CY1109678T1 - Νεα παραγωγα 3-φαινυλπροπιονικου οξεος και χρηση αυτων ως συνδετηρες του υποδοχεα ppar-γαμμα - Google Patents
Νεα παραγωγα 3-φαινυλπροπιονικου οξεος και χρηση αυτων ως συνδετηρες του υποδοχεα ppar-γαμμαInfo
- Publication number
- CY1109678T1 CY1109678T1 CY20091101346T CY091101346T CY1109678T1 CY 1109678 T1 CY1109678 T1 CY 1109678T1 CY 20091101346 T CY20091101346 T CY 20091101346T CY 091101346 T CY091101346 T CY 091101346T CY 1109678 T1 CY1109678 T1 CY 1109678T1
- Authority
- CY
- Cyprus
- Prior art keywords
- alkyl
- ppar
- aryl
- formula
- phynylpropynic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
- C07D263/24—Oxygen atoms attached in position 2 with hydrocarbon radicals, substituted by oxygen atoms, attached to other ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/421—1,3-Oxazoles, e.g. pemoline, trimethadione
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/84—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/36—One oxygen atom
- C07D263/38—One oxygen atom attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
- Child & Adolescent Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
- Psychiatry (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Η εφεύρεση αφορά νέες ενώσεις που είναι παράγωγα 3-φαινυλπροπιονικού οξέος του τύπου I όπου το W αντιπροσωπεύει COOH ομάδα ή βιοϊσοστερή αυτών ή -CΟΟ-C1-C4-αλκύλ ομάδα, το Υ αντιπροσωπεύει ΝΗ, N-C1-C10-αλκύλ, Ο ή S, το Ζ αντιπροσωπεύει N-C1-C10-αλκύλ, Ν-αρύλ, Ν-ετεροαρύλ, S ή Ο, το Χ αντιπροσωπεύει Ο, S, N-C1-C10-αλκύλ, Ν-αρύλ, NSO2 C1-C10-αλκύλ, N-SO2-αρύλ ή Ν-SO2-ετεροραύλ, τα R1 έως R6 έκαστο ανεξαρτήτως αντιπροσωπεύει άτομο υδρογόνου ή έναν υποκατάστατη που ορίζεται στην περιγραφή, το Α είναι όπως ορίζεται στην περιγραφή, το n αντιπροσωπεύει ακέραιο από 0 έως 4, συμπεριλαμβανομένου και φαρμακευτικώς αποδεκτά άλατα αυτών. Οι ενώσεις είναι οι συνδετήρες του PPAR-γάμμα υποδοχέα και είναι χρήσιμες ως φάρμακα.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL372332A PL372332A1 (pl) | 2005-01-19 | 2005-01-19 | Nowe związki, pochodne kwasu 3-fenylopropionowego |
| EP06703590A EP1874745B1 (en) | 2005-01-19 | 2006-01-17 | New 3-phenylpropionic acid derivatives and their use as ppar- gamma receptor ligands |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1109678T1 true CY1109678T1 (el) | 2014-08-13 |
Family
ID=36046977
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20091101346T CY1109678T1 (el) | 2005-01-19 | 2009-12-30 | Νεα παραγωγα 3-φαινυλπροπιονικου οξεος και χρηση αυτων ως συνδετηρες του υποδοχεα ppar-γαμμα |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US7309791B2 (el) |
| EP (1) | EP1874745B1 (el) |
| JP (1) | JP2008527021A (el) |
| KR (1) | KR100889447B1 (el) |
| CN (1) | CN101098862A (el) |
| AT (1) | ATE448214T1 (el) |
| AU (1) | AU2006207492B8 (el) |
| BR (1) | BRPI0606501A2 (el) |
| CA (1) | CA2590575C (el) |
| CY (1) | CY1109678T1 (el) |
| DE (1) | DE602006010353D1 (el) |
| DK (1) | DK1874745T3 (el) |
| ES (1) | ES2336358T3 (el) |
| HR (1) | HRP20090647T1 (el) |
| IL (1) | IL183564A0 (el) |
| MX (1) | MX2007008114A (el) |
| NO (1) | NO20074173L (el) |
| PL (2) | PL372332A1 (el) |
| PT (1) | PT1874745E (el) |
| RS (1) | RS51215B (el) |
| RU (1) | RU2369602C2 (el) |
| SI (1) | SI1874745T1 (el) |
| UA (1) | UA89940C2 (el) |
| WO (1) | WO2006077206A1 (el) |
| ZA (1) | ZA200705889B (el) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL371841A1 (pl) * | 2004-12-20 | 2006-06-26 | ADAMED Sp.z o.o. | Nowe związki pochodne kwasu 3-fenylopropionowego |
| EP1951692B1 (en) * | 2005-11-07 | 2010-08-18 | Irm Llc | Oxazole and thiazole ppar modulator |
| WO2009132310A1 (en) * | 2008-04-25 | 2009-10-29 | Wisconsin Alumni Research Foundation | Inhibitors of udp-galactopyranose mutase thwart mycobacterial growth |
| EP2380884B1 (en) * | 2008-12-01 | 2014-02-12 | Mitsubishi Tanabe Pharma Corporation | Carboxylic acid derivative containing thiazole ring and pharmaceutical use thereof |
| JP6663866B2 (ja) * | 2014-07-03 | 2020-03-13 | セルジーン クオンティセル リサーチ，インク． | リジン特異的なデメチラーゼ−１の阻害剤 |
| US10080757B2 (en) | 2016-03-11 | 2018-09-25 | Wisconsin Alumni Research Foundation | Inhibitors of UDP-galactopyranose mutase |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1552125A (en) | 1975-06-07 | 1979-09-05 | Lilly Industries Ltd | 2-acylamino oxazoles |
| JPS58125039A (ja) | 1982-01-21 | 1983-07-25 | Konishiroku Photo Ind Co Ltd | 写真用２当量イエロ−カプラ− |
| US5296486A (en) * | 1991-09-24 | 1994-03-22 | Boehringer Ingelheim Pharmaceuticals, Inc. | Leukotriene biosynthesis inhibitors |
| JPH07505647A (ja) | 1992-04-10 | 1995-06-22 | スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー | 複素環化合物および２型糖尿病の治療におけるそれらの使用 |
| WO1995025107A1 (en) | 1994-03-12 | 1995-09-21 | Yuhan Corporation | Triazole compounds and processes for the preparation thereof |
| GB9604242D0 (en) * | 1996-02-28 | 1996-05-01 | Glaxo Wellcome Inc | Chemical compounds |
| NZ503712A (en) | 1997-10-02 | 2003-07-25 | Sankyo Co | Amidopropionic acid derivatives |
| JP4618845B2 (ja) | 1999-06-09 | 2011-01-26 | 杏林製薬株式会社 | ヒトペルオキシゾーム増殖薬活性化受容体（ＰＰＡＲ）αアゴニストとしての置換フェニルプロピオン酸誘導体 |
| WO2001017994A1 (en) | 1999-09-08 | 2001-03-15 | Glaxo Group Limited | Oxazole ppar antagonists |
| FR2808798A1 (fr) * | 2000-05-09 | 2001-11-16 | Hoechst Marion Roussel Inc | Nouveaux derives antagonistes du recepteur de la vitronectine |
| EP1414806A1 (en) | 2001-07-30 | 2004-05-06 | Novo Nordisk A/S | Novel vinyl n-(2-benzoylphenyl)-l-tyrosine derivatives and their use as antidiabetics etc |
| JP2004536152A (ja) | 2001-07-30 | 2004-12-02 | ノボ ノルディスク アクティーゼルスカブ | 新規ビニルｎ−（２−ベンゾイルフェニル）−ｌ−チロシン誘導体及び抗糖尿病剤等へのそれらの使用 |
| PL371841A1 (pl) * | 2004-12-20 | 2006-06-26 | ADAMED Sp.z o.o. | Nowe związki pochodne kwasu 3-fenylopropionowego |
| PL372356A1 (pl) | 2005-01-20 | 2006-07-24 | ADAMED Sp.z o.o. | Nowe związki, pochodne kwasu 3-fenylopropionowego |
-
2005
- 2005-01-19 PL PL372332A patent/PL372332A1/pl unknown
-
2006
- 2006-01-12 US US11/332,709 patent/US7309791B2/en not_active Expired - Fee Related
- 2006-01-17 EP EP06703590A patent/EP1874745B1/en active Active
- 2006-01-17 AU AU2006207492A patent/AU2006207492B8/en not_active Ceased
- 2006-01-17 MX MX2007008114A patent/MX2007008114A/es active IP Right Grant
- 2006-01-17 KR KR1020077018743A patent/KR100889447B1/ko not_active IP Right Cessation
- 2006-01-17 DE DE602006010353T patent/DE602006010353D1/de active Active
- 2006-01-17 JP JP2007551662A patent/JP2008527021A/ja active Pending
- 2006-01-17 WO PCT/EP2006/050234 patent/WO2006077206A1/en active Application Filing
- 2006-01-17 CN CNA2006800017398A patent/CN101098862A/zh active Pending
- 2006-01-17 RU RU2007131423/04A patent/RU2369602C2/ru not_active IP Right Cessation
- 2006-01-17 PL PL06703590T patent/PL1874745T3/pl unknown
- 2006-01-17 BR BRPI0606501-5A patent/BRPI0606501A2/pt not_active IP Right Cessation
- 2006-01-17 ES ES06703590T patent/ES2336358T3/es active Active
- 2006-01-17 PT PT06703590T patent/PT1874745E/pt unknown
- 2006-01-17 CA CA2590575A patent/CA2590575C/en not_active Expired - Fee Related
- 2006-01-17 AT AT06703590T patent/ATE448214T1/de active
- 2006-01-17 UA UAA200709387A patent/UA89940C2/ru unknown
- 2006-01-17 RS RSP-2010/0003A patent/RS51215B/sr unknown
- 2006-01-17 SI SI200630532T patent/SI1874745T1/sl unknown
- 2006-01-17 DK DK06703590T patent/DK1874745T3/da active
-
2007
- 2007-03-06 US US11/714,984 patent/US7629370B2/en not_active Expired - Fee Related
- 2007-05-30 IL IL183564A patent/IL183564A0/en unknown
- 2007-07-18 ZA ZA200705889A patent/ZA200705889B/xx unknown
- 2007-08-14 NO NO20074173A patent/NO20074173L/no not_active Application Discontinuation
-
2009
- 2009-12-04 HR HR20090647T patent/HRP20090647T1/hr unknown
- 2009-12-30 CY CY20091101346T patent/CY1109678T1/el unknown
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