CR7387A - Nuevos compuestos heterociclicos activos como inhibidores de las beta- lactamasas - Google Patents

Nuevos compuestos heterociclicos activos como inhibidores de las beta- lactamasas

Info

Publication number
CR7387A
CR7387A CR7387A CR7387A CR7387A CR 7387 A CR7387 A CR 7387A CR 7387 A CR7387 A CR 7387A CR 7387 A CR7387 A CR 7387A CR 7387 A CR7387 A CR 7387A
Authority
CR
Costa Rica
Prior art keywords
inhibitors
lactamasas
beta
new active
heterociclic compounds
Prior art date
Application number
CR7387A
Other languages
English (en)
Inventor
Jozsef Aszodi
Claude Fromentin
Maxime Lampilas
David Alan Rowlands
Original Assignee
Novexel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27619669&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CR7387(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novexel filed Critical Novexel
Publication of CR7387A publication Critical patent/CR7387A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4995—Pyrazines or piperazines forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Los derivados de azacicloalcanos de la formula estructural I son inhibidores selectivos de estearoil-coenzima A deltta-9 desaturasa (SCD1) con respecto a otras estearoil-coenzima A desaturasas conocidas.
CR7387A 2002-01-28 2004-07-13 Nuevos compuestos heterociclicos activos como inhibidores de las beta- lactamasas CR7387A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0200951A FR2835186B1 (fr) 2002-01-28 2002-01-28 Nouveaux composes heterocycliques, actifs comme inhibiteurs de beta-lactamases

Publications (1)

Publication Number Publication Date
CR7387A true CR7387A (es) 2010-10-25

Family

ID=27619669

Family Applications (2)

Application Number Title Priority Date Filing Date
CR7387A CR7387A (es) 2002-01-28 2004-07-13 Nuevos compuestos heterociclicos activos como inhibidores de las beta- lactamasas
CR20120356A CR20120356A (es) 2002-01-28 2012-06-28 Nuevos compuestos heterocíclicos activos como inhibidores de beta-lactamasas

Family Applications After (1)

Application Number Title Priority Date Filing Date
CR20120356A CR20120356A (es) 2002-01-28 2012-06-28 Nuevos compuestos heterocíclicos activos como inhibidores de beta-lactamasas

Country Status (45)

Country Link
US (4) US7612087B2 (es)
EP (2) EP1480644B1 (es)
JP (1) JP4472346B2 (es)
KR (1) KR100979079B1 (es)
CN (3) CN101406471A (es)
AR (2) AR038234A1 (es)
AT (1) ATE484281T1 (es)
AU (1) AU2003214335B2 (es)
BE (1) BE2016C069I2 (es)
BR (1) BRPI0307267B8 (es)
CA (1) CA2474043C (es)
CL (1) CL2011000009A1 (es)
CO (1) CO5601014A2 (es)
CR (2) CR7387A (es)
CY (3) CY1111061T1 (es)
DE (1) DE60334527D1 (es)
DK (2) DK2279737T3 (es)
EA (1) EA007220B1 (es)
EC (1) ECSP045193A (es)
ES (2) ES2401855T3 (es)
FR (1) FR2835186B1 (es)
HK (2) HK1077205A1 (es)
HR (1) HRP20040686B1 (es)
HU (1) HUS1600055I1 (es)
IL (1) IL163167A (es)
JO (1) JO2646B1 (es)
LT (1) LTC1480644I2 (es)
MA (1) MA26351A1 (es)
MX (1) MXPA04006621A (es)
MY (1) MY140638A (es)
NL (1) NL300847I2 (es)
NO (2) NO335195B1 (es)
NZ (1) NZ533936A (es)
OA (1) OA12761A (es)
PE (1) PE20030969A1 (es)
PL (1) PL220725B1 (es)
PT (2) PT1480644E (es)
RS (1) RS52137B (es)
SI (2) SI2279737T1 (es)
TN (1) TNSN04137A1 (es)
TW (1) TWI293071B (es)
UA (1) UA80271C2 (es)
UY (1) UY27626A1 (es)
WO (1) WO2003063864A2 (es)
ZA (1) ZA200405607B (es)

Families Citing this family (85)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2812635B1 (fr) * 2000-08-01 2002-10-11 Aventis Pharma Sa Nouveaux composes heterocycliques, preparation et utilisation comme medicaments notamment comme anti- bacteriens
FR2835186B1 (fr) * 2002-01-28 2006-10-20 Aventis Pharma Sa Nouveaux composes heterocycliques, actifs comme inhibiteurs de beta-lactamases
FR2844273B1 (fr) 2002-09-05 2008-04-04 Aventis Pharma Sa Nouveaux composes heterocycliques, procede et intermediaires de preparation et utilisation comme medicament, notamment comme inhibiteurs de beta-lactamases et anti-bacteriens.
US7439253B2 (en) * 2002-12-06 2008-10-21 Novexel Heterocyclic compounds, their preparation and their use as medicaments, in particular as antibacterials and beta-lactamase inhibitors
FR2848210B1 (fr) * 2002-12-06 2007-10-19 Aventis Pharma Sa Nouveaux composes heterocycliques, leur preparation et leur utilisation comme medicaments, notamment comme anti-bacteriens et inhibiteurs de beta-lactamases
US8900637B2 (en) * 2005-12-02 2014-12-02 Lupin Limited Stable taste masked formulations of cephalosporins
DK1965798T3 (da) * 2005-12-07 2011-11-28 Basilea Pharmaceutica Ag Nyttige monobactam-antibiotika
JP5539717B2 (ja) * 2006-07-14 2014-07-02 塩野義製薬株式会社 オキシム化合物およびその使用
AU2007309195A1 (en) * 2006-10-23 2008-05-02 Irm Llc Cathepsin proteases inhibitors
US8563732B2 (en) * 2007-05-31 2013-10-22 Shionogi & Co., Ltd. Oxyimino compounds and the use thereof
FR2921060B1 (fr) * 2007-09-14 2012-06-15 Novexel Nouveau procede de preparation d'une piperidine disubsituee et nouveaux intermediaires
WO2009091856A2 (en) * 2008-01-18 2009-07-23 Merck & Co., Inc. Beta-lactamase inhibitors
WO2009114921A1 (en) * 2008-03-17 2009-09-24 Dmitrienko Gary I INHIBITORS OF CLASS B AND CLASS D β-LACTAMASES
FR2930553B1 (fr) * 2008-04-29 2010-05-21 Novexel Composes azabicycliques, leur preparation et leur utilisation comme medicaments, notamment inhibiteurs de beta-lactamases
EP2346820B1 (en) * 2008-06-11 2013-02-13 Shionogi & Co., Ltd. Oxycarbamoyl compounds and the use thereof
FR2936798B1 (fr) * 2008-10-03 2012-09-28 Novexel Nouveaux composes heterocycliques azotes, leur preparation et leur utilisation comme medicaments antibacteriens.
FR2937034B1 (fr) * 2008-10-10 2012-11-23 Novexel Nouveaux composes heterocycliques azotes, leur preparation et leur utilisation comme medicaments antibacteriens
FR2936951B1 (fr) * 2008-10-10 2010-12-03 Novexel Nouvelles combinaisons de composes heterocycliques azotes antibacteriens avec d'autres composes antibacteriens et leur utilisation comme medicaments
FR2951171A1 (fr) 2009-10-09 2011-04-15 Novexel Nouveau sel de sodium d'un compose azabicyclique sous forme enantiomere cristallisee et nouvelles formes polymorphes et pseudopolymorphes ainsi que leur preparation
AU2014244235B2 (en) * 2009-10-09 2016-04-21 Pfizer Ireland Pharmaceuticals Polymorphic and pseudopolymorphic forms of a pharmaceutical compound
LT3412676T (lt) 2010-08-10 2020-07-27 Melinta Therapeutics, Inc. Cikliniai borono rūgšties dariniai, jų gamybos būdas ir terapinis panaudojimas
US8772490B2 (en) * 2010-12-22 2014-07-08 Meiji Seika Pharma Co., Ltd. Optically active diazabicyclooctane derivatives and process for preparing the same
CN104892490B (zh) * 2010-12-22 2017-07-21 明治制果药业株式会社 用于制备光学活性二氮杂环辛烷衍生物的中间体化合物的化合物
CN105294690B (zh) * 2011-06-17 2018-07-10 辉瑞抗感染公司 制备包括反-7-氧代-6-(磺基氧基)-1,6-二氮杂二环[3,2,1]辛烷-2-甲酰胺的杂环化合物及其盐的方法
KR101512738B1 (ko) * 2011-08-27 2015-04-17 욱크하르트 리미티드 1,6-디아자-비시클로[3,2,1]옥탄-7-온 유도체 및 세균 감염 치료에서의 그 유도체의 용도
US20130053565A1 (en) * 2011-08-29 2013-02-28 University Of Utah Research Foundation Substituted 3-piperidone compounds
US9102683B2 (en) 2011-08-29 2015-08-11 University Of Utah Research Foundation Heterocyclic compounds
WO2013033461A1 (en) 2011-08-31 2013-03-07 Rempex Pharmaceuticals, Inc. Heterocyclic boronic acid ester derivatives and therapeutic uses thereof
US8969567B2 (en) * 2011-09-13 2015-03-03 Wockhardt Ltd. Nitrogen containing compounds and their use
CA2846107C (en) * 2011-09-13 2016-06-21 Wockhardt Limited Nitrogen containing compounds and their use
US9505761B2 (en) 2011-12-02 2016-11-29 Fedora Pharmaceuticals Inc. Bicyclic compounds and their use as antibacterial agents and beta-lactamase inhibitors
US8796257B2 (en) 2011-12-02 2014-08-05 Naeja Pharmaceutical Inc. Bicyclic compounds and their use as antibacterial agents and β-lactamase inhibitors
US8916709B2 (en) 2012-03-30 2014-12-23 Cubist Pharmaceuticals, Inc. 1,2,4-oxadiazole and 1,2,4-thiadiazole β-lactamase inhibitors
KR20150003777A (ko) 2012-03-30 2015-01-09 큐비스트 파마슈티컬즈 인코포레이티드 이속사졸 β-락타마제 억제제
RU2014143821A (ru) 2012-03-30 2016-05-27 Кьюбист Фармасьютикалз, Инк. 1, 3, 4-ОКСАДИАЗОЛЬНЫЕ И 1, 3, 4-ТИАДИАЗОЛЬНЫЕ ИНГИБИТОРЫ β-ЛАКТАМАЗЫ
US8969570B2 (en) 2012-03-30 2015-03-03 Cubist Pharmaceuticals, Inc. Beta-lactamase inhibitors
AR090539A1 (es) * 2012-04-02 2014-11-19 Astrazeneca Ab COMPUESTOS INHIBIDORES DE b LACTAMASA
US9156858B2 (en) 2012-05-23 2015-10-13 Rempex Pharmaceuticals, Inc. Boronic acid derivatives and therapeutic uses thereof
BR112014029368B1 (pt) 2012-05-30 2020-10-27 Meiji Seika Pharma Co., Ltd inibidor de beta-lactamase e processo para preparar o mesmo
US10561675B2 (en) 2012-06-06 2020-02-18 Rempex Pharmaceuticals, Inc. Cyclic boronic acid ester derivatives and therapeutic uses thereof
ES2672100T3 (es) * 2012-08-25 2018-06-12 Wockhardt Limited Derivados de 1,6-diazabiciclo[3,2,1]octano-7-ona y su uso en el tratamiento de infecciones bacterianas
UA111925C2 (uk) 2012-12-11 2016-06-24 Федора Фармасьютікалз Інк. БІЦИКЛІЧНІ СПОЛУКИ ТА ЇХ ВИКОРИСТАННЯ ЯК АНТИБАКТЕРІАЛЬНИХ АГЕНТІВ ТА ІНГІБІТОРІВ β-ЛАКТАМАЗИ
CA2894891A1 (en) 2013-01-04 2014-07-10 Rempex Pharmaceuticals, Inc. Boronic acid derivatives and therapeutic uses thereof
JP6324409B2 (ja) 2013-01-04 2018-05-16 レンペックス・ファーマシューティカルズ・インコーポレイテッド ボロン酸誘導体及びその治療的使用
US9241947B2 (en) 2013-01-04 2016-01-26 Rempex Pharmaceuticals, Inc. Boronic acid derivatives and therapeutic uses thereof
US9101638B2 (en) 2013-01-04 2015-08-11 Rempex Pharmaceuticals, Inc. Boronic acid derivatives and therapeutic uses thereof
US9120795B2 (en) 2013-03-14 2015-09-01 Cubist Pharmaceuticals, Inc. Crystalline form of a β-lactamase inhibitor
AR097744A1 (es) 2013-09-24 2016-04-13 Meiji Seika Pharma Co Ltd Proceso para producir derivado de diazabiciclooctano y su intermediario
US9120796B2 (en) 2013-10-02 2015-09-01 Cubist Pharmaceuticals, Inc. B-lactamase inhibitor picoline salt
WO2015053297A1 (ja) 2013-10-08 2015-04-16 Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 ジアザビシクロオクタン誘導体の結晶とその製造法
WO2015125031A1 (en) * 2014-02-20 2015-08-27 Wockhardt Limited Pharmaceutical combinations comprising antibacterial agents
CN103896936A (zh) * 2014-03-20 2014-07-02 西安交通大学 (5s,6r)氯唑西林青霉噻唑酸盐及其制备方法和应用
LT3140310T (lt) 2014-05-05 2019-11-25 Rempex Pharmaceuticals Inc Boronato druskų sintezė ir jų panaudojimas
EP3139930A4 (en) 2014-05-05 2018-01-17 Rempex Pharmaceuticals, Inc. Salts and polymorphs of cyclic boronic acid ester derivatives and therapeutic uses thereof
WO2015179308A1 (en) 2014-05-19 2015-11-26 Rempex Pharmaceuticals, Inc. Boronic acid derivatives and therapeutic uses thereof
CN104059083B (zh) * 2014-05-27 2017-01-04 浙江工业大学 一种手性二环己内酰胺类化合物的不对称合成方法
EP3164406A4 (en) 2014-07-01 2018-04-04 Rempex Pharmaceuticals, Inc. Boronic acid derivatives and therapeutic uses thereof
CA2966632C (en) 2014-11-17 2023-10-03 Entasis Therapeutics Limited Combination therapy for treatment of resistant bacterial infections
US10662205B2 (en) 2014-11-18 2020-05-26 Qpex Biopharma, Inc. Cyclic boronic acid ester derivatives and therapeutic uses thereof
AR102915A1 (es) 2014-12-05 2017-04-05 Meiji Seika Pharma Co Ltd Proceso de producción de cristales de derivado de diazabiciclooctano y preparación liofilizada estable
WO2016149393A1 (en) 2015-03-17 2016-09-22 Rempex Pharmaceuticals, Inc. Boronic acid derivatives and therapeutic uses thereof
WO2016177862A1 (en) * 2015-05-07 2016-11-10 Mutabilis Heterocyclic compounds and their use in preventing or treating bacterial infections
KR20170131661A (ko) * 2015-09-16 2017-11-29 수안주 파마 코포레이션 리미티드 β-락타메이즈 억제제 및 이의 용도
CN108137567A (zh) 2015-10-02 2018-06-08 乐高化学生物科学股份有限公司 用于抑制β-内酰胺酶的组合物和方法
WO2017156458A1 (en) 2016-03-11 2017-09-14 University Of South Florida Beta-lactamase inhibitors, formulations, and uses thereof
ES2734773T3 (es) 2016-05-27 2019-12-11 Valoralia I Mas D Sl Compuestos de dihidrooxadiazina para tratar infecciones y cáncer
DK3478693T3 (da) 2016-06-30 2021-09-20 Qpex Biopharma Inc Boronsyrederivater og terapeutiske anvendelser deraf
CN106279163A (zh) * 2016-08-12 2017-01-04 上海龙翔生物医药开发有限公司 一种合成阿维巴坦及其中间体光学异构体的方法
CN107789355B (zh) * 2016-09-07 2022-04-12 湘北威尔曼制药股份有限公司 含有哌拉西林的复方药物组合物及其应用
SI3512851T1 (sl) 2016-09-16 2022-11-30 Entasis Therapeutics Limited Inhibitorske spojine beta-laktamaze
JOP20190061A1 (ar) * 2016-09-28 2019-03-26 Novartis Ag مثبطات بيتا-لاكتاماز
CN106699756B (zh) * 2016-12-30 2019-10-29 淄博鑫泉医药技术服务有限公司 β内酰胺酶抑制剂阿维巴坦的合成方法
MX2019009362A (es) 2017-02-06 2019-10-22 Mutabilis Compuestos heterociclicos novedosos y sus usos en la prevencion o el tratamiento de infecciones bacterianas.
HUE057592T2 (hu) 2017-05-08 2022-05-28 Entasis Therapeutics Inc Vegyületek és eljárások bakteriális fertõzések kezelésére
WO2018234962A1 (en) 2017-06-20 2018-12-27 Wockhardt Limited PROCESS FOR O-SULFONATION OF 1,6-DIAZABICYCLO [3.2.1] OCTANE COMPOUNDS
CA3078627A1 (en) 2017-10-11 2019-04-18 Qpex Biopharma, Inc. Boronic acid derivatives and synthesis thereof
CN109678856B (zh) * 2017-10-18 2020-09-25 新发药业有限公司 一种阿维巴坦中间体的制备方法
WO2019093450A1 (ja) * 2017-11-10 2019-05-16 塩野義製薬株式会社 ジアザビシクロオクタン誘導体
CA3097127A1 (en) 2018-04-20 2019-10-24 Qpex Biopharma, Inc. Boronic acid derivatives and therapeutic uses thereof
US11905286B2 (en) 2018-08-09 2024-02-20 Antabio Sas Diazabicyclooctanones as inhibitors of serine beta-lactamases
CN109942579B (zh) * 2019-04-18 2021-06-22 成都千禧莱医药科技有限公司 β-内酰胺酶抑制剂含脲双环化合物及其制备方法和应用
EP4146650A4 (en) * 2020-09-01 2024-01-17 Ningxia Academy of Agriculture and Forestry Sciences BETA-LACTAMASE INHIBITORS AND THEIR PRODUCTION
WO2022047790A1 (en) * 2020-09-07 2022-03-10 Ningxia Academy Of Agriculture And Forestry Sciences Amidine substituted bicyclic compounds, their preparation, their use as antibacterial agents and beta-lactamase inhibitors
WO2023060369A1 (en) * 2021-10-11 2023-04-20 Ningxia Academy Of Agriculture And Forestry Sciences Novel carbimidate substituted bicyclic compounds and their use as beta-lactamase inhibitors
CN116375706A (zh) * 2023-02-22 2023-07-04 时森海(杭州)医药科技有限公司 阿维巴坦钠关键中间体及其制备方法

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0260057A3 (en) 1986-09-02 1989-02-01 The University Of Melbourne 2-oxo-4-carboxy-pyrimidines
HU210264B (en) 1989-06-09 1995-03-28 Upjohn Co Process for producing amines of condensed ring-systems containing nitrogen and pharmaceutical compositions containing them
FR2676230B1 (fr) 1991-05-07 1993-08-27 Centre Nat Rech Scient Nouveaux derives de pyrrolo [1,4]-benzodiazepines, leur procede de preparation et medicaments les contenant.
JPH05339263A (ja) 1992-06-08 1993-12-21 Wakunaga Pharmaceut Co Ltd ジヒドロピリジン誘導体
DE69434805T2 (de) 1993-09-29 2007-02-22 Nabi, Boca Raton Ringerweiterte Nukleoside und Nukleotide
WO1995018129A1 (en) * 1993-12-29 1995-07-06 Pfizer Inc. Diazabicyclic neurokinin antagonists
EP0702004A2 (de) 1994-09-15 1996-03-20 Ciba-Geigy Ag 2,9-Diamino- und 2-amino-8-carbamoyl-4-hydroxy-alkansäureamid-derivative
GB9505538D0 (en) 1995-03-18 1995-05-03 Ciba Geigy Ag New compounds
SE9504618D0 (sv) 1995-12-22 1995-12-22 Astra Ab New Compounds
US6020368A (en) * 1996-01-03 2000-02-01 Hinks; Jeremy David Carbamoyloxy derivatives of mutiline and their use as antibacterials
UA51716C2 (uk) 1996-07-08 2002-12-16 Авентіс Фармасьютікалз Продактс Інк. Сполуки, що мають гіпотензивну, кардіопротекторну, анти-ішемічну та антиліполітичну властивості, фармацевтична композиція та способи лікування
DE19627431A1 (de) 1996-07-08 1998-01-15 Bayer Ag Heterocyclisch kondensierte Pyridine
HUP0001741A3 (en) * 1996-08-02 2000-11-28 Smithkline Beecham Plc Azabicyclic carbamoyloxy mutilin derivatives for antibacterial use, process for preparing them, pharmaceuticals contg. them and their use
TW527355B (en) 1997-07-02 2003-04-11 Bristol Myers Squibb Co Inhibitors of farnesyl protein transferase
US5994340A (en) * 1997-08-29 1999-11-30 Synphar Laboratories, Inc. Azetidinone derivatives as β-lactamase inhibitors
US6197339B1 (en) 1997-09-30 2001-03-06 Pharmacia & Upjohn Company Sustained release tablet formulation to treat Parkinson's disease
UY25225A1 (es) * 1997-10-29 2000-12-29 Smithkline Beecham Plc Derivados de pleuromutilina utiles como agentes antimicrobianos
US6329389B1 (en) 1998-04-08 2001-12-11 Takeda Chemical Industries, Ltd. Amine compounds, their production and use
WO2000000479A1 (en) 1998-06-30 2000-01-06 Du Pont Pharmaceuticals Company 1,3-benzodiazepin-2-ones and 1,3-benzoxazepin-2-ones useful as hiv reverse transcriptase inhibitors
GB9818731D0 (en) 1998-08-27 1998-10-21 Univ Portsmouth Compounds
TR200101754T2 (tr) 1998-12-18 2002-05-21 Schering Corporation Farnezil protein transferaz inhibitörleri
CO5180550A1 (es) 1999-04-19 2002-07-30 Smithkline Beecham Corp Inhibidores de fab i
CA2386517A1 (en) 1999-10-07 2001-04-12 Takeda Chemical Industries, Ltd. Amine derivatives
US20030105118A1 (en) 2000-04-18 2003-06-05 Shuji Masumoto Tricyclic quinazolinediones
FR2812635B1 (fr) * 2000-08-01 2002-10-11 Aventis Pharma Sa Nouveaux composes heterocycliques, preparation et utilisation comme medicaments notamment comme anti- bacteriens
JP2004522781A (ja) 2001-02-22 2004-07-29 スクール オブ ファーマシー， ユニヴァーシティ オブ ロンドン 腫瘍処置のためのプロドラッグとしてのインドリンおよびテトラヒドロ−キノリン
FR2825705B1 (fr) * 2001-06-08 2005-05-20 Aventis Pharma Sa Nouveaux composes heterocycliques, leur preparation et leur utilisation comme medicaments, notamment comme anti-bacteriens
FR2835186B1 (fr) 2002-01-28 2006-10-20 Aventis Pharma Sa Nouveaux composes heterocycliques, actifs comme inhibiteurs de beta-lactamases
US7439253B2 (en) * 2002-12-06 2008-10-21 Novexel Heterocyclic compounds, their preparation and their use as medicaments, in particular as antibacterials and beta-lactamase inhibitors

Also Published As

Publication number Publication date
EP1480644B1 (fr) 2010-10-13
NO335195B1 (no) 2014-10-20
TWI293071B (en) 2008-02-01
MXPA04006621A (es) 2004-10-04
PL220725B1 (pl) 2015-12-31
PT2279737E (pt) 2013-02-01
HRP20040686A2 (en) 2004-12-31
NO20043587L (no) 2004-08-27
FR2835186A1 (fr) 2003-08-01
KR20040081473A (ko) 2004-09-21
EP2279737A1 (fr) 2011-02-02
PL371601A1 (en) 2005-06-27
TNSN04137A1 (fr) 2007-03-12
HK1105864A1 (en) 2008-02-29
CY1114417T1 (el) 2016-08-31
US7612087B2 (en) 2009-11-03
KR100979079B1 (ko) 2010-08-31
EA200400981A1 (ru) 2005-02-24
OA12761A (fr) 2006-07-04
HK1077205A1 (en) 2006-02-10
EA007220B1 (ru) 2006-08-25
YU65804A (sh) 2006-08-17
CO5601014A2 (es) 2006-01-31
UA80271C2 (uk) 2007-09-10
ZA200405607B (en) 2005-09-28
CN100482225C (zh) 2009-04-29
PE20030969A1 (es) 2003-12-12
TW200303305A (en) 2003-09-01
SI2279737T1 (sl) 2013-07-31
AR038234A1 (es) 2005-01-05
CY2016042I2 (el) 2017-03-15
NL300847I2 (es) 2017-01-03
US20100048528A1 (en) 2010-02-25
FR2835186B1 (fr) 2006-10-20
DK1480644T3 (da) 2011-01-24
DE60334527D1 (de) 2010-11-25
NO2016024I2 (no) 2016-12-15
NO2016024I1 (no) 2016-12-15
EP2279737B1 (fr) 2012-10-31
WO2003063864A3 (fr) 2004-03-11
US20050020572A1 (en) 2005-01-27
MY140638A (en) 2010-01-15
US20110245254A1 (en) 2011-10-06
ES2401855T3 (es) 2013-04-25
CN1994301A (zh) 2007-07-11
US20090215747A1 (en) 2009-08-27
SI1480644T1 (sl) 2011-03-31
CL2011000009A1 (es) 2011-03-25
JP2005523897A (ja) 2005-08-11
HRP20040686B1 (hr) 2013-02-28
CN100563653C (zh) 2009-12-02
AR100790A2 (es) 2016-11-02
CA2474043C (fr) 2011-08-02
JP4472346B2 (ja) 2010-06-02
IL163167A (en) 2010-04-15
CN1655781A (zh) 2005-08-17
WO2003063864A2 (fr) 2003-08-07
MA26351A1 (fr) 2004-10-01
PT1480644E (pt) 2011-01-17
NZ533936A (en) 2007-05-31
UY27626A1 (es) 2003-08-29
RS52137B (en) 2012-08-31
ATE484281T1 (de) 2010-10-15
CY1111061T1 (el) 2015-06-11
LTPA2016037I1 (lt) 2017-01-10
BE2016C069I2 (es) 2022-05-17
CA2474043A1 (fr) 2003-08-07
AU2003214335B2 (en) 2007-04-05
BR0307267A (pt) 2004-12-07
CY2016042I1 (el) 2017-03-15
LTC1480644I2 (lt) 2018-09-10
CN101406471A (zh) 2009-04-15
ECSP045193A (es) 2004-08-27
DK2279737T3 (da) 2013-02-11
JO2646B1 (en) 2012-06-17
HUS1600055I1 (hu) 2017-01-30
CR20120356A (es) 2012-10-05
EP1480644A2 (fr) 2004-12-01
ES2356813T3 (es) 2011-04-13
BRPI0307267B8 (pt) 2021-05-25
BRPI0307267B1 (pt) 2016-02-10

Similar Documents

Publication Publication Date Title
CR7387A (es) Nuevos compuestos heterociclicos activos como inhibidores de las beta- lactamasas
CR10858A (es) Derivados de azacicloalcanos como inhibidores de estearoil-coenzima a delta-9 desaturasa
CY1119136T1 (el) Παραγωγο n3 αλκυλιωμενου βενζιμιδαζολιου ως αναστολεας μεκ
PA8527001A1 (es) Poliarilcarboxamidas utiles como agentes reductores de lipidos
ECSP12006640A (es) Inhibidores heterocíclicos de aspartil proteasa
CR8744A (es) Compuestos terapeuticos
EA200600925A1 (ru) Производные триазола в качестве антагонистов вазопрессина
UY26186A1 (es) Inhibidores de metaloproteasas
CR8387A (es) Compuestos de pirazolilo e imidazolilo biciclicos y uso de los mismos
ES2183331T3 (es) Inhibidores de sulfamida-metaloproteasa.
ECSP055729A (es) Nuevos inhibidores biciclicos de la lipasa sensible a hormonas
ATE389635T1 (de) Pharmazeutisch wirksame piperidinderivate
PT1305286E (pt) Ciclopentanoindoles composicoes que contem os referidos compostos e metodos de tratamento
ECSP088145A (es) Derivados bicíclicos como inhibidores de la cinasa p38
EA200501928A1 (ru) Пирролодигидроизохинолины как ингибиторы pde10
DOP2002000433A (es) 2-tio-3,5-diciano-4-fenil-6-aminopiridinas substituidas y su uso
UY27897A1 (es) Derivados de piperidina novedosos
CR8687A (es) Nuevos imidazoles
SV2003001099A (es) Nuevos derivados de acido sulfonico ref.pc23084
UY29892A1 (es) Nuevos derivados de cromano, composiciones farmaceuticas conteniendolos, procesos de preparacion y aplicaciones
UY27452A1 (es) Compuestos de benzimidazol sustituido y su uso para el tratamiento del cancer
ES2060818T3 (es) Derivados de indol, benzofurano y benzotiofeno sustituidos como inhibidores de la 5-lipooxigenasa.
EA200700550A1 (ru) Производные алкилидентетрагидронафталина, способ их получения и их применение в качестве противовоспалительных средств
ATE430726T1 (de) N-acylamino-benzyletherderivate als selektive inhibitoren der monoaminoxidase b
ECSP034754A (es) Derivados de beta-carbolina y su uso farmaceutico contra depresion y ansiedad