CR20160514A - Derivados de indol para uso en medicina - Google Patents
Derivados de indol para uso en medicinaInfo
- Publication number
- CR20160514A CR20160514A CR20160514A CR20160514A CR20160514A CR 20160514 A CR20160514 A CR 20160514A CR 20160514 A CR20160514 A CR 20160514A CR 20160514 A CR20160514 A CR 20160514A CR 20160514 A CR20160514 A CR 20160514A
- Authority
- CR
- Costa Rica
- Prior art keywords
- medicine
- indol derivatives
- dioxygenase
- indol
- derivatives
- Prior art date
Links
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical class C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 title 1
- 101710136122 Tryptophan 2,3-dioxygenase Proteins 0.000 abstract 2
- 102000057288 Tryptophan 2,3-dioxygenases Human genes 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 102000006639 indoleamine 2,3-dioxygenase Human genes 0.000 abstract 2
- 108020004201 indoleamine 2,3-dioxygenase Proteins 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
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- A61K31/33—Heterocyclic compounds
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- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
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- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
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- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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- A61K31/415—1,2-Diazoles
- A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
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- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
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- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
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- A61K31/4164—1,3-Diazoles
- A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
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- A61K31/4196—1,2,4-Triazoles
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- A61K31/4355—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having oxygen as a ring hetero atom
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- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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- A61K31/47—Quinolines; Isoquinolines
- A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
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Abstract
Se proporciona un compuesto inhibidor de la triptófano-2,3-dioxigenasa (TDO) y/o indoleamina -2,3-dioxigenasa (IDO) para su uso en medicina, cuyo compuesto comprende la siguiente Fórmula: en donde X1, X2, X3, X4, y X5 pueden ser iguales o diferentes y cada uno se selecciona independientemente a partir de C, N y O
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GB201406154A GB201406154D0 (en) | 2014-04-04 | 2014-04-04 | Pharmaceutical compound |
GB201502156A GB201502156D0 (en) | 2015-02-10 | 2015-02-10 | Pharmaceutical compound |
PCT/EP2015/055823 WO2015150097A1 (en) | 2014-04-04 | 2015-03-19 | Indole derivatives for use in medicine |
Publications (1)
Publication Number | Publication Date |
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CR20160514A true CR20160514A (es) | 2017-07-26 |
Family
ID=52686389
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CR20160514A CR20160514A (es) | 2014-04-04 | 2015-03-19 | Derivados de indol para uso en medicina |
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EP (1) | EP3125883B1 (es) |
JP (2) | JP6554117B2 (es) |
KR (1) | KR20160140892A (es) |
CN (1) | CN106715417B (es) |
AU (1) | AU2015239886B2 (es) |
BR (1) | BR112016022785B8 (es) |
CA (1) | CA2944240A1 (es) |
CR (1) | CR20160514A (es) |
CY (1) | CY1123548T1 (es) |
DK (1) | DK3125883T3 (es) |
EA (1) | EA032760B1 (es) |
ES (1) | ES2823825T3 (es) |
GE (1) | GEP20217247B (es) |
HR (1) | HRP20201621T1 (es) |
HU (1) | HUE052099T2 (es) |
LT (1) | LT3125883T (es) |
MA (1) | MA39840B1 (es) |
MX (1) | MX2016012984A (es) |
NZ (1) | NZ725860A (es) |
PL (1) | PL3125883T3 (es) |
PT (1) | PT3125883T (es) |
RS (1) | RS60878B1 (es) |
SI (1) | SI3125883T1 (es) |
UA (1) | UA121386C2 (es) |
WO (1) | WO2015150097A1 (es) |
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BR112023017582A2 (pt) | 2021-03-05 | 2023-12-05 | Univ Basel | Composições para o tratamento de doenças ou condições associadas ao ebv |
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KR20240046323A (ko) | 2021-07-13 | 2024-04-08 | 비온테크 에스이 | 암에 대한 병용 요법에 있어서 cd40 및 cd137에 대한 다중특이 결합제 |
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