MXPA04009784A - Tiazolidin-4-carbonitrilos y analogos y su uso como inhibidores de dipeptidil-peptidas. - Google Patents

Tiazolidin-4-carbonitrilos y analogos y su uso como inhibidores de dipeptidil-peptidas.

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Publication number
MXPA04009784A
MXPA04009784A MXPA04009784A MXPA04009784A MXPA04009784A MX PA04009784 A MXPA04009784 A MX PA04009784A MX PA04009784 A MXPA04009784 A MX PA04009784A MX PA04009784 A MXPA04009784 A MX PA04009784A MX PA04009784 A MXPA04009784 A MX PA04009784A
Authority
MX
Mexico
Prior art keywords
compounds
discloses
pharmaceutically acceptable
peptidas
carbonitriles
Prior art date
Application number
MXPA04009784A
Other languages
English (en)
Inventor
Sankaranarayanan Alagundi
Original Assignee
Torrent Pharmaceuticlas Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Torrent Pharmaceuticlas Ltd filed Critical Torrent Pharmaceuticlas Ltd
Publication of MXPA04009784A publication Critical patent/MXPA04009784A/es

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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • A61P5/16—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4 for decreasing, blocking or antagonising the activity of the thyroid hormones
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    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D277/06—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Abstract

La invencion describe una serie novedosa de compuesto representada por la formula general (I), sus derivados, analogos, formas tautomericas, estereoisomeros, polimorfos, sales farmaceuticamente aceptables, solvatos en donde X, n, k, z, R1, R2, R3, R4, R5 y R6 son como se definieron en la especificacion que son utiles en (I) normalizacion de niveles de glucosa sanguinea elevados en la diabetes, (ii) tratamiento de padecimientos relacionados con la intolerancia a la glucosa y (iii) para barrido de radicales libres en mamiferos. La invencion describe tambien la composicion farmaceuticamente aceptable que comprende esos compuestos, el metodo para la preparacion de los compuestos como se definieron anteriormente y el metodo para tratar mamiferos incluyendo al ser humano por medio de la administracion de una cantidad efectiva de dichos compuestos a un sujeto que necesita de los mismos. La invencion describe ademas el uso de esos compuestos en la manufactura de un medicamento util para el tratamiento de diferentes condiciones de enfermedad como se establecio anteriormente.(ver formula I).
MXPA04009784A 2002-04-08 2003-04-03 Tiazolidin-4-carbonitrilos y analogos y su uso como inhibidores de dipeptidil-peptidas. MXPA04009784A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37022402P 2002-04-08 2002-04-08
PCT/IB2003/001330 WO2003084940A1 (en) 2002-04-08 2003-04-03 Thiazolidine-4-carbonitriles and analogues and their use as dipeptidyl-peptidas inhibitors

Publications (1)

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MXPA04009784A true MXPA04009784A (es) 2004-12-13

Family

ID=28792036

Family Applications (1)

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MXPA04009784A MXPA04009784A (es) 2002-04-08 2003-04-03 Tiazolidin-4-carbonitrilos y analogos y su uso como inhibidores de dipeptidil-peptidas.

Country Status (13)

Country Link
US (1) US7138416B2 (es)
EP (1) EP1492777A1 (es)
JP (1) JP2005532283A (es)
KR (1) KR20040105853A (es)
CN (1) CN1633420A (es)
AU (1) AU2003214534B2 (es)
BR (1) BR0308816A (es)
CA (1) CA2481995A1 (es)
MX (1) MXPA04009784A (es)
PL (1) PL372814A1 (es)
RU (1) RU2004132719A (es)
WO (1) WO2003084940A1 (es)
ZA (1) ZA200407295B (es)

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