CY1108634T1 - Μεθοδος και συσκευη για την προετοιμασια δειγματων ιστου για παραλληλη αναλυση - Google Patents

Μεθοδος και συσκευη για την προετοιμασια δειγματων ιστου για παραλληλη αναλυση

Info

Publication number
CY1108634T1
CY1108634T1 CY20081101407T CY081101407T CY1108634T1 CY 1108634 T1 CY1108634 T1 CY 1108634T1 CY 20081101407 T CY20081101407 T CY 20081101407T CY 081101407 T CY081101407 T CY 081101407T CY 1108634 T1 CY1108634 T1 CY 1108634T1
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CY
Cyprus
Prior art keywords
tumors
hundreds
samples
breast cancer
quickly find
Prior art date
Application number
CY20081101407T
Other languages
English (en)
Inventor
Stephen B Leighton
Juha Kononen
Olli Kallioniemi
Original Assignee
The United States Government As Represented By
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The United States Government As Represented By filed Critical The United States Government As Represented By
Publication of CY1108634T1 publication Critical patent/CY1108634T1/el

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/36—Embedding or analogous mounting of samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54306—Solid-phase reaction mechanisms
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/34—Microscope slides, e.g. mounting specimens on microscope slides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00702—Processes involving means for analysing and characterising the products
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/02—Devices for withdrawing samples
    • G01N1/04—Devices for withdrawing samples in the solid state, e.g. by cutting
    • G01N1/08—Devices for withdrawing samples in the solid state, e.g. by cutting involving an extracting tool, e.g. core bit
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/2813—Producing thin layers of samples on a substrate, e.g. smearing, spinning-on
    • G01N2001/282—Producing thin layers of samples on a substrate, e.g. smearing, spinning-on with mapping; Identification of areas; Spatial correlated pattern
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/36—Embedding or analogous mounting of samples
    • G01N2001/368—Mounting multiple samples in one block, e.g. TMA [Tissue Microarrays]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Analytical Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Clinical Laboratory Science (AREA)
  • Optics & Photonics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Polymerisation Methods In General (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Liquid Deposition Of Substances Of Which Semiconductor Devices Are Composed (AREA)

Abstract

Τεχνολογία με βάση τις συστοιχίες που διευκολύνει τη γρήγορη εύρεση του συσχετισμένου αριθμού γονιδιακών αντιγράφων και προφίλ έκφρασης πολύ μεγάλου αριθμού ανθρώπινων όγκων. Εκατοντάδες κυλινδρικές βιοψίες ιστού (διαμέτρου 0,6 mm) από μορφολογικά αντιπροσωπευτικές περιοχές των μεμονωμένων όγκων μπορούν να τοποθετηθούν σε συστοιχία σε ένα μόνο τμήμα παραφίνης. Οι διαδοχικές τομές τέτοιων συστοιχιών παρέχουν στόχους για παράλληλη in situ οπτικοποίηση και ποσοτικοποίηση των στόχων DNA, RNA ή πρωτεϊνών. Παραδείγματος χάριν, ενισχύσεις έξι τόπων (mybL2, erbB2, Cyclin-D1, myc, 17q23 και 20ql3) καθορίσθηκαν γρήγορα με φθορίζοντα in situ υβριδισμό από 372 δείγματα καρκίνου του μαστού μονιμοποιημένα σε αιθανόλη. Η διαστρωμάτωση των όγκων με δεδομένα έκφρασης υποδοχέα οιστρογόνου και p53 αποκάλυψε διακριτά μοτίβα γονιδιακής ενίσχυσης στις διάφορες υπο-ομάδες του καρκίνου του μαστού που μπορεί να έχουν προγνωστική χρησιμότητα. Η τεχνολογία συστοιχιών ιστών χρησιμεύει στη γρήγορη εύρεση του μοριακού προφίλ εκατοντάδων δειγμάτων φυσιολογικών και παθολογικών ιστών ή κυτταρικών καλλιεργειών.
CY20081101407T 1998-02-25 2008-12-03 Μεθοδος και συσκευη για την προετοιμασια δειγματων ιστου για παραλληλη αναλυση CY1108634T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7597998P 1998-02-25 1998-02-25
EP06016017A EP1715340B1 (en) 1998-02-25 1999-02-24 Method and apparatus for preparing tissue specimens for parallel analysis

Publications (1)

Publication Number Publication Date
CY1108634T1 true CY1108634T1 (el) 2014-04-09

Family

ID=22129137

Family Applications (2)

Application Number Title Priority Date Filing Date
CY20061101587T CY1105756T1 (el) 1998-02-25 2006-11-02 Μεθοδος και συσκευη για τη διαμορφωση συστοιχιων γρηγορης ευρεσης μοριακου προφιλ
CY20081101407T CY1108634T1 (el) 1998-02-25 2008-12-03 Μεθοδος και συσκευη για την προετοιμασια δειγματων ιστου για παραλληλη αναλυση

Family Applications Before (1)

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CY20061101587T CY1105756T1 (el) 1998-02-25 2006-11-02 Μεθοδος και συσκευη για τη διαμορφωση συστοιχιων γρηγορης ευρεσης μοριακου προφιλ

Country Status (11)

Country Link
EP (3) EP1715340B1 (el)
JP (2) JP4374139B2 (el)
AT (2) ATE335199T1 (el)
AU (1) AU754047B2 (el)
CA (2) CA2318984C (el)
CY (2) CY1105756T1 (el)
DE (2) DE69932607T2 (el)
DK (2) DK1068528T3 (el)
ES (2) ES2272057T3 (el)
PT (2) PT1068528E (el)
WO (1) WO1999044063A2 (el)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6969614B1 (en) * 1999-02-16 2005-11-29 The United States Of America As Represented By The Department Of Health And Human Services Methods for the isolation and analysis of cellular protein content
US6142681A (en) 1999-02-22 2000-11-07 Vialogy Corporation Method and apparatus for interpreting hybridized bioelectronic DNA microarray patterns using self-scaling convergent reverberant dynamics
US6136541A (en) 1999-02-22 2000-10-24 Vialogy Corporation Method and apparatus for analyzing hybridized biochip patterns using resonance interactions employing quantum expressor functions
US6692916B2 (en) 1999-06-28 2004-02-17 Source Precision Medicine, Inc. Systems and methods for characterizing a biological condition or agent using precision gene expression profiles
US6960439B2 (en) 1999-06-28 2005-11-01 Source Precision Medicine, Inc. Identification, monitoring and treatment of disease and characterization of biological condition using gene expression profiles
WO2001020044A2 (en) * 1999-09-17 2001-03-22 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health & Human Services, The National Institutes Of Health Signal counting for in situ hybridization
US6406840B1 (en) 1999-12-17 2002-06-18 Biomosaic Systems, Inc. Cell arrays and the uses thereof
US7003403B1 (en) 2000-06-15 2006-02-21 The United States Of America As Represented By The Department Of Health And Human Services Quantifying gene relatedness via nonlinear prediction of gene
EP1305595A2 (en) 2000-06-22 2003-05-02 Clinomics Laboratories, Inc. Frozen tissue microarrays and methods for using the same
WO2002008281A2 (en) * 2000-07-26 2002-01-31 Stanford University Bstp-cad protein and related reagents and methods of use thereof
WO2002008260A2 (en) * 2000-07-26 2002-01-31 Stanford University Bstp-ecg1 protein and related reagents and methods of use thereof
AU2001278076A1 (en) * 2000-07-26 2002-02-05 Applied Genomics, Inc. Bstp-5 proteins and related reagents and methods of use thereof
WO2002057200A2 (en) * 2000-08-15 2002-07-25 Bioforce Nanosciences, Inc. Nanoscale molecular arrayer
WO2002077231A2 (en) * 2000-11-13 2002-10-03 Incyte Genomics, Inc. Nucleic acid-associated proteins
US7171030B2 (en) 2000-11-30 2007-01-30 University Of Medicine & Denistry Of New Jersey Systems for analyzing microtissue arrays
US7079673B2 (en) 2002-02-05 2006-07-18 University Of Medicine & Denistry Of Nj Systems for analyzing microtissue arrays
US6466690C1 (en) 2000-12-19 2008-11-18 Bacus Res Lab Inc Method and apparatus for processing an image of a tissue sample microarray
US6534307B1 (en) 2001-02-08 2003-03-18 Clinomics Biosciences, Inc. Frozen tissue microarrayer
US6716619B1 (en) 2001-02-08 2004-04-06 Clinomics Biosciences, Inc. Stylet for use with tissue microarrayer and molds
AU2002240336A1 (en) * 2001-02-14 2002-08-28 Tularik Inc. Methods for the diagnosis and treatment of tumors employing the hepsin gene
WO2002064838A2 (en) * 2001-02-14 2002-08-22 Tularik Inc. Amplified cancer gene wip1
KR100786906B1 (ko) * 2001-03-19 2007-12-17 비이체르 인스트루먼츠 조직 어레이 장치
US6387633B1 (en) * 2001-05-11 2002-05-14 Supratek Pharma, Inc. Method for identifying unstable genes
WO2003029480A2 (en) 2001-08-31 2003-04-10 The Government Of The United States Of America, Asrepresented By The Secretary Of The Department Of Health And Human Services Measurements of multiple molecules using a cryoarray
CA2466502A1 (en) 2001-11-09 2003-05-15 Source Precision Medicine, Inc. Identification, monitoring and treatment of disease and characterization of biological condition using gene expression profiles
WO2003100381A1 (en) * 2002-05-24 2003-12-04 Monsanto Technology Llc. Seed coring system and method for arranging seed cores for analysis
HU2464U (en) * 2002-06-25 2003-03-28 Szekeres Gyoergy Dr Hand instrument set for constructing tissue array
US20050112622A1 (en) * 2003-08-11 2005-05-26 Ring Brian Z. Reagents and methods for use in cancer diagnosis, classification and therapy
US8012693B2 (en) 2003-12-16 2011-09-06 3M Innovative Properties Company Analysis of chemically crosslinked cellular samples
JP2007535681A (ja) 2004-04-30 2007-12-06 バイオフォース・ナノサイエンシィズ・インコーポレーテッド 物質を表面上に堆積させるための方法と装置
US7854899B2 (en) 2004-08-26 2010-12-21 The United States Of America As Represented By The Secretary Of Health And Human Services Template methods and devices for preparing sample arrays
US8484000B2 (en) 2004-09-02 2013-07-09 Vialogy Llc Detecting events of interest using quantum resonance interferometry
US7405056B2 (en) 2005-03-02 2008-07-29 Edward Lam Tissue punch and tissue sample labeling methods and devices for microarray preparation, archiving and documentation
US7504225B2 (en) 2005-05-12 2009-03-17 Applied Genomics, Inc. Reagents and methods for use in cancer diagnosis, classification and therapy
JP5406019B2 (ja) * 2006-05-17 2014-02-05 セルーメン、インコーポレイテッド 自動化組織分析のための方法
DE102008000036B4 (de) * 2008-01-10 2010-09-30 Leica Biosystems Nussloch Gmbh Verfahren zum Anfertigen histologischer Schnitte und Mikrotom mit einer Aufbring- und Schneideinrichtung
US20190300945A1 (en) 2010-04-05 2019-10-03 Prognosys Biosciences, Inc. Spatially Encoded Biological Assays
US10787701B2 (en) 2010-04-05 2020-09-29 Prognosys Biosciences, Inc. Spatially encoded biological assays
JP5629939B2 (ja) * 2010-09-09 2014-11-26 株式会社パソロジー研究所 パイルアップ組織アレイ
EP2629078B1 (en) 2010-11-19 2019-04-17 Olympus Corporation Method for preparing biological sample
EP2686688B1 (en) 2011-03-17 2019-05-08 Cernostics, Inc. Systems and compositions for diagnosing barrett's esophagus and methods of using the same
GB201106254D0 (en) 2011-04-13 2011-05-25 Frisen Jonas Method and product
DE102011075037A1 (de) * 2011-04-29 2012-10-31 Hamilton Bonaduz Ag Stanzvorrichtung mit Aufnahmeplatte
DE102011075039A1 (de) * 2011-04-29 2012-10-31 Hamilton Bonaduz Ag Stanzvorrichtung mit beleuchteter Aufnahmeplatte
JP5862671B2 (ja) * 2011-08-23 2016-02-16 日本電気株式会社 情報処理システム、情報処理方法、情報処理装置およびその制御方法と制御プログラム
JP2013185920A (ja) * 2012-03-07 2013-09-19 Pathology Institute 組織アレイシートの製造方法およびその製造装置
FR2998823B1 (fr) * 2012-11-30 2015-06-05 Oberthur Technologies Dispositif de decoupe pour test de delaminage
CN118240918A (zh) 2013-06-25 2024-06-25 普罗格诺西斯生物科学公司 采用微流控装置的空间编码生物分析
JP6367741B2 (ja) * 2015-03-12 2018-08-01 学校法人北里研究所 生体組織標本アレイ切片、生体組織標本アレイ、シート状生体組織標本アレイ、生体組織標本ブロック及びそれらの製造方法
EP4119677B1 (en) 2015-04-10 2023-06-28 Spatial Transcriptomics AB Spatially distinguished, multiplex nucleic acid analysis of biological specimens
US11926867B2 (en) 2019-01-06 2024-03-12 10X Genomics, Inc. Generating capture probes for spatial analysis
US11649485B2 (en) 2019-01-06 2023-05-16 10X Genomics, Inc. Generating capture probes for spatial analysis
US11821035B1 (en) 2020-01-29 2023-11-21 10X Genomics, Inc. Compositions and methods of making gene expression libraries
WO2021252591A1 (en) 2020-06-10 2021-12-16 10X Genomics, Inc. Methods for determining a location of an analyte in a biological sample
WO2021263111A1 (en) 2020-06-25 2021-12-30 10X Genomics, Inc. Spatial analysis of dna methylation
CN116593262B (zh) * 2023-07-13 2023-09-26 南京普恩瑞生物科技有限公司 基于pdx/pdtx肿瘤活组织生物样本和数据库的分子标志物检测产品及其制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2563343B1 (fr) * 1984-04-19 1986-06-13 Rhone Poulenc Sante Dispositif pour effectuer des prelevements dans des milieux semi-solides
IT8521051V0 (it) * 1985-03-08 1985-03-08 Lepetit Spa Formatore di pozzetti.
US4820504A (en) * 1986-02-12 1989-04-11 City Of Hope Multi-specimen tissue blocks and slides
GB8626920D0 (en) * 1986-11-11 1986-12-10 Gadson D R Examination of multiple samples for analysis
US4914022A (en) * 1987-10-21 1990-04-03 Amc Cancer Research Center Method for preparing multiple tissue samples for microscopic investigation and testing
EP0332322A2 (en) * 1988-02-26 1989-09-13 Elsevier Science Publishing Co., Inc. Data creating, storage and processing system
US5002377A (en) 1988-07-07 1991-03-26 City Of Hope Multi-specimen slides for immunohistologic procedures
JPH0835921A (ja) * 1994-07-22 1996-02-06 Kanagawa Kagaku Gijutsu Akad 試料ブロック及びその自動検査装置
CN1249418C (zh) * 1997-09-11 2006-04-05 生物风险公司 一种生产目标物质的高密度阵列的方法及高密度阵列

Also Published As

Publication number Publication date
EP1068528A2 (en) 2001-01-17
JP4374139B2 (ja) 2009-12-02
ES2272057T3 (es) 2007-04-16
AU2875799A (en) 1999-09-15
ATE335199T1 (de) 2006-08-15
WO1999044063B1 (en) 1999-12-02
EP1715340B1 (en) 2008-09-03
PT1715340E (pt) 2008-12-16
JP2002505432A (ja) 2002-02-19
DE69932607T2 (de) 2007-10-25
CY1105756T1 (el) 2010-12-22
ATE407360T1 (de) 2008-09-15
DK1715340T3 (da) 2009-01-26
CA2318984C (en) 2009-04-28
EP1980852A1 (en) 2008-10-15
JP2009244269A (ja) 2009-10-22
PT1068528E (pt) 2006-12-29
DK1068528T3 (da) 2006-11-27
WO1999044063A3 (en) 1999-11-04
ES2317380T3 (es) 2009-04-16
DE69939503D1 (de) 2008-10-16
EP1715340A2 (en) 2006-10-25
EP1068528B1 (en) 2006-08-02
DE69932607D1 (de) 2006-09-14
CA2318984A1 (en) 1999-09-02
EP1715340A3 (en) 2006-11-29
WO1999044063A2 (en) 1999-09-02
CA2627799A1 (en) 1999-09-02
AU754047B2 (en) 2002-10-31

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