ECSP034754A - Derivados de beta-carbolina y su uso farmaceutico contra depresion y ansiedad - Google Patents

Derivados de beta-carbolina y su uso farmaceutico contra depresion y ansiedad

Info

Publication number
ECSP034754A
ECSP034754A EC2003004754A ECSP034754A ECSP034754A EC SP034754 A ECSP034754 A EC SP034754A EC 2003004754 A EC2003004754 A EC 2003004754A EC SP034754 A ECSP034754 A EC SP034754A EC SP034754 A ECSP034754 A EC SP034754A
Authority
EC
Ecuador
Prior art keywords
carbolina
anxiety
beta
derivatives
pharmaceutical use
Prior art date
Application number
EC2003004754A
Other languages
English (en)
Inventor
Konstanze Hurth
Thomas J Troxler
Daniel Hoyer
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of ECSP034754A publication Critical patent/ECSP034754A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La invención proporciona compuestos de la fórmula I: en donde R1 a R5 son como se definen en la descripción, y su preparación. Los compuestos de la fórmula I son útiles como productos farmacéuticos
EC2003004754A 2001-04-03 2003-08-27 Derivados de beta-carbolina y su uso farmaceutico contra depresion y ansiedad ECSP034754A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0108337.7A GB0108337D0 (en) 2001-04-03 2001-04-03 Organic compounds

Publications (1)

Publication Number Publication Date
ECSP034754A true ECSP034754A (es) 2003-10-28

Family

ID=9912165

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2003004754A ECSP034754A (es) 2001-04-03 2003-08-27 Derivados de beta-carbolina y su uso farmaceutico contra depresion y ansiedad

Country Status (27)

Country Link
US (1) US6861430B2 (es)
EP (1) EP1377578B1 (es)
JP (1) JP4405732B2 (es)
KR (1) KR100564840B1 (es)
CN (1) CN1309721C (es)
AR (1) AR035451A1 (es)
AT (1) ATE517104T1 (es)
AU (1) AU2002316828B2 (es)
BR (1) BR0208566B1 (es)
CA (1) CA2440014C (es)
CZ (1) CZ295992B6 (es)
EC (1) ECSP034754A (es)
ES (1) ES2368389T3 (es)
GB (1) GB0108337D0 (es)
HU (1) HUP0400317A3 (es)
IL (1) IL157545A0 (es)
MX (1) MXPA03009057A (es)
MY (1) MY134026A (es)
NO (1) NO20034413D0 (es)
NZ (1) NZ528370A (es)
PE (1) PE20021018A1 (es)
PL (1) PL210861B1 (es)
PT (1) PT1377578E (es)
RU (1) RU2003130644A (es)
SK (1) SK12222003A3 (es)
WO (1) WO2002081471A1 (es)
ZA (1) ZA200306108B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10164139A1 (de) 2001-12-27 2003-07-10 Bayer Ag 2-Heteroarylcarbonsäureamide
ES2427166T3 (es) 2003-06-23 2013-10-29 Ono Pharmaceutical Co., Ltd. Compuesto heterocíclico tricíclico novedoso
AR051780A1 (es) * 2004-11-29 2007-02-07 Japan Tobacco Inc Compuestos en anillo fusionados que contienen nitrogeno y utilizacion de los mismos
ES2459742T3 (es) 2004-12-22 2014-05-12 Ono Pharmaceutical Co., Ltd. Compuesto tricíclico y uso del mismo
US20070149557A1 (en) * 2005-11-21 2007-06-28 Amgen Inc. CXCR3 antagonists
US7879859B2 (en) 2005-11-21 2011-02-01 Merck Sharp & Dohme Corp. Diagnosis and treatment of type 2 diabetes and other disorders
WO2009011836A1 (en) * 2007-07-19 2009-01-22 Merck & Co., Inc. Beta carboline derivatives as antidiabetic compounds
WO2009016329A1 (en) * 2007-07-31 2009-02-05 Cambridge Enterprise Limited Use of gabaa receptor antagonists to treat cognitive impairment in patients with psychiatric conditions
US8338604B2 (en) 2008-06-20 2012-12-25 Bristol-Myers Squibb Company Imidazopyridine and imidazopyrazine compounds useful as kinase inhibitors
CA3017886A1 (en) 2008-11-19 2010-05-27 Envivo Pharmaceuticals, Inc. Treatment of cognitive disorders with (r)-7-chloro-n-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide and pharmaceutically acceptable salts thereof
TW201028414A (en) * 2009-01-16 2010-08-01 Merck Sharp & Dohme Oxadiazole beta carboline derivatives as antidiabetic compounds
AU2011205483A1 (en) 2010-01-15 2012-07-26 Merck Sharp & Dohme Corp. Oxadiazole beta carboline derivatives as antidiabetic compounds
DK3029039T3 (en) 2010-05-17 2017-12-04 Forum Pharmaceuticals Inc PHARMACEUTICAL FORMS CONTAINING CRYSTALLINIC FORMS OF (R) -7-CHLOR-N- (QUINUCLIDIN-3-YL) BENZO (B) THIOPHEN-2-CARBOXAMIDE HYDROCHLORIDE MONOHYDRATE
WO2013169646A1 (en) 2012-05-08 2013-11-14 Envivo Pharmaceuticals, Inc. Methods of maintaining, treating or improving cognitive function
CN111349096B (zh) * 2020-04-14 2021-03-09 石河子大学 一种吲哚类化合物及其制备方法、应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4118741A1 (de) * 1991-06-05 1992-12-10 Schering Ag Neue hetaryloxy-(beta)-carboline, deren herstellung und verwendung in arzneimitteln
US6057340A (en) * 1998-02-03 2000-05-02 American Home Products Corporation Oxazole derivatives as serotonin-1A receptor agonists
AU761020B2 (en) 1998-06-12 2003-05-29 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) Beta-carboline compounds

Also Published As

Publication number Publication date
US20040132735A1 (en) 2004-07-08
CN1309721C (zh) 2007-04-11
IL157545A0 (en) 2004-03-28
KR20040008150A (ko) 2004-01-28
CA2440014C (en) 2010-11-23
EP1377578B1 (en) 2011-07-20
EP1377578A1 (en) 2004-01-07
NZ528370A (en) 2005-10-28
AU2002316828B2 (en) 2006-05-11
SK12222003A3 (sk) 2004-06-08
AR035451A1 (es) 2004-05-26
ZA200306108B (en) 2004-07-05
JP2004525178A (ja) 2004-08-19
PE20021018A1 (es) 2003-01-13
KR100564840B1 (ko) 2006-03-28
CN1500090A (zh) 2004-05-26
CA2440014A1 (en) 2002-10-17
ATE517104T1 (de) 2011-08-15
HUP0400317A3 (en) 2007-10-29
PT1377578E (pt) 2011-09-23
GB0108337D0 (en) 2001-05-23
BR0208566A (pt) 2004-03-30
HUP0400317A2 (hu) 2004-09-28
CZ295992B6 (cs) 2005-12-14
US6861430B2 (en) 2005-03-01
MXPA03009057A (es) 2004-02-12
MY134026A (en) 2007-11-30
PL362571A1 (en) 2004-11-02
WO2002081471A1 (en) 2002-10-17
PL210861B1 (pl) 2012-03-30
JP4405732B2 (ja) 2010-01-27
CZ20032655A3 (cs) 2003-12-17
BR0208566B1 (pt) 2013-12-24
NO20034413L (no) 2003-10-02
RU2003130644A (ru) 2005-04-10
NO20034413D0 (no) 2003-10-02
ES2368389T3 (es) 2011-11-16

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