CY1107503T1 - Αντιβιοτικα διπλης δρασης - Google Patents

Αντιβιοτικα διπλης δρασης

Info

Publication number
CY1107503T1
CY1107503T1 CY20071101315T CY071101315T CY1107503T1 CY 1107503 T1 CY1107503 T1 CY 1107503T1 CY 20071101315 T CY20071101315 T CY 20071101315T CY 071101315 T CY071101315 T CY 071101315T CY 1107503 T1 CY1107503 T1 CY 1107503T1
Authority
CY
Cyprus
Prior art keywords
double action
antibodies
action antibodies
compounds
variety
Prior art date
Application number
CY20071101315T
Other languages
English (en)
Inventor
Christian Hubschawerlen
Jean-Luc Specklin
Original Assignee
Morphochem Aktiengesellschaft für kombinatorische Chemie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Morphochem Aktiengesellschaft für kombinatorische Chemie filed Critical Morphochem Aktiengesellschaft für kombinatorische Chemie
Publication of CY1107503T1 publication Critical patent/CY1107503T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Η παρούσα εφεύρεση αφορά σε χημικές ενώσεις με χημικό τύπο (Ι) οι οποίες είναι χρήσιμοι αντιμικροβιακοί παράγοντες και αποτελεσματικές έναντι μιας ποικιλίας πολυανθεκτικών βακτηρίων.
CY20071101315T 2001-10-04 2007-10-11 Αντιβιοτικα διπλης δρασης CY1107503T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32716201P 2001-10-04 2001-10-04
EP02796533A EP1432705B1 (en) 2001-10-04 2002-10-04 Dual action antibiotics

Publications (1)

Publication Number Publication Date
CY1107503T1 true CY1107503T1 (el) 2013-03-13

Family

ID=23275422

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20071101315T CY1107503T1 (el) 2001-10-04 2007-10-11 Αντιβιοτικα διπλης δρασης

Country Status (21)

Country Link
US (2) US7820823B2 (el)
EP (1) EP1432705B1 (el)
JP (2) JP4398245B2 (el)
KR (2) KR100927864B1 (el)
CN (2) CN101381365B (el)
AT (1) ATE369363T1 (el)
AU (1) AU2002361948B2 (el)
BR (1) BRPI0213063B8 (el)
CA (1) CA2460572C (el)
CY (1) CY1107503T1 (el)
DE (1) DE60221684T2 (el)
DK (1) DK1432705T3 (el)
ES (1) ES2287354T3 (el)
HK (1) HK1128469A1 (el)
HU (1) HU229935B1 (el)
IL (2) IL160769A0 (el)
NZ (1) NZ531879A (el)
PL (1) PL210850B1 (el)
PT (1) PT1432705E (el)
WO (2) WO2003031443A1 (el)
ZA (1) ZA200401909B (el)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2459766A1 (en) 2001-09-11 2003-03-20 Astrazeneca Ab Oxazolidinone and/or isoxazoline as antibacterial agents
WO2003031443A1 (en) 2001-10-04 2003-04-17 Morphochem Aktiengesellschaft für kombinatorische Chemie Dual actions antibiotics comprising a oxazoldinone and a quinolone or naphthyridinone moiety
JP4805139B2 (ja) * 2003-04-30 2011-11-02 モルホケム アクツィエンゲゼルシャフト フューア コンビナートリッシュ ヒェミー 炭疽および他の感染を治療するためのオキサゾリジノン‐キノリンハイブリッド抗生物質の使用
WO2004101552A1 (en) * 2003-05-14 2004-11-25 Orchid Chemicals & Pharmaceuticals Ltd Oxazolidinone derivatives as antibacterial agents
DE10340485B4 (de) * 2003-09-03 2015-05-13 Morphochem AG Aktiengesellschaft für kombinatorische Chemie Verfahren zur Herstellung von Oxazolidinon-Chinolon Hybriden
RU2371443C2 (ru) 2003-12-18 2009-10-27 Морфохем Акциенгезельшафт Фюр Комбинаторише Хеми Оксазолидинон-хинолонгибридные антибиотики
US8158797B2 (en) 2003-12-18 2012-04-17 Morphochem Aktiengesellschaft Fur Kombinatorische Chemie Oxazolidinone-quinolone hybrid antibiotics
EP1557416A1 (en) * 2004-01-23 2005-07-27 Morphochem Aktiengesellschaft Für Kombinatorische Chemie Oxazolidinone-quinolone hybrid antibiotics
WO2005111030A1 (en) * 2004-05-12 2005-11-24 Warner-Lambert Company Llc Quinolone antibacterial agents
US20060105941A1 (en) * 2004-11-12 2006-05-18 Allergan, Inc. Mixed antibiotic codrugs
GB0505969D0 (en) 2005-03-23 2005-04-27 Novartis Ag Organic compounds
AR054608A1 (es) 2005-08-08 2007-06-27 Actelion Pharmaceuticals Ltd Derivados de oxazolidinona enlazados a quinolonas como antibacterianos
US8129411B2 (en) 2005-12-30 2012-03-06 Novartis Ag Organic compounds
US7456279B2 (en) * 2006-03-28 2008-11-25 The Procter & Gamble Company Coupling process for preparing quinolone intermediates
EP2181993A1 (en) * 2006-03-31 2010-05-05 Research Foundation Itsuu Laboratory Antimicrobial oxazolidinone derivatives
US8124623B2 (en) 2006-11-10 2012-02-28 Actelion Pharmaceuticals Ltd. 5-hydroxymethyl-oxazolidin-2-one-derivatives and their uses as antibacterials
CL2007003332A1 (es) 2006-11-24 2008-06-20 Actelion Pharmaceuticals Ltd Compuestos derivados de heterociclos condensados; compuestos intermediarios; composicion farmaceutica; y uso en la prevencion o tratamiento de infecciones bacterianas.
BRPI0813900A2 (pt) 2007-06-25 2014-12-30 Novartis Ag Derivados de n5-(2-etoxietil)-n3-(2-piridinil)-3,5-piperidinodicarboxa mida para uso como inibidores de renina
AU2008317353B2 (en) * 2007-10-24 2014-08-07 Merck Sharp & Dohme Llc Heterocycle phenyl amide T-type calcium channel antagonists
KR101283222B1 (ko) * 2008-05-09 2013-07-11 액테리온 파마슈티칼 리미티드 세균성 장 질환 치료용 5-하이드록시메틸-옥사졸리딘-1-온 유도체
WO2010081851A1 (en) 2009-01-14 2010-07-22 Genoscience Pharma Piperidin-4-ylpiperazine compounds for the treatment of hcv infection
MX2015011948A (es) 2013-03-08 2015-12-09 Allergan Inc Antibioticos conjugados directamente relacionados con farmacos esteroides.
KR20150125663A (ko) 2013-03-08 2015-11-09 알러간, 인코포레이티드 사이클로스포린 a 스테로이드 켤레물
CN103145615B (zh) * 2013-03-20 2015-07-29 浙江医药股份有限公司 一种奈诺沙星螯合物的后处理方法
CN105338972A (zh) 2013-05-28 2016-02-17 莫弗凯姆联合化学股份公司 用于胃肠外治疗或预防细菌性疾病的噁唑烷酮-喹诺酮杂合物抗菌剂
WO2014191109A1 (en) 2013-05-28 2014-12-04 Morphochem Aktiengesellschaft für kombinatorische Chemie Combination therapy comprising oxazolidinone-quinolones for use in treating bacterial infections
CN103421008B (zh) * 2013-09-07 2015-05-27 吉首大学 一类多靶点呋喃酮-喹啉酮型化合物及其制法和用途
CN107286182A (zh) * 2016-04-12 2017-10-24 李靖 新型噁唑烷酮‑氟喹诺酮衍生物及用途
CN107648181B (zh) * 2016-07-25 2021-05-04 广东赛法洛药业有限公司 一种利他唑酮磷脂复合物及其制备方法和应用
US10087171B2 (en) 2016-12-19 2018-10-02 Actelion Pharmaceuticals Ltd Crystalline forms of cadazolid
CN109942546B (zh) * 2019-04-16 2022-04-08 西南大学 喹诺酮嘧啶类化合物及其制备方法和应用
WO2023072794A1 (en) * 2021-10-26 2023-05-04 F. Hoffmann-La Roche Ag Piperazinylsulfonylaryl compounds for treatment of bacterial infections

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4840956A (en) * 1986-02-18 1989-06-20 Warner-Lambert Company Novel disubstituted-7-pyrrolidinoquinoline antibacterial agents
NZ222047A (en) 1986-10-08 1991-01-29 Bristol Myers Co Quinoline - or naphthyridine - carboxylic acid anti-bacterial agents
JPH0269478A (ja) 1988-09-05 1990-03-08 Sagami Chem Res Center キノロンカルボン酸誘導体
US5491139A (en) * 1988-10-24 1996-02-13 The Procter & Gamble Company Antimicrobial quinolonyl lactams
US5153203A (en) 1989-03-30 1992-10-06 Wakunaga Seiyaku Kabushiki Kaisha Quinolone derivatives and salts thereof, preparation processes thereof, and antibacterial agents containing the same
KR100257418B1 (ko) * 1991-11-01 2000-05-15 로렌스 티. 마이젠헬더 치환된 아릴-및 헤테로아릴-페닐옥사졸리디논
US5221676A (en) * 1992-02-06 1993-06-22 Warner-Lambert Company 7-substituted quinolones and naphthyridones as antibacterial agents
PT911327E (pt) * 1995-09-22 2002-05-31 Wakunaga Pharma Co Ltd Novos derivados do acido piridonocarboxilico ou seus sais e agente antibacteriano compreendendo os mesmos como o ingrediente activo
DE19601265A1 (de) 1996-01-16 1997-07-17 Bayer Ag 2-Oxo- und 2-Thio-1,2-dihydrochinolinyl-oxazolidinone
GB9702213D0 (en) * 1996-02-24 1997-03-26 Zeneca Ltd Chemical compounds
DE19633480A1 (de) * 1996-08-20 1998-02-26 Bayer Ag Oral applizierbare Formulierungen von Chinolon- und Naphthyridoncarbonsäuren
GB9725244D0 (en) * 1997-11-29 1998-01-28 Zeneca Ltd Chemical compounds
KR20010015910A (ko) * 1998-01-23 2001-02-26 로렌스 티. 마이젠헬더 옥사졸리디논 조합 라이브러리, 조성물 및 제조 방법
TW572757B (en) 1998-08-24 2004-01-21 Bristol Myers Squibb Co Novel isoxazolinone antibacterial agents
KR100324621B1 (ko) 1999-04-27 2002-02-27 박호군 퀴놀론이 치환된 옥사졸리디논 유도체 및 그의 제조 방법과 항균제로서의 용도
CN1367780A (zh) 1999-07-28 2002-09-04 法玛西雅厄普约翰美国公司 噁唑烷酮类化合物、其制备方法及其应用
US6518285B2 (en) 1999-12-21 2003-02-11 Ortho Mcneil Pharmaceutical, Inc. Piperidinyloxy and pyrrolidinyloxy oxazolidinone antibacterials
ATE319710T1 (de) 2000-12-21 2006-03-15 Pharmacia & Upjohn Co Llc Antimikrobielle chinolonderivate und ihre verwendung zur behandlung bakterieller infektionen
ES2186550B2 (es) 2001-06-27 2003-11-16 Vita Lab Nuevos derivados de oxazolidinonas como antibacterianos.
WO2003031443A1 (en) 2001-10-04 2003-04-17 Morphochem Aktiengesellschaft für kombinatorische Chemie Dual actions antibiotics comprising a oxazoldinone and a quinolone or naphthyridinone moiety
WO2003031441A1 (en) 2001-10-04 2003-04-17 Morphochen Aktiengesellschaft Für Kombinatorische Chemie Multiple action compounds
US20040132764A1 (en) * 2002-10-23 2004-07-08 Morphochem Aktiengesellschaft Fuer Kombinatorische Chemie Antibiotics for the treatment of infections in acidic environments
WO2004069816A1 (en) 2003-02-07 2004-08-19 Ranbaxy Laboratories Limited Oxazolidinone derivatives as antimicrobials
JP4805139B2 (ja) 2003-04-30 2011-11-02 モルホケム アクツィエンゲゼルシャフト フューア コンビナートリッシュ ヒェミー 炭疽および他の感染を治療するためのオキサゾリジノン‐キノリンハイブリッド抗生物質の使用
DE10340485B4 (de) 2003-09-03 2015-05-13 Morphochem AG Aktiengesellschaft für kombinatorische Chemie Verfahren zur Herstellung von Oxazolidinon-Chinolon Hybriden
US8158797B2 (en) * 2003-12-18 2012-04-17 Morphochem Aktiengesellschaft Fur Kombinatorische Chemie Oxazolidinone-quinolone hybrid antibiotics
RU2371443C2 (ru) 2003-12-18 2009-10-27 Морфохем Акциенгезельшафт Фюр Комбинаторише Хеми Оксазолидинон-хинолонгибридные антибиотики
AR054608A1 (es) 2005-08-08 2007-06-27 Actelion Pharmaceuticals Ltd Derivados de oxazolidinona enlazados a quinolonas como antibacterianos
KR200430712Y1 (ko) 2006-08-30 2006-11-13 명 식 신 천장등
US8124623B2 (en) * 2006-11-10 2012-02-28 Actelion Pharmaceuticals Ltd. 5-hydroxymethyl-oxazolidin-2-one-derivatives and their uses as antibacterials
MY148847A (en) 2006-11-10 2013-06-14 Actelion Pharmaceuticals Ltd 5-hydroxymethyl-oxazolidin-2-one derivatives
CL2007003332A1 (es) 2006-11-24 2008-06-20 Actelion Pharmaceuticals Ltd Compuestos derivados de heterociclos condensados; compuestos intermediarios; composicion farmaceutica; y uso en la prevencion o tratamiento de infecciones bacterianas.
KR101283222B1 (ko) 2008-05-09 2013-07-11 액테리온 파마슈티칼 리미티드 세균성 장 질환 치료용 5-하이드록시메틸-옥사졸리딘-1-온 유도체

Also Published As

Publication number Publication date
HK1128469A1 (en) 2009-10-30
HU229935B1 (en) 2015-01-28
WO2003031443A1 (en) 2003-04-17
EP1432705B1 (en) 2007-08-08
JP4398245B2 (ja) 2010-01-13
DK1432705T3 (da) 2007-09-17
US20050096343A1 (en) 2005-05-05
ZA200401909B (en) 2005-05-25
PT1432705E (pt) 2007-08-27
BR0213063A (pt) 2004-09-28
CN101381365A (zh) 2009-03-11
ATE369363T1 (de) 2007-08-15
BRPI0213063B1 (pt) 2018-02-14
IL160769A0 (en) 2004-08-31
PL367517A1 (en) 2005-02-21
KR100927864B1 (ko) 2009-11-23
EP1432705A2 (en) 2004-06-30
IL160769A (en) 2009-12-24
WO2003032962A2 (en) 2003-04-24
KR100987696B1 (ko) 2010-10-13
US8329908B2 (en) 2012-12-11
JP2010006814A (ja) 2010-01-14
AU2002361948B2 (en) 2007-03-29
US7820823B2 (en) 2010-10-26
ES2287354T3 (es) 2007-12-16
BRPI0213063B8 (pt) 2021-05-25
CA2460572C (en) 2011-11-08
DE60221684D1 (de) 2007-09-20
CA2460572A1 (en) 2003-04-24
US20110059946A1 (en) 2011-03-10
KR20040055781A (ko) 2004-06-26
JP2005529061A (ja) 2005-09-29
KR20090100426A (ko) 2009-09-23
HUP0402126A2 (hu) 2005-02-28
NZ531879A (en) 2005-10-28
HUP0402126A3 (en) 2012-10-29
CN101381365B (zh) 2011-07-06
PL210850B1 (pl) 2012-03-30
DE60221684T2 (de) 2008-04-30
WO2003032962A3 (en) 2003-07-17
CN1630655A (zh) 2005-06-22

Similar Documents

Publication Publication Date Title
CY1107503T1 (el) Αντιβιοτικα διπλης δρασης
CY1109886T1 (el) Καινοφανεις ενωσεις ως αντι-φλεγμονωδεις, ανοσοτροποποιητικοι και αντι υπερπλαστικοι παραγοντες
CY1114008T1 (el) Θειενοπυριμιδινικες ενωσεις και χρηση τους
CY1108409T1 (el) Υβριδικα αντιβιοτικα οξαζολιδινονης-κινολονης
CY1105575T1 (el) Ενωσεις αμιδιου και χρηση αυτων
CY1106801T1 (el) Νεες ετεροκυκλικες ενωσεις, η παρασκευη τους και η χρηση τους ως φαρμακα, ιδιαιτερα ως αντιβακτηριακα
CY1116784T1 (el) Αντιμικροβιακες ενωσεις και μεθοδοι για χρηση αυτων
CY1110821T1 (el) Antibakthpiakoi πapaγontες τρικυκλικης tετραϋδροκινολινης
DE60229736D1 (de) Spiroinden- und spiroindan-verbindungen
CY1111317T1 (el) Παραγωγα 4-φαινυλοπυριδινης και χρηση αυτων ως ανταγωνιστων υποδοχεων της νκ-1
CY1105386T1 (el) Βενζοϋλοσουλφοναμιδια και σουλφονυλβενζαμιδινες για χρηση σαν παραγοντες κατα του ογκου
CY1106870T1 (el) Σταθεροποιηση ραπαμυκινης ή παραγωγων ραπαμυκινης
CY1109068T1 (el) Υποκατεστημενες πυριδινυλαμινες
ES2172864T3 (es) 2-metoxibenzofenonas fungicidas.
BR9804214A (pt) Compostos.
DE60135919D1 (de) Farnesyl transferase-hemmende 6-heterocyclylmethyl-chinolin und chinazol-derivate
CY1108567T1 (el) Αντιθρομβωτικες ενωσεις
CY1106381T1 (el) Βιοκτονος συνθεση καθαρισμου
DE50208918D1 (de) 6-aminomorphinanderivate, herstellungsverfahren dafür und deren verwendung
DE60025744D1 (de) Kondensierte dihydrochinolinon-derivate zur hemmung von mrp1
CY1107101T1 (el) Μεθοδος συνθεσης παραγωγων της 1,3-διϋδρο-2h-3-βενζαζεπιν-2-ονης και εφαρμογη στη συνθεση της ιβαβραδινης και των αλατων προσθηκης με φαρμακευτικως αποδεκτο οξυ
CY1105813T1 (el) Φαρμακευτικοι συνδυασμοι που βασιζονται σε παραγωγα πυριδοϊνδολονης και σε αντικαρκινικα μεσα
DK1644385T3 (da) Siliciumforbindelser og deres anvendelse
BR0206922A (pt) Compostos orgânicos
BR0209828A (pt) Compostos orgânicos