CR20230382A - Derivados de tetrahidroazepina bicíclicos para el tratamiento del cáncer - Google Patents

Derivados de tetrahidroazepina bicíclicos para el tratamiento del cáncer

Info

Publication number
CR20230382A
CR20230382A CR20230382A CR20230382A CR20230382A CR 20230382 A CR20230382 A CR 20230382A CR 20230382 A CR20230382 A CR 20230382A CR 20230382 A CR20230382 A CR 20230382A CR 20230382 A CR20230382 A CR 20230382A
Authority
CR
Costa Rica
Prior art keywords
sup
cancer
treatment
bicyclic
tetrahydroazepine
Prior art date
Application number
CR20230382A
Other languages
English (en)
Inventor
Holger Kuehne
Bernd Kuhn
Adrian Britschgi
Roman Hutter
Marco Brandstaetter
Laetitia Janine Martin
Juergen Wichmann
Thomas Luebbers
Barbara Johanna Mueller
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of CR20230382A publication Critical patent/CR20230382A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Abstract

La presente invención proporciona nuevos derivados de tetrahidroazepina bicíclicos que tienen la Fórmula general (I) <img alt="" src="data:image/png;base64,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 (***)
CR20230382A 2021-02-12 2022-02-10 Derivados de tetrahidroazepina bicíclicos para el tratamiento del cáncer CR20230382A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP21156877 2021-02-12
EP21186928 2021-07-21
PCT/EP2022/053257 WO2022171745A1 (en) 2021-02-12 2022-02-10 Bicyclic tetrahydroazepine derivatives for the treatment of cancer

Publications (1)

Publication Number Publication Date
CR20230382A true CR20230382A (es) 2023-09-06

Family

ID=80461879

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20230382A CR20230382A (es) 2021-02-12 2022-02-10 Derivados de tetrahidroazepina bicíclicos para el tratamiento del cáncer

Country Status (12)

Country Link
EP (1) EP4291558A1 (es)
JP (1) JP2024506339A (es)
KR (1) KR20230146052A (es)
AU (1) AU2022221124A1 (es)
CA (1) CA3210553A1 (es)
CL (1) CL2023002362A1 (es)
CO (1) CO2023010694A2 (es)
CR (1) CR20230382A (es)
IL (1) IL304595A (es)
PE (1) PE20231505A1 (es)
TW (1) TW202246257A (es)
WO (1) WO2022171745A1 (es)

Families Citing this family (2)

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WO2024033389A1 (en) * 2022-08-11 2024-02-15 F. Hoffmann-La Roche Ag Bicyclic tetrahydrothiazepine derivatives

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JP2024506339A (ja) 2024-02-13
PE20231505A1 (es) 2023-09-26
KR20230146052A (ko) 2023-10-18
IL304595A (en) 2023-09-01
TW202246257A (zh) 2022-12-01
EP4291558A1 (en) 2023-12-20
CO2023010694A2 (es) 2023-08-18
AU2022221124A1 (en) 2023-08-03
CL2023002362A1 (es) 2023-12-29
WO2022171745A1 (en) 2022-08-18
CA3210553A1 (en) 2022-08-18

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