PE20180158A1 - Coagonistas de los receptores de glucagon y de glp-1 - Google Patents

Coagonistas de los receptores de glucagon y de glp-1

Info

Publication number
PE20180158A1
PE20180158A1 PE2017001204A PE2017001204A PE20180158A1 PE 20180158 A1 PE20180158 A1 PE 20180158A1 PE 2017001204 A PE2017001204 A PE 2017001204A PE 2017001204 A PE2017001204 A PE 2017001204A PE 20180158 A1 PE20180158 A1 PE 20180158A1
Authority
PE
Peru
Prior art keywords
glucagon
leucine
alanine
glp
lysine
Prior art date
Application number
PE2017001204A
Other languages
English (en)
Inventor
Paul E Carrington
Qiaolin Deng
Ravi Nargund
Anandan Palani
Thomas Joseph Tucker
Chengwei Wu
Elisabetta Bianchi
Federica Orvieto
Antonello Pessi
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=54397022&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20180158(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of PE20180158A1 publication Critical patent/PE20180158A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/26—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

SE REFIERE A UN PEPTIDO QUE COMPRENDE LA SECUENCIA DE AMINOACIDOS: HX2QGTX6TSDX10SX12YLX15X16RX18AQDFVQWLX27DT (SEQ ID N°: 20), DONDE X2 ES D-SERINA, L-ALANINA, ENTRE OTROS; X6 ES L-FENILALANINA, PARA-FLUOROFENILALANINA, ENTRE OTROS; X10 ES L-LISINA O PARA-AMINOMETILFENILALANINA; X12 ES L-LISINA O L-LEUCINA; X15 ES ACIDO L-GLUTAMICO, L-LEUCINA, ENTRE OTROS; X16 ES L-ALANINA, ACIDO L-GLUTAMICO, ENTRE OTROS; X18 ES L-ALANINA O L-ARGININA; X27 ES L-LEUCINA, METIONINA SULFONA O L-NORLEUCINA; EN DONDE DICHO POLIPEPTIDO TIENE LA SECUENCIA DE AMINOACIDOS DE SEC ID N°: 7, 8, 9, 10, 12, 13, 14, 15, 16, 17, 18 O 19. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS POLIPEPTIDOS SON ANALOGOS DE GLUCAGON Y TIENEN ACTIVIDAD AGONISTA SOBRE EL RECEPTOR DEL PEPTIDO SIMILAR A GLUCAGON 1 (GLP-1) Y SOBRE EL RECEPTOR DE GLUCAGON (GCG) SIENDO UTILES EN EL TRATAMIENTO DE TRASTORNOS METABOLICOS COMO DIABETES, OBESIDAD
PE2017001204A 2014-10-24 2015-10-22 Coagonistas de los receptores de glucagon y de glp-1 PE20180158A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462068157P 2014-10-24 2014-10-24
US201562208869P 2015-08-24 2015-08-24

Publications (1)

Publication Number Publication Date
PE20180158A1 true PE20180158A1 (es) 2018-01-18

Family

ID=54397022

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2017001204A PE20180158A1 (es) 2014-10-24 2015-10-22 Coagonistas de los receptores de glucagon y de glp-1

Country Status (26)

Country Link
US (2) US10413593B2 (es)
EP (2) EP3209682B1 (es)
JP (1) JP6581656B2 (es)
KR (1) KR101996739B1 (es)
CN (1) CN107108715A (es)
AU (1) AU2015335828B2 (es)
BR (1) BR112017008160A8 (es)
CA (2) CA3093383A1 (es)
CL (1) CL2017000982A1 (es)
CO (1) CO2017003832A2 (es)
CR (1) CR20170164A (es)
DO (1) DOP2017000102A (es)
EA (1) EA201790914A1 (es)
GT (1) GT201700085A (es)
IL (1) IL251741A0 (es)
MA (1) MA55068A (es)
MD (1) MD20170055A2 (es)
MX (1) MX2017005280A (es)
NI (1) NI201700048A (es)
PE (1) PE20180158A1 (es)
PH (1) PH12017500761A1 (es)
SG (1) SG11201703238TA (es)
SV (1) SV2017005425A (es)
TN (1) TN2017000148A1 (es)
TW (1) TW201625672A (es)
WO (1) WO2016065090A1 (es)

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CN114349828B (zh) * 2020-11-27 2023-12-08 江苏师范大学 Glp-1/胰高血糖素受体双重激动剂及其应用
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CN112608378B (zh) * 2020-12-09 2023-09-08 江苏师范大学 一类glp-1/胆囊收缩素-1受体双重激动剂及其应用
CN116891522B (zh) * 2022-04-01 2024-05-14 南京知和医药科技有限公司 一种长效胰高血糖素样肽-1衍生物及其制备方法和用途
CN115536739B (zh) * 2022-07-04 2023-04-14 北京惠之衡生物科技有限公司 一种glp-1受体和gcg受体共激动多肽衍生物的制备方法
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Also Published As

Publication number Publication date
SV2017005425A (es) 2018-04-04
KR20170073638A (ko) 2017-06-28
MD20170055A2 (ro) 2017-09-30
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BR112017008160A8 (pt) 2023-04-11
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DOP2017000102A (es) 2017-07-15
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AU2015335828A1 (en) 2017-05-11
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