CS216231B2 - Method of making the esters of the n-substituted acid of the 9,10-dihydrolysergic - Google Patents
Method of making the esters of the n-substituted acid of the 9,10-dihydrolysergic Download PDFInfo
- Publication number
- CS216231B2 CS216231B2 CS784790A CS479078A CS216231B2 CS 216231 B2 CS216231 B2 CS 216231B2 CS 784790 A CS784790 A CS 784790A CS 479078 A CS479078 A CS 479078A CS 216231 B2 CS216231 B2 CS 216231B2
- Authority
- CS
- Czechoslovakia
- Prior art keywords
- mmol
- dihydrolysergic
- formula
- benzene
- hydrogen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
YU1819/77A YU40004B (en) | 1977-07-21 | 1977-07-21 | Praocess for preparing n-substituted esters of 9,10-dihydrlysergic acid |
Publications (1)
Publication Number | Publication Date |
---|---|
CS216231B2 true CS216231B2 (en) | 1982-10-29 |
Family
ID=25555705
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CS784790A CS216231B2 (en) | 1977-07-21 | 1978-07-18 | Method of making the esters of the n-substituted acid of the 9,10-dihydrolysergic |
Country Status (11)
Country | Link |
---|---|
US (1) | US4230859A (de) |
EP (1) | EP0000533B1 (de) |
JP (1) | JPS5436296A (de) |
AT (1) | AT363195B (de) |
CS (1) | CS216231B2 (de) |
DE (1) | DE2860896D1 (de) |
ES (1) | ES471716A1 (de) |
FI (1) | FI64369C (de) |
PT (1) | PT68278A (de) |
SU (1) | SU784775A3 (de) |
YU (1) | YU40004B (de) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4563461A (en) * | 1983-03-10 | 1986-01-07 | Eli Lilly And Company | Selective method for blocking 5HT2 receptors |
FR2584721B1 (fr) * | 1985-07-11 | 1987-10-02 | Rhone Poulenc Sante | Procede de preparation des derives n-methyles du dihydrolysergate de methyle ou du methoxylumilysergate de methyle |
FR2584720B1 (fr) * | 1985-07-11 | 1987-10-02 | Rhone Poulenc Sante | Procede de preparation de derives n-methyles de l'ergoline |
US4772709A (en) * | 1985-10-01 | 1988-09-20 | Eli Lilly And Company | Process of making ketoalkanol esters of dihydrolysergic acid |
US4734501A (en) * | 1985-10-01 | 1988-03-29 | Eli Lilly And Company | N-alkylation of dihydrolysergic acid |
US4810710A (en) * | 1985-10-01 | 1989-03-07 | Eli Lilly And Company | 4-hydroxycyclohexyl 1-isopropyl-9,10-dihydro-lysergate for the treatment of migraine |
US4845224A (en) * | 1985-10-01 | 1989-07-04 | Eli Lilly And Company | Cycloalkanol esters of dihydrolysergic acid having peripheral serotonin antagonist properties |
US4939258A (en) * | 1985-10-01 | 1990-07-03 | Eli Lilly And Company | Cycloalkanol esters of dihydrolysergic acid |
US4847261A (en) * | 1985-10-01 | 1989-07-11 | Eli Lilly And Company | Alkoxy cycloalkanol esters of dihydrolysergic acid having peripheral serotonin antagonists properties |
US4683236A (en) * | 1985-10-01 | 1987-07-28 | Eli Lilly And Company | Cycloalkanol esters of dihydrolysergic acid useful as 5Ht2 receptor antagonists |
US4820713A (en) * | 1985-10-01 | 1989-04-11 | Eli Lilly And Company | Ketoalkanol esters of dihydrolysergic acid useful as 5HT receptor antagonists |
US4713384A (en) * | 1985-10-01 | 1987-12-15 | Eli Lilly And Company | Selective method for blocking 5HT2 receptors |
US4968802A (en) * | 1985-10-01 | 1990-11-06 | Eli Lilly And Company | Process of making alkoxy cycloalkanol esters of dihydrolysergic acid |
US4762842A (en) * | 1985-10-01 | 1988-08-09 | Eli Lilly And Company | Selective method for blocking 5HT2 receptors |
US4713385A (en) * | 1985-10-01 | 1987-12-15 | Eli Lilly And Company | Alkoxy and dialkoxyalkyl esters of dihydrolysergic acid and related compounds useful as 5HT receptor antagonists |
US4906639A (en) * | 1985-10-01 | 1990-03-06 | Eli Lilly And Company | Cycloalkanol esters of dihydrolysergic acid |
US4714704A (en) * | 1985-10-01 | 1987-12-22 | Eli Lilly And Company | Alkoxy cycloalkanol esters of dihydrolysergic acid useful as 5HT receptor antagonists |
US4683237A (en) * | 1985-12-20 | 1987-07-28 | Eli Lilly And Company | Fluoroalkyl esters of dihydrolysergic acid useful as 5HT2 receptor antagonists |
US4704396A (en) * | 1985-12-20 | 1987-11-03 | Eli Lilly And Company | Phenacyl esters of 1-substituted-6-(substituted and unsubstituted) dihydrolysergic acids useful as 5HT receptor antagonists |
US4704395A (en) * | 1985-12-20 | 1987-11-03 | Eli Lilly And Company | Cyclic ether esters of 2-substituted-6-(substituted and unsubstituted) dihydrolysergic acid useful as 5HT receptor antagonists |
US4782063A (en) * | 1987-05-11 | 1988-11-01 | Eli Lilly And Company | Ergoline esters useful as serotonin antagonists |
US4835159A (en) * | 1987-05-11 | 1989-05-30 | Eli Lilly And Company | Ergoline esters useful as serotonin antagonists |
US4981859A (en) * | 1987-06-15 | 1991-01-01 | Cycloalkylamides of (8 beta )-1-alkyl-6-(substituted)ergolines | |
US4931447A (en) * | 1987-06-15 | 1990-06-05 | Eli Lilly And Company | Cycloalkylamides of (8β)-1-alkyl-6-(substituted) ergolines |
JPH01106511U (de) * | 1988-01-02 | 1989-07-18 | ||
JPH02125915U (de) * | 1989-03-29 | 1990-10-17 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA631701A (en) * | 1961-11-28 | Sandoz A.G. | Compounds of the lysergic acid series alkylated at the indol nitrogen atom | |
FR1175276A (fr) * | 1956-05-18 | 1959-03-23 | Sandoz Ag | Nouveaux dérivés de la série de l'acide lysergique et leur préparation |
CH344731A (de) * | 1956-05-18 | 1960-02-29 | Sandoz Ag | Verfahren zur Herstellung von neuen, am Indolstickstoff alkylierten Derivaten der Lysergsäure-Reihe |
US3228943A (en) * | 1962-06-11 | 1966-01-11 | Lumilysergol derivatives | |
US3232942A (en) * | 1964-06-02 | 1966-02-01 | Sandoz Ltd | 1-substituted (+)-lysergol |
GB1298277A (en) * | 1969-04-18 | 1972-11-29 | Sandoz Ltd | Preparation of ergot peptide alkaloids |
US3879554A (en) * | 1970-03-20 | 1975-04-22 | Farmaceutici Italia | Use of 1,6-dimethyl-8-{62 -(5-bromonicotinoyloxymethyl)-10 {60 -methoxyergoline in treating cerebral and peripheral metabolic vascular disorders |
NL159384B (nl) * | 1971-03-13 | 1979-02-15 | Farmaceutici Italia | Werkwijze voor het bereiden van een geneesmiddel met een adrenolytische activiteit, alsmede werkwijze voor het bereiden van een ester van 1-methyl-10-methoxylumilysergol. |
DE2330912C3 (de) * | 1972-06-22 | 1979-01-11 | Societa Farmaceutici Italia S.P.A., Mailand (Italien) | Verfahren zur Herstellung von Bromergolinverbindungen |
-
1977
- 1977-07-21 YU YU1819/77A patent/YU40004B/xx unknown
-
1978
- 1978-06-29 FI FI782081A patent/FI64369C/fi not_active IP Right Cessation
- 1978-07-06 AT AT0490078A patent/AT363195B/de not_active IP Right Cessation
- 1978-07-07 US US05/922,692 patent/US4230859A/en not_active Expired - Lifetime
- 1978-07-12 PT PT68278A patent/PT68278A/pt unknown
- 1978-07-14 ES ES471716A patent/ES471716A1/es not_active Expired
- 1978-07-18 DE DE7878100419T patent/DE2860896D1/de not_active Expired
- 1978-07-18 CS CS784790A patent/CS216231B2/cs unknown
- 1978-07-18 EP EP78100419A patent/EP0000533B1/de not_active Expired
- 1978-07-20 SU SU782637592A patent/SU784775A3/ru active
- 1978-07-21 JP JP8850978A patent/JPS5436296A/ja active Granted
Also Published As
Publication number | Publication date |
---|---|
PT68278A (en) | 1978-08-01 |
FI64369C (fi) | 1983-11-10 |
FI782081A (fi) | 1979-01-22 |
FI64369B (fi) | 1983-07-29 |
EP0000533B1 (de) | 1981-08-05 |
ATA490078A (de) | 1980-12-15 |
AT363195B (de) | 1981-07-10 |
YU40004B (en) | 1985-06-30 |
US4230859A (en) | 1980-10-28 |
DE2860896D1 (en) | 1981-11-05 |
SU784775A3 (ru) | 1980-11-30 |
ES471716A1 (es) | 1979-10-01 |
JPS5648512B2 (de) | 1981-11-16 |
YU181977A (en) | 1983-01-21 |
EP0000533A1 (de) | 1979-02-07 |
JPS5436296A (en) | 1979-03-16 |
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