CR20220317A - Anticuerpos anti-cd73 y usos de estos - Google Patents

Anticuerpos anti-cd73 y usos de estos

Info

Publication number
CR20220317A
CR20220317A CR20220317A CR20220317A CR20220317A CR 20220317 A CR20220317 A CR 20220317A CR 20220317 A CR20220317 A CR 20220317A CR 20220317 A CR20220317 A CR 20220317A CR 20220317 A CR20220317 A CR 20220317A
Authority
CR
Costa Rica
Prior art keywords
antibodies
disclosed
vectors
cells
methods
Prior art date
Application number
CR20220317A
Other languages
English (en)
Inventor
Shaun M Stewart
Juan Carlos Almagro
Rebecca A Buonpane
Jing Zhou
Horacio G Nastri
Original Assignee
Incyte Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Corp filed Critical Incyte Corp
Publication of CR20220317A publication Critical patent/CR20220317A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Fats And Perfumes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Se describen anticuerpos anti-CD73. También se describen ácidos núcleicos, vectores, células y composiciones farmacéuticas relacionados. También se describen métodos para tratar el cáncer con los anticuerpos anti-CD73.,
CR20220317A 2020-01-03 2020-12-30 Anticuerpos anti-cd73 y usos de estos CR20220317A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202062956847P 2020-01-03 2020-01-03
PCT/US2020/067533 WO2021138467A1 (en) 2020-01-03 2020-12-30 Anti-cd73 antibodies and uses thereof

Publications (1)

Publication Number Publication Date
CR20220317A true CR20220317A (es) 2022-09-02

Family

ID=74347717

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20220317A CR20220317A (es) 2020-01-03 2020-12-30 Anticuerpos anti-cd73 y usos de estos

Country Status (17)

Country Link
EP (1) EP4084825A1 (es)
JP (1) JP2023509448A (es)
KR (1) KR20220121850A (es)
CN (1) CN115135341A (es)
AR (1) AR120936A1 (es)
AU (1) AU2020417804A1 (es)
BR (1) BR112022013236A2 (es)
CA (1) CA3166533A1 (es)
CL (1) CL2022001769A1 (es)
CO (1) CO2022009248A2 (es)
CR (1) CR20220317A (es)
EC (1) ECSP22051701A (es)
IL (1) IL294436A (es)
MX (1) MX2022007575A (es)
PE (1) PE20221409A1 (es)
TW (1) TW202128768A (es)
WO (1) WO2021138467A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117903140A (zh) 2018-02-27 2024-04-19 因赛特公司 作为a2a/a2b抑制剂的咪唑并嘧啶和***并嘧啶
CA3100731A1 (en) 2018-05-18 2019-11-21 Incyte Corporation Fused pyrimidine derivatives as a2a / a2b inhibitors
TWI829716B (zh) 2018-07-05 2024-01-21 美商英塞特公司 作為a2a/a2b 抑制劑之稠合吡嗪衍生物
TWI829857B (zh) 2019-01-29 2024-01-21 美商英塞特公司 作為a2a / a2b抑制劑之吡唑并吡啶及***并吡啶
MX2023007850A (es) * 2020-12-29 2023-09-11 Incyte Corp Terapia combinada que comprende inhibidores de adora2a/adora2b (a2a/a2b), inhibidores de muerte programada/ligando 1 de muerte programada (pd-1/pd-l1) y anticuerpos de cumulo de diferenciacion 73 (anti-cd73).
CN113025567A (zh) * 2021-03-31 2021-06-25 中国人民解放军陆军特色医学中心 一种椎间盘单细胞的分离方法
WO2023201267A1 (en) 2022-04-13 2023-10-19 Gilead Sciences, Inc. Combination therapy for treating trop-2 expressing cancers
WO2024040194A1 (en) 2022-08-17 2024-02-22 Capstan Therapeutics, Inc. Conditioning for in vivo immune cell engineering

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4634665A (en) 1980-02-25 1987-01-06 The Trustees Of Columbia University In The City Of New York Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US4399216A (en) 1980-02-25 1983-08-16 The Trustees Of Columbia University Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US5179017A (en) 1980-02-25 1993-01-12 The Trustees Of Columbia University In The City Of New York Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US5156840A (en) 1982-03-09 1992-10-20 Cytogen Corporation Amine-containing porphyrin derivatives
US5057313A (en) 1986-02-25 1991-10-15 The Center For Molecular Medicine And Immunology Diagnostic and therapeutic antibody conjugates
DE3920358A1 (de) 1989-06-22 1991-01-17 Behringwerke Ag Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
EP0617706B1 (en) 1991-11-25 2001-10-17 Enzon, Inc. Multivalent antigen-binding proteins
US5714350A (en) 1992-03-09 1998-02-03 Protein Design Labs, Inc. Increasing antibody affinity by altering glycosylation in the immunoglobulin variable region
US5827690A (en) 1993-12-20 1998-10-27 Genzyme Transgenics Corporatiion Transgenic production of antibodies in milk
US5731168A (en) 1995-03-01 1998-03-24 Genentech, Inc. Method for making heteromultimeric polypeptides
US5869046A (en) 1995-04-14 1999-02-09 Genentech, Inc. Altered polypeptides with increased half-life
JP4667383B2 (ja) 2003-06-13 2011-04-13 バイオジェン・アイデック・エムエイ・インコーポレイテッド アグリコシル抗ｃｄ１５４（ｃｄ４０リガンド）抗体およびその使用
JP2007503206A (ja) 2003-08-22 2007-02-22 バイオジェン・アイデック・エムエイ・インコーポレイテッド 変更されたエフェクター機能を有する改良された抗体およびその抗体を産生する方法
JP6755866B2 (ja) * 2014-11-10 2020-09-16 メディミューン リミテッド Ｃｄ７３特異的結合分子及びその使用
GB2538120A (en) * 2014-11-11 2016-11-09 Medimmune Ltd Therapeutic combinations comprising anti-CD73 antibodies and uses thereof
MX2017006624A (es) * 2014-11-21 2017-08-21 Bristol Myers Squibb Co Anticuerpos contra cd73 y sus usos.
CN109476740A (zh) * 2016-03-04 2019-03-15 百时美施贵宝公司 利用抗cd73抗体的联合治疗
WO2018013611A1 (en) * 2016-07-11 2018-01-18 Corvus Pharmaceuticals, Inc. Anti-cd73 antibodies
MY188386A (en) * 2017-01-24 2021-12-07 I Mab Biopharma Us Ltd Anti-cd73 antibodies and uses thereof
JP7319992B2 (ja) * 2018-03-09 2023-08-02 アジェナス インコーポレイテッド 抗ｃｄ７３抗体およびそれらの使用方法
MX2020009366A (es) * 2018-03-09 2020-10-14 Phanes Therapeutics Inc Anticuerpos anti-cd73 y usos de los mismos.
US20210214459A1 (en) * 2018-05-31 2021-07-15 Novartis Ag Antibody molecules to cd73 and uses thereof

Also Published As

Publication number Publication date
JP2023509448A (ja) 2023-03-08
AR120936A1 (es) 2022-03-30
CL2022001769A1 (es) 2023-01-20
CO2022009248A2 (es) 2022-08-19
CA3166533A1 (en) 2021-07-08
PE20221409A1 (es) 2022-09-20
AU2020417804A1 (en) 2022-07-21
BR112022013236A2 (pt) 2022-09-06
KR20220121850A (ko) 2022-09-01
MX2022007575A (es) 2022-09-23
TW202128768A (zh) 2021-08-01
CN115135341A (zh) 2022-09-30
IL294436A (en) 2022-09-01
EP4084825A1 (en) 2022-11-09
ECSP22051701A (es) 2022-08-31
US20210230293A1 (en) 2021-07-29
WO2021138467A1 (en) 2021-07-08

Similar Documents

Publication Publication Date Title
CR20220317A (es) Anticuerpos anti-cd73 y usos de estos
MX2020009514A (es) Anticuerpos anti-claudina 18.2 (cldn18.2).
EP4339287A3 (en) Modified cells and methods of therapy
WO2019006418A3 (en) ADENO-ASSOCIATED VIRAL VECTORS FOR GENE THERAPY
PH12020551923A1 (en) Methods and compositions for treating cancer
CR20220396A (es) Anticuerpos y proteínas de fusión que se unen a ccr8 y usos de estos
MX2021002415A (es) Celulas madre hematopoyeticas modificadas geneticamente y usos de las mismas.
MX2020009366A (es) Anticuerpos anti-cd73 y usos de los mismos.
AU2018236742B2 (en) Compositions of adenosine deaminase-2 (ada2), variants thereof and methods of using same
ZA202004730B (en) Anti-claudin 18.2 antibodies and uses thereof
CA3156451A1 (en) ANTIBODIES WITH SPECIFICITY FOR NECTIN-4 AND THEIR USES
MX2021006681A (es) Anticuerpos anti-claudina y usos de los mismos.
MX2018006973A (es) Anticuerpos anti-cd73 humanizados.
PH12020551907A1 (en) Antagonizing cd73 antibody
WO2021007428A3 (en) Molecules, compositions and methods for treatment of cancer
WO2019090148A3 (en) Compositions and methods related to therapeutic cell systems for tumor growth inhibition
MX2020003339A (es) Arn guía de cpf1 modificado.
MX2020006901A (es) Composiciones de pares de bases no naturales y procedimientos de uso.
WO2019056023A3 (en) Claudin6 antibodies and methods of treating cancer
EA202191257A1 (ru) Противораковая терапия на основе иммуноцитов, связывающих liv1
MX2021012003A (es) Anticuerpos multiespecificos contra antigeno de cancer de la bomba de eflujo y composiciones, reactivos, kits y metodos relacionados con los mismos.
BR112022012867A2 (pt) Tratamento de câncer com inibidores de cdk12/13
BR112022005114A2 (pt) Anticorpo, composição farmacêutica, métodos para tratar câncer e para produzir um conjugado anticorpo-fármaco e um anticorpo, ácido nucleico, vetor, célula hospedeira, e, conjugado anticorpo-fármaco
WO2022082073A3 (en) Compositions and methods for muc18 targeting
MX2020009522A (es) Anticuerpos anti-folato del receptor 1 y usos de los mismos.