EA200970923A1 - АНТИ-EpСАМ АНТИТЕЛО И ЕГО ПРИМЕНЕНИЕ - Google Patents

АНТИ-EpСАМ АНТИТЕЛО И ЕГО ПРИМЕНЕНИЕ

Info

Publication number
EA200970923A1
EA200970923A1 EA200970923A EA200970923A EA200970923A1 EA 200970923 A1 EA200970923 A1 EA 200970923A1 EA 200970923 A EA200970923 A EA 200970923A EA 200970923 A EA200970923 A EA 200970923A EA 200970923 A1 EA200970923 A1 EA 200970923A1
Authority
EA
Eurasian Patent Office
Prior art keywords
antibody
epsam
application
therapeutic
designated
Prior art date
Application number
EA200970923A
Other languages
English (en)
Other versions
EA023679B1 (ru
Inventor
Анна Мария Анастаси
Фиорелла Петронцелли
Рита Де Сантис
Саверио Альберти
Original Assignee
Сигма-Тау Индустрие Фармасьютике Риуните С.П.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Сигма-Тау Индустрие Фармасьютике Риуните С.П.А. filed Critical Сигма-Тау Индустрие Фармасьютике Риуните С.П.А.
Publication of EA200970923A1 publication Critical patent/EA200970923A1/ru
Publication of EA023679B1 publication Critical patent/EA023679B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77—Internalization into the cell

Abstract

Описывается анти-ЕрСАМ антитело, обозначенное как ST3232/10, мышиного происхождения, которое демонстрирует свойства, подходящие для терапевтического и диагностического применения. Указанное антитело демонстрирует высокую аффинность для нативного антигена и хорошую опухолевую специфичность.
EA200970923A 2007-04-04 2008-04-02 АНТИ-EpCAM АНТИТЕЛО И ЕГО ПРИМЕНЕНИЕ EA023679B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07105628 2007-04-04
PCT/EP2008/053913 WO2008122551A2 (en) 2007-04-04 2008-04-02 Anti-epcam antibody and uses thereof

Publications (2)

Publication Number Publication Date
EA200970923A1 true EA200970923A1 (ru) 2010-04-30
EA023679B1 EA023679B1 (ru) 2016-06-30

Family

ID=38458122

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200970923A EA023679B1 (ru) 2007-04-04 2008-04-02 АНТИ-EpCAM АНТИТЕЛО И ЕГО ПРИМЕНЕНИЕ

Country Status (21)

Country Link
US (1) US8318911B2 (ru)
EP (1) EP2142570B1 (ru)
JP (1) JP5631733B2 (ru)
KR (1) KR101683884B1 (ru)
CN (1) CN101970497B (ru)
AT (1) ATE512988T1 (ru)
AU (1) AU2008235566B2 (ru)
BR (1) BRPI0810096A8 (ru)
CA (1) CA2682296C (ru)
CY (1) CY1111819T1 (ru)
DK (1) DK2142570T3 (ru)
EA (1) EA023679B1 (ru)
ES (1) ES2367675T3 (ru)
HR (1) HRP20110620T1 (ru)
IL (1) IL201196A0 (ru)
MX (1) MX2009010444A (ru)
PL (1) PL2142570T3 (ru)
PT (1) PT2142570E (ru)
RS (1) RS52040B (ru)
SI (1) SI2142570T1 (ru)
WO (1) WO2008122551A2 (ru)

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US9169516B2 (en) 2003-01-24 2015-10-27 University Of Utah Research Foundation Methods of predicting mortality risk by determining telomere length
JP5840950B2 (ja) 2008-12-22 2016-01-06 ユニバーシティ・オブ・ユタ・リサーチ・ファウンデイション 単色マルチプレックス定量ｐｃｒ
GB0909904D0 (en) * 2009-06-09 2009-07-22 Affitech As Product
CN103561771B (zh) 2011-03-17 2019-01-04 伯明翰大学 重新定向的免疫治疗
CN107315086B (zh) * 2011-06-29 2019-09-10 中央研究院 使用表面涂层对生物物质的捕获、纯化和释放
EP2819695B1 (en) * 2012-03-02 2018-06-27 Academia Sinica ANTI-EPITHELIAL CELL ADHESION MOLECULE (EpCAM) ANTIBODIES AND METHODS OF USE THEREOF
US9494500B2 (en) 2012-10-29 2016-11-15 Academia Sinica Collection and concentration system for biologic substance of interest and use thereof
JP6546158B2 (ja) 2013-05-22 2019-07-17 テロメア ダイアグノスティクス インコーポレイテッド 短いテロメアの存在量の測定
EP3126814B1 (en) 2014-04-01 2019-06-12 Academia Sinica Methods and systems for cancer diagnosis and prognosis
EP2998026B1 (en) 2014-08-26 2024-01-17 Academia Sinica Collector architecture layout design
AU2015372584A1 (en) 2014-12-30 2017-06-29 Telomere Diagnostics, Inc. Multiplex quantitative PCR
EP3328897A1 (en) 2015-07-31 2018-06-06 Sutro Biopharma, Inc. ANTI-EpCAM ANTIBODIES, COMPOSITIONS COMPRISING ANTI-EpCAM ANTIBODIES AND METHODS OF MAKING AND USING ANTI-EPCAM ANTIBODIES
US10107726B2 (en) 2016-03-16 2018-10-23 Cellmax, Ltd. Collection of suspended cells using a transferable membrane
WO2017173091A1 (en) * 2016-03-30 2017-10-05 Musc Foundation For Research Development Methods for treatment and diagnosis of cancer by targeting glycoprotein a repetitions predominant (garp) and for providing effective immunotherapy alone or in combination
AU2017301826A1 (en) 2016-07-26 2019-03-14 Tessa Therapeutics Ltd. Chimeric antigen receptor
WO2020018964A1 (en) 2018-07-20 2020-01-23 Fred Hutchinson Cancer Research Center Compositions and methods for controlled expression of antigen-specific receptors
JP2022514262A (ja) 2018-12-17 2022-02-10 レビトープ リミテッド 双子型免疫細胞エンゲージャー
WO2020216210A1 (zh) * 2019-04-22 2020-10-29 江苏恒瑞医药股份有限公司 抗EpCAM抗体及其应用
US11851499B2 (en) 2019-06-11 2023-12-26 Bioatla, Inc. Conditionally active anti-EpCAM antibodies, antibody fragments, their immunoconjugates and uses thereof
CN110950959B (zh) * 2020-02-25 2020-07-03 和铂医药(上海)有限责任公司 靶向EpCAM的抗体及其制备和应用
CN112094350B (zh) * 2020-06-01 2024-01-05 普众发现医药科技(上海)有限公司 可应用于肿瘤细胞捕获的小鼠抗细胞表面糖蛋白cd326的单克隆抗体

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4675187A (en) 1983-05-16 1987-06-23 Bristol-Myers Company BBM-1675, a new antibiotic complex
US5525338A (en) 1992-08-21 1996-06-11 Immunomedics, Inc. Detection and therapy of lesions with biotin/avidin conjugates
IT1245748B (it) 1990-12-21 1994-10-14 Mini Ricerca Scient Tecnolog Preparazione includente anticorpi monoclonali biotinilati, avidina e biotina, per la diagnosi di affezioni tumorali e suo impiego
US5578287A (en) * 1992-06-09 1996-11-26 Neorx Corporation Three-step pretargeting methods using improved biotin-active agent
JP3427871B2 (ja) * 1996-06-24 2003-07-22 戸田工業株式会社 コバルト被着型針状磁性酸化鉄粒子粉末
ITRM20010079A1 (it) 2001-02-16 2002-08-16 Sigma Tau Ind Farmaceuti Amminoderivati della biotina e loro coniugati con chelanti macrociclici.
US20050180979A1 (en) * 2004-02-13 2005-08-18 Micromet Ag Anti-EpCAM immunoglobulins
US7435804B2 (en) * 2004-10-19 2008-10-14 Phage Biotechnology, Inc. Method for obtaining single chain antibodies to human interferon α2b

Also Published As

Publication number Publication date
US8318911B2 (en) 2012-11-27
AU2008235566A1 (en) 2008-10-16
SI2142570T1 (sl) 2012-01-31
ATE512988T1 (de) 2011-07-15
MX2009010444A (es) 2009-10-20
JP5631733B2 (ja) 2014-11-26
RS52040B (en) 2012-04-30
CY1111819T1 (el) 2015-10-07
EP2142570A2 (en) 2010-01-13
KR101683884B1 (ko) 2016-12-07
CN101970497B (zh) 2017-05-10
US20100092491A1 (en) 2010-04-15
CA2682296A1 (en) 2008-10-16
HRP20110620T1 (hr) 2011-09-30
WO2008122551A3 (en) 2008-12-04
BRPI0810096A8 (pt) 2017-12-26
WO2008122551A2 (en) 2008-10-16
CA2682296C (en) 2017-02-28
ES2367675T3 (es) 2011-11-07
CN101970497A (zh) 2011-02-09
IL201196A0 (en) 2010-05-17
EP2142570B1 (en) 2011-06-15
PL2142570T3 (pl) 2011-11-30
PT2142570E (pt) 2011-09-13
JP2010523096A (ja) 2010-07-15
EA023679B1 (ru) 2016-06-30
BRPI0810096A2 (pt) 2014-10-21
KR20100016237A (ko) 2010-02-12
AU2008235566B2 (en) 2013-06-06
DK2142570T3 (da) 2011-10-03
WO2008122551A9 (en) 2009-02-05

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): TJ

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TM RU