AR054608A1 - Derivados de oxazolidinona enlazados a quinolonas como antibacterianos - Google Patents

Derivados de oxazolidinona enlazados a quinolonas como antibacterianos

Info

Publication number
AR054608A1
AR054608A1 ARP060103389A ARP060103389A AR054608A1 AR 054608 A1 AR054608 A1 AR 054608A1 AR P060103389 A ARP060103389 A AR P060103389A AR P060103389 A ARP060103389 A AR P060103389A AR 054608 A1 AR054608 A1 AR 054608A1
Authority
AR
Argentina
Prior art keywords
quinolones
antibacterials
oxazolidinone derivatives
derivatives linked
haloalkyl
Prior art date
Application number
ARP060103389A
Other languages
English (en)
Original Assignee
Actelion Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd
Publication of AR054608A1 publication Critical patent/AR054608A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Abstract

La presente se relaciona con nuevos antibioticos quiméricos de formula (1) en la cual R1 es CH2NHCOR5, heteroarilmetilo, heteroariloximetil o heteroarilaminometilo; R2 es H, OH, OSO3H, OPO3H2, OCH2OPO3H2, OCOCH2CH2COOH, OCOR6; R3 es H o halogeno; R4 es alquilo C1-3, haloalquilo C1-3 o cicloalquilo; R5 es alquilo o haloalquilo; y R6 es el residuo de un aminoácido natural o de dimetilaminoglicina. Estos compuestos son utiles en la produccion de medicamentos para el tratamiento de infecciones (por ejemplo, infecciones bacteriales).
ARP060103389A 2005-08-08 2006-08-03 Derivados de oxazolidinona enlazados a quinolonas como antibacterianos AR054608A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP2005008573 2005-08-08

Publications (1)

Publication Number Publication Date
AR054608A1 true AR054608A1 (es) 2007-06-27

Family

ID=37620798

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP060103389A AR054608A1 (es) 2005-08-08 2006-08-03 Derivados de oxazolidinona enlazados a quinolonas como antibacterianos

Country Status (16)

Country Link
US (1) US20100222302A1 (es)
EP (2) EP2256120A1 (es)
JP (1) JP2009504631A (es)
KR (1) KR20080038397A (es)
CN (1) CN101238135B (es)
AR (1) AR054608A1 (es)
AU (1) AU2006277662A1 (es)
BR (1) BRPI0614730A2 (es)
CA (1) CA2616977A1 (es)
IL (1) IL189322A0 (es)
MX (1) MX2008001415A (es)
NO (1) NO20081180L (es)
RU (1) RU2008108477A (es)
TW (1) TW200740829A (es)
WO (1) WO2007017828A2 (es)
ZA (1) ZA200802194B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003031443A1 (en) 2001-10-04 2003-04-17 Morphochem Aktiengesellschaft für kombinatorische Chemie Dual actions antibiotics comprising a oxazoldinone and a quinolone or naphthyridinone moiety
BRPI0409955A (pt) 2003-04-30 2006-04-25 Morphochem Ag Komb Chemie uso de antibióticos hìbridos de oxazolidinona - quinolina para o tratamento de antrax e outras infecções
DE10340485B4 (de) 2003-09-03 2015-05-13 Morphochem AG Aktiengesellschaft für kombinatorische Chemie Verfahren zur Herstellung von Oxazolidinon-Chinolon Hybriden
NZ547382A (en) 2003-12-18 2009-11-27 Morphochem Ag Komb Chemie Oxazolidinone-quinolone hybrid antibiotics
US8158797B2 (en) 2003-12-18 2012-04-17 Morphochem Aktiengesellschaft Fur Kombinatorische Chemie Oxazolidinone-quinolone hybrid antibiotics
AU2006277682A1 (en) * 2005-04-21 2007-02-15 Targanta Therapeutics Inc. Phosphonated fluoroquinolones, antibacterial analogs thereof, and methods for the prevention and treatment of bone and joint infections
US8124623B2 (en) 2006-11-10 2012-02-28 Actelion Pharmaceuticals Ltd. 5-hydroxymethyl-oxazolidin-2-one-derivatives and their uses as antibacterials
CL2007003332A1 (es) * 2006-11-24 2008-06-20 Actelion Pharmaceuticals Ltd Compuestos derivados de heterociclos condensados; compuestos intermediarios; composicion farmaceutica; y uso en la prevencion o tratamiento de infecciones bacterianas.
CL2008001002A1 (es) 2007-04-11 2008-10-17 Actelion Pharmaceuticals Ltd Compuestos derivados de oxazolidinona; composicion farmaceutica que comprende a dichos compuestos; y su uso para preparar un medicamento para tratar una infeccion bacteriana.
WO2011031744A1 (en) * 2009-09-09 2011-03-17 Achaogen, Inc. Antibacterial fluoroquinolone analogs
LT3003289T (lt) 2013-05-28 2019-06-25 Morphochem Gmbh Oksazolidinono-chinolono hibrido kaip antibakterinio preparato įvedimas
WO2014191109A1 (en) 2013-05-28 2014-12-04 Morphochem Aktiengesellschaft für kombinatorische Chemie Combination therapy comprising oxazolidinone-quinolones for use in treating bacterial infections
US10087171B2 (en) 2016-12-19 2018-10-02 Actelion Pharmaceuticals Ltd Crystalline forms of cadazolid
KR102476708B1 (ko) 2017-11-01 2022-12-09 삼성전자주식회사 광학 필터, 및 이를 포함하는 카메라 모듈 및 전자 장치
KR20190113062A (ko) * 2018-03-27 2019-10-08 삼성전자주식회사 근적외선 흡수 필름, 광학 필터 및 전자 장치
CN115772176A (zh) * 2022-12-02 2023-03-10 常州兰陵制药有限公司 左氧氟沙星关键药物中间体的合成方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4806541A (en) * 1985-09-24 1989-02-21 Hoffmann-La Roche Inc. Quinoline derivatives
DK164287A (da) 1986-03-31 1987-10-01 Sankyo Co Quinolin-3-carboxylsyrederivater og fremgangsmaade til fremstilling deraf og deres anvendelse
JPH04128288A (ja) * 1990-09-18 1992-04-28 Teikoku Chem Ind Corp Ltd キノロンカルボン酸誘導体及びその製造方法
EP1349853B1 (en) * 2000-12-21 2006-03-08 Pharmacia & Upjohn Company LLC Antimicrobial quinolone derivatives and use of the same to treat bacterial infections
WO2003031443A1 (en) 2001-10-04 2003-04-17 Morphochem Aktiengesellschaft für kombinatorische Chemie Dual actions antibiotics comprising a oxazoldinone and a quinolone or naphthyridinone moiety
BR0307151A (pt) 2002-02-01 2004-12-07 Astrazeneca Ab Composto ou um sal do mesmo, processo para a preparação do mesmo, composição farmacêutica, uso do composto ou de um seu sal, método para produzir um efeito antiangiogênico e/ou redutor da permeabilidade vascular em um animal de sangue quente, como um ser humano, que necessita de um tratamento do tipo referido, e, processos para a preparação de 5-bromo-7- azaindol, e para a produção de 5-metóxi-7-azaindol
US6803469B2 (en) 2002-08-05 2004-10-12 The Procter & Gamble Company Process for preparing quinolone antibiotic intermediates
BRPI0409955A (pt) 2003-04-30 2006-04-25 Morphochem Ag Komb Chemie uso de antibióticos hìbridos de oxazolidinona - quinolina para o tratamento de antrax e outras infecções
EP1646629B1 (en) * 2003-07-02 2010-06-23 Merck Sharp & Dohme Corp. Cyclopropyl group substituted oxazolidinone antibiotics and derivatives thereof
NZ547382A (en) * 2003-12-18 2009-11-27 Morphochem Ag Komb Chemie Oxazolidinone-quinolone hybrid antibiotics

Also Published As

Publication number Publication date
MX2008001415A (es) 2008-04-04
CA2616977A1 (en) 2007-02-15
WO2007017828A2 (en) 2007-02-15
AU2006277662A1 (en) 2007-02-15
BRPI0614730A2 (pt) 2016-11-01
TW200740829A (en) 2007-11-01
EP1931684A2 (en) 2008-06-18
CN101238135B (zh) 2011-05-11
ZA200802194B (en) 2009-03-25
JP2009504631A (ja) 2009-02-05
NO20081180L (no) 2008-04-15
KR20080038397A (ko) 2008-05-06
WO2007017828A3 (en) 2007-07-19
EP2256120A1 (en) 2010-12-01
CN101238135A (zh) 2008-08-06
US20100222302A1 (en) 2010-09-02
IL189322A0 (en) 2008-06-05
RU2008108477A (ru) 2009-09-20

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