磁性酸化鉄粒子粉末
ITRM20010079A1 (it) 2001-02-16 2002-08-16 Sigma Tau Ind Farmaceuti Amminoderivati della biotina e loro coniugati con chelanti macrociclici.
US20050180979A1 (en) * 2004-02-13 2005-08-18 Micromet Ag Anti-EpCAM immunoglobulins
US7435804B2 (en) * 2004-10-19 2008-10-14 Phage Biotechnology, Inc. Method for obtaining single chain antibodies to human interferon α2b

Also Published As

Publication number Publication date
US20100092491A1 (en) 2010-04-15
AU2008235566A1 (en) 2008-10-16
EA200970923A1 (ru) 2010-04-30
PT2142570E (pt) 2011-09-13
CN101970497B (zh) 2017-05-10
WO2008122551A2 (en) 2008-10-16
MX2009010444A (es) 2009-10-20
EP2142570A2 (en) 2010-01-13
CA2682296A1 (en) 2008-10-16
IL201196A0 (en) 2010-05-17
KR20100016237A (ko) 2010-02-12
HRP20110620T1 (hr) 2011-09-30
ES2367675T3 (es) 2011-11-07
RS52040B (en) 2012-04-30
JP2010523096A (ja) 2010-07-15
SI2142570T1 (sl) 2012-01-31
KR101683884B1 (ko) 2016-12-07
DK2142570T3 (da) 2011-10-03
WO2008122551A3 (en) 2008-12-04
JP5631733B2 (ja) 2014-11-26
PL2142570T3 (pl) 2011-11-30
EP2142570B1 (en) 2011-06-15
ATE512988T1 (de) 2011-07-15
CA2682296C (en) 2017-02-28
EA023679B1 (ru) 2016-06-30
WO2008122551A9 (en) 2009-02-05
US8318911B2 (en) 2012-11-27
CN101970497A (zh) 2011-02-09
AU2008235566B2 (en) 2013-06-06
BRPI0810096A2 (pt) 2014-10-21
BRPI0810096A8 (pt) 2017-12-26

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