CY1111241T1 - Μεθοδος μειωσης α,β-ακορεστων κετονων σε οπιοεiδεις συνθεσεις - Google Patents
Μεθοδος μειωσης α,β-ακορεστων κετονων σε οπιοεiδεις συνθεσειςInfo
- Publication number
- CY1111241T1 CY1111241T1 CY20111100129T CY111100129T CY1111241T1 CY 1111241 T1 CY1111241 T1 CY 1111241T1 CY 20111100129 T CY20111100129 T CY 20111100129T CY 111100129 T CY111100129 T CY 111100129T CY 1111241 T1 CY1111241 T1 CY 1111241T1
- Authority
- CY
- Cyprus
- Prior art keywords
- reducing
- composition
- uncontinued
- cetones
- diimide
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Rheumatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Η παρούσα εφεύρεση απευθύνεται σε μία διεργασία για τη μείωση του επιπέδου α,β-ακόρεστης κετόνης σε μία οπιοειδή αναλγητική σύνθεση με υδρογόνωση με διιμίδιο ή πρόγονο διιμιδίου.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US65879105P | 2005-03-04 | 2005-03-04 | |
EP09158939A EP2112153B1 (en) | 2005-03-04 | 2006-02-27 | Method of reducing alpha, beta- unsaturated ketones in opioid compositions |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1111241T1 true CY1111241T1 (el) | 2015-06-11 |
Family
ID=36301669
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20091100790T CY1109262T1 (el) | 2005-03-04 | 2009-07-23 | Μεθοδος μειωσης α,β-ακορεστων κετονων σε οπιοειδεις συνθεσεις |
CY20111100129T CY1111241T1 (el) | 2005-03-04 | 2011-02-03 | Μεθοδος μειωσης α,β-ακορεστων κετονων σε οπιοεiδεις συνθεσεις |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20091100790T CY1109262T1 (el) | 2005-03-04 | 2009-07-23 | Μεθοδος μειωσης α,β-ακορεστων κετονων σε οπιοειδεις συνθεσεις |
Country Status (19)
Country | Link |
---|---|
US (1) | US7939543B2 (el) |
EP (2) | EP2112153B1 (el) |
JP (1) | JP5314894B2 (el) |
KR (1) | KR100941761B1 (el) |
CN (1) | CN101133062B (el) |
AT (2) | ATE487722T1 (el) |
CA (1) | CA2598774C (el) |
CY (2) | CY1109262T1 (el) |
DE (2) | DE602006006558D1 (el) |
DK (2) | DK2112153T3 (el) |
ES (2) | ES2355870T3 (el) |
HK (2) | HK1111695A1 (el) |
HR (2) | HRP20090387T1 (el) |
ME (2) | ME01184B (el) |
PL (2) | PL1861405T3 (el) |
PT (2) | PT2112153E (el) |
RS (2) | RS51131B (el) |
SI (2) | SI1861405T1 (el) |
WO (1) | WO2006094672A1 (el) |
Families Citing this family (50)
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US7776314B2 (en) | 2002-06-17 | 2010-08-17 | Grunenthal Gmbh | Abuse-proofed dosage system |
ES2289542T3 (es) * | 2003-08-06 | 2008-02-01 | Grunenthal Gmbh | Forma farmaceutica protegida contra un posible abuso. |
DE102005005446A1 (de) | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Bruchfeste Darreichungsformen mit retardierter Freisetzung |
US20070048228A1 (en) * | 2003-08-06 | 2007-03-01 | Elisabeth Arkenau-Maric | Abuse-proofed dosage form |
DE10336400A1 (de) | 2003-08-06 | 2005-03-24 | Grünenthal GmbH | Gegen Missbrauch gesicherte Darreichungsform |
DE10361596A1 (de) | 2003-12-24 | 2005-09-29 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform |
US8075872B2 (en) | 2003-08-06 | 2011-12-13 | Gruenenthal Gmbh | Abuse-proofed dosage form |
TWI365880B (en) | 2004-03-30 | 2012-06-11 | Euro Celtique Sa | Process for preparing oxycodone hydrochloride having less than 25 ppm 14-hydroxycodeinone and oxycodone hydrochloride composition,pharmaceutical dosage form,sustained release oeal dosage form and pharmaceutically acceptable package having less than 25 pp |
DE102004032049A1 (de) | 2004-07-01 | 2006-01-19 | Grünenthal GmbH | Gegen Missbrauch gesicherte, orale Darreichungsform |
DE102005005449A1 (de) | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform |
MX2008010921A (es) * | 2006-03-02 | 2008-09-03 | Mallinckrodt Inc | Procesos para preparar productos de morfinan-6-ona con bajos niveles de compuestos de cetona alfa, beta-insaturados. |
CN104761561A (zh) * | 2006-12-04 | 2015-07-08 | 诺拉姆科有限公司 | 减少羟考酮碱中杂质的方法 |
WO2008070658A1 (en) | 2006-12-04 | 2008-06-12 | Noramco, Inc. | Process for preparing oxycodone having reduced levels of 14-hydroxycodeinone |
DE102007011485A1 (de) | 2007-03-07 | 2008-09-11 | Grünenthal GmbH | Darreichungsform mit erschwertem Missbrauch |
JP5373764B2 (ja) | 2007-04-16 | 2013-12-18 | マリンクロッド エルエルシー | 触媒性水素転移反応を使用する新規なオピエート還元 |
FR2923484B1 (fr) * | 2007-11-09 | 2012-11-09 | Sanofi Aventis | Procede de preparation de composes morphiniques |
US8383152B2 (en) | 2008-01-25 | 2013-02-26 | Gruenenthal Gmbh | Pharmaceutical dosage form |
CN102105136B (zh) * | 2008-03-11 | 2014-11-26 | 蒂宝制药公司 | 包含非-阿片类止痛剂和阿片类止痛剂的组合的胃滞留型缓释剂型 |
US8372432B2 (en) * | 2008-03-11 | 2013-02-12 | Depomed, Inc. | Gastric retentive extended-release dosage forms comprising combinations of a non-opioid analgesic and an opioid analgesic |
SI2273983T1 (sl) | 2008-05-09 | 2016-11-30 | Gruenenthal Gmbh | Postopek za pripravo intermediatne praškaste formulacije in končne trdne odmerne oblike z uporabo stopnje strjevanja z razprševanjem |
AU2010275755B2 (en) * | 2009-07-22 | 2014-04-24 | Grünenthal GmbH | Oxidation-stabilized tamper-resistant dosage form |
TW201105316A (en) * | 2009-07-22 | 2011-02-16 | Gruenenthal Gmbh | Hot-melt extruded pharmaceutical dosage form |
CN102596252A (zh) * | 2009-08-31 | 2012-07-18 | 蒂宝制药公司 | 用于对乙酰氨基酚的立即和延长释放的胃滞留药物组合物 |
US9198861B2 (en) | 2009-12-22 | 2015-12-01 | Mallinckrodt Llc | Methods of producing stabilized solid dosage pharmaceutical compositions containing morphinans |
US8597681B2 (en) | 2009-12-22 | 2013-12-03 | Mallinckrodt Llc | Methods of producing stabilized solid dosage pharmaceutical compositions containing morphinans |
EP2377866B1 (en) | 2010-03-23 | 2014-02-26 | Siegfried AG | Preparation of low impurity opiates in a continuous flow reactor |
EP2580218B1 (en) | 2010-06-11 | 2015-02-25 | Rhodes Technologies | Process for n-dealkylation of tertiary amines |
ES2666404T3 (es) | 2010-06-11 | 2018-05-04 | Rhodes Technologies | Procesos catalizados por metales de transición para la preparación de compuestos de N-alilo y uso de los mismos |
CN103179954A (zh) | 2010-09-02 | 2013-06-26 | 格吕伦塔尔有限公司 | 包含阴离子聚合物的抗破碎剂型 |
MX2013002377A (es) | 2010-09-02 | 2013-04-29 | Gruenenthal Gmbh | Forma de dosificacion resistente a manipulacion que comprende una sal inorganica. |
US8858963B1 (en) | 2011-05-17 | 2014-10-14 | Mallinckrodt Llc | Tamper resistant composition comprising hydrocodone and acetaminophen for rapid onset and extended duration of analgesia |
US9050335B1 (en) | 2011-05-17 | 2015-06-09 | Mallinckrodt Llc | Pharmaceutical compositions for extended release of oxycodone and acetaminophen resulting in a quick onset and prolonged period of analgesia |
US8741885B1 (en) | 2011-05-17 | 2014-06-03 | Mallinckrodt Llc | Gastric retentive extended release pharmaceutical compositions |
RS56527B1 (sr) | 2011-07-29 | 2018-02-28 | Gruenenthal Gmbh | Tableta za trenutno oslobađanje leka rezistentna na zloupotrebu |
US10201502B2 (en) | 2011-07-29 | 2019-02-12 | Gruenenthal Gmbh | Tamper-resistant tablet providing immediate drug release |
MX356421B (es) | 2012-02-28 | 2018-05-29 | Gruenenthal Gmbh | Forma de dosificacion resistente a la manipulacion indebida que comprende un compuesto farmacologicamente activo y un polimero anionico. |
EA201401139A1 (ru) | 2012-04-18 | 2015-03-31 | Грюненталь Гмбх | Устойчивая к разрушению и к сбросу дозы фармацевтическая лекарственная форма |
US10064945B2 (en) | 2012-05-11 | 2018-09-04 | Gruenenthal Gmbh | Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc |
EP2970320B1 (en) * | 2013-03-15 | 2020-10-28 | Johnson Matthey Public Limited Company | Morphine sulfate methanolic solvate, processes for making same and related compositions and methods for treating pain |
CA2913209A1 (en) | 2013-05-29 | 2014-12-04 | Grunenthal Gmbh | Tamper resistant dosage form with bimodal release profile |
CA2917136C (en) | 2013-07-12 | 2022-05-31 | Grunenthal Gmbh | Tamper-resistant dosage form containing ethylene-vinyl acetate polymer |
WO2015078891A1 (en) | 2013-11-26 | 2015-06-04 | Farmaceutici Formenti S.P.A. | Preparation of a powdery pharmaceutical composition by means of cryo-milling |
US9062062B1 (en) | 2013-12-18 | 2015-06-23 | Cody Laboratories, Inc. | Synthesis of oxycodone hydrochloride |
US10227354B2 (en) | 2013-12-18 | 2019-03-12 | Cody Laboratories, Inc. | Conversion of oxycodone base to oxycodone hydrochloride |
US8846923B1 (en) | 2013-12-18 | 2014-09-30 | Cody Laboratories, Inc. | Preparation of 14-hydroxycodeinone sulfate |
WO2015173195A1 (en) | 2014-05-12 | 2015-11-19 | Grünenthal GmbH | Tamper resistant immediate release capsule formulation comprising tapentadol |
MX2016015417A (es) | 2014-05-26 | 2017-02-22 | Gruenenthal Gmbh | Multiparticulas protegidas contra vertido de dosis etanolico. |
US20170342084A1 (en) | 2014-07-09 | 2017-11-30 | Rhodes Technologies | Reduction of alpha, beta-unsaturated ketone levels in morphinan derivative compositions |
EP3285745A1 (en) | 2015-04-24 | 2018-02-28 | Grünenthal GmbH | Tamper-resistant dosage form with immediate release and resistance against solvent extraction |
JP2018526414A (ja) | 2015-09-10 | 2018-09-13 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | 乱用抑止性の即放性製剤を用いた経口過剰摂取に対する保護 |
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TWI365880B (en) * | 2004-03-30 | 2012-06-11 | Euro Celtique Sa | Process for preparing oxycodone hydrochloride having less than 25 ppm 14-hydroxycodeinone and oxycodone hydrochloride composition,pharmaceutical dosage form,sustained release oeal dosage form and pharmaceutically acceptable package having less than 25 pp |
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2006
- 2006-02-27 AT AT09158939T patent/ATE487722T1/de active
- 2006-02-27 SI SI200630344T patent/SI1861405T1/sl unknown
- 2006-02-27 EP EP09158939A patent/EP2112153B1/en active Active
- 2006-02-27 PL PL06707309T patent/PL1861405T3/pl unknown
- 2006-02-27 KR KR1020077022566A patent/KR100941761B1/ko active IP Right Grant
- 2006-02-27 RS RSP-2009/0347A patent/RS51131B/sr unknown
- 2006-02-27 DE DE602006006558T patent/DE602006006558D1/de active Active
- 2006-02-27 CN CN200680006690.5A patent/CN101133062B/zh active Active
- 2006-02-27 EP EP06707309A patent/EP1861405B1/en active Active
- 2006-02-27 DE DE602006018208T patent/DE602006018208D1/de active Active
- 2006-02-27 CA CA2598774A patent/CA2598774C/en active Active
- 2006-02-27 WO PCT/EP2006/001798 patent/WO2006094672A1/en active Application Filing
- 2006-02-27 US US11/885,402 patent/US7939543B2/en active Active
- 2006-02-27 ME MEP-2009-248A patent/ME01184B/me unknown
- 2006-02-27 SI SI200630885T patent/SI2112153T1/sl unknown
- 2006-02-27 RS RS20110031A patent/RS51568B/en unknown
- 2006-02-27 ES ES09158939T patent/ES2355870T3/es active Active
- 2006-02-27 AT AT06707309T patent/ATE430153T1/de active
- 2006-02-27 ES ES06707309T patent/ES2326491T3/es active Active
- 2006-02-27 JP JP2007557403A patent/JP5314894B2/ja active Active
- 2006-02-27 DK DK09158939.0T patent/DK2112153T3/da active
- 2006-02-27 DK DK06707309T patent/DK1861405T3/da active
- 2006-02-27 PT PT09158939T patent/PT2112153E/pt unknown
- 2006-02-27 PT PT06707309T patent/PT1861405E/pt unknown
- 2006-02-27 PL PL09158939T patent/PL2112153T3/pl unknown
- 2006-02-27 ME MEP-2011-17A patent/ME01594B/me unknown
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2008
- 2008-03-06 HK HK08102671.4A patent/HK1111695A1/xx unknown
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2009
- 2009-07-07 HR HR20090387T patent/HRP20090387T1/xx unknown
- 2009-07-23 CY CY20091100790T patent/CY1109262T1/el unknown
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2010
- 2010-04-13 HK HK10103566.6A patent/HK1135107A1/xx unknown
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2011
- 2011-02-01 HR HR20110078T patent/HRP20110078T1/hr unknown
- 2011-02-03 CY CY20111100129T patent/CY1111241T1/el unknown
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