CY1105756T1 - Μεθοδος και συσκευη για τη διαμορφωση συστοιχιων γρηγορης ευρεσης μοριακου προφιλ - Google Patents

Μεθοδος και συσκευη για τη διαμορφωση συστοιχιων γρηγορης ευρεσης μοριακου προφιλ

Info

Publication number
CY1105756T1
CY1105756T1 CY20061101587T CY061101587T CY1105756T1 CY 1105756 T1 CY1105756 T1 CY 1105756T1 CY 20061101587 T CY20061101587 T CY 20061101587T CY 061101587 T CY061101587 T CY 061101587T CY 1105756 T1 CY1105756 T1 CY 1105756T1
Authority
CY
Cyprus
Prior art keywords
tumors
hundreds
breast cancer
tissue
array
Prior art date
Application number
CY20061101587T
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English (en)
Inventor
Stephen B. Leighton
Juha Kononen
Olli Kallioniemi
Original Assignee
The United States Government As Represented By The Department Of Health And Human Services
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The United States Government As Represented By The Department Of Health And Human Services filed Critical The United States Government As Represented By The Department Of Health And Human Services
Publication of CY1105756T1 publication Critical patent/CY1105756T1/el

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/36—Embedding or analogous mounting of samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54306—Solid-phase reaction mechanisms
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/34—Microscope slides, e.g. mounting specimens on microscope slides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00702—Processes involving means for analysing and characterising the products
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/02—Devices for withdrawing samples
    • G01N1/04—Devices for withdrawing samples in the solid state, e.g. by cutting
    • G01N1/08—Devices for withdrawing samples in the solid state, e.g. by cutting involving an extracting tool, e.g. core bit
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/2813—Producing thin layers of samples on a substrate, e.g. smearing, spinning-on
    • G01N2001/282—Producing thin layers of samples on a substrate, e.g. smearing, spinning-on with mapping; Identification of areas; Spatial correlated pattern
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/36—Embedding or analogous mounting of samples
    • G01N2001/368—Mounting multiple samples in one block, e.g. TMA [Tissue Microarrays]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Analytical Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Clinical Laboratory Science (AREA)
  • Optics & Photonics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Polymerisation Methods In General (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Liquid Deposition Of Substances Of Which Semiconductor Devices Are Composed (AREA)

Abstract

Τεχνολογία με βάση τις συστοιχίες που διευκολύνει τη γρήγορη εύρεση του συσχετισμένου αριθμού γονιδιακών αντιγράφων και προφίλ έκφρασης πολύ μεγάλου αριθμού ανθρώπινων όγκων. Εκατοντάδες κυλινδρικές βιοψίες ιστού (διαμέτρου 0,6 mm) από μορφολογικά αντιπροσωπευτικές περιοχές των μεμονωμένων όγκων μπορούν να τοποθετηθούν σε συστοιχία σε ένα μόνο τμήμα παραφίνης. Οι διαδοχικές τομές τέτοιων συστοιχιών παρέχουν στόχους για παράλληλη in situ οπτικοποίηση και ποσοτικοποίηση των στόχων DNA, RNA ή πρωτεϊνών. Παραδείγματος χάριν, ενισχύσεις έξι τόπων (mybL2, erbB2, Cyclin-D1, myc, 17q23 και 20ql3) καθορίσθηκαν γρήγορα με φθορίζοντα in situ υβριδισμό από 372 δείγματα καρκίνου του μαστού μονιμοποιημένα σε αιθανόλη. Η διαστρωμάτωση των όγκων με δεδομένα έκφρασης υποδοχέα οιστρογόνου και p53 αποκάλυψε διακριτά μοτίβα γονιδιακής ενίσχυσης στις διάφορες υπο-ομάδες του καρκίνου του μαστού που μπορεί να έχουν προγνωστική χρησιμότητα. Η τεχνολογία συστοιχιών ιστών χρησιμεύει στη γρήγορη εύρεση του μοριακού προφίλ εκατοντάδων δειγμάτων φυσιολογικών και παθολογικών ιστών ή κυτταρικών καλλιεργειών.
CY20061101587T 1998-02-25 2006-11-02 Μεθοδος και συσκευη για τη διαμορφωση συστοιχιων γρηγορης ευρεσης μοριακου προφιλ CY1105756T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7597998P 1998-02-25 1998-02-25
PCT/US1999/004001 WO1999044063A2 (en) 1998-02-25 1999-02-24 Tumor tissue microarrays for rapid molecular profiling

Publications (1)

Publication Number Publication Date
CY1105756T1 true CY1105756T1 (el) 2010-12-22

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ID=22129137

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Application Number Title Priority Date Filing Date
CY20061101587T CY1105756T1 (el) 1998-02-25 2006-11-02 Μεθοδος και συσκευη για τη διαμορφωση συστοιχιων γρηγορης ευρεσης μοριακου προφιλ
CY20081101407T CY1108634T1 (el) 1998-02-25 2008-12-03 Μεθοδος και συσκευη για την προετοιμασια δειγματων ιστου για παραλληλη αναλυση

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Country Status (11)

Country Link
EP (3) EP1715340B1 (el)
JP (2) JP4374139B2 (el)
AT (2) ATE335199T1 (el)
AU (1) AU754047B2 (el)
CA (2) CA2318984C (el)
CY (2) CY1105756T1 (el)
DE (2) DE69932607T2 (el)
DK (2) DK1068528T3 (el)
ES (2) ES2272057T3 (el)
PT (2) PT1068528E (el)
WO (1) WO1999044063A2 (el)

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Also Published As

Publication number Publication date
EP1068528A2 (en) 2001-01-17
JP4374139B2 (ja) 2009-12-02
ES2272057T3 (es) 2007-04-16
AU2875799A (en) 1999-09-15
ATE335199T1 (de) 2006-08-15
WO1999044063B1 (en) 1999-12-02
EP1715340B1 (en) 2008-09-03
PT1715340E (pt) 2008-12-16
JP2002505432A (ja) 2002-02-19
DE69932607T2 (de) 2007-10-25
ATE407360T1 (de) 2008-09-15
DK1715340T3 (da) 2009-01-26
CA2318984C (en) 2009-04-28
EP1980852A1 (en) 2008-10-15
CY1108634T1 (el) 2014-04-09
JP2009244269A (ja) 2009-10-22
PT1068528E (pt) 2006-12-29
DK1068528T3 (da) 2006-11-27
WO1999044063A3 (en) 1999-11-04
ES2317380T3 (es) 2009-04-16
DE69939503D1 (de) 2008-10-16
EP1715340A2 (en) 2006-10-25
EP1068528B1 (en) 2006-08-02
DE69932607D1 (de) 2006-09-14
CA2318984A1 (en) 1999-09-02
EP1715340A3 (en) 2006-11-29
WO1999044063A2 (en) 1999-09-02
CA2627799A1 (en) 1999-09-02
AU754047B2 (en) 2002-10-31

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