HK1128469A1 - Dual action antibiotics - Google Patents

Dual action antibiotics

Info

Publication number
HK1128469A1
HK1128469A1 HK09107592.8A HK09107592A HK1128469A1 HK 1128469 A1 HK1128469 A1 HK 1128469A1 HK 09107592 A HK09107592 A HK 09107592A HK 1128469 A1 HK1128469 A1 HK 1128469A1
Authority
HK
Hong Kong
Prior art keywords
dual action
antibiotics
action antibiotics
compounds
variety
Prior art date
Application number
HK09107592.8A
Other languages
English (en)
Inventor
Christian Hubschwerlen
Jean-Luc Specklin
Original Assignee
Morphochem Ag Komb Chemie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Morphochem Ag Komb Chemie filed Critical Morphochem Ag Komb Chemie
Publication of HK1128469A1 publication Critical patent/HK1128469A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
HK09107592.8A 2001-10-04 2009-08-18 Dual action antibiotics HK1128469A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US32716201P 2001-10-04 2001-10-04

Publications (1)

Publication Number Publication Date
HK1128469A1 true HK1128469A1 (en) 2009-10-30

Family

ID=23275422

Family Applications (1)

Application Number Title Priority Date Filing Date
HK09107592.8A HK1128469A1 (en) 2001-10-04 2009-08-18 Dual action antibiotics

Country Status (21)

Country Link
US (2) US7820823B2 (xx)
EP (1) EP1432705B1 (xx)
JP (2) JP4398245B2 (xx)
KR (2) KR100987696B1 (xx)
CN (2) CN1630655A (xx)
AT (1) ATE369363T1 (xx)
AU (1) AU2002361948B2 (xx)
BR (1) BRPI0213063B8 (xx)
CA (1) CA2460572C (xx)
CY (1) CY1107503T1 (xx)
DE (1) DE60221684T2 (xx)
DK (1) DK1432705T3 (xx)
ES (1) ES2287354T3 (xx)
HK (1) HK1128469A1 (xx)
HU (1) HU229935B1 (xx)
IL (2) IL160769A0 (xx)
NZ (1) NZ531879A (xx)
PL (1) PL210850B1 (xx)
PT (1) PT1432705E (xx)
WO (2) WO2003031443A1 (xx)
ZA (1) ZA200401909B (xx)

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WO2004096221A1 (en) 2003-04-30 2004-11-11 Morphochem Aktiengesellschaft für kombinatorische Chemie Use of oxazolidinone-quinoline hybrid antibiotics for the treatment of anthrax and other infections
WO2004101552A1 (en) * 2003-05-14 2004-11-25 Orchid Chemicals & Pharmaceuticals Ltd Oxazolidinone derivatives as antibacterial agents
DE10340485B4 (de) * 2003-09-03 2015-05-13 Morphochem AG Aktiengesellschaft für kombinatorische Chemie Verfahren zur Herstellung von Oxazolidinon-Chinolon Hybriden
EP1557416A1 (en) * 2004-01-23 2005-07-27 Morphochem Aktiengesellschaft Für Kombinatorische Chemie Oxazolidinone-quinolone hybrid antibiotics
US8158797B2 (en) 2003-12-18 2012-04-17 Morphochem Aktiengesellschaft Fur Kombinatorische Chemie Oxazolidinone-quinolone hybrid antibiotics
CA2549675C (en) * 2003-12-18 2012-11-20 Morphochem Aktiengesellschaft Fur Kombinatorische Chemie Oxazolidinone-quinolone hybrid antibiotics
WO2005111030A1 (en) * 2004-05-12 2005-11-24 Warner-Lambert Company Llc Quinolone antibacterial agents
US20060105941A1 (en) * 2004-11-12 2006-05-18 Allergan, Inc. Mixed antibiotic codrugs
GB0505969D0 (en) 2005-03-23 2005-04-27 Novartis Ag Organic compounds
AR054608A1 (es) 2005-08-08 2007-06-27 Actelion Pharmaceuticals Ltd Derivados de oxazolidinona enlazados a quinolonas como antibacterianos
US8129411B2 (en) 2005-12-30 2012-03-06 Novartis Ag Organic compounds
KR101084521B1 (ko) * 2006-03-28 2011-11-18 워너 칠콧 컴퍼니 엘엘씨 퀴놀론 중간체를 제조하기 위한 커플링 방법
KR20080110877A (ko) * 2006-03-31 2008-12-19 재단법인 이쯔우 연구소 헤테로환을 갖는 신규 화합물
US8124623B2 (en) 2006-11-10 2012-02-28 Actelion Pharmaceuticals Ltd. 5-hydroxymethyl-oxazolidin-2-one-derivatives and their uses as antibacterials
CL2007003332A1 (es) 2006-11-24 2008-06-20 Actelion Pharmaceuticals Ltd Compuestos derivados de heterociclos condensados; compuestos intermediarios; composicion farmaceutica; y uso en la prevencion o tratamiento de infecciones bacterianas.
BRPI0813900A2 (pt) 2007-06-25 2014-12-30 Novartis Ag Derivados de n5-(2-etoxietil)-n3-(2-piridinil)-3,5-piperidinodicarboxa mida para uso como inibidores de renina
RU2010120671A (ru) * 2007-10-24 2011-11-27 Мерк Шарп Энд Домэ Корп. (Us) Гетероциклические фениламидные антагонисты кальциевых каналов т-типа
PL2296651T3 (pl) * 2008-05-09 2012-12-31 Actelion Pharmaceuticals Ltd Pochodne 5-hydroksymetylooksazolidyn-2-onu do leczenia bakteryjnych chorób jelitowych
WO2010081851A1 (en) 2009-01-14 2010-07-22 Genoscience Pharma Piperidin-4-ylpiperazine compounds for the treatment of hcv infection
SG11201507241UA (en) 2013-03-08 2015-10-29 Allergan Inc Cyclosporine a-steroid conjugates
MX2015011948A (es) 2013-03-08 2015-12-09 Allergan Inc Antibioticos conjugados directamente relacionados con farmacos esteroides.
CN103145615B (zh) * 2013-03-20 2015-07-29 浙江医药股份有限公司 一种奈诺沙星螯合物的后处理方法
US9993469B2 (en) * 2013-05-28 2018-06-12 Morphochem Aktiengesellschaft Für Kombinatorishe Chemie Combination therapy comprising oxazolidinone-quinolones for use in treating bacterial infections
WO2014191075A1 (en) 2013-05-28 2014-12-04 Morphochem Aktiengesellschaft für kombinatorische Chemie Oxazolidinone-quinolone hybrid antibacterials for the parenteral treatment or prophylaxis of bacterial diseases
CN103421008B (zh) * 2013-09-07 2015-05-27 吉首大学 一类多靶点呋喃酮-喹啉酮型化合物及其制法和用途
CN107286182A (zh) * 2016-04-12 2017-10-24 李靖 新型噁唑烷酮‑氟喹诺酮衍生物及用途
CN107648181B (zh) * 2016-07-25 2021-05-04 广东赛法洛药业有限公司 一种利他唑酮磷脂复合物及其制备方法和应用
US10087171B2 (en) 2016-12-19 2018-10-02 Actelion Pharmaceuticals Ltd Crystalline forms of cadazolid
CN109942546B (zh) * 2019-04-16 2022-04-08 西南大学 喹诺酮嘧啶类化合物及其制备方法和应用
CN118201916A (zh) * 2021-10-26 2024-06-14 豪夫迈·罗氏有限公司 用于治疗细菌感染的哌嗪基磺酰基芳基化合物

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DE19633480A1 (de) * 1996-08-20 1998-02-26 Bayer Ag Oral applizierbare Formulierungen von Chinolon- und Naphthyridoncarbonsäuren
GB9725244D0 (en) * 1997-11-29 1998-01-28 Zeneca Ltd Chemical compounds
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TW572757B (en) 1998-08-24 2004-01-21 Bristol Myers Squibb Co Novel isoxazolinone antibacterial agents
KR100324621B1 (ko) 1999-04-27 2002-02-27 박호군 퀴놀론이 치환된 옥사졸리디논 유도체 및 그의 제조 방법과 항균제로서의 용도
IL147503A0 (en) 1999-07-28 2002-08-14 Upjohn Co Oxazolidinone compounds and methods of preparation and use thereof
US6518285B2 (en) 1999-12-21 2003-02-11 Ortho Mcneil Pharmaceutical, Inc. Piperidinyloxy and pyrrolidinyloxy oxazolidinone antibacterials
US6689769B2 (en) * 2000-12-21 2004-02-10 Pharmacia & Upjohn Company Antimicrobial quinolone derivatives and use of the same to treat bacterial infections
ES2186550B2 (es) 2001-06-27 2003-11-16 Vita Lab Nuevos derivados de oxazolidinonas como antibacterianos.
WO2003031441A1 (en) 2001-10-04 2003-04-17 Morphochen Aktiengesellschaft Für Kombinatorische Chemie Multiple action compounds
WO2003031443A1 (en) 2001-10-04 2003-04-17 Morphochem Aktiengesellschaft für kombinatorische Chemie Dual actions antibiotics comprising a oxazoldinone and a quinolone or naphthyridinone moiety
US20040132764A1 (en) 2002-10-23 2004-07-08 Morphochem Aktiengesellschaft Fuer Kombinatorische Chemie Antibiotics for the treatment of infections in acidic environments
WO2004069816A1 (en) 2003-02-07 2004-08-19 Ranbaxy Laboratories Limited Oxazolidinone derivatives as antimicrobials
WO2004096221A1 (en) 2003-04-30 2004-11-11 Morphochem Aktiengesellschaft für kombinatorische Chemie Use of oxazolidinone-quinoline hybrid antibiotics for the treatment of anthrax and other infections
DE10340485B4 (de) 2003-09-03 2015-05-13 Morphochem AG Aktiengesellschaft für kombinatorische Chemie Verfahren zur Herstellung von Oxazolidinon-Chinolon Hybriden
CA2549675C (en) 2003-12-18 2012-11-20 Morphochem Aktiengesellschaft Fur Kombinatorische Chemie Oxazolidinone-quinolone hybrid antibiotics
US8158797B2 (en) 2003-12-18 2012-04-17 Morphochem Aktiengesellschaft Fur Kombinatorische Chemie Oxazolidinone-quinolone hybrid antibiotics
AR054608A1 (es) 2005-08-08 2007-06-27 Actelion Pharmaceuticals Ltd Derivados de oxazolidinona enlazados a quinolonas como antibacterianos
KR200430712Y1 (ko) 2006-08-30 2006-11-13 명 식 신 천장등
DK2086968T3 (da) 2006-11-10 2012-03-19 Actelion Pharmaceuticals Ltd 5-hydroxymethyl-oxazolidin-2-on-derivater
US8124623B2 (en) * 2006-11-10 2012-02-28 Actelion Pharmaceuticals Ltd. 5-hydroxymethyl-oxazolidin-2-one-derivatives and their uses as antibacterials
CL2007003332A1 (es) 2006-11-24 2008-06-20 Actelion Pharmaceuticals Ltd Compuestos derivados de heterociclos condensados; compuestos intermediarios; composicion farmaceutica; y uso en la prevencion o tratamiento de infecciones bacterianas.
PL2296651T3 (pl) 2008-05-09 2012-12-31 Actelion Pharmaceuticals Ltd Pochodne 5-hydroksymetylooksazolidyn-2-onu do leczenia bakteryjnych chorób jelitowych

Also Published As

Publication number Publication date
BRPI0213063B1 (pt) 2018-02-14
WO2003032962A2 (en) 2003-04-24
PL210850B1 (pl) 2012-03-30
KR100927864B1 (ko) 2009-11-23
WO2003032962A3 (en) 2003-07-17
JP4398245B2 (ja) 2010-01-13
JP2005529061A (ja) 2005-09-29
EP1432705A2 (en) 2004-06-30
PT1432705E (pt) 2007-08-27
AU2002361948B2 (en) 2007-03-29
KR20040055781A (ko) 2004-06-26
DK1432705T3 (da) 2007-09-17
WO2003031443A1 (en) 2003-04-17
CN101381365B (zh) 2011-07-06
JP2010006814A (ja) 2010-01-14
US8329908B2 (en) 2012-12-11
CY1107503T1 (el) 2013-03-13
BRPI0213063B8 (pt) 2021-05-25
US20050096343A1 (en) 2005-05-05
US20110059946A1 (en) 2011-03-10
BR0213063A (pt) 2004-09-28
DE60221684D1 (de) 2007-09-20
HU229935B1 (en) 2015-01-28
US7820823B2 (en) 2010-10-26
HUP0402126A3 (en) 2012-10-29
NZ531879A (en) 2005-10-28
CA2460572A1 (en) 2003-04-24
CN101381365A (zh) 2009-03-11
CA2460572C (en) 2011-11-08
ATE369363T1 (de) 2007-08-15
ES2287354T3 (es) 2007-12-16
KR100987696B1 (ko) 2010-10-13
DE60221684T2 (de) 2008-04-30
PL367517A1 (en) 2005-02-21
CN1630655A (zh) 2005-06-22
IL160769A0 (en) 2004-08-31
KR20090100426A (ko) 2009-09-23
EP1432705B1 (en) 2007-08-08
HUP0402126A2 (hu) 2005-02-28
ZA200401909B (en) 2005-05-25
IL160769A (en) 2009-12-24

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Legal Events

Date Code Title Description
PE Patent expired

Effective date: 20220929