CR20170164A - Coagonistas de los receptores de glucagón y de glp-1 - Google Patents

Coagonistas de los receptores de glucagón y de glp-1

Info

Publication number
CR20170164A
CR20170164A CR20170164A CR20170164A CR20170164A CR 20170164 A CR20170164 A CR 20170164A CR 20170164 A CR20170164 A CR 20170164A CR 20170164 A CR20170164 A CR 20170164A CR 20170164 A CR20170164 A CR 20170164A
Authority
CR
Costa Rica
Prior art keywords
glucagon
receptor
glp
coagonists
peptide
Prior art date
Application number
CR20170164A
Other languages
English (en)
Inventor
E Paul Carrington
Qiaolin Deng
Anandan Palani
Federica Orvieto
Antonello Pessi
Chengwei Wu
Ravi Nargund
Thomas Joseph Tucker
Elisabetta Bianchi
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=54397022&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CR20170164(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of CR20170164A publication Critical patent/CR20170164A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/26—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Se describen análogos peptídicos de glucagón, que se han modificado para que sean resistentes a la escisión e inactivación por dipeptidilpeptidasa IV (DPP-IV) y para incrementar la semivida in vivo del análogo peptídico mientras que permite que el análogo peptídico tenga una actividad agonista relativamente equilibrada en el receptor del péptido 5 similar al glucagón 1 (GLP-1) y en el receptor de glucagón (GCG), y al uso de dichos coagonistas de receptor de GLP-1/receptor de GCG para el tratamiento de trastornos metabólicos tales como diabetes, hesteatosis hepática no alcohólica (NAFLD), esteatohepatitis no alcohólica (NASH) y obesidad.
CR20170164A 2014-10-24 2015-10-22 Coagonistas de los receptores de glucagón y de glp-1 CR20170164A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462068157P 2014-10-24 2014-10-24
US201562208869P 2015-08-24 2015-08-24
PCT/US2015/056794 WO2016065090A1 (en) 2014-10-24 2015-10-22 Co-agonists of the glucagon and glp-1 receptors

Publications (1)

Publication Number Publication Date
CR20170164A true CR20170164A (es) 2017-08-29

Family

ID=54397022

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20170164A CR20170164A (es) 2014-10-24 2015-10-22 Coagonistas de los receptores de glucagón y de glp-1

Country Status (26)

Country Link
US (2) US10413593B2 (es)
EP (2) EP3825324A1 (es)
JP (1) JP6581656B2 (es)
KR (1) KR101996739B1 (es)
CN (1) CN107108715A (es)
AU (1) AU2015335828B2 (es)
BR (1) BR112017008160A8 (es)
CA (2) CA3093383A1 (es)
CL (1) CL2017000982A1 (es)
CO (1) CO2017003832A2 (es)
CR (1) CR20170164A (es)
DO (1) DOP2017000102A (es)
EA (1) EA201790914A1 (es)
GT (1) GT201700085A (es)
IL (1) IL251741A0 (es)
MA (1) MA55068A (es)
MD (1) MD20170055A2 (es)
MX (1) MX2017005280A (es)
NI (1) NI201700048A (es)
PE (1) PE20180158A1 (es)
PH (1) PH12017500761A1 (es)
SG (1) SG11201703238TA (es)
SV (1) SV2017005425A (es)
TN (1) TN2017000148A1 (es)
TW (1) TW201625672A (es)
WO (1) WO2016065090A1 (es)

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UA116217C2 (uk) 2012-10-09 2018-02-26 Санофі Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону
JP2016503771A (ja) 2012-12-21 2016-02-08 サノフイ エキセンジン−４誘導体
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AR105284A1 (es) 2015-07-10 2017-09-20 Sanofi Sa Derivados de exendina-4 como agonistas peptídicos duales específicos de los receptores de glp-1 / glucagón
US10793615B2 (en) 2015-10-27 2020-10-06 Merck Sharp & Dohme Corp. Long-acting co-agonists of the glucagon and GLP-1 receptors
EP3664833B1 (en) * 2017-08-09 2023-05-31 Sanofi Glp-1/glucagon receptor agonists in the treatment of fatty liver disease and steatohepatitis
BR112020005841A8 (pt) * 2017-09-25 2023-04-11 Merck Sharp & Dohme Peptídeo coagonista do receptor de gcg/glp-1, composição, método para tratar um paciente de uma doença ou distúrbio metabólico, e, uso de um ou mais peptídeos coagonistas.
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CN116891522B (zh) * 2022-04-01 2024-05-14 南京知和医药科技有限公司 一种长效胰高血糖素样肽-1衍生物及其制备方法和用途
CN115536739B (zh) * 2022-07-04 2023-04-14 北京惠之衡生物科技有限公司 一种glp-1受体和gcg受体共激动多肽衍生物的制备方法
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EA201790914A1 (ru) 2017-08-31
US20160114000A1 (en) 2016-04-28
KR20170073638A (ko) 2017-06-28
DOP2017000102A (es) 2017-07-15
TN2017000148A1 (en) 2018-10-19
BR112017008160A2 (pt) 2018-03-06
MD20170055A2 (ro) 2017-09-30
CA2964379C (en) 2023-08-15
AU2015335828B2 (en) 2018-08-23
GT201700085A (es) 2018-11-27
IL251741A0 (en) 2017-06-29
BR112017008160A8 (pt) 2023-04-11
JP6581656B2 (ja) 2019-09-25
CA3093383A1 (en) 2016-04-28
EP3209682A1 (en) 2017-08-30
WO2016065090A1 (en) 2016-04-28
SV2017005425A (es) 2018-04-04
US10413593B2 (en) 2019-09-17
CO2017003832A2 (es) 2017-06-30
NI201700048A (es) 2017-06-12
AU2015335828A1 (en) 2017-05-11
SG11201703238TA (en) 2017-05-30
EP3825324A1 (en) 2021-05-26
PH12017500761A1 (en) 2017-10-09
CL2017000982A1 (es) 2017-11-10
MA55068A (fr) 2022-01-05
PE20180158A1 (es) 2018-01-18
KR101996739B1 (ko) 2019-10-01
CN107108715A (zh) 2017-08-29
CA2964379A1 (en) 2016-04-28
EP3209682B1 (en) 2020-12-30
MX2017005280A (es) 2017-08-15
US20170360893A1 (en) 2017-12-21
TW201625672A (zh) 2016-07-16
JP2017537068A (ja) 2017-12-14

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